YOR376W_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YOR376W is not an essential gene.

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR376W / YOR376W

Click on Significant Values for Screen Details ID:SGTC_393|Compound:acivicin|FD-Score:3.00|P-value:5.45E-4 ID:SGTC_675|Compound:1309-0189|FD-Score:-2.85|P-value:9.47E-4 ID:SGTC_682|Compound:0kpi-0099|FD-Score:3.20|P-value:2.44E-4 ID:SGTC_731|Compound:3966-0296|FD-Score:-3.02|P-value:4.99E-4 ID:SGTC_912|Compound:3474-0017|FD-Score:4.86|P-value:6.29E-8 ID:SGTC_969|Compound:1313-0238|FD-Score:3.27|P-value:1.90E-4 ID:SGTC_1129|Compound:3453-1384|FD-Score:3.69|P-value:3.01E-5 ID:SGTC_1133|Compound:3473-0247|FD-Score:-2.99|P-value:5.53E-4 ID:SGTC_1204|Compound:4049-0315|FD-Score:3.02|P-value:5.05E-4 ID:SGTC_1208|Compound:2323-2347|FD-Score:2.91|P-value:7.79E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.00|P-value:5.39E-4 ID:SGTC_1463|Compound:k081-0032|FD-Score:-3.21|P-value:2.32E-4 ID:SGTC_1503|Compound:4585-0012|FD-Score:2.92|P-value:7.43E-4 ID:SGTC_1522|Compound:st012842|FD-Score:3.37|P-value:1.25E-4 ID:SGTC_1592|Compound:4',5'-dihydroxyflavone|FD-Score:3.48|P-value:7.51E-5 ID:SGTC_1718|Compound:roemerine|FD-Score:3.22|P-value:2.28E-4 ID:SGTC_1722|Compound:st034304|FD-Score:-3.70|P-value:2.79E-5 ID:SGTC_1754|Compound:st042065|FD-Score:-3.10|P-value:3.68E-4 ID:SGTC_2049|Compound:5262831|FD-Score:-3.63|P-value:3.76E-5 ID:SGTC_2053|Compound:5265679|FD-Score:-3.33|P-value:1.43E-4 ID:SGTC_2116|Compound:5511452|FD-Score:3.16|P-value:2.92E-4 ID:SGTC_2282|Compound:7944268|FD-Score:-4.34|P-value:1.10E-6 ID:SGTC_2291|Compound:7917025|FD-Score:-7.07|P-value:6.55E-15 ID:SGTC_2425|Compound:5628681|FD-Score:-3.21|P-value:2.29E-4 ID:SGTC_2428|Compound:5615643|FD-Score:4.90|P-value:4.78E-8 ID:SGTC_2593|Compound:nobiletin|FD-Score:5.78|P-value:1.62E-10 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:3.16|P-value:2.88E-4 ID:SGTC_3193|Compound:9111931|FD-Score:-2.90|P-value:7.76E-4 ID:SGTC_3207|Compound:9114163|FD-Score:-3.12|P-value:3.37E-4 ID:SGTC_3245|Compound:9134821|FD-Score:-2.85|P-value:9.59E-4 ID:SGTC_3249|Compound:9135183|FD-Score:3.72|P-value:2.61E-5 ID:SGTC_393|Compound:acivicin|FD-Score:3.00|P-value:5.45E-4 ID:SGTC_675|Compound:1309-0189|FD-Score:-2.85|P-value:9.47E-4 ID:SGTC_682|Compound:0kpi-0099|FD-Score:3.20|P-value:2.44E-4 ID:SGTC_731|Compound:3966-0296|FD-Score:-3.02|P-value:4.99E-4 ID:SGTC_912|Compound:3474-0017|FD-Score:4.86|P-value:6.29E-8 ID:SGTC_969|Compound:1313-0238|FD-Score:3.27|P-value:1.90E-4 ID:SGTC_1129|Compound:3453-1384|FD-Score:3.69|P-value:3.01E-5 ID:SGTC_1133|Compound:3473-0247|FD-Score:-2.99|P-value:5.53E-4 ID:SGTC_1204|Compound:4049-0315|FD-Score:3.02|P-value:5.05E-4 ID:SGTC_1208|Compound:2323-2347|FD-Score:2.91|P-value:7.79E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.00|P-value:5.39E-4 ID:SGTC_1463|Compound:k081-0032|FD-Score:-3.21|P-value:2.32E-4 ID:SGTC_1503|Compound:4585-0012|FD-Score:2.92|P-value:7.43E-4 ID:SGTC_1522|Compound:st012842|FD-Score:3.37|P-value:1.25E-4 ID:SGTC_1592|Compound:4',5'-dihydroxyflavone|FD-Score:3.48|P-value:7.51E-5 ID:SGTC_1718|Compound:roemerine|FD-Score:3.22|P-value:2.28E-4 ID:SGTC_1722|Compound:st034304|FD-Score:-3.70|P-value:2.79E-5 ID:SGTC_1754|Compound:st042065|FD-Score:-3.10|P-value:3.68E-4 ID:SGTC_2049|Compound:5262831|FD-Score:-3.63|P-value:3.76E-5 ID:SGTC_2053|Compound:5265679|FD-Score:-3.33|P-value:1.43E-4 ID:SGTC_2116|Compound:5511452|FD-Score:3.16|P-value:2.92E-4 ID:SGTC_2282|Compound:7944268|FD-Score:-4.34|P-value:1.10E-6 ID:SGTC_2291|Compound:7917025|FD-Score:-7.07|P-value:6.55E-15 ID:SGTC_2425|Compound:5628681|FD-Score:-3.21|P-value:2.29E-4 ID:SGTC_2428|Compound:5615643|FD-Score:4.90|P-value:4.78E-8 ID:SGTC_2593|Compound:nobiletin|FD-Score:5.78|P-value:1.62E-10 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:3.16|P-value:2.88E-4 ID:SGTC_3193|Compound:9111931|FD-Score:-2.90|P-value:7.76E-4 ID:SGTC_3207|Compound:9114163|FD-Score:-3.12|P-value:3.37E-4 ID:SGTC_3245|Compound:9134821|FD-Score:-2.85|P-value:9.59E-4 ID:SGTC_3249|Compound:9135183|FD-Score:3.72|P-value:2.61E-5

Top fitness defect scores for YOR376W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2593 nobiletin 5.78 86.2 µM 1.62E-10 6 3.84E-9
2 SGTC_2428 5615643 4.90 7.8 µM 4.78E-8 20 4.76E-7
3 SGTC_912 3474-0017 4.86 2.2 µM 6.29E-8 13 6.01E-7
4 SGTC_3249 9135183 3.72 49.5 µM 2.61E-5 60S ribosome export 15 1.01E-4
5 SGTC_1129 3453-1384 3.69 223.0 µM 3.01E-5 48 1.14E-4
6 SGTC_1592 4',5'-dihydroxyflavone 3.48 8.8 µM 7.51E-5 60S ribosome export 26 2.48E-4
7 SGTC_1522 st012842 3.37 45.6 µM 1.25E-4 RNA pol III & RNase P/MRP 50 3.82E-4
8 SGTC_969 1313-0238 3.27 134.0 µM 1.90E-4 mitochondrial processes 48 5.46E-4
9 SGTC_1718 roemerine 3.22 11.9 µM 2.28E-4 redox potentiating 98 6.39E-4
10 SGTC_682 0kpi-0099 3.20 17.0 µM 2.44E-4 107 6.76E-4
11 SGTC_2603 homopterocarpin 3.16 100.0 µM 2.88E-4 91 7.79E-4
12 SGTC_2116 5511452 3.16 16.9 µM 2.92E-4 42 7.88E-4
13 SGTC_1204 4049-0315 3.02 18.3 µM 5.05E-4 78 0.00126
14 SGTC_393 acivicin 3.00 6.2 µM 5.45E-4 45 0.00134
15 SGTC_1503 4585-0012 2.92 61.3 µM 7.43E-4 60 0.00175
16 SGTC_1208 2323-2347 2.91 50.3 µM 7.79E-4 44 0.00182
17 SGTC_1121 fusaric acid 2.83 630.5 nM 0.00103 94 0.00232
18 SGTC_1686 st019653 2.78 115.5 µM 0.00125 mitochondrial processes 46 0.00274
19 SGTC_321 4534-3890 2.68 65.3 µM 0.00176 RPP1 & pyrimidine depletion 49 0.00365
20 SGTC_3248 9135562 2.68 49.5 µM 0.00176 62 0.00366

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.132 2.03E-14 YCR015C_p YCR015C_p hom Putative protein of unknown function; YCR015C is not an essential gene
0.126 2.67E-13 YCR004C YCP4 hom Protein of unknown function, has sequence and structural similarity to flavodoxins; predicted to be palmitoylated; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.126 2.83E-13 YML126C ERG13 het 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) synthase, catalyzes the formation of HMG-CoA from acetyl-CoA and acetoacetyl-CoA; involved in the second step in mevalonate biosynthesis
0.118 6.49E-12 YGL110C CUE3 hom Protein of unknown function; has a CUE domain that binds ubiquitin, which may facilitate intramolecular monoubiquitination
0.113 4.60E-11 YIL155C GUT2 hom Mitochondrial glycerol-3-phosphate dehydrogenase; expression is repressed by both glucose and cAMP and derepressed by non-fermentable carbon sources in a Snf1p, Rsf1p, Hap2/3/4/5 complex dependent manner
0.110 1.83E-10 YDR224C HTB1 het Histone H2B, core histone protein required for chromatin assembly and chromosome function; nearly identical to HTB2; Rad6p-Bre1p-Lge1p mediated ubiquitination regulates transcriptional activation, meiotic DSB formation and H3 methylation
0.102 3.11E-9 YFR012W DCV1 hom Protein of unknown function; deletion mutant shows strong genetic interaction with cdc28-as1 mutant in the presence of 1-NM-PP1; DCV1 has a paralog, YOL019W, that arose from the whole genome duplication
0.102 3.71E-9 YLR361C-A_p YLR361C-A_p hom Putative protein of unknown function
0.099 1.07E-8 YDL120W YFH1 het Mitochondrial matrix iron chaperone; oxidizes and stores iron; interacts with Isu1p to promote Fe-S cluster assembly; mutation results in multiple Fe/S-dependent enzyme deficiencies; human frataxin homolog is mutated in Friedrich's ataxia
0.098 1.20E-8 YPR186C PZF1 het Transcription factor IIIA (TFIIIA); essential DNA binding protein required for transcription of 5S rRNA by RNA polymerase III; not involved in transcription of other RNAP III genes; nine conserved zinc fingers; may also bind 5S rRNA
0.097 1.97E-8 YKL062W MSN4 hom Transcriptional activator; activated in stress conditions, which results in translocation from the cytoplasm to the nucleus; binds DNA at stress response elements of responsive genes, inducing gene expression; MSN4 has a paralog, MSN2, that arose from the whole genome duplication
0.096 2.58E-8 YMR105C PGM2 hom Phosphoglucomutase; catalyzes the conversion from glucose-1-phosphate to glucose-6-phosphate, which is a key step in hexose metabolism; functions as the acceptor for a Glc-phosphotransferase; protein abundance increases in response to DNA replication stress
0.095 3.98E-8 YDR376W ARH1 het Oxidoreductase of the mitochondrial inner membrane, involved in cytoplasmic and mitochondrial iron homeostasis and required for activity of Fe-S cluster-containing enzymes; one of the few mitochondrial proteins essential for viability
0.093 5.87E-8 YMR196W_p YMR196W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YMR196W is not an essential gene
0.093 7.18E-8 YLR012C_p YLR012C_p hom Putative protein of unknown function; YLR012C is not an essential gene