YOR379C_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YOR378W

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR379C / YOR379C

Click on Significant Values for Screen Details ID:SGTC_79|Compound:0052-0007|FD-Score:3.91|P-value:3.77E-5 ID:SGTC_217|Compound:ketoconazole|FD-Score:3.43|P-value:2.54E-4 ID:SGTC_227|Compound:fluconazole|FD-Score:3.32|P-value:3.77E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:3.77|P-value:6.61E-5 ID:SGTC_490|Compound:phenamil|FD-Score:3.28|P-value:4.31E-4 ID:SGTC_588|Compound:3970-1144|FD-Score:4.82|P-value:5.26E-7 ID:SGTC_648|Compound:0375-0473|FD-Score:3.35|P-value:3.35E-4 ID:SGTC_672|Compound:1441-0018|FD-Score:3.08|P-value:8.62E-4 ID:SGTC_804|Compound:1595-0054|FD-Score:3.54|P-value:1.63E-4 ID:SGTC_1071|Compound:trifluoperazine|FD-Score:3.69|P-value:9.19E-5 ID:SGTC_1124|Compound:fisetin|FD-Score:-4.53|P-value:3.15E-6 ID:SGTC_1153|Compound:4055-0057|FD-Score:-3.98|P-value:3.80E-5 ID:SGTC_1163|Compound:k060-0048|FD-Score:3.13|P-value:7.30E-4 ID:SGTC_1195|Compound:1502-0147|FD-Score:3.23|P-value:5.17E-4 ID:SGTC_1344|Compound:1488-0097|FD-Score:4.74|P-value:8.08E-7 ID:SGTC_1350|Compound:1495-0454|FD-Score:3.41|P-value:2.67E-4 ID:SGTC_1363|Compound:1636-0063|FD-Score:3.44|P-value:2.37E-4 ID:SGTC_1381|Compound:2324-0066|FD-Score:-3.50|P-value:2.54E-4 ID:SGTC_1479|Compound:0549-0158|FD-Score:3.27|P-value:4.58E-4 ID:SGTC_1562|Compound:morin hydrate|FD-Score:4.11|P-value:1.59E-5 ID:SGTC_1576|Compound:erythromycin ethylsuccinate|FD-Score:3.07|P-value:9.21E-4 ID:SGTC_1663|Compound:st014140|FD-Score:3.15|P-value:6.92E-4 ID:SGTC_1713|Compound:st033146|FD-Score:5.35|P-value:3.26E-8 ID:SGTC_1715|Compound:st032160|FD-Score:-3.45|P-value:3.01E-4 ID:SGTC_1774|Compound:st048371|FD-Score:3.50|P-value:1.93E-4 ID:SGTC_2010|Compound:4012422|FD-Score:4.52|P-value:2.36E-6 ID:SGTC_2286|Compound:7945697|FD-Score:4.29|P-value:6.89E-6 ID:SGTC_2288|Compound:7946289|FD-Score:3.87|P-value:4.33E-5 ID:SGTC_2308|Compound:7584454|FD-Score:3.57|P-value:1.46E-4 ID:SGTC_2310|Compound:7668677|FD-Score:3.23|P-value:5.16E-4 ID:SGTC_2550|Compound:chrysin dimethyl ether|FD-Score:3.27|P-value:4.53E-4 ID:SGTC_2560|Compound:caryophyllene|FD-Score:-3.48|P-value:2.74E-4 ID:SGTC_2730|Compound:imipramine|FD-Score:3.99|P-value:2.61E-5 ID:SGTC_2852|Compound:9023854|FD-Score:-3.38|P-value:3.92E-4 ID:SGTC_2989|Compound:9073649|FD-Score:3.18|P-value:6.12E-4 ID:SGTC_3231|Compound:9132313|FD-Score:3.77|P-value:6.61E-5 ID:SGTC_3306|Compound:9127676|FD-Score:3.05|P-value:9.69E-4 ID:SGTC_79|Compound:0052-0007|FD-Score:3.91|P-value:3.77E-5 ID:SGTC_217|Compound:ketoconazole|FD-Score:3.43|P-value:2.54E-4 ID:SGTC_227|Compound:fluconazole|FD-Score:3.32|P-value:3.77E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:3.77|P-value:6.61E-5 ID:SGTC_490|Compound:phenamil|FD-Score:3.28|P-value:4.31E-4 ID:SGTC_588|Compound:3970-1144|FD-Score:4.82|P-value:5.26E-7 ID:SGTC_648|Compound:0375-0473|FD-Score:3.35|P-value:3.35E-4 ID:SGTC_672|Compound:1441-0018|FD-Score:3.08|P-value:8.62E-4 ID:SGTC_804|Compound:1595-0054|FD-Score:3.54|P-value:1.63E-4 