YOR385W_p

Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YOR385W is not an essential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR385W / YOR385W

Click on Significant Values for Screen Details ID:SGTC_24|Compound:0417-1663|FD-Score:3.21|P-value:7.17E-4 ID:SGTC_155|Compound:k072-0202|FD-Score:3.20|P-value:7.42E-4 ID:SGTC_211|Compound:3455-0679|FD-Score:-3.47|P-value:2.76E-4 ID:SGTC_396|Compound:dithiazanine|FD-Score:3.54|P-value:2.18E-4 ID:SGTC_397|Compound:arbidol|FD-Score:3.68|P-value:1.29E-4 ID:SGTC_409|Compound:arachidonic acid|FD-Score:-5.65|P-value:9.57E-9 ID:SGTC_413|Compound:propylparaben|FD-Score:-3.88|P-value:5.63E-5 ID:SGTC_548|Compound:1436-0017|FD-Score:3.22|P-value:6.86E-4 ID:SGTC_599|Compound:1935-0052|FD-Score:4.45|P-value:4.97E-6 ID:SGTC_729|Compound:4092-0585|FD-Score:4.67|P-value:1.74E-6 ID:SGTC_789|Compound:1309-1135|FD-Score:5.84|P-value:3.32E-9 ID:SGTC_857|Compound:0438-0306|FD-Score:3.92|P-value:4.95E-5 ID:SGTC_877|Compound:0771-0151|FD-Score:3.18|P-value:8.12E-4 ID:SGTC_1068|Compound:loratadine|FD-Score:3.13|P-value:9.57E-4 ID:SGTC_1093|Compound:fluphenazine|FD-Score:5.53|P-value:2.04E-8 ID:SGTC_1120|Compound:ficusin|FD-Score:-3.55|P-value:2.11E-4 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:3.97|P-value:4.09E-5 ID:SGTC_1263|Compound:0774-1208|FD-Score:3.27|P-value:5.92E-4 ID:SGTC_1322|Compound:1348-1070|FD-Score:3.80|P-value:8.07E-5 ID:SGTC_1330|Compound:1469-0054|FD-Score:3.90|P-value:5.39E-5 ID:SGTC_1334|Compound:1486-0610|FD-Score:4.34|P-value:8.17E-6 ID:SGTC_1352|Compound:1496-0991|FD-Score:3.65|P-value:1.48E-4 ID:SGTC_1359|Compound:1582-0056|FD-Score:3.85|P-value:6.70E-5 ID:SGTC_1372|Compound:2752-0194|FD-Score:3.83|P-value:7.31E-5 ID:SGTC_1391|Compound:3442-0225|FD-Score:-3.86|P-value:6.31E-5 ID:SGTC_1428|Compound:4049-0204|FD-Score:3.82|P-value:7.48E-5 ID:SGTC_1510|Compound:1123-0200|FD-Score:3.49|P-value:2.65E-4 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:3.43|P-value:3.34E-4 ID:SGTC_1575|Compound:cyproterone acetate|FD-Score:-4.15|P-value:1.81E-5 ID:SGTC_1608|Compound:st001473|FD-Score:-3.35|P-value:4.25E-4 ID:SGTC_1726|Compound:st035556|FD-Score:3.13|P-value:9.57E-4 ID:SGTC_1799|Compound:st045822|FD-Score:3.21|P-value:7.11E-4 ID:SGTC_1823|Compound:3-hydroxy-2-naphthoic acid|FD-Score:3.28|P-value:5.64E-4 ID:SGTC_1885|Compound:st057546|FD-Score:3.99|P-value:3.79E-5 ID:SGTC_1901|Compound:st060216|FD-Score:-3.87|P-value:5.85E-5 ID:SGTC_1902|Compound:st060212|FD-Score:-3.44|P-value:3.14E-4 ID:SGTC_1985|Compound:st071382|FD-Score:-3.27|P-value:5.66E-4 ID:SGTC_1986|Compound:st071812|FD-Score:3.38|P-value:3.92E-4 ID:SGTC_2179|Compound:6298986|FD-Score:4.56|P-value:3.00E-6 