YOR384W / FRE5

Putative ferric reductase with similarity to Fre2p; expression induced by low iron levels; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR384W / FRE5

Click on Significant Values for Screen Details ID:SGTC_111|Compound:0083-0039|FD-Score:-3.54|P-value:4.77E-4 ID:SGTC_117|Compound:lucigenin|FD-Score:3.92|P-value:1.36E-4 ID:SGTC_265|Compound:mycophenolic acid|FD-Score:3.85|P-value:1.78E-4 ID:SGTC_715|Compound:0868-0130|FD-Score:-3.48|P-value:5.73E-4 ID:SGTC_776|Compound:4476-4378|FD-Score:5.03|P-value:1.47E-6 ID:SGTC_817|Compound:1391-0715|FD-Score:5.16|P-value:8.32E-7 ID:SGTC_832|Compound:4083-0019|FD-Score:-3.50|P-value:5.47E-4 ID:SGTC_842|Compound:0271-0008|FD-Score:3.67|P-value:3.36E-4 ID:SGTC_972|Compound:1319-0219|FD-Score:4.58|P-value:1.07E-5 ID:SGTC_1341|Compound:1486-1360|FD-Score:3.71|P-value:2.94E-4 ID:SGTC_1523|Compound:st012844|FD-Score:-3.73|P-value:2.52E-4 ID:SGTC_1598|Compound:3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin|FD-Score:3.75|P-value:2.55E-4 ID:SGTC_1612|Compound:st002233|FD-Score:3.72|P-value:2.76E-4 ID:SGTC_1750|Compound:st081859|FD-Score:-3.54|P-value:4.83E-4 ID:SGTC_2106|Compound:5357045|FD-Score:4.99|P-value:1.78E-6 ID:SGTC_2108|Compound:5365811|FD-Score:-5.04|P-value:1.28E-6 ID:SGTC_2136|Compound:5328288|FD-Score:3.61|P-value:3.99E-4 ID:SGTC_2398|Compound:5228213|FD-Score:-3.55|P-value:4.61E-4 ID:SGTC_2424|Compound:5537928|FD-Score:3.72|P-value:2.83E-4 ID:SGTC_2478|Compound:5763493|FD-Score:4.29|P-value:3.46E-5 ID:SGTC_2523|Compound:spermine|FD-Score:-3.45|P-value:6.41E-4 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:5.27|P-value:4.89E-7 ID:SGTC_2666|Compound:tannic acid|FD-Score:7.60|P-value:8.37E-13 ID:SGTC_2953|Compound:9074162|FD-Score:4.11|P-value:6.87E-5 ID:SGTC_2964|Compound:9083345|FD-Score:-3.90|P-value:1.38E-4 ID:SGTC_2965|Compound:9082772|FD-Score:3.72|P-value:2.79E-4 ID:SGTC_2994|Compound:9053520|FD-Score:5.07|P-value:1.24E-6 ID:SGTC_3030|Compound:9087619|FD-Score:-3.50|P-value:5.44E-4 ID:SGTC_3043|Compound:9092303|FD-Score:4.16|P-value:5.64E-5 ID:SGTC_3265|Compound:9137266|FD-Score:4.16|P-value:5.63E-5 ID:SGTC_3318|Compound:9139014|FD-Score:4.11|P-value:6.88E-5 ID:SGTC_111|Compound:0083-0039|FD-Score:-3.54|P-value:4.77E-4 ID:SGTC_117|Compound:lucigenin|FD-Score:3.92|P-value:1.36E-4 ID:SGTC_265|Compound:mycophenolic acid|FD-Score:3.85|P-value:1.78E-4 ID:SGTC_715|Compound:0868-0130|FD-Score:-3.48|P-value:5.73E-4 ID:SGTC_776|Compound:4476-4378|FD-Score:5.03|P-value:1.47E-6 ID:SGTC_817|Compound:1391-0715|FD-Score:5.16|P-value:8.32E-7 ID:SGTC_832|Compound:4083-0019|FD-Score:-3.50|P-value:5.47E-4 ID:SGTC_842|Compound:0271-0008|FD-Score:3.67|P-value:3.36E-4 ID:SGTC_972|Compound:1319-0219|FD-Score:4.58|P-value:1.07E-5 ID:SGTC_1341|Compound:1486-1360|FD-Score:3.71|P-value:2.94E-4 ID:SGTC_1523|Compound:st012844|FD-Score:-3.73|P-value:2.52E-4 ID:SGTC_1598|Compound:3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin|FD-Score:3.75|P-value:2.55E-4 ID:SGTC_1612|Compound:st002233|FD-Score:3.72|P-value:2.76E-4 ID:SGTC_1750|Compound:st081859|FD-Score:-3.54|P-value:4.83E-4 ID:SGTC_2106|Compound:5357045|FD-Score:4.99|P-value:1.78E-6 ID:SGTC_2108|Compound:5365811|FD-Score:-5.04|P-value:1.28E-6 ID:SGTC_2136|Compound:5328288|FD-Score:3.61|P-value:3.99E-4 ID:SGTC_2398|Compound:5228213|FD-Score:-3.55|P-value:4.61E-4 ID:SGTC_2424|Compound:5537928|FD-Score:3.72|P-value:2.83E-4 ID:SGTC_2478|Compound:5763493|FD-Score:4.29|P-value:3.46E-5 ID:SGTC_2523|Compound:spermine|FD-Score:-3.45|P-value:6.41E-4 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:5.27|P-value:4.89E-7 ID:SGTC_2666|Compound:tannic acid|FD-Score:7.60|P-value:8.37E-13 ID:SGTC_2953|Compound:9074162|FD-Score:4.11|P-value:6.87E-5 ID:SGTC_2964|Compound:9083345|FD-Score:-3.90|P-value:1.38E-4 ID:SGTC_2965|Compound:9082772|FD-Score:3.72|P-value:2.79E-4 ID:SGTC_2994|Compound:9053520|FD-Score:5.07|P-value:1.24E-6 ID:SGTC_3030|Compound:9087619|FD-Score:-3.50|P-value:5.44E-4 ID:SGTC_3043|Compound:9092303|FD-Score:4.16|P-value:5.64E-5 ID:SGTC_3265|Compound:9137266|FD-Score:4.16|P-value:5.63E-5 ID:SGTC_3318|Compound:9139014|FD-Score:4.11|P-value:6.88E-5

Top fitness defect scores for YOR384W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2666 tannic acid 7.60 100.0 µM 8.37E-13 iron homeostasis 4 1.52E-14
2 SGTC_2627 acetyl isogambogic acid 5.27 100.0 µM 4.89E-7 TSC3-RPN4 23 6.74E-8
3 SGTC_817 1391-0715 5.16 46.0 µM 8.32E-7 5 1.24E-7
4 SGTC_2994 9053520 5.07 71.4 µM 1.24E-6 RPP1 & pyrimidine depletion 8 1.97E-7
5 SGTC_776 4476-4378 5.03 112.0 µM 1.47E-6 ERG2 10 2.40E-7
6 SGTC_2106 5357045 4.99 167.3 µM 1.78E-6 6 2.97E-7
7 SGTC_972 1319-0219 4.58 195.0 µM 1.07E-5 10 2.34E-6
8 SGTC_2478 5763493 4.29 32.3 µM 3.46E-5 19 9.05E-6
9 SGTC_3265 9137266 4.16 49.5 µM 5.63E-5 7 1.58E-5
10 SGTC_3043 9092303 4.16 49.5 µM 5.64E-5 12 1.59E-5
11 SGTC_2953 9074162 4.11 66.5 µM 6.87E-5 19 1.99E-5
12 SGTC_3318 9139014 4.11 38.6 µM 6.88E-5 11 1.99E-5
13 SGTC_117 lucigenin 3.92 22.1 µM 1.36E-4 redox potentiating 83 4.37E-5
14 SGTC_265 mycophenolic acid 3.85 32.9 µM 1.78E-4 RPP1 & pyrimidine depletion 22 5.95E-5
15 SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 3.75 19.1 µM 2.55E-4 22 8.97E-5
16 SGTC_1612 st002233 3.72 45.4 µM 2.76E-4 24 9.85E-5
17 SGTC_2965 9082772 3.72 38.6 µM 2.79E-4 mitochondrial response to ROS 46 9.98E-5
18 SGTC_2424 5537928 3.72 59.2 µM 2.83E-4 43 1.01E-4
19 SGTC_1341 1486-1360 3.71 280.0 µM 2.94E-4 33 1.06E-4
20 SGTC_842 0271-0008 3.67 11.1 µM 3.36E-4 heme biosynthesis & mitochondrial translocase 27 1.24E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.154 2.81E-19 YOR382W FIT2 hom Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall
0.095 4.00E-8 YDL141W BPL1 het Biotin:apoprotein ligase, covalently modifies proteins with the addition of biotin, required for acetyl-CoA carboxylase (Acc1p) holoenzyme formation
0.093 6.76E-8 YBR272C HSM3 hom Proteasome-interacting protein involved in the assembly of the base subcomplex of the 19S proteasomal regulatory particle (RP); involved in DNA mismatch repair during slow growth; weak similarity to Msh1p; related to human 19S subunit S5b; structural study suggests Hsm3p is a scaffold protein for Rpt1p-Rpt2p complex formation
0.084 1.03E-6 YOR318C_d YOR318C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; transcript is predicted to be spliced but there is no evidence that it is spliced in vivo
0.083 1.53E-6 YER057C HMF1 hom Member of the p14.5 protein family with similarity to Mmf1p, functionally complements Mmf1p function when targeted to mitochondria; heat shock inducible; high-dosage growth inhibitor; forms a homotrimer in vitro
0.080 3.35E-6 YKL048C ELM1 hom Serine/threonine protein kinase that regulates cellular morphogenesis, septin behavior, and cytokinesis; required for the regulation of other kinases, such as Kin4p; forms part of the bud neck ring
0.080 3.73E-6 YHR200W RPN10 hom Non-ATPase base subunit of the 19S regulatory particle (RP) of the 26S proteasome; N-terminus plays a role in maintaining the structural integrity of the RP; binds selectively to polyubiquitin chains; homolog of the mammalian S5a protein
0.079 4.07E-6 YOR171C LCB4 hom Sphingoid long-chain base kinase, responsible for synthesis of long-chain base phosphates, which function as signaling molecules, regulates synthesis of ceramide from exogenous long-chain bases, localizes to the Golgi and late endosomes
0.079 4.68E-6 YLR108C YLR108C hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YLR108C is not an esssential gene; protein abundance increases in response to DNA replication stress; YLR108C has a paralog, YDR132C, that arose from the whole genome duplication
0.078 6.90E-6 YOR044W IRC23 hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion localizes to the ER; null mutant displays increased levels of spontaneous Rad52p foci; IRC23 has a paralog, BSC2, that arose from the whole genome duplication
0.076 9.38E-6 YKL122C SRP21 het Subunit of the signal recognition particle (SRP), which functions in protein targeting to the endoplasmic reticulum membrane; not found in mammalian SRP; forms a pre-SRP structure in the nucleolus that is translocated to the cytoplasm
0.075 1.40E-5 YAL028W FRT2 hom Tail-anchored ER membrane protein of unknown function; interacts with homolog Frt1p; promotes growth in conditions of high Na+, alkaline pH, or cell wall stress, possibly via a role in posttranslational translocation; potential Cdc28p substrate; FRT2 has a paralog, FRT1, that arose from the whole genome duplication
0.074 1.90E-5 YML009C MRPL39 hom Mitochondrial ribosomal protein of the large subunit
0.070 5.28E-5 YGR073C_d YGR073C_d het Dubious open reading frame unlikely to encode a functional protein, extensively overlaps essential SMD1 gene encoding a U6 snRNP protein
0.069 6.27E-5 YOL019W-A_p YOL019W-A_p hom Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching