Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YOR376W is not an essential gene.
Zygosity: Homozygous strain
fixedexpanded
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Top fitness defect scores for YOR376W deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Correlation | pval | ORF | Gene | Zygosity | Description |
---|---|---|---|---|---|
0.132 | 2.03E-14 | YCR015C_p | YCR015C_p | hom | Putative protein of unknown function; YCR015C is not an essential gene |
0.126 | 2.67E-13 | YCR004C | YCP4 | hom | Protein of unknown function, has sequence and structural similarity to flavodoxins; predicted to be palmitoylated; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies |
0.126 | 2.83E-13 | YML126C | ERG13 | het | 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) synthase, catalyzes the formation of HMG-CoA from acetyl-CoA and acetoacetyl-CoA; involved in the second step in mevalonate biosynthesis |
0.118 | 6.49E-12 | YGL110C | CUE3 | hom | Protein of unknown function; has a CUE domain that binds ubiquitin, which may facilitate intramolecular monoubiquitination |
0.113 | 4.60E-11 | YIL155C | GUT2 | hom | Mitochondrial glycerol-3-phosphate dehydrogenase; expression is repressed by both glucose and cAMP and derepressed by non-fermentable carbon sources in a Snf1p, Rsf1p, Hap2/3/4/5 complex dependent manner |
0.110 | 1.83E-10 | YDR224C | HTB1 | het | Histone H2B, core histone protein required for chromatin assembly and chromosome function; nearly identical to HTB2; Rad6p-Bre1p-Lge1p mediated ubiquitination regulates transcriptional activation, meiotic DSB formation and H3 methylation |
0.102 | 3.11E-9 | YFR012W | DCV1 | hom | Protein of unknown function; deletion mutant shows strong genetic interaction with cdc28-as1 mutant in the presence of 1-NM-PP1; DCV1 has a paralog, YOL019W, that arose from the whole genome duplication |
0.102 | 3.71E-9 | YLR361C-A_p | YLR361C-A_p | hom | Putative protein of unknown function |
0.099 | 1.07E-8 | YDL120W | YFH1 | het | Mitochondrial matrix iron chaperone; oxidizes and stores iron; interacts with Isu1p to promote Fe-S cluster assembly; mutation results in multiple Fe/S-dependent enzyme deficiencies; human frataxin homolog is mutated in Friedrich's ataxia |
0.098 | 1.20E-8 | YPR186C | PZF1 | het | Transcription factor IIIA (TFIIIA); essential DNA binding protein required for transcription of 5S rRNA by RNA polymerase III; not involved in transcription of other RNAP III genes; nine conserved zinc fingers; may also bind 5S rRNA |
0.097 | 1.97E-8 | YKL062W | MSN4 | hom | Transcriptional activator; activated in stress conditions, which results in translocation from the cytoplasm to the nucleus; binds DNA at stress response elements of responsive genes, inducing gene expression; MSN4 has a paralog, MSN2, that arose from the whole genome duplication |
0.096 | 2.58E-8 | YMR105C | PGM2 | hom | Phosphoglucomutase; catalyzes the conversion from glucose-1-phosphate to glucose-6-phosphate, which is a key step in hexose metabolism; functions as the acceptor for a Glc-phosphotransferase; protein abundance increases in response to DNA replication stress |
0.095 | 3.98E-8 | YDR376W | ARH1 | het | Oxidoreductase of the mitochondrial inner membrane, involved in cytoplasmic and mitochondrial iron homeostasis and required for activity of Fe-S cluster-containing enzymes; one of the few mitochondrial proteins essential for viability |
0.093 | 5.87E-8 | YMR196W_p | YMR196W_p | hom | Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YMR196W is not an essential gene |
0.093 | 7.18E-8 | YLR012C_p | YLR012C_p | hom | Putative protein of unknown function; YLR012C is not an essential gene |