ID:SGTC_2285|Compound:7945142|FD-Score:3.47|P-value:2.87E-4 ID:SGTC_2309|Compound:7664088|FD-Score:3.27|P-value:5.76E-4 ID:SGTC_2315|Compound:7733312|FD-Score:-3.34|P-value:4.47E-4 ID:SGTC_2360|Compound:9040895|FD-Score:5.57|P-value:1.60E-8 ID:SGTC_2366|Compound:9070441|FD-Score:-3.59|P-value:1.79E-4 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:3.12|P-value:9.72E-4 ID:SGTC_2485|Compound:5633444|FD-Score:5.99|P-value:1.39E-9 ID:SGTC_2487|Compound:5918373|FD-Score:3.52|P-value:2.34E-4 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:-3.17|P-value:8.21E-4 ID:SGTC_2572|Compound:astragaloside iv|FD-Score:3.27|P-value:5.90E-4 ID:SGTC_2706|Compound:st078239|FD-Score:-4.26|P-value:1.14E-5 ID:SGTC_2709|Compound:st078560|FD-Score:3.30|P-value:5.36E-4 ID:SGTC_2854|Compound:9024559|FD-Score:-3.77|P-value:8.73E-5 ID:SGTC_2856|Compound:9022925|FD-Score:5.22|P-value:1.07E-7 ID:SGTC_2870|Compound:9038528|FD-Score:3.13|P-value:9.51E-4 ID:SGTC_2871|Compound:9038510|FD-Score:4.28|P-value:1.09E-5 ID:SGTC_2874|Compound:9043904|FD-Score:4.29|P-value:1.00E-5 ID:SGTC_2887|Compound:9044784|FD-Score:3.31|P-value:5.08E-4 ID:SGTC_3045|Compound:9092950|FD-Score:4.85|P-value:7.44E-7 ID:SGTC_3058|Compound:9093861|FD-Score:3.23|P-value:6.62E-4 ID:SGTC_3171|Compound:9103192|FD-Score:3.15|P-value:8.84E-4 ID:SGTC_3215|Compound:9129942|FD-Score:4.34|P-value:8.31E-6 ID:SGTC_3217|Compound:9129673|FD-Score:-4.24|P-value:1.26E-5 ID:SGTC_3219|Compound:9131112|FD-Score:3.37|P-value:4.10E-4 ID:SGTC_3222|Compound:9128301|FD-Score:7.14|P-value:6.91E-13 ID:SGTC_3332|Compound:9141069|FD-Score:3.90|P-value:5.32E-5 ID:SGTC_3335|Compound:9143315|FD-Score:4.92|P-value:5.17E-7 ID:SGTC_24|Compound:0417-1663|FD-Score:3.21|P-value:7.17E-4 ID:SGTC_155|Compound:k072-0202|FD-Score:3.20|P-value:7.42E-4 ID:SGTC_211|Compound:3455-0679|FD-Score:-3.47|P-value:2.76E-4 ID:SGTC_396|Compound:dithiazanine|FD-Score:3.54|P-value:2.18E-4 ID:SGTC_397|Compound:arbidol|FD-Score:3.68|P-value:1.29E-4 ID:SGTC_409|Compound:arachidonic acid|FD-Score:-5.65|P-value:9.57E-9 ID:SGTC_413|Compound:propylparaben|FD-Score:-3.88|P-value:5.63E-5 ID:SGTC_548|Compound:1436-0017|FD-Score:3.22|P-value:6.86E-4 ID:SGTC_599|Compound:1935-0052|FD-Score:4.45|P-value:4.97E-6 ID:SGTC_729|Compound:4092-0585|FD-Score:4.67|P-value:1.74E-6 ID:SGTC_789|Compound:1309-1135|FD-Score:5.84|P-value:3.32E-9 ID:SGTC_857|Compound:0438-0306|FD-Score:3.92|P-value:4.95E-5 ID:SGTC_877|Compound:0771-0151|FD-Score:3.18|P-value:8.12E-4 ID:SGTC_1068|Compound:loratadine|FD-Score:3.13|P-value:9.57E-4 ID:SGTC_1093|Compound:fluphenazine|FD-Score:5.53|P-value:2.04E-8 ID:SGTC_1120|Compound:ficusin|FD-Score:-3.55|P-value:2.11E-4 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:3.97|P-value:4.09E-5 ID:SGTC_1263|Compound:0774-1208|FD-Score:3.27|P-value:5.92E-4 ID:SGTC_1322|Compound:1348-1070|FD-Score:3.80|P-value:8.07E-5 ID:SGTC_1330|Compound:1469-0054|FD-Score:3.90|P-value:5.39E-5 ID:SGTC_1334|Compound:1486-0610|FD-Score:4.34|P-value:8.17E-6 ID:SGTC_1352|Compound:1496-0991|FD-Score:3.65|P-value:1.48E-4 ID:SGTC_1359|Compound:1582-0056|FD-Score:3.85|P-value:6.70E-5 ID:SGTC_1372|Compound:2752-0194|FD-Score:3.83|P-value:7.31E-5 ID:SGTC_1391|Compound:3442-0225|FD-Score:-3.86|P-value:6.31E-5 ID:SGTC_1428|Compound:4049-0204|FD-Score:3.82|P-value:7.48E-5 ID:SGTC_1510|Compound:1123-0200|FD-Score:3.49|P-value:2.65E-4 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:3.43|P-value:3.34E-4 ID:SGTC_1575|Compound:cyproterone acetate|FD-Score:-4.15|P-value:1.81E-5 ID:SGTC_1608|Compound:st001473|FD-Score:-3.35|P-value:4.25E-4 ID:SGTC_1726|Compound:st035556|FD-Score:3.13|P-value:9.57E-4 ID:SGTC_1799|Compound:st045822|FD-Score:3.21|P-value:7.11E-4 ID:SGTC_1823|Compound:3-hydroxy-2-naphthoic acid|FD-Score:3.28|P-value:5.64E-4 ID:SGTC_1885|Compound:st057546|FD-Score:3.99|P-value:3.79E-5 ID:SGTC_1901|Compound:st060216|FD-Score:-3.87|P-value:5.85E-5 ID:SGTC_1902|Compound:st060212|FD-Score:-3.44|P-value:3.14E-4 ID:SGTC_1985|Compound:st071382|FD-Score:-3.27|P-value:5.66E-4 ID:SGTC_1986|Compound:st071812|FD-Score:3.38|P-value:3.92E-4 ID:SGTC_2179|Compound:6298986|FD-Score:4.56|P-value:3.00E-6 ID:SGTC_2285|Compound:7945142|FD-Score:3.47|P-value:2.87E-4 ID:SGTC_2309|Compound:7664088|FD-Score:3.27|P-value:5.76E-4 ID:SGTC_2315|Compound:7733312|FD-Score:-3.34|P-value:4.47E-4 ID:SGTC_2360|Compound:9040895|FD-Score:5.57|P-value:1.60E-8 ID:SGTC_2366|Compound:9070441|FD-Score:-3.59|P-value:1.79E-4 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:3.12|P-value:9.72E-4 ID:SGTC_2485|Compound:5633444|FD-Score:5.99|P-value:1.39E-9 ID:SGTC_2487|Compound:5918373|FD-Score:3.52|P-value:2.34E-4 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:-3.17|P-value:8.21E-4 ID:SGTC_2572|Compound:astragaloside iv|FD-Score:3.27|P-value:5.90E-4 ID:SGTC_2706|Compound:st078239|FD-Score:-4.26|P-value:1.14E-5 ID:SGTC_2709|Compound:st078560|FD-Score:3.30|P-value:5.36E-4 ID:SGTC_2854|Compound:9024559|FD-Score:-3.77|P-value:8.73E-5 ID:SGTC_2856|Compound:9022925|FD-Score:5.22|P-value:1.07E-7 ID:SGTC_2870|Compound:9038528|FD-Score:3.13|P-value:9.51E-4 ID:SGTC_2871|Compound:9038510|FD-Score:4.28|P-value:1.09E-5 ID:SGTC_2874|Compound:9043904|FD-Score:4.29|P-value:1.00E-5 ID:SGTC_2887|Compound:9044784|FD-Score:3.31|P-value:5.08E-4 ID:SGTC_3045|Compound:9092950|FD-Score:4.85|P-value:7.44E-7 ID:SGTC_3058|Compound:9093861|FD-Score:3.23|P-value:6.62E-4 ID:SGTC_3171|Compound:9103192|FD-Score:3.15|P-value:8.84E-4 ID:SGTC_3215|Compound:9129942|FD-Score:4.34|P-value:8.31E-6 ID:SGTC_3217|Compound:9129673|FD-Score:-4.24|P-value:1.26E-5 ID:SGTC_3219|Compound:9131112|FD-Score:3.37|P-value:4.10E-4 ID:SGTC_3222|Compound:9128301|FD-Score:7.14|P-value:6.91E-13 ID:SGTC_3332|Compound:9141069|FD-Score:3.90|P-value:5.32E-5 ID:SGTC_3335|Compound:9143315|FD-Score:4.92|P-value:5.17E-7

