YOR376W-A_p

Putative protein of unknown function; identified by fungal homology and RT-PCR

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR376W-A / YOR376W-A

Click on Significant Values for Screen Details ID:SGTC_4|Compound:0960-0234|FD-Score:2.83|P-value:9.14E-4 ID:SGTC_47|Compound:0149-0135|FD-Score:3.50|P-value:5.66E-5 ID:SGTC_236|Compound:1509-0011|FD-Score:4.74|P-value:8.33E-8 ID:SGTC_359|Compound:0081-0058|FD-Score:-3.15|P-value:2.23E-4 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:3.15|P-value:2.63E-4 ID:SGTC_425|Compound:3825-7017|FD-Score:-3.21|P-value:1.71E-4 ID:SGTC_473|Compound:2-arachidonoylglycerol|FD-Score:3.57|P-value:4.08E-5 ID:SGTC_493|Compound:zm226600|FD-Score:2.85|P-value:8.53E-4 ID:SGTC_552|Compound:k242-0005|FD-Score:2.84|P-value:8.73E-4 ID:SGTC_685|Compound:1278-0033|FD-Score:3.13|P-value:2.86E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-3.91|P-value:6.74E-6 ID:SGTC_873|Compound:0591-4978|FD-Score:3.18|P-value:2.34E-4 ID:SGTC_878|Compound:0828-0289|FD-Score:-4.09|P-value:2.62E-6 ID:SGTC_958|Compound:1222-0007|FD-Score:-3.12|P-value:2.49E-4 ID:SGTC_1092|Compound:toremifene|FD-Score:-5.34|P-value:1.50E-9 ID:SGTC_1093|Compound:fluphenazine|FD-Score:-3.76|P-value:1.44E-5 ID:SGTC_1099|Compound:5-nonyloxytryptamine|FD-Score:-3.00|P-value:4.09E-4 ID:SGTC_1105|Compound:epirubicin|FD-Score:-3.59|P-value:3.26E-5 ID:SGTC_1118|Compound:chelidonine|FD-Score:-5.56|P-value:3.27E-10 ID:SGTC_1127|Compound:asiatic acid|FD-Score:2.94|P-value:6.11E-4 ID:SGTC_1152|Compound:3909-8331|FD-Score:-4.43|P-value:4.06E-7 ID:SGTC_1157|Compound:4092-0394|FD-Score:3.15|P-value:2.62E-4 ID:SGTC_1212|Compound:0520-0165|FD-Score:3.10|P-value:3.26E-4 ID:SGTC_1299|Compound:1079-1439|FD-Score:-3.09|P-value:2.86E-4 ID:SGTC_1635|Compound:st007035|FD-Score:3.85|P-value:1.09E-5 ID:SGTC_1725|Compound:st036284|FD-Score:3.59|P-value:3.86E-5 ID:SGTC_1728|Compound:st035614|FD-Score:-3.00|P-value:4.13E-4 ID:SGTC_1730|Compound:st033808|FD-Score:-4.71|P-value:8.02E-8 ID:SGTC_1810|Compound:st050138|FD-Score:3.89|P-value:8.94E-6 ID:SGTC_1924|Compound:st058459|FD-Score:4.19|P-value:1.86E-6 ID:SGTC_2165|Compound:5727197|FD-Score:3.90|P-value:8.33E-6 ID:SGTC_2246|Compound:7293507|FD-Score:3.46|P-value:6.91E-5 ID:SGTC_2265|Compound:7929201|FD-Score:-3.17|P-value:2.06E-4 ID:SGTC_2280|Compound:7785178|FD-Score:-3.27|P-value:1.36E-4 ID:SGTC_2381|Compound:9035592|FD-Score:4.37|P-value:7.30E-7 ID:SGTC_2395|Compound:5646831|FD-Score:-3.46|P-value:5.77E-5 ID:SGTC_2401|Compound:5128683|FD-Score:5.95|P-value:2.48E-11 ID:SGTC_2446|Compound:5162541|FD-Score:-2.99|P-value:4.29E-4 ID:SGTC_2454|Compound:5-benzylidenerhodanine|FD-Score:3.16|P-value:2.51E-4 ID:SGTC_2486|Compound:5283202|FD-Score:-3.27|P-value:1.34E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:2.83|P-value:9.05E-4 ID:SGTC_2785|Compound:7756463|FD-Score:3.69|P-value:2.32E-5 ID:SGTC_2800|Compound:7887935|FD-Score:-3.22|P-value:1.69E-4 ID:SGTC_2921|Compound:7974240|FD-Score:4.11|P-value:2.96E-6 ID:SGTC_2924|Compound:9010168|FD-Score:3.72|P-value:2.08E-5 ID:SGTC_3044|Compound:9093193|FD-Score:-3.11|P-value:2.67E-4 ID:SGTC_3168|Compound:9103419|FD-Score:5.02|P-value:1.50E-8 ID:SGTC_3264|Compound:9137442|FD-Score:3.15|P-value:2.65E-4 ID:SGTC_4|Compound:0960-0234|FD-Score:2.83|P-value:9.14E-4 ID:SGTC_47|Compound:0149-0135|FD-Score:3.50|P-value:5.66E-5 ID:SGTC_236|Compound:1509-0011|FD-Score:4.74|P-value:8.33E-8 