YOR372C / NDD1

Transcriptional activator essential for nuclear division; localized to the nucleus; essential component of the mechanism that activates the expression of a set of late-S-phase-specific genes

Zygosity: Heterozygous strain
fixedexpanded
Profile for YOR372C / NDD1

Click on Significant Values for Screen Details ID:SGTC_79|Compound:0052-0007|FD-Score:-4.52|P-value:3.59E-6 ID:SGTC_119|Compound:0121-0043|FD-Score:5.47|P-value:4.14E-8 ID:SGTC_268|Compound:camptothecin|FD-Score:3.26|P-value:7.26E-4 ID:SGTC_291|Compound:4130-1278|FD-Score:-3.35|P-value:4.36E-4 ID:SGTC_362|Compound:0310-0100|FD-Score:-3.11|P-value:9.76E-4 ID:SGTC_394|Compound:menadione|FD-Score:-3.77|P-value:9.16E-5 ID:SGTC_420|Compound:mitomycin C|FD-Score:-3.11|P-value:9.86E-4 ID:SGTC_436|Compound:n,n-dimethylsphingosine|FD-Score:3.30|P-value:6.28E-4 ID:SGTC_673|Compound:1082-0474|FD-Score:5.67|P-value:1.35E-8 ID:SGTC_773|Compound:4358-1457|FD-Score:4.17|P-value:2.26E-5 ID:SGTC_955|Compound:1216-0110|FD-Score:-3.17|P-value:8.00E-4 ID:SGTC_1015|Compound:4130-4525|FD-Score:3.99|P-value:4.70E-5 ID:SGTC_1026|Compound:k007-1105|FD-Score:3.30|P-value:6.25E-4 ID:SGTC_1139|Compound:k015-0024|FD-Score:-3.72|P-value:1.12E-4 ID:SGTC_1252|Compound:0493-0875|FD-Score:-3.31|P-value:5.01E-4 ID:SGTC_1537|Compound:2',6'-dihydroxyflavanone|FD-Score:3.44|P-value:3.85E-4 ID:SGTC_1602|Compound:st001878|FD-Score:-3.48|P-value:2.72E-4 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:3.25|P-value:7.48E-4 ID:SGTC_1798|Compound:st045719|FD-Score:-3.75|P-value:9.85E-5 ID:SGTC_1962|Compound:st076595|FD-Score:3.55|P-value:2.57E-4 ID:SGTC_2060|Compound:5238662|FD-Score:-3.67|P-value:1.34E-4 ID:SGTC_2195|Compound:6536160|FD-Score:3.89|P-value:6.95E-5 ID:SGTC_2198|Compound:6589944|FD-Score:-3.18|P-value:7.75E-4 ID:SGTC_2240|Compound:6690706|FD-Score:3.56|P-value:2.46E-4 ID:SGTC_2243|Compound:6634756|FD-Score:-3.69|P-value:1.21E-4 ID:SGTC_2301|Compound:7769476|FD-Score:4.34|P-value:1.07E-5 ID:SGTC_2316|Compound:5844804|FD-Score:3.47|P-value:3.52E-4 ID:SGTC_2331|Compound:7980721|FD-Score:-4.38|P-value:7.08E-6 ID:SGTC_2337|Compound:9009472|FD-Score:-8.08|P-value:6.84E-16 ID:SGTC_2338|Compound:7999974|FD-Score:3.58|P-value:2.36E-4 ID:SGTC_2393|Compound:9031399|FD-Score:-8.78|P-value:1.99E-18 ID:SGTC_2396|Compound:5342950|FD-Score:4.02|P-value:4.14E-5 ID:SGTC_2398|Compound:5228213|FD-Score:-5.01|P-value:3.38E-7 ID:SGTC_2585|Compound:alliin|FD-Score:-5.13|P-value:1.87E-7 ID:SGTC_2586|Compound:curcumin|FD-Score:4.11|P-value:2.86E-5 ID:SGTC_2620|Compound:irigenin|FD-Score:-3.90|P-value:5.40E-5 ID:SGTC_2628|Compound:lathosterol|FD-Score:5.26|P-value:1.26E-7 ID:SGTC_2730|Compound:imipramine|FD-Score:4.19|P-value:2.06E-5 ID:SGTC_2739|Compound:tacrine|FD-Score:5.21|P-value:1.65E-7 ID:SGTC_2764|Compound:methyldopa|FD-Score:-3.19|P-value:7.66E-4 ID:SGTC_2771|Compound:fluoxetine|FD-Score:3.93|P-value:5.96E-5 ID:SGTC_2788|Compound:5282734|FD-Score:4.86|P-value:9.83E-7 ID:SGTC_2790|Compound:5423970|FD-Score:3.62|P-value:2.03E-4 ID:SGTC_2848|Compound:9016370|FD-Score:-3.15|P-value:8.50E-4 ID:SGTC_2936|Compound:9038235|FD-Score:-3.50|P-value:2.50E-4 ID:SGTC_3047|Compound:9092122|FD-Score:3.82|P-value:9.15E-5 ID:SGTC_3056|Compound:9094900|FD-Score:5.06|P-value:3.59E-7 ID:SGTC_3058|Compound:9093861|FD-Score:-5.23|P-value:1.08E-7 ID:SGTC_3126|Compound:9127922|FD-Score:4.63|P-value:2.90E-6 ID:SGTC_3197|Compound:9113331|FD-Score:3.98|P-value:4.83E-5 ID:SGTC_3237|Compound:9133362|FD-Score:3.75|P-value:1.21E-4 ID:SGTC_3345|Compound:9148410|FD-Score:3.17|P-value:9.88E-4 ID:SGTC_79|Compound:0052-0007|FD-Score:-4.52|P-value:3.59E-6 ID:SGTC_119|Compound:0121-0043|FD-Score:5.47|P-value:4.14E-8 ID:SGTC_268|Compound:camptothecin|FD-Score:3.26|P-value:7.26E-4 ID:SGTC_291|Compound:4130-1278|FD-Score:-3.35|P-value:4.36E-4 ID:SGTC_362|Compound:0310-0100|FD-Score:-3.11|P-value:9.76E-4 ID:SGTC_394|Compound:menadione|FD-Score:-3.77|P-value:9.16E-5 ID:SGTC_420|Compound:mitomycin C|FD-Score:-3.11|P-value:9.86E-4 ID:SGTC_436|Compound:n,n-dimethylsphingosine|FD-Score:3.30|P-value:6.28E-4 ID:SGTC_673|Compound:1082-0474|FD-Score:5.67|P-value:1.35E-8 ID:SGTC_773|Compound:4358-1457|FD-Score:4.17|P-value:2.26E-5 ID:SGTC_955|Compound:1216-0110|FD-Score:-3.17|P-value:8.00E-4 ID:SGTC_1015|Compound:4130-4525|FD-Score:3.99|P-value:4.70E-5 ID:SGTC_1026|Compound:k007-1105|FD-Score:3.30|P-value:6.25E-4 ID:SGTC_1139|Compound:k015-0024|FD-Score:-3.72|P-value:1.12E-4 ID:SGTC_1252|Compound:0493-0875|FD-Score:-3.31|P-value:5.01E-4 ID:SGTC_1537|Compound:2',6'-dihydroxyflavanone|FD-Score:3.44|P-value:3.85E-4 ID:SGTC_1602|Compound:st001878|FD-Score:-3.48|P-value:2.72E-4 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:3.25|P-value:7.48E-4 ID:SGTC_1798|Compound:st045719|FD-Score:-3.75|P-value:9.85E-5 ID:SGTC_1962|Compound:st076595|FD-Score:3.55|P-value:2.57E-4 ID:SGTC_2060|Compound:5238662|FD-Score:-3.67|P-value:1.34E-4 ID:SGTC_2195|Compound:6536160|FD-Score:3.89|P-value:6.95E-5 ID:SGTC_2198|Compound:6589944|FD-Score:-3.18|P-value:7.75E-4 ID:SGTC_2240|Compound:6690706|FD-Score:3.56|P-value:2.46E-4 ID:SGTC_2243|Compound:6634756|FD-Score:-3.69|P-value:1.21E-4 ID:SGTC_2301|Compound:7769476|FD-Score:4.34|P-value:1.07E-5 ID:SGTC_2316|Compound:5844804|FD-Score:3.47|P-value:3.52E-4 ID:SGTC_2331|Compound:7980721|FD-Score:-4.38|P-value:7.08E-6 ID:SGTC_2337|Compound:9009472|FD-Score:-8.08|P-value:6.84E-16 ID:SGTC_2338|Compound:7999974|FD-Score:3.58|P-value:2.36E-4 ID:SGTC_2393|Compound:9031399|FD-Score:-8.78|P-value:1.99E-18 ID:SGTC_2396|Compound:5342950|FD-Score:4.02|P-value:4.14E-5 ID:SGTC_2398|Compound:5228213|FD-Score:-5.01|P-value:3.38E-7 ID:SGTC_2585|Compound:alliin|FD-Score:-5.13|P-value:1.87E-7 ID:SGTC_2586|Compound:curcumin|FD-Score:4.11|P-value:2.86E-5 ID:SGTC_2620|Compound:irigenin|FD-Score:-3.90|P-value:5.40E-5 ID:SGTC_2628|Compound:lathosterol|FD-Score:5.26|P-value:1.26E-7 ID:SGTC_2730|Compound:imipramine|FD-Score:4.19|P-value:2.06E-5 ID:SGTC_2739|Compound:tacrine|FD-Score:5.21|P-value:1.65E-7 ID:SGTC_2764|Compound:methyldopa|FD-Score:-3.19|P-value:7.66E-4 ID:SGTC_2771|Compound:fluoxetine|FD-Score:3.93|P-value:5.96E-5 ID:SGTC_2788|Compound:5282734|FD-Score:4.86|P-value:9.83E-7 ID:SGTC_2790|Compound:5423970|FD-Score:3.62|P-value:2.03E-4 ID:SGTC_2848|Compound:9016370|FD-Score:-3.15|P-value:8.50E-4 ID:SGTC_2936|Compound:9038235|FD-Score:-3.50|P-value:2.50E-4 ID:SGTC_3047|Compound:9092122|FD-Score:3.82|P-value:9.15E-5 ID:SGTC_3056|Compound:9094900|FD-Score:5.06|P-value:3.59E-7 ID:SGTC_3058|Compound:9093861|FD-Score:-5.23|P-value:1.08E-7 ID:SGTC_3126|Compound:9127922|FD-Score:4.63|P-value:2.90E-6 ID:SGTC_3197|Compound:9113331|FD-Score:3.98|P-value:4.83E-5 ID:SGTC_3237|Compound:9133362|FD-Score:3.75|P-value:1.21E-4 ID:SGTC_3345|Compound:9148410|FD-Score:3.17|P-value:9.88E-4

Top fitness defect scores for YOR372C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_673 1082-0474 5.67 110.0 µM 1.35E-8 RSC complex & mRNA processing 30 7.16E-9 0.15
2 SGTC_119 0121-0043 5.47 24.8 µM 4.14E-8 mitochondrial stress 9 2.27E-8 0.25
3 SGTC_2628 lathosterol 5.26 100.0 µM 1.26E-7 3 7.18E-8 0.13
4 SGTC_2739 tacrine 5.21 100.9 µM 1.65E-7 heme requiring 3 9.53E-8 0.76
5 SGTC_3056 9094900 5.06 49.5 µM 3.59E-7 3 2.12E-7 0.62
6 SGTC_2788 5282734 4.86 71.4 µM 9.83E-7 2 6.01E-7 0.32
7 SGTC_3126 9127922 4.63 49.5 µM 2.90E-6 fatty acid desaturase (OLE1) 21 1.84E-6 0.01
8 SGTC_2301 7769476 4.34 200.0 µM 1.07E-5 11 7.12E-6 0.45
9 SGTC_2730 imipramine 4.19 71.3 µM 2.06E-5 5 1.40E-5 0.17
10 SGTC_773 4358-1457 4.17 44.6 µM 2.26E-5 9 1.54E-5 0.44
11 SGTC_2586 curcumin 4.11 80.0 µM 2.86E-5 iron homeostasis 8 1.97E-5 0.03
12 SGTC_2396 5342950 4.02 42.8 µM 4.14E-5 RSC complex & mRNA processing 34 2.88E-5 0.03
13 SGTC_1015 4130-4525 3.99 82.0 µM 4.70E-5 60S ribosome export 8 3.28E-5 0.11
14 SGTC_3197 9113331 3.98 49.5 µM 4.83E-5 9 3.38E-5 0.09
15 SGTC_2771 fluoxetine 3.93 41.0 µM 5.96E-5 1 4.20E-5 0.29
16 SGTC_2195 6536160 3.89 144.2 µM 6.95E-5 60S ribosome export 2 4.92E-5 0.13
17 SGTC_3047 9092122 3.82 49.5 µM 9.15E-5 7 6.54E-5 0.16
18 SGTC_3237 9133362 3.75 49.5 µM 1.21E-4 4 8.70E-5 0.06
19 SGTC_2790 5423970 3.62 71.4 µM 2.03E-4 endomembrane recycling 21 1.50E-4 0.13
20 SGTC_2338 7999974 3.58 200.0 µM 2.36E-4 12 1.74E-4 0.02

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.129 5.52E-14 YDL003W MCD1 het Essential alpha-kleisin subunit of the cohesin complex; required for sister chromatid cohesion in mitosis and meiosis; apoptosis induces cleavage and translocation of a C-terminal fragment to mitochondria; expression peaks in S phase
0.104 1.47E-9 YGR278W CWC22 het Spliceosome-associated protein that is required for pre-mRNA splicing; necessary for Prp2p function at the first catalytic step of splicing; has similarity to S. pombe Cwf22p; CWC22 is an essential protein
0.100 7.31E-9 YFL034C-B MOB2 het Activator of Cbk1p kinase; component of the RAM signaling network that regulates cellular polarity and morphogenesis; activation of Cbk1p facilitates the Ace2p-dependent daughter cell-specific transcription of genes involved in cell separation; similar to Mob1p
0.095 3.70E-8 YDR149C_d YDR149C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps the verified gene NUM1; null mutation blocks anaerobic growth
0.088 3.33E-7 YPL092W SSU1 hom Plasma membrane sulfite pump involved in sulfite metabolism and required for efficient sulfite efflux; major facilitator superfamily protein
0.086 6.87E-7 YER186C_p YER186C_p hom Putative protein of unknown function
0.086 7.26E-7 YCL063W VAC17 hom Phosphoprotein involved in vacuole inheritance; degraded in late M phase of the cell cycle; acts as a vacuole-specific receptor for myosin Myo2p
0.082 1.88E-6 YNL220W ADE12 hom Adenylosuccinate synthase, catalyzes the first step in synthesis of adenosine monophosphate from inosine 5'monophosphate during purine nucleotide biosynthesis; exhibits binding to single-stranded autonomously replicating (ARS) core sequence
0.079 4.69E-6 YBR143C SUP45 het Polypeptide release factor (eRF1) in translation termination; mutant form acts as a recessive omnipotent suppressor; methylated by Mtq2p-Trm112p in ternary complex eRF1-eRF3-GTP; mutation of methylation site confers resistance to zymocin; has a role in cytokinesis through interaction with Mlc1p
0.079 4.92E-6 YOL111C MDY2 hom Protein with a role in insertion of tail-anchored proteins into the ER membrane; forms a complex with Get4p; required for efficient mating; involved in shmoo formation and nuclear migration in the pre-zygote; associates with ribosomes
0.079 5.03E-6 YKL165C MCD4 het Protein involved in glycosylphosphatidylinositol (GPI) anchor synthesis; multimembrane-spanning protein that localizes to the endoplasmic reticulum; highly conserved among eukaryotes
0.075 1.29E-5 YMR203W TOM40 het Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; constitutes the core element of the protein conducting pore
0.073 2.30E-5 YGL263W COS12 hom Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins
0.073 2.25E-5 YML127W RSC9 het Component of the RSC chromatin remodeling complex; DNA-binding protein involved in the synthesis of rRNA and in transcriptional repression and activation of genes regulated by the Target of Rapamycin (TOR) pathway
0.072 2.73E-5 YAL043C PTA1 het Subunit of holo-CPF, a multiprotein complex and functional homolog of mammalian CPSF, required for the cleavage and polyadenylation of mRNA and snoRNA 3' ends; involved in pre-tRNA processing; binds to the phosphorylated CTD of RNAPII