YOR375C / GDH1

NADP(+)-dependent glutamate dehydrogenase; synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh3p; expression regulated by nitrogen and carbon sources; GDH1 has a paralog, GDH3, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR375C / GDH1

Click on Significant Values for Screen Details ID:SGTC_51|Compound:1013-0126|FD-Score:3.09|P-value:9.62E-4 ID:SGTC_372|Compound:0155-0182|FD-Score:3.31|P-value:4.50E-4 ID:SGTC_593|Compound:1203-0218|FD-Score:3.11|P-value:9.19E-4 ID:SGTC_599|Compound:1935-0052|FD-Score:4.62|P-value:2.02E-6 ID:SGTC_746|Compound:1095-0025|FD-Score:5.11|P-value:1.77E-7 ID:SGTC_753|Compound:1322-0200|FD-Score:3.58|P-value:1.70E-4 ID:SGTC_865|Compound:0488-0499|FD-Score:4.24|P-value:1.15E-5 ID:SGTC_1137|Compound:ixabepilone|FD-Score:3.96|P-value:3.68E-5 ID:SGTC_1254|Compound:0550-0035|FD-Score:3.23|P-value:6.10E-4 ID:SGTC_1262|Compound:0737-0114|FD-Score:-3.23|P-value:8.45E-4 ID:SGTC_1436|Compound:4092-1007|FD-Score:3.89|P-value:5.09E-5 ID:SGTC_1537|Compound:2',6'-dihydroxyflavanone|FD-Score:-3.18|P-value:9.82E-4 ID:SGTC_1705|Compound:st027868|FD-Score:4.11|P-value:1.99E-5 ID:SGTC_1718|Compound:roemerine|FD-Score:4.26|P-value:1.03E-5 ID:SGTC_1739|Compound:st037196|FD-Score:4.04|P-value:2.68E-5 ID:SGTC_1743|Compound:st037606|FD-Score:-3.77|P-value:1.15E-4 ID:SGTC_1745|Compound:st081495|FD-Score:-5.70|P-value:1.15E-8 ID:SGTC_1783|Compound:st039459|FD-Score:3.22|P-value:6.25E-4 ID:SGTC_1977|Compound:st070720|FD-Score:3.34|P-value:4.07E-4 ID:SGTC_1986|Compound:st071812|FD-Score:-4.18|P-value:2.26E-5 ID:SGTC_2036|Compound:5160441|FD-Score:-3.24|P-value:7.97E-4 ID:SGTC_2287|Compound:7945887|FD-Score:-3.32|P-value:6.03E-4 ID:SGTC_2309|Compound:7664088|FD-Score:3.81|P-value:6.88E-5 ID:SGTC_2311|Compound:7694451|FD-Score:3.42|P-value:3.06E-4 ID:SGTC_2391|Compound:6285546|FD-Score:3.57|P-value:1.73E-4 ID:SGTC_2407|Compound:paclitaxel|FD-Score:5.11|P-value:1.76E-7 ID:SGTC_2409|Compound:alverine citrate|FD-Score:-3.43|P-value:4.18E-4 ID:SGTC_2430|Compound:5571206|FD-Score:4.19|P-value:1.41E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:5.01|P-value:2.97E-7 ID:SGTC_2607|Compound:solasodine|FD-Score:-3.24|P-value:7.99E-4 ID:SGTC_2782|Compound:7736369|FD-Score:3.79|P-value:7.38E-5 ID:SGTC_2787|Compound:5284540|FD-Score:4.56|P-value:2.71E-6 ID:SGTC_2788|Compound:5282734|FD-Score:3.23|P-value:6.04E-4 ID:SGTC_51|Compound:1013-0126|FD-Score:3.09|P-value:9.62E-4 ID:SGTC_372|Compound:0155-0182|FD-Score:3.31|P-value:4.50E-4 ID:SGTC_593|Compound:1203-0218|FD-Score:3.11|P-value:9.19E-4 ID:SGTC_599|Compound:1935-0052|FD-Score:4.62|P-value:2.02E-6 ID:SGTC_746|Compound:1095-0025|FD-Score:5.11|P-value:1.77E-7 ID:SGTC_753|Compound:1322-0200|FD-Score:3.58|P-value:1.70E-4 ID:SGTC_865|Compound:0488-0499|FD-Score:4.24|P-value:1.15E-5 ID:SGTC_1137|Compound:ixabepilone|FD-Score:3.96|P-value:3.68E-5 ID:SGTC_1254|Compound:0550-0035|FD-Score:3.23|P-value:6.10E-4 ID:SGTC_1262|Compound:0737-0114|FD-Score:-3.23|P-value:8.45E-4 ID:SGTC_1436|Compound:4092-1007|FD-Score:3.89|P-value:5.09E-5 ID:SGTC_1537|Compound:2',6'-dihydroxyflavanone|FD-Score:-3.18|P-value:9.82E-4 ID:SGTC_1705|Compound:st027868|FD-Score:4.11|P-value:1.99E-5 ID:SGTC_1718|Compound:roemerine|FD-Score:4.26|P-value:1.03E-5 ID:SGTC_1739|Compound:st037196|FD-Score:4.04|P-value:2.68E-5 ID:SGTC_1743|Compound:st037606|FD-Score:-3.77|P-value:1.15E-4 ID:SGTC_1745|Compound:st081495|FD-Score:-5.70|P-value:1.15E-8 ID:SGTC_1783|Compound:st039459|FD-Score:3.22|P-value:6.25E-4 ID:SGTC_1977|Compound:st070720|FD-Score:3.34|P-value:4.07E-4 ID:SGTC_1986|Compound:st071812|FD-Score:-4.18|P-value:2.26E-5 ID:SGTC_2036|Compound:5160441|FD-Score:-3.24|P-value:7.97E-4 ID:SGTC_2287|Compound:7945887|FD-Score:-3.32|P-value:6.03E-4 ID:SGTC_2309|Compound:7664088|FD-Score:3.81|P-value:6.88E-5 ID:SGTC_2311|Compound:7694451|FD-Score:3.42|P-value:3.06E-4 ID:SGTC_2391|Compound:6285546|FD-Score:3.57|P-value:1.73E-4 ID:SGTC_2407|Compound:paclitaxel|FD-Score:5.11|P-value:1.76E-7 ID:SGTC_2409|Compound:alverine citrate|FD-Score:-3.43|P-value:4.18E-4 ID:SGTC_2430|Compound:5571206|FD-Score:4.19|P-value:1.41E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:5.01|P-value:2.97E-7 ID:SGTC_2607|Compound:solasodine|FD-Score:-3.24|P-value:7.99E-4 ID:SGTC_2782|Compound:7736369|FD-Score:3.79|P-value:7.38E-5 ID:SGTC_2787|Compound:5284540|FD-Score:4.56|P-value:2.71E-6 ID:SGTC_2788|Compound:5282734|FD-Score:3.23|P-value:6.04E-4

Top fitness defect scores for YOR375C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2407 paclitaxel 5.11 400.0 µM 1.76E-7 14 1.63E-7
2 SGTC_746 1095-0025 5.11 46.6 µM 1.77E-7 RSC & ERG11 6 1.64E-7
3 SGTC_2582 agaric acid 5.01 100.0 µM 2.97E-7 redox potentiating 221 2.78E-7
4 SGTC_599 1935-0052 4.62 86.5 µM 2.02E-6 6 1.94E-6
5 SGTC_2787 5284540 4.56 71.4 µM 2.71E-6 12 2.62E-6
6 SGTC_1718 roemerine 4.26 11.9 µM 1.03E-5 redox potentiating 45 1.01E-5
7 SGTC_865 0488-0499 4.24 301.0 µM 1.15E-5 13 1.13E-5
8 SGTC_2430 5571206 4.19 200.0 µM 1.41E-5 49 1.39E-5
9 SGTC_1705 st027868 4.11 56.3 µM 1.99E-5 7 1.97E-5
10 SGTC_1739 st037196 4.04 92.5 µM 2.68E-5 19 2.66E-5
11 SGTC_1137 ixabepilone 3.96 100.0 µM 3.68E-5 23 3.68E-5
12 SGTC_1436 4092-1007 3.89 8.3 µM 5.09E-5 12 5.10E-5
13 SGTC_2309 7664088 3.81 163.9 µM 6.88E-5 37 6.92E-5
14 SGTC_2782 7736369 3.79 71.4 µM 7.38E-5 48 7.42E-5
15 SGTC_753 1322-0200 3.58 289.0 µM 1.70E-4 33 1.72E-4
16 SGTC_2391 6285546 3.57 200.0 µM 1.73E-4 27 1.76E-4
17 SGTC_2311 7694451 3.42 200.0 µM 3.06E-4 41 3.13E-4
18 SGTC_1977 st070720 3.34 65.3 µM 4.07E-4 23 4.17E-4
19 SGTC_372 0155-0182 3.31 15.9 µM 4.50E-4 mitochondrial response to ROS 50 4.61E-4
20 SGTC_2788 5282734 3.23 71.4 µM 6.04E-4 86 6.21E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.153 6.22E-19 YNL027W CRZ1 hom Transcription factor, activates transcription of stress response genes; nuclear localization is positively regulated by calcineurin-mediated dephosphorylation; rapidly localizes to the nucleus under blue light stress
0.149 4.68E-18 YBR082C UBC4 hom Ubiquitin-conjugating enzyme (E2); mediates degradation of abnormal or excess proteins, including calmodulin and histone H3; interacts with many SCF ubiquitin protein ligases; component of the cellular stress response; UBC4 has a paralog, UBC5, that arose from the whole genome duplication
0.142 1.23E-16 YNL106C INP52 hom Polyphosphatidylinositol phosphatase, dephosphorylates a number of phosphatidylinositols (PIs) to PI; involved in endocytosis; hyperosmotic stress causes translocation to actin patches; synaptojanin-like protein with a Sac1 domain
0.140 3.01E-16 YOR050C_d YOR050C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutation is viable
0.136 2.82E-15 YDL242W_d YDL242W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.134 7.42E-15 YML103C NUP188 hom Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC organization and nucleocytoplasmic transport; homologous to human NUP188
0.126 2.09E-13 YOR049C RSB1 hom Suppressor of sphingoid long chain base (LCB) sensitivity of an LCB-lyase mutation; putative integral membrane transporter or flippase that may transport LCBs from the cytoplasmic side toward the extracytoplasmic side of the membrane
0.122 1.27E-12 YML052W SUR7 hom Plasma membrane protein that localizes to furrow-like invaginations (MCC patches); component of eisosomes; associated with endocytosis, along with Pil1p and Lsp1p; sporulation and plasma membrane sphingolipid content are altered in mutants
0.120 3.13E-12 YPL232W SSO1 hom Plasma membrane t-SNARE involved in fusion of secretory vesicles at the plasma membrane and in vesicle fusion during sporulation; forms a complex with Sec9p that binds v-SNARE Snc2p; syntaxin homolog; functionally redundant with Sso2p
0.119 4.68E-12 YDR376W ARH1 het Oxidoreductase of the mitochondrial inner membrane, involved in cytoplasmic and mitochondrial iron homeostasis and required for activity of Fe-S cluster-containing enzymes; one of the few mitochondrial proteins essential for viability
0.114 3.21E-11 YEL007W MIT1 hom Transcriptional regulator of pseudohyphal growth; protein with sequence similarity to S. pombe gti1+ (gluconate transport inducer 1) and C. albicans Wor1
0.114 3.94E-11 YMR109W MYO5 hom One of two type I myosins; contains proline-rich tail homology 2 (TH2) and SH3 domains; MYO5 deletion has little effect on growth, but myo3 myo5 double deletion causes severe defects in growth and actin cytoskeleton organization
0.113 4.89E-11 YKL213C DOA1 hom WD repeat protein required for ubiquitin-mediated protein degradation; forms a complex with Cdc48p; plays a role in controlling cellular ubiquitin concentration; also promotes efficient NHEJ in postdiauxic/stationary phase; protein increases in abundance and relocalizes from nucleus to nuclear periphery upon DNA replication stress
0.111 1.39E-10 YGR144W THI4 hom Thiazole synthase, abundant protein involved in the formation of the thiazole moiety of thiamine during thiamine biosynthesis; acts more as a co-substrate rather than an enzyme by providing the sulphur source for thiazole formation; undergoes a single turnover only; required for mitochondrial genome stability in response to DNA damaging agents
0.110 1.54E-10 YJL169W_d YJL169W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL168C/SET2