ID:SGTC_1071|Compound:trifluoperazine|FD-Score:3.69|P-value:9.19E-5 ID:SGTC_1124|Compound:fisetin|FD-Score:-4.53|P-value:3.15E-6 ID:SGTC_1153|Compound:4055-0057|FD-Score:-3.98|P-value:3.80E-5 ID:SGTC_1163|Compound:k060-0048|FD-Score:3.13|P-value:7.30E-4 ID:SGTC_1195|Compound:1502-0147|FD-Score:3.23|P-value:5.17E-4 ID:SGTC_1344|Compound:1488-0097|FD-Score:4.74|P-value:8.08E-7 ID:SGTC_1350|Compound:1495-0454|FD-Score:3.41|P-value:2.67E-4 ID:SGTC_1363|Compound:1636-0063|FD-Score:3.44|P-value:2.37E-4 ID:SGTC_1381|Compound:2324-0066|FD-Score:-3.50|P-value:2.54E-4 ID:SGTC_1479|Compound:0549-0158|FD-Score:3.27|P-value:4.58E-4 ID:SGTC_1562|Compound:morin hydrate|FD-Score:4.11|P-value:1.59E-5 ID:SGTC_1576|Compound:erythromycin ethylsuccinate|FD-Score:3.07|P-value:9.21E-4 ID:SGTC_1663|Compound:st014140|FD-Score:3.15|P-value:6.92E-4 ID:SGTC_1713|Compound:st033146|FD-Score:5.35|P-value:3.26E-8 ID:SGTC_1715|Compound:st032160|FD-Score:-3.45|P-value:3.01E-4 ID:SGTC_1774|Compound:st048371|FD-Score:3.50|P-value:1.93E-4 ID:SGTC_2010|Compound:4012422|FD-Score:4.52|P-value:2.36E-6 ID:SGTC_2286|Compound:7945697|FD-Score:4.29|P-value:6.89E-6 ID:SGTC_2288|Compound:7946289|FD-Score:3.87|P-value:4.33E-5 ID:SGTC_2308|Compound:7584454|FD-Score:3.57|P-value:1.46E-4 ID:SGTC_2310|Compound:7668677|FD-Score:3.23|P-value:5.16E-4 ID:SGTC_2550|Compound:chrysin dimethyl ether|FD-Score:3.27|P-value:4.53E-4 ID:SGTC_2560|Compound:caryophyllene|FD-Score:-3.48|P-value:2.74E-4 ID:SGTC_2730|Compound:imipramine|FD-Score:3.99|P-value:2.61E-5 ID:SGTC_2852|Compound:9023854|FD-Score:-3.38|P-value:3.92E-4 ID:SGTC_2989|Compound:9073649|FD-Score:3.18|P-value:6.12E-4 ID:SGTC_3231|Compound:9132313|FD-Score:3.77|P-value:6.61E-5 ID:SGTC_3306|Compound:9127676|FD-Score:3.05|P-value:9.69E-4

Top fitness defect scores for YOR379C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1713 st033146 5.35 12.8 µM 3.26E-8 6 4.52E-8
2 SGTC_588 3970-1144 4.82 52.9 µM 5.26E-7 12 7.00E-7
3 SGTC_1344 1488-0097 4.74 29.1 µM 8.08E-7 9 1.07E-6
4 SGTC_2010 4012422 4.52 159.0 µM 2.36E-6 10 3.07E-6
5 SGTC_2286 7945697 4.29 125.0 µM 6.89E-6 43 8.82E-6
6 SGTC_1562 morin hydrate 4.11 59.1 µM 1.59E-5 14 2.01E-5
7 SGTC_2730 imipramine 3.99 71.3 µM 2.61E-5 21 3.28E-5
8 SGTC_79 0052-0007 3.91 94.1 µM 3.77E-5 43 4.70E-5
9 SGTC_2288 7946289 3.87 167.3 µM 4.33E-5 30 5.38E-5
10 SGTC_457 grayanotoxin iii 3.77 135.0 µM 6.61E-5 80 8.16E-5
11 SGTC_3231 9132313 3.77 49.5 µM 6.61E-5 10 8.17E-5
12 SGTC_1071 trifluoperazine 3.69 6.3 µM 9.19E-5 33 1.13E-4
13 SGTC_2308 7584454 3.57 197.6 µM 1.46E-4 35 1.78E-4
14 SGTC_804 1595-0054 3.54 20.9 µM 1.63E-4 sphingolipid biosynthesis & PDR1 49 1.99E-4
15 SGTC_1774 st048371 3.50 48.5 µM 1.93E-4 RNA processing & uracil transport 34 2.34E-4
16 SGTC_1363 1636-0063 3.44 10.4 µM 2.37E-4 Golgi 46 2.87E-4
17 SGTC_217 ketoconazole 3.43 989.0 nM 2.54E-4 ergosterol depletion effects on membrane 44 3.06E-4
18 SGTC_1350 1495-0454 3.41 146.0 µM 2.67E-4 52 3.22E-4
19 SGTC_648 0375-0473 3.35 33.3 µM 3.35E-4 34 4.02E-4
20 SGTC_227 fluconazole 3.32 33.5 µM 3.77E-4 azole & statin 115 4.52E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.122 1.37E-12 YJL195C_d YJL195C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL194W/CDC6
0.101 4.91E-9 YJL134W LCB3 hom Long-chain base-1-phosphate phosphatase; specific for dihydrosphingosine-1-phosphate, regulates ceramide and long-chain base phosphates levels, involved in incorporation of exogenous long chain bases in sphingolipids; LCB3 has a paralog, YSR3, that arose from the whole genome duplication
0.096 2.26E-8 YJL135W_d YJL135W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified genes YJL134W/LCB3
0.091 1.23E-7 YPR128C ANT1 hom Peroxisomal adenine nucleotide transporter; involved in beta-oxidation of medium-chain fatty acid; required for peroxisome proliferation
0.091 1.38E-7 YDR420W HKR1 hom Mucin family member that functions as an osmosensor in the Sho1p-mediated HOG pathway with Msb2p; proposed to be a negative regulator of filamentous growth; mutant displays defects in beta-1,3 glucan synthesis and bud site selection
0.090 1.61E-7 YPL036W PMA2 hom Plasma membrane H+-ATPase, isoform of Pma1p, involved in pumping protons out of the cell; regulator of cytoplasmic pH and plasma membrane potential
0.089 2.41E-7 YJL054W TIM54 het Component of the mitochondrial TIM22 complex involved in insertion of polytopic proteins into the inner membrane
0.089 2.87E-7 YNR033W ABZ1 hom Para-aminobenzoate (PABA) synthase; has similarity to Escherichia coli PABA synthase components PabA and PabB; required for the synthesis of para-aminobenzoic acid, an important intermediate for folate and ubiquinone Q biosynthesis; protein abundance increases in response to DNA replication stress
0.087 4.37E-7 YHR042W NCP1 het NADP-cytochrome P450 reductase; involved in ergosterol biosynthesis; associated and coordinately regulated with Erg11p
0.084 1.19E-6 YJL087C TRL1 het tRNA ligase, required for tRNA splicing and for both splicing and translation of HAC1 mRNA in the UPR; has phosphodiesterase, polynucleotide kinase, and ligase activities; localized at the inner nuclear envelope and partially to polysomes
0.083 1.71E-6 YOR047C STD1 hom Protein involved in control of glucose-regulated gene expression; interacts with kinase Snf1p, glucose sensors Snf3p and Rgt2p, TATA-binding Spt15p; regulator of transcription factor Rgt1p; interactions with Pma1p appear to propagate [GAR+]
0.081 2.62E-6 YDL220C CDC13 het Single stranded DNA-binding protein found at TG1-3 telomere G-tails; regulates telomere replication through recruitment of specific sub-complexes, but the essential function is telomere capping; autophagy and proteasome are involved in Cdc13p degradation
0.080 3.88E-6 YOR174W MED4 het Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation
0.079 5.02E-6 YLR104W_p LCL2_p hom Putative protein of unknown function; mutant is deficient in amounts of cell wall mannosylphosphate and has long chronological lifespan; genetic interactions suggest a role in ER-associated protein degradation (ERAD)
0.076 9.59E-6 YDR417C_d YDR417C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RPL12B/YDR418W