YOR381W / FRE3

Ferric reductase, reduces siderophore-bound iron prior to uptake by transporters; expression induced by low iron levels

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR381W / FRE3

Click on Significant Values for Screen Details ID:SGTC_45|Compound:0kpi-0036|FD-Score:-4.40|P-value:4.99E-6 ID:SGTC_239|Compound:5hr heat shock (37°C) + mitomycin C|FD-Score:-4.59|P-value:1.99E-6 ID:SGTC_265|Compound:mycophenolic acid|FD-Score:3.30|P-value:4.95E-4 ID:SGTC_349|Compound:k015-0014|FD-Score:3.64|P-value:1.38E-4 ID:SGTC_350|Compound:k064-0020|FD-Score:3.12|P-value:9.32E-4 ID:SGTC_355|Compound:1311-2252|FD-Score:-3.37|P-value:3.44E-4 ID:SGTC_360|Compound:0957-0399|FD-Score:-5.30|P-value:5.05E-8 ID:SGTC_389|Compound:tpck|FD-Score:3.64|P-value:1.39E-4 ID:SGTC_451|Compound:chloral hydrate|FD-Score:4.50|P-value:3.43E-6 ID:SGTC_530|Compound:4358-1714|FD-Score:4.74|P-value:1.09E-6 ID:SGTC_569|Compound:4130-2812|FD-Score:3.18|P-value:7.43E-4 ID:SGTC_689|Compound:0833-0039|FD-Score:3.12|P-value:9.26E-4 ID:SGTC_694|Compound:1315-0438|FD-Score:3.23|P-value:6.29E-4 ID:SGTC_737|Compound:1950-0117|FD-Score:-3.75|P-value:8.13E-5 ID:SGTC_754|Compound:3474-0146|FD-Score:-3.26|P-value:5.23E-4 ID:SGTC_797|Compound:k781-0471|FD-Score:3.78|P-value:8.01E-5 ID:SGTC_965|Compound:1291-5240|FD-Score:-3.13|P-value:8.08E-4 ID:SGTC_1001|Compound:4048-4355|FD-Score:3.51|P-value:2.28E-4 ID:SGTC_1007|Compound:4101-0031|FD-Score:3.13|P-value:8.87E-4 ID:SGTC_1122|Compound:capsaicin|FD-Score:3.77|P-value:8.16E-5 ID:SGTC_1127|Compound:asiatic acid|FD-Score:5.19|P-value:1.07E-7 ID:SGTC_1225|Compound:1216-0074|FD-Score:3.45|P-value:2.88E-4 ID:SGTC_1250|Compound:0485-0349|FD-Score:3.68|P-value:1.20E-4 ID:SGTC_1362|Compound:1611-0397|FD-Score:3.86|P-value:5.84E-5 ID:SGTC_1558|Compound:st069300|FD-Score:5.60|P-value:1.10E-8 ID:SGTC_1650|Compound:st011916|FD-Score:4.78|P-value:8.93E-7 ID:SGTC_1721|Compound:st082152|FD-Score:4.78|P-value:8.67E-7 ID:SGTC_1767|Compound:st044992|FD-Score:3.19|P-value:7.31E-4 ID:SGTC_1927|Compound:st060202|FD-Score:3.20|P-value:7.08E-4 ID:SGTC_2044|Compound:5102272|FD-Score:4.40|P-value:5.54E-6 ID:SGTC_2336|Compound:9001819|FD-Score:3.57|P-value:1.85E-4 ID:SGTC_2399|Compound:5884133|FD-Score:-3.22|P-value:6.05E-4 ID:SGTC_2483|Compound:5729050|FD-Score:3.14|P-value:8.57E-4 ID:SGTC_2626|Compound:ethyl orsellinate|FD-Score:3.45|P-value:2.82E-4 ID:SGTC_2643|Compound:anethole|FD-Score:3.55|P-value:1.95E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:-3.32|P-value:4.21E-4 ID:SGTC_2754|Compound:granisetron|FD-Score:-3.16|P-value:7.40E-4 ID:SGTC_2821|Compound:7996764|FD-Score:-4.33|P-value:6.84E-6 ID:SGTC_2827|Compound:7993847|FD-Score:5.33|P-value:4.88E-8 ID:SGTC_3065|Compound:9113888|FD-Score:-3.28|P-value:4.85E-4 