ID:SGTC_359|Compound:0081-0058|FD-Score:-3.15|P-value:2.23E-4 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:3.15|P-value:2.63E-4 ID:SGTC_425|Compound:3825-7017|FD-Score:-3.21|P-value:1.71E-4 ID:SGTC_473|Compound:2-arachidonoylglycerol|FD-Score:3.57|P-value:4.08E-5 ID:SGTC_493|Compound:zm226600|FD-Score:2.85|P-value:8.53E-4 ID:SGTC_552|Compound:k242-0005|FD-Score:2.84|P-value:8.73E-4 ID:SGTC_685|Compound:1278-0033|FD-Score:3.13|P-value:2.86E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-3.91|P-value:6.74E-6 ID:SGTC_873|Compound:0591-4978|FD-Score:3.18|P-value:2.34E-4 ID:SGTC_878|Compound:0828-0289|FD-Score:-4.09|P-value:2.62E-6 ID:SGTC_958|Compound:1222-0007|FD-Score:-3.12|P-value:2.49E-4 ID:SGTC_1092|Compound:toremifene|FD-Score:-5.34|P-value:1.50E-9 ID:SGTC_1093|Compound:fluphenazine|FD-Score:-3.76|P-value:1.44E-5 ID:SGTC_1099|Compound:5-nonyloxytryptamine|FD-Score:-3.00|P-value:4.09E-4 ID:SGTC_1105|Compound:epirubicin|FD-Score:-3.59|P-value:3.26E-5 ID:SGTC_1118|Compound:chelidonine|FD-Score:-5.56|P-value:3.27E-10 ID:SGTC_1127|Compound:asiatic acid|FD-Score:2.94|P-value:6.11E-4 ID:SGTC_1152|Compound:3909-8331|FD-Score:-4.43|P-value:4.06E-7 ID:SGTC_1157|Compound:4092-0394|FD-Score:3.15|P-value:2.62E-4 ID:SGTC_1212|Compound:0520-0165|FD-Score:3.10|P-value:3.26E-4 ID:SGTC_1299|Compound:1079-1439|FD-Score:-3.09|P-value:2.86E-4 ID:SGTC_1635|Compound:st007035|FD-Score:3.85|P-value:1.09E-5 ID:SGTC_1725|Compound:st036284|FD-Score:3.59|P-value:3.86E-5 ID:SGTC_1728|Compound:st035614|FD-Score:-3.00|P-value:4.13E-4 ID:SGTC_1730|Compound:st033808|FD-Score:-4.71|P-value:8.02E-8 ID:SGTC_1810|Compound:st050138|FD-Score:3.89|P-value:8.94E-6 ID:SGTC_1924|Compound:st058459|FD-Score:4.19|P-value:1.86E-6 ID:SGTC_2165|Compound:5727197|FD-Score:3.90|P-value:8.33E-6 ID:SGTC_2246|Compound:7293507|FD-Score:3.46|P-value:6.91E-5 ID:SGTC_2265|Compound:7929201|FD-Score:-3.17|P-value:2.06E-4 ID:SGTC_2280|Compound:7785178|FD-Score:-3.27|P-value:1.36E-4 ID:SGTC_2381|Compound:9035592|FD-Score:4.37|P-value:7.30E-7 ID:SGTC_2395|Compound:5646831|FD-Score:-3.46|P-value:5.77E-5 ID:SGTC_2401|Compound:5128683|FD-Score:5.95|P-value:2.48E-11 ID:SGTC_2446|Compound:5162541|FD-Score:-2.99|P-value:4.29E-4 ID:SGTC_2454|Compound:5-benzylidenerhodanine|FD-Score:3.16|P-value:2.51E-4 ID:SGTC_2486|Compound:5283202|FD-Score:-3.27|P-value:1.34E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:2.83|P-value:9.05E-4 ID:SGTC_2785|Compound:7756463|FD-Score:3.69|P-value:2.32E-5 ID:SGTC_2800|Compound:7887935|FD-Score:-3.22|P-value:1.69E-4 ID:SGTC_2921|Compound:7974240|FD-Score:4.11|P-value:2.96E-6 ID:SGTC_2924|Compound:9010168|FD-Score:3.72|P-value:2.08E-5 ID:SGTC_3044|Compound:9093193|FD-Score:-3.11|P-value:2.67E-4 ID:SGTC_3168|Compound:9103419|FD-Score:5.02|P-value:1.50E-8 ID:SGTC_3264|Compound:9137442|FD-Score:3.15|P-value:2.65E-4

Top fitness defect scores for YOR376W-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2401 5128683 5.95 200.0 µM 2.48E-11 9 1.34E-9
2 SGTC_3168 9103419 5.02 49.5 µM 1.50E-8 60S ribosome export 3 2.58E-7
3 SGTC_236 1509-0011 4.74 5.3 µM 8.33E-8 339 1.06E-6
4 SGTC_2381 9035592 4.37 200.0 µM 7.30E-7 10 6.33E-6
5 SGTC_1924 st058459 4.19 75.1 µM 1.86E-6 6 1.37E-5
6 SGTC_2921 7974240 4.11 10.7 µM 2.96E-6 49 2.01E-5
7 SGTC_2165 5727197 3.90 32.1 µM 8.33E-6 32 4.72E-5
8 SGTC_1810 st050138 3.89 53.0 µM 8.94E-6 PDR1 13 5.00E-5
9 SGTC_1635 st007035 3.85 42.4 µM 1.09E-5 218 5.88E-5
10 SGTC_2924 9010168 3.72 62.8 µM 2.08E-5 cell wall signaling 47 1.01E-4
11 SGTC_2785 7756463 3.69 72.7 µM 2.32E-5 36 1.10E-4
12 SGTC_1725 st036284 3.59 20.6 µM 3.86E-5 42 1.67E-4
13 SGTC_473 2-arachidonoylglycerol 3.57 10.0 µM 4.08E-5 25 1.76E-4
14 SGTC_47 0149-0135 3.50 24.2 µM 5.66E-5 TSC3-RPN4 30 2.30E-4
15 SGTC_2246 7293507 3.46 91.6 µM 6.91E-5 45 2.71E-4
16 SGTC_873 0591-4978 3.18 488.0 µM 2.34E-4 41 7.46E-4
17 SGTC_2454 5-benzylidenerhodanine 3.16 10.4 µM 2.51E-4 TRP & mitochondrial translation 81 7.91E-4
18 SGTC_1157 4092-0394 3.15 27.6 µM 2.62E-4 57 8.19E-4
19 SGTC_423 5-fluorouracil 3.15 457.0 µM 2.63E-4 exosome 58 8.21E-4
20 SGTC_3264 9137442 3.15 49.5 µM 2.65E-4 28 8.28E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.240 3.26E-45 YHR050W-A_p YHR050W-A_p hom Protein of unknown function; identified by expression profiling and mass spectrometry
0.223 6.12E-39 YJL166W QCR8 hom Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.209 2.90E-34 YJR120W YJR120W hom Protein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p
0.196 2.48E-30 YDR375C BCS1 hom Protein translocase and chaperone required for Complex III assembly; member of the AAA ATPase family; forms a homo-oligomeric complex in the mitochondrial inner membrane that translocates the C-terminal domain of Rip1p from the matrix across the inner membrane, and then delivers it to an assembly intermediate of respiratory Complex III in an ATP-dependent reaction; also required for assembly of the Qcr10p subunit; mutations in human homolog BCS1L linked to neonatal diseases
0.192 3.21E-29 YKL087C CYT2 hom Cytochrome c1 heme lyase, involved in maturation of cytochrome c1, which is a subunit of the mitochondrial ubiquinol-cytochrome-c reductase; links heme covalently to apocytochrome c1
0.190 1.19E-28 YMR151W_d YIM2_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 5% of ORF overlaps the verified gene IMP1
0.188 4.20E-28 YPL013C MRPS16 hom Mitochondrial ribosomal protein of the small subunit
0.187 6.96E-28 YEL059C-A SOM1 hom Subunit of the mitochondrial inner membrane peptidase, which is required for maturation of mitochondrial proteins of the intermembrane space; Som1p facilitates cleavage of a subset of substrates; contains twin cysteine-x9-cysteine motifs
0.186 1.97E-27 YGR183C QCR9 hom Subunit 9 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; required for electron transfer at the ubiquinol oxidase site of the complex
0.183 1.09E-26 YPL215W CBP3 hom Mitochondrial protein required for assembly of cytochrome bc1 complex; forms a complex with Cbp6p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex
0.177 6.71E-25 YGL237C HAP2 hom Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences sufficient for both complex assembly and DNA binding
0.176 1.01E-24 YIR021W MRS1 hom Protein required for the splicing of two mitochondrial group I introns (BI3 in COB and AI5beta in COX1); forms a splicing complex, containing four subunits of Mrs1p and two subunits of the BI3-encoded maturase, that binds to the BI3 RNA
0.173 6.03E-24 YOR065W CYT1 hom Cytochrome c1, component of the mitochondrial respiratory chain; expression is regulated by the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex
0.173 7.98E-24 YDR230W_d YDR230W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20
0.172 8.52E-24 YOR330C MIP1 hom Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit