YOR373W / NUD1

Component of the spindle pole body outer plaque; acts through the mitotic exit network to specify asymmetric spindle pole body inheritance

Zygosity: Heterozygous strain
fixedexpanded
Profile for YOR373W / NUD1

Click on Significant Values for Screen Details ID:SGTC_44|Compound:0929-0055|FD-Score:4.18|P-value:2.25E-5 ID:SGTC_65|Compound:0798-0905|FD-Score:-4.00|P-value:4.64E-5 ID:SGTC_480|Compound:am 92016|FD-Score:3.66|P-value:1.80E-4 ID:SGTC_623|Compound:k072-0108|FD-Score:3.18|P-value:9.57E-4 ID:SGTC_790|Compound:1575-0012|FD-Score:-4.68|P-value:2.42E-6 ID:SGTC_1204|Compound:4049-0315|FD-Score:3.52|P-value:2.96E-4 ID:SGTC_1336|Compound:1486-0901|FD-Score:4.12|P-value:2.94E-5 ID:SGTC_1822|Compound:st052468|FD-Score:3.19|P-value:9.44E-4 ID:SGTC_1938|Compound:st074717|FD-Score:-4.86|P-value:1.06E-6 ID:SGTC_1946|Compound:st076057|FD-Score:-4.23|P-value:1.83E-5 ID:SGTC_2163|Compound:5671233|FD-Score:3.93|P-value:6.22E-5 ID:SGTC_2307|Compound:7538926|FD-Score:3.76|P-value:1.20E-4 ID:SGTC_2309|Compound:7664088|FD-Score:-3.88|P-value:7.60E-5 ID:SGTC_2310|Compound:7668677|FD-Score:-3.82|P-value:9.38E-5 ID:SGTC_2311|Compound:7694451|FD-Score:-3.68|P-value:1.64E-4 ID:SGTC_2314|Compound:7727897|FD-Score:-3.51|P-value:3.07E-4 ID:SGTC_2407|Compound:paclitaxel|FD-Score:-3.17|P-value:9.74E-4 ID:SGTC_2491|Compound:paeonol|FD-Score:-3.19|P-value:9.09E-4 ID:SGTC_2898|Compound:9056270|FD-Score:-3.88|P-value:7.64E-5 ID:SGTC_44|Compound:0929-0055|FD-Score:4.18|P-value:2.25E-5 ID:SGTC_65|Compound:0798-0905|FD-Score:-4.00|P-value:4.64E-5 ID:SGTC_480|Compound:am 92016|FD-Score:3.66|P-value:1.80E-4 ID:SGTC_623|Compound:k072-0108|FD-Score:3.18|P-value:9.57E-4 ID:SGTC_790|Compound:1575-0012|FD-Score:-4.68|P-value:2.42E-6 ID:SGTC_1204|Compound:4049-0315|FD-Score:3.52|P-value:2.96E-4 ID:SGTC_1336|Compound:1486-0901|FD-Score:4.12|P-value:2.94E-5 ID:SGTC_1822|Compound:st052468|FD-Score:3.19|P-value:9.44E-4 ID:SGTC_1938|Compound:st074717|FD-Score:-4.86|P-value:1.06E-6 ID:SGTC_1946|Compound:st076057|FD-Score:-4.23|P-value:1.83E-5 ID:SGTC_2163|Compound:5671233|FD-Score:3.93|P-value:6.22E-5 ID:SGTC_2307|Compound:7538926|FD-Score:3.76|P-value:1.20E-4 ID:SGTC_2309|Compound:7664088|FD-Score:-3.88|P-value:7.60E-5 ID:SGTC_2310|Compound:7668677|FD-Score:-3.82|P-value:9.38E-5 ID:SGTC_2311|Compound:7694451|FD-Score:-3.68|P-value:1.64E-4 ID:SGTC_2314|Compound:7727897|FD-Score:-3.51|P-value:3.07E-4 ID:SGTC_2407|Compound:paclitaxel|FD-Score:-3.17|P-value:9.74E-4 ID:SGTC_2491|Compound:paeonol|FD-Score:-3.19|P-value:9.09E-4 ID:SGTC_2898|Compound:9056270|FD-Score:-3.88|P-value:7.64E-5

Top fitness defect scores for YOR373W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_44 0929-0055 4.18 61.2 µM 2.25E-5 6 1.44E-5 0.11
2 SGTC_1336 1486-0901 4.12 104.0 µM 2.94E-5 3 1.91E-5 0.66
3 SGTC_2163 5671233 3.93 125.0 µM 6.22E-5 13 4.19E-5 0.05
4 SGTC_2307 7538926 3.76 6.3 µM 1.20E-4 25 8.35E-5 0.16
5 SGTC_480 am 92016 3.66 50.0 µM 1.80E-4 12 1.27E-4 0.17
6 SGTC_1204 4049-0315 3.52 18.3 µM 2.96E-4 14 2.14E-4 0.10
7 SGTC_1822 st052468 3.19 42.0 µM 9.44E-4 2 7.22E-4 0.06
8 SGTC_623 k072-0108 3.18 16.9 µM 9.57E-4 heme biosynthesis & mitochondrial translocase 24 7.32E-4 0.01
9 SGTC_1865 st057639 3.13 52.2 µM 0.00113 9 8.67E-4 0.01
10 SGTC_1819 st053448 3.09 58.6 µM 0.00129 amide catabolism 7 0.00100 0.01
11 SGTC_2136 5328288 3.01 199.3 µM 0.00165 19 0.00130 0.19
12 SGTC_2569 tetrandrine 2.95 100.0 µM 0.00198 14 0.00156 0.02
13 SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 2.93 13.2 µM 0.00215 19 0.00170 0.03
14 SGTC_2361 9034121 2.84 116.0 µM 0.00278 RSC complex & mRNA processing 34 0.00223 0.01
15 SGTC_347 4534-1311 2.75 26.2 µM 0.00370 RPP1 & pyrimidine depletion 13 0.00302 0.07
16 SGTC_77 0828-0286 2.69 12.5 µM 0.00441 TSC3-RPN4 27 0.00362 0.04
17 SGTC_2265 7929201 2.66 200.0 µM 0.00469 19 0.00386 0.01
18 SGTC_2403 6032726 2.66 181.2 µM 0.00477 17 0.00393 0.02
19 SGTC_2268 7933382 2.66 153.8 µM 0.00481 24 0.00396 4.04E-4
20 SGTC_2276 7947513 2.65 42.1 µM 0.00492 16 0.00406 0.11

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.157 6.73E-20 YDL235C YPD1 het Phosphorelay intermediate protein, phosphorylated by the plasma membrane sensor Sln1p in response to osmotic stress and then in turn phosphorylates the response regulators Ssk1p in the cytosol and Skn7p in the nucleus
0.148 5.73E-18 YOR151C RPB2 het RNA polymerase II second largest subunit B150, part of central core; similar to bacterial beta subunit
0.114 2.96E-11 YPL020C ULP1 het Protease that specifically cleaves Smt3p protein conjugates; required for cell cycle progression; associates with nucleoporins and may interact with septin rings during telophase; sequestered to the nucleolus under stress conditions
0.114 3.11E-11 YNL039W BDP1 het Essential subunit of RNA polymerase III transcription factor (TFIIIB), which is involved in transcription of genes encoding tRNAs, 5S rRNA, U6 snRNA, and other small RNAs
0.105 1.23E-9 YGR110W CLD1 hom Mitochondrial cardiolipin-specific phospholipase; functions upstream of Taz1p to generate monolyso-cardiolipin; transcription increases upon genotoxic stress; involved in restricting Ty1 transposition; has homology to mammalian CGI-58
0.100 5.83E-9 YDR165W TRM82 hom Catalytic subunit of a tRNA methyltransferase complex; Trm8p and Trm82p comprise an enzyme that catalyzes a methyl-transfer from S-adenosyl-l-methionine to the N(7) atom of guanine at position 46 in tRNA; Trm8 lacks catalytic activity if not bound to Trm82p
0.100 6.29E-9 YDR143C SAN1 hom Ubiquitin-protein ligase; involved in the proteasome-dependent degradation of aberrant nuclear proteins; targets substrates with regions of exposed hydrophobicity containing 5 or more contiguous hydrophobic residues; contains intrinsically disordered regions that contribute to substrate recognition
0.096 2.95E-8 YDR059C UBC5 hom Ubiquitin-conjugating enzyme; mediates selective degradation of short-lived, abnormal, or excess proteins, including histone H3; central component of the cellular stress response; expression is heat inducible; protein abundance increases in response to DNA replication stress; UBC5 has a paralog, UBC4, that arose from the whole genome duplication
0.095 3.25E-8 YGR187C HGH1 hom Nonessential protein of unknown function; predicted to be involved in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; similar to mammalian BRP16 (Brain protein 16); relative distribution to the nucleus increases upon DNA replication stress
0.088 3.19E-7 YOR270C VPH1 hom Subunit a of vacuolar-ATPase V0 domain; one of two isoforms (Vph1p and Stv1p); Vph1p is located in V-ATPase complexes of the vacuole while Stv1p is located in V-ATPase complexes of the Golgi and endosomes; relative distribution to the vacuolar membrane decreases upon DNA replication stress
0.084 1.17E-6 YIR043C YIR043C hom Possible pseudogene in strain S288C; YIR043C and the adjacent ORF, YIR044C, together may encode a non-functional member of the conserved, often subtelomerically-encoded Cos protein family
0.082 1.90E-6 YPL217C BMS1 het GTPase required for synthesis of 40S ribosomal subunits and for processing the 35S pre-rRNA at sites A0, A1, and A2; interacts with Rcl1p, which stimulates its GTPase and U3 snoRNA binding activities; has similarity to Tsr1p
0.081 2.74E-6 YPL215W CBP3 hom Mitochondrial protein required for assembly of cytochrome bc1 complex; forms a complex with Cbp6p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex
0.080 3.50E-6 YOR136W IDH2 hom Subunit of mitochondrial NAD(+)-dependent isocitrate dehydrogenase, which catalyzes the oxidation of isocitrate to alpha-ketoglutarate in the TCA cycle; phosphorylated
0.078 5.99E-6 YNR046W TRM112 het Protein involved in methylation of tRNA, rRNA, and translation factors; subunit of tRNA methyltransferase (MTase) complexes in combination with Trm9p and Trm11p; interacts with and stabilizes 18S rRNA methyltransferase Bud23p; subunit of complex with Mtq2p that methylates Sup45p (eRF1) in the ternary complex eRF1-eRF3-GTP; deletion confers resistance to zymocin; relative distribution to the nucleus increases upon DNA replication stress