ID:SGTC_3080|Compound:9117754|FD-Score:-3.86|P-value:5.15E-5 ID:SGTC_3085|Compound:9117376|FD-Score:3.79|P-value:7.61E-5 ID:SGTC_3131|Compound:9127911|FD-Score:-3.14|P-value:7.89E-4 ID:SGTC_3141|Compound:9094609|FD-Score:3.41|P-value:3.34E-4 ID:SGTC_3211|Compound:9128781|FD-Score:-3.15|P-value:7.54E-4 ID:SGTC_3298|Compound:9116858|FD-Score:4.12|P-value:1.97E-5 ID:SGTC_3322|Compound:9139058|FD-Score:-3.14|P-value:7.99E-4 ID:SGTC_45|Compound:0kpi-0036|FD-Score:-4.40|P-value:4.99E-6 ID:SGTC_239|Compound:5hr heat shock (37°C) + mitomycin C|FD-Score:-4.59|P-value:1.99E-6 ID:SGTC_265|Compound:mycophenolic acid|FD-Score:3.30|P-value:4.95E-4 ID:SGTC_349|Compound:k015-0014|FD-Score:3.64|P-value:1.38E-4 ID:SGTC_350|Compound:k064-0020|FD-Score:3.12|P-value:9.32E-4 ID:SGTC_355|Compound:1311-2252|FD-Score:-3.37|P-value:3.44E-4 ID:SGTC_360|Compound:0957-0399|FD-Score:-5.30|P-value:5.05E-8 ID:SGTC_389|Compound:tpck|FD-Score:3.64|P-value:1.39E-4 ID:SGTC_451|Compound:chloral hydrate|FD-Score:4.50|P-value:3.43E-6 ID:SGTC_530|Compound:4358-1714|FD-Score:4.74|P-value:1.09E-6 ID:SGTC_569|Compound:4130-2812|FD-Score:3.18|P-value:7.43E-4 ID:SGTC_689|Compound:0833-0039|FD-Score:3.12|P-value:9.26E-4 ID:SGTC_694|Compound:1315-0438|FD-Score:3.23|P-value:6.29E-4 ID:SGTC_737|Compound:1950-0117|FD-Score:-3.75|P-value:8.13E-5 ID:SGTC_754|Compound:3474-0146|FD-Score:-3.26|P-value:5.23E-4 ID:SGTC_797|Compound:k781-0471|FD-Score:3.78|P-value:8.01E-5 ID:SGTC_965|Compound:1291-5240|FD-Score:-3.13|P-value:8.08E-4 ID:SGTC_1001|Compound:4048-4355|FD-Score:3.51|P-value:2.28E-4 ID:SGTC_1007|Compound:4101-0031|FD-Score:3.13|P-value:8.87E-4 ID:SGTC_1122|Compound:capsaicin|FD-Score:3.77|P-value:8.16E-5 ID:SGTC_1127|Compound:asiatic acid|FD-Score:5.19|P-value:1.07E-7 ID:SGTC_1225|Compound:1216-0074|FD-Score:3.45|P-value:2.88E-4 ID:SGTC_1250|Compound:0485-0349|FD-Score:3.68|P-value:1.20E-4 ID:SGTC_1362|Compound:1611-0397|FD-Score:3.86|P-value:5.84E-5 ID:SGTC_1558|Compound:st069300|FD-Score:5.60|P-value:1.10E-8 ID:SGTC_1650|Compound:st011916|FD-Score:4.78|P-value:8.93E-7 ID:SGTC_1721|Compound:st082152|FD-Score:4.78|P-value:8.67E-7 ID:SGTC_1767|Compound:st044992|FD-Score:3.19|P-value:7.31E-4 ID:SGTC_1927|Compound:st060202|FD-Score:3.20|P-value:7.08E-4 ID:SGTC_2044|Compound:5102272|FD-Score:4.40|P-value:5.54E-6 ID:SGTC_2336|Compound:9001819|FD-Score:3.57|P-value:1.85E-4 ID:SGTC_2399|Compound:5884133|FD-Score:-3.22|P-value:6.05E-4 ID:SGTC_2483|Compound:5729050|FD-Score:3.14|P-value:8.57E-4 ID:SGTC_2626|Compound:ethyl orsellinate|FD-Score:3.45|P-value:2.82E-4 ID:SGTC_2643|Compound:anethole|FD-Score:3.55|P-value:1.95E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:-3.32|P-value:4.21E-4 ID:SGTC_2754|Compound:granisetron|FD-Score:-3.16|P-value:7.40E-4 ID:SGTC_2821|Compound:7996764|FD-Score:-4.33|P-value:6.84E-6 ID:SGTC_2827|Compound:7993847|FD-Score:5.33|P-value:4.88E-8 ID:SGTC_3065|Compound:9113888|FD-Score:-3.28|P-value:4.85E-4 ID:SGTC_3080|Compound:9117754|FD-Score:-3.86|P-value:5.15E-5 ID:SGTC_3085|Compound:9117376|FD-Score:3.79|P-value:7.61E-5 ID:SGTC_3131|Compound:9127911|FD-Score:-3.14|P-value:7.89E-4 ID:SGTC_3141|Compound:9094609|FD-Score:3.41|P-value:3.34E-4 ID:SGTC_3211|Compound:9128781|FD-Score:-3.15|P-value:7.54E-4 ID:SGTC_3298|Compound:9116858|FD-Score:4.12|P-value:1.97E-5 ID:SGTC_3322|Compound:9139058|FD-Score:-3.14|P-value:7.99E-4

Top fitness defect scores for YOR381W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1558 st069300 5.60 45.6 µM 1.10E-8 3 1.10E-8
2 SGTC_2827 7993847 5.33 71.4 µM 4.88E-8 6 4.85E-8
3 SGTC_1127 asiatic acid 5.19 681.4 nM 1.07E-7 7 1.06E-7
4 SGTC_1721 st082152 4.78 9.3 µM 8.67E-7 60S ribosome export 10 8.58E-7
5 SGTC_1650 st011916 4.78 45.8 µM 8.93E-7 5 8.83E-7
6 SGTC_530 4358-1714 4.74 28.0 µM 1.09E-6 22 1.07E-6
7 SGTC_451 chloral hydrate 4.50 100.0 µM 3.43E-6 35 3.39E-6
8 SGTC_2044 5102272 4.40 200.0 µM 5.54E-6 3 5.46E-6
9 SGTC_3298 9116858 4.12 71.4 µM 1.97E-5 8 1.94E-5
10 SGTC_1362 1611-0397 3.86 101.0 µM 5.84E-5 23 5.74E-5
11 SGTC_3085 9117376 3.79 49.5 µM 7.61E-5 13 7.48E-5
12 SGTC_797 k781-0471 3.78 270.0 µM 8.01E-5 RPP1 & pyrimidine depletion 24 7.87E-5
13 SGTC_1122 capsaicin 3.77 818.6 nM 8.16E-5 36 8.02E-5
14 SGTC_1250 0485-0349 3.68 40.2 µM 1.20E-4 44 1.17E-4
15 SGTC_349 k015-0014 3.64 24.0 µM 1.38E-4 29 1.36E-4
16 SGTC_389 tpck 3.64 16.7 µM 1.39E-4 35 1.37E-4
17 SGTC_2336 9001819 3.57 198.7 µM 1.85E-4 heme biosynthesis & mitochondrial translocase 72 1.81E-4
18 SGTC_2643 anethole 3.55 100.0 µM 1.95E-4 24 1.91E-4
19 SGTC_1001 4048-4355 3.51 44.4 µM 2.28E-4 copper-dependent oxidative stress 52 2.24E-4
20 SGTC_2626 ethyl orsellinate 3.45 100.0 µM 2.82E-4 48 2.77E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.109 2.74E-10 YNL299W TRF5 hom Non-canonical poly(A) polymerase, involved in nuclear RNA degradation as a component of the TRAMP complex; catalyzes polyadenylation of hypomodified tRNAs, and snoRNA and rRNA precursors; overlapping but non-redundant functions with Pap2p
0.099 1.05E-8 YNL268W LYP1 hom Lysine permease; one of three amino acid permeases (Alp1p, Can1p, Lyp1p) responsible for uptake of cationic amino acids
0.096 2.52E-8 YIL017C VID28 hom GID Complex subunit, serves as adaptor for regulatory subunit Vid24p; protein involved in proteasome-dependent catabolite degradation of fructose-1,6-bisphosphatase (FBPase); localized to the nucleus and the cytoplasm
0.095 3.79E-8 YGR290W_d YGR290W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; putative HLH protein; partially overlaps the verified ORF MAL11/YGR289C (a high-affinity maltose transporter)
0.092 9.31E-8 YDR019C GCV1 hom T subunit of the mitochondrial glycine decarboxylase complex, required for the catabolism of glycine to 5,10-methylene-THF; expression is regulated by levels of levels of 5,10-methylene-THF in the cytoplasm
0.082 2.16E-6 YPL028W ERG10 het Acetyl-CoA C-acetyltransferase (acetoacetyl-CoA thiolase), cytosolic enzyme that transfers an acetyl group from one acetyl-CoA molecule to another, forming acetoacetyl-CoA; involved in the first step in mevalonate biosynthesis
0.073 2.43E-5 YNL200C YNL200C hom NADHX epimerase; catalyzes isomerization of (R)- and (S)-NADHX; homologous to AIBP in mammals and the N- terminal domain of YjeF in E.coli; enzyme is widespread in eukaryotes, prokaryotes and archaea; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.072 2.86E-5 YKL095W YJU2 het Essential protein required for pre-mRNA splicing; associates transiently with the spliceosomal NTC (nineteen complex) and acts after Prp2p to promote the first catalytic reaction of splicing
0.071 3.77E-5 YLR263W RED1 hom Protein component of the synaptonemal complex axial elements, involved in chromosome segregation during the first meiotic division; critical for coupling checkpoint signaling to SC formation; interacts with Hop1p, Mec3p and Ddc1p
0.071 3.96E-5 YPL046C ELC1 hom Elongin C, conserved among eukaryotes; forms a complex with Cul3p that polyubiquitylates monoubiquitylated RNA polymerase II to trigger its proteolysis; plays a role in global genomic repair
0.069 5.66E-5 YPL232W SSO1 hom Plasma membrane t-SNARE involved in fusion of secretory vesicles at the plasma membrane and in vesicle fusion during sporulation; forms a complex with Sec9p that binds v-SNARE Snc2p; syntaxin homolog; functionally redundant with Sso2p
0.068 7.42E-5 YDL043C PRP11 het Subunit of the SF3a splicing factor complex, required for spliceosome assembly
0.067 9.64E-5 YKL163W PIR3 hom O-glycosylated covalently-bound cell wall protein; required for cell wall stability; expression is cell cycle regulated, peaking in M/G1 and also subject to regulation by the cell integrity pathway; PIR3 has a paralog, HSP150, that arose from the whole genome duplication
0.067 1.05E-4 YER021W RPN3 het Essential, non-ATPase regulatory subunit of the 26S proteasome lid, similar to the p58 subunit of the human 26S proteasome; temperature-sensitive alleles cause metaphase arrest, suggesting a role for the proteasome in cell cycle control
0.064 2.24E-4 YPL101W ELP4 hom Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex; which is required for modification of wobble nucleosides in tRNA; required for Elongator structural integrity