Top fitness defect scores for YOR385W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3222 9128301 7.14 49.5 µM 6.91E-13 60S ribosome export 2 4.83E-13
2 SGTC_2485 5633444 5.99 17.8 µM 1.39E-9 redox potentiating 12 1.08E-9
3 SGTC_789 1309-1135 5.84 70.6 µM 3.32E-9 ERG2 7 2.60E-9
4 SGTC_2360 9040895 5.57 200.0 µM 1.60E-8 RPP1 & pyrimidine depletion 6 1.28E-8
5 SGTC_1093 fluphenazine 5.53 8.0 µM 2.04E-8 4 1.63E-8
6 SGTC_2856 9022925 5.22 19.5 µM 1.07E-7 8 8.76E-8
7 SGTC_3335 9143315 4.92 29.6 µM 5.17E-7 fatty acid desaturase (OLE1) 4 4.33E-7
8 SGTC_3045 9092950 4.85 49.5 µM 7.44E-7 10 6.25E-7
9 SGTC_729 4092-0585 4.67 94.1 µM 1.74E-6 11 1.48E-6
10 SGTC_2179 6298986 4.56 200.0 µM 3.00E-6 heme requiring 11 2.57E-6
11 SGTC_599 1935-0052 4.45 86.5 µM 4.97E-6 13 4.29E-6
12 SGTC_1334 1486-0610 4.34 236.0 µM 8.17E-6 60S ribosome export 8 7.09E-6
13 SGTC_3215 9129942 4.34 49.5 µM 8.31E-6 7 7.21E-6
14 SGTC_2874 9043904 4.29 71.4 µM 1.00E-5 7 8.74E-6
15 SGTC_2871 9038510 4.28 13.0 µM 1.09E-5 11 9.52E-6
16 SGTC_1885 st057546 3.99 99.9 µM 3.79E-5 20 3.36E-5
17 SGTC_1135 dihydrocapsaicin 3.97 536.7 nM 4.09E-5 36 3.63E-5
18 SGTC_857 0438-0306 3.92 1.4 µM 4.95E-5 copper-dependent oxidative stress 14 4.40E-5
19 SGTC_3332 9141069 3.90 11.2 µM 5.32E-5 17 4.73E-5
20 SGTC_1330 1469-0054 3.90 61.8 µM 5.39E-5 iron homeostasis 18 4.79E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.105 1.15E-9 YNL193W_p YNL193W_p hom Putative protein of unknown function; exhibits a two-hybrid interaction with Yhr151cp in a large-scale analysis
0.099 9.91E-9 YDR490C PKH1 hom Serine/threonine protein kinase involved in sphingolipid-mediated signaling pathway that controls endocytosis; activates Ypk1p and Ykr2p, components of signaling cascade required for maintenance of cell wall integrity; redundant with Pkh2p
0.086 6.70E-7 YBL078C ATG8 hom Component of autophagosomes and Cvt vesicles; unique ubiquitin-like protein whose conjugation target is the lipid phosphatidylethanolamine (PE); Atg8p-PE is anchored to membranes, is involved in phagophore expansion, and may mediate membrane fusion during autophagosome formation; deconjugation of Atg8p-PE is required for efficient autophagosome biogenesis
0.083 1.32E-6 YFR012W-A_p YFR012W-A_p hom Putative protein of unknown function; identified by homology
0.079 4.29E-6 YMR316W DIA1 hom Protein of unknown function, involved in invasive and pseudohyphal growth; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
0.074 1.59E-5 YHR133C NSG1 hom Protein involved in regulation of sterol biosynthesis; specifically stabilizes Hmg2p, one of two HMG-CoA isoenzymes that catalyze the rate-limiting step in sterol biosynthesis; homolog of mammalian INSIG proteins; forms foci at the nuclear periphery upon DNA replication stress
0.074 1.60E-5 YER139C RTR1 hom CTD phosphatase; dephosphorylates S5-P in the C-terminal domain of Rpo21p; has a cysteine-rich motif required for function and conserved in eukaryotes; shuttles between the nucleus and cytoplasm; RTR1 has a paralog, RTR2, that arose from the whole genome duplication
0.073 2.31E-5 YJL218W_p YJL218W_p hom Putative acetyltransferase; similar to bacterial galactoside O-acetyltransferases; induced by oleate in an OAF1/PIP2-dependent manner; promoter contains an oleate response element consensus sequence; non-essential gene
0.073 2.38E-5 YBR236C ABD1 het Methyltransferase, catalyzes the transfer of a methyl group from S-adenosylmethionine to the GpppN terminus of capped mRNA
0.070 4.85E-5 YDR009W GAL3 hom Transcriptional regulator; involved in activation of the GAL genes in response to galactose; forms a complex with Gal80p to relieve Gal80p inhibition of Gal4p; binds galactose and ATP but does not have galactokinase activity; GAL3 has a paralog, GAL1, that arose from the whole genome duplication
0.067 1.06E-4 YKR084C HBS1 hom GTPase with similarity to translation release factors; together with binding partner Dom34p, facilitates ribosomal subunit dissociation and peptidyl-tRNA release when translation is stalled; genetically implicated in mRNA no-go decay
0.067 1.09E-4 YKR031C SPO14 hom Phospholipase D; catalyzes the hydrolysis of phosphatidylcholine, producing choline and phosphatidic acid; involved in Sec14p-independent secretion; required for meiosis and spore formation; differently regulated in secretion and meiosis; participates in transcription initiation and/or early elongation of specific genes; interacts with foot domain of RNA polymerase II; deletion results in abnormal CTD-Ser5 phosphorylation of RNA polymerase II at specific promoter regions
0.066 1.29E-4 YMR013W-A_d YMR013W-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the characterized snoRNA gene snR73
0.066 1.34E-4 YDR426C_d YDR426C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SNX41
0.065 1.48E-4 YOR352W TFB6 hom Subunit of TFIIH complex; facilities dissociation of the Ssl2p helices from TFIIH; expression levels regulated by Arg5,6p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus