YOR386W / PHR1

DNA photolyase involved in photoreactivation, repairs pyrimidine dimers in the presence of visible light; induced by DNA damage; regulated by transcriptional repressor Rph1p

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR386W / PHR1

Click on Significant Values for Screen Details ID:SGTC_47|Compound:0149-0135|FD-Score:4.04|P-value:4.23E-5 ID:SGTC_49|Compound:0717-0965|FD-Score:4.34|P-value:1.16E-5 ID:SGTC_53|Compound:0973-0023|FD-Score:-3.13|P-value:8.76E-4 ID:SGTC_169|Compound:k015-0017|FD-Score:-3.43|P-value:3.06E-4 ID:SGTC_264|Compound:promethazine|FD-Score:4.04|P-value:4.25E-5 ID:SGTC_278|Compound:4092-0821|FD-Score:3.22|P-value:9.07E-4 ID:SGTC_309|Compound:k408-0051|FD-Score:5.89|P-value:4.43E-9 ID:SGTC_380|Compound:3970-0968|FD-Score:3.31|P-value:6.48E-4 ID:SGTC_518|Compound:1021-0119|FD-Score:3.75|P-value:1.35E-4 ID:SGTC_630|Compound:4356-0227|FD-Score:3.61|P-value:2.24E-4 ID:SGTC_733|Compound:4069-0007|FD-Score:3.86|P-value:8.54E-5 ID:SGTC_850|Compound:0388-0143|FD-Score:3.57|P-value:2.60E-4 ID:SGTC_864|Compound:0469-0573|FD-Score:3.36|P-value:5.52E-4 ID:SGTC_954|Compound:1189-0853|FD-Score:4.42|P-value:8.14E-6 ID:SGTC_984|Compound:1492-0255|FD-Score:4.50|P-value:5.81E-6 ID:SGTC_994|Compound:3910-0338|FD-Score:-3.83|P-value:6.81E-5 ID:SGTC_1049|Compound:3226-0134|FD-Score:3.53|P-value:2.98E-4 ID:SGTC_1094|Compound:duloxetine|FD-Score:3.60|P-value:2.33E-4 ID:SGTC_1095|Compound:3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran|FD-Score:3.51|P-value:3.27E-4 ID:SGTC_1116|Compound:jasmonic acid|FD-Score:3.46|P-value:3.90E-4 ID:SGTC_1220|Compound:1838-0075|FD-Score:3.56|P-value:2.70E-4 ID:SGTC_1289|Compound:0976-0073|FD-Score:3.33|P-value:6.23E-4 ID:SGTC_1303|Compound:1160-0052|FD-Score:3.32|P-value:6.31E-4 ID:SGTC_1372|Compound:2752-0194|FD-Score:3.48|P-value:3.62E-4 ID:SGTC_1373|Compound:2887-0003|FD-Score:-3.43|P-value:3.07E-4 ID:SGTC_1506|Compound:4226-2149|FD-Score:3.62|P-value:2.19E-4 ID:SGTC_1565|Compound:sinapyl alcohol|FD-Score:3.49|P-value:3.55E-4 ID:SGTC_1677|Compound:st019204|FD-Score:3.29|P-value:6.98E-4 ID:SGTC_1856|Compound:st057054|FD-Score:-3.19|P-value:7.11E-4 ID:SGTC_1860|Compound:st056228|FD-Score:4.29|P-value:1.49E-5 ID:SGTC_2067|Compound:5224629|FD-Score:3.50|P-value:3.41E-4 ID:SGTC_2122|Compound:5258151|FD-Score:4.06|P-value:3.89E-5 ID:SGTC_2161|Compound:5662504|FD-Score:3.48|P-value:3.67E-4 ID:SGTC_2396|Compound:5342950|FD-Score:4.00|P-value:5.04E-5 ID:SGTC_2399|Compound:5884133|FD-Score:-3.76|P-value:8.89E-5 ID:SGTC_2400|Compound:5203494|FD-Score:3.75|P-value:1.34E-4 ID:SGTC_2402|Compound:5553605|FD-Score:-3.17|P-value:7.65E-4 ID:SGTC_2403|Compound:6032726|FD-Score:6.12|P-value:1.12E-9 ID:SGTC_2406|Compound:ethylparaben|FD-Score:5.91|P-value:3.79E-9 ID:SGTC_2411|Compound:st077133|FD-Score:3.37|P-value:5.33E-4 ID:SGTC_2424|Compound:5537928|FD-Score:-3.53|P-value:2.15E-4 ID:SGTC_2428|Compound:5615643|FD-Score:-4.14|P-value:1.86E-5 ID:SGTC_2431|Compound:5490079|FD-Score:3.93|P-value:6.50E-5 ID:SGTC_2475|Compound:5812728|FD-Score:3.20|P-value:9.68E-4 ID:SGTC_2507|Compound:purpurin|FD-Score:3.39|P-value:4.90E-4 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:4.36|P-value:1.06E-5 ID:SGTC_2690|Compound:usnic acid|FD-Score:-3.10|P-value:9.67E-4 ID:SGTC_2691|Compound:st077356|FD-Score:3.60|P-value:2.33E-4 ID:SGTC_2819|Compound:7996655|FD-Score:-3.49|P-value:2.44E-4 ID:SGTC_2938|Compound:9059746|FD-Score:-4.04|P-value:2.83E-5 ID:SGTC_3020|Compound:9089140|FD-Score:4.28|P-value:1.55E-5 ID:SGTC_3116|Compound:9124943|FD-Score:4.04|P-value:4.23E-5 ID:SGTC_3263|Compound:9137018|FD-Score:4.70|P-value:2.28E-6 ID:SGTC_47|Compound:0149-0135|FD-Score:4.04|P-value:4.23E-5 ID:SGTC_49|Compound:0717-0965|FD-Score:4.34|P-value:1.16E-5 ID:SGTC_53|Compound:0973-0023|FD-Score:-3.13|P-value:8.76E-4 ID:SGTC_169|Compound:k015-0017|FD-Score:-3.43|P-value:3.06E-4 ID:SGTC_264|Compound:promethazine|FD-Score:4.04|P-value:4.25E-5 ID:SGTC_278|Compound:4092-0821|FD-Score:3.22|P-value:9.07E-4 ID:SGTC_309|Compound:k408-0051|FD-Score:5.89|P-value:4.43E-9 ID:SGTC_380|Compound:3970-0968|FD-Score:3.31|P-value:6.48E-4 ID:SGTC_518|Compound:1021-0119|FD-Score:3.75|P-value:1.35E-4 ID:SGTC_630|Compound:4356-0227|FD-Score:3.61|P-value:2.24E-4 ID:SGTC_733|Compound:4069-0007|FD-Score:3.86|P-value:8.54E-5 ID:SGTC_850|Compound:0388-0143|FD-Score:3.57|P-value:2.60E-4 ID:SGTC_864|Compound:0469-0573|FD-Score:3.36|P-value:5.52E-4 ID:SGTC_954|Compound:1189-0853|FD-Score:4.42|P-value:8.14E-6 ID:SGTC_984|Compound:1492-0255|FD-Score:4.50|P-value:5.81E-6 ID:SGTC_994|Compound:3910-0338|FD-Score:-3.83|P-value:6.81E-5 ID:SGTC_1049|Compound:3226-0134|FD-Score:3.53|P-value:2.98E-4 ID:SGTC_1094|Compound:duloxetine|FD-Score:3.60|P-value:2.33E-4 ID:SGTC_1095|Compound:3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran|FD-Score:3.51|P-value:3.27E-4 ID:SGTC_1116|Compound:jasmonic acid|FD-Score:3.46|P-value:3.90E-4 ID:SGTC_1220|Compound:1838-0075|FD-Score:3.56|P-value:2.70E-4 ID:SGTC_1289|Compound:0976-0073|FD-Score:3.33|P-value:6.23E-4 ID:SGTC_1303|Compound:1160-0052|FD-Score:3.32|P-value:6.31E-4 ID:SGTC_1372|Compound:2752-0194|FD-Score:3.48|P-value:3.62E-4 ID:SGTC_1373|Compound:2887-0003|FD-Score:-3.43|P-value:3.07E-4 ID:SGTC_1506|Compound:4226-2149|FD-Score:3.62|P-value:2.19E-4 ID:SGTC_1565|Compound:sinapyl alcohol|FD-Score:3.49|P-value:3.55E-4 ID:SGTC_1677|Compound:st019204|FD-Score:3.29|P-value:6.98E-4 ID:SGTC_1856|Compound:st057054|FD-Score:-3.19|P-value:7.11E-4 ID:SGTC_1860|Compound:st056228|FD-Score:4.29|P-value:1.49E-5 ID:SGTC_2067|Compound:5224629|FD-Score:3.50|P-value:3.41E-4 ID:SGTC_2122|Compound:5258151|FD-Score:4.06|P-value:3.89E-5 ID:SGTC_2161|Compound:5662504|FD-Score:3.48|P-value:3.67E-4 ID:SGTC_2396|Compound:5342950|FD-Score:4.00|P-value:5.04E-5 ID:SGTC_2399|Compound:5884133|FD-Score:-3.76|P-value:8.89E-5 ID:SGTC_2400|Compound:5203494|FD-Score:3.75|P-value:1.34E-4 ID:SGTC_2402|Compound:5553605|FD-Score:-3.17|P-value:7.65E-4 ID:SGTC_2403|Compound:6032726|FD-Score:6.12|P-value:1.12E-9 ID:SGTC_2406|Compound:ethylparaben|FD-Score:5.91|P-value:3.79E-9 ID:SGTC_2411|Compound:st077133|FD-Score:3.37|P-value:5.33E-4 ID:SGTC_2424|Compound:5537928|FD-Score:-3.53|P-value:2.15E-4 ID:SGTC_2428|Compound:5615643|FD-Score:-4.14|P-value:1.86E-5 ID:SGTC_2431|Compound:5490079|FD-Score:3.93|P-value:6.50E-5 ID:SGTC_2475|Compound:5812728|FD-Score:3.20|P-value:9.68E-4 ID:SGTC_2507|Compound:purpurin|FD-Score:3.39|P-value:4.90E-4 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:4.36|P-value:1.06E-5 ID:SGTC_2690|Compound:usnic acid|FD-Score:-3.10|P-value:9.67E-4 ID:SGTC_2691|Compound:st077356|FD-Score:3.60|P-value:2.33E-4 ID:SGTC_2819|Compound:7996655|FD-Score:-3.49|P-value:2.44E-4 ID:SGTC_2938|Compound:9059746|FD-Score:-4.04|P-value:2.83E-5 ID:SGTC_3020|Compound:9089140|FD-Score:4.28|P-value:1.55E-5 ID:SGTC_3116|Compound:9124943|FD-Score:4.04|P-value:4.23E-5 ID:SGTC_3263|Compound:9137018|FD-Score:4.70|P-value:2.28E-6

Top fitness defect scores for YOR386W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2403 6032726 6.12 181.2 µM 1.12E-9 10 4.69E-10
2 SGTC_2406 ethylparaben 5.91 405.7 µM 3.79E-9 10 1.66E-9
3 SGTC_309 k408-0051 5.89 1.5 µM 4.43E-9 13 1.96E-9
4 SGTC_3263 9137018 4.70 49.5 µM 2.28E-6 6 1.28E-6
5 SGTC_984 1492-0255 4.50 2.9 µM 5.81E-6 SWF1 & branched chain AA biosynthesis 22 3.39E-6
6 SGTC_954 1189-0853 4.42 2.9 µM 8.14E-6 endomembrane recycling 26 4.82E-6
7 SGTC_2588 indole-3-carbinol 4.36 100.0 µM 1.06E-5 32 6.37E-6
8 SGTC_49 0717-0965 4.34 32.1 µM 1.16E-5 60S ribosome export 14 6.99E-6
9 SGTC_1860 st056228 4.29 74.6 µM 1.49E-5 10 9.02E-6
10 SGTC_3020 9089140 4.28 49.5 µM 1.55E-5 19 9.41E-6
11 SGTC_2122 5258151 4.06 111.7 µM 3.89E-5 21 2.45E-5
12 SGTC_3116 9124943 4.04 49.5 µM 4.23E-5 14 2.68E-5
13 SGTC_47 0149-0135 4.04 24.2 µM 4.23E-5 TSC3-RPN4 17 2.68E-5
14 SGTC_264 promethazine 4.04 12.5 mM 4.25E-5 DNA intercalators 50 2.69E-5
15 SGTC_2396 5342950 4.00 42.8 µM 5.04E-5 RSC complex & mRNA processing 43 3.21E-5
16 SGTC_2431 5490079 3.93 200.0 µM 6.50E-5 37 4.19E-5
17 SGTC_733 4069-0007 3.86 56.1 µM 8.54E-5 ERAD & cell cycle 90 5.57E-5
18 SGTC_2400 5203494 3.75 178.7 µM 1.34E-4 RSC complex & mRNA processing 29 8.93E-5
19 SGTC_518 1021-0119 3.75 62.6 µM 1.35E-4 ERG2 55 8.96E-5
20 SGTC_1506 4226-2149 3.62 212.0 µM 2.19E-4 38 1.48E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.129 5.20E-14 YOL053W AIM39 hom Putative protein of unknown function; null mutant displays elevated frequency of mitochondrial genome loss
0.128 1.00E-13 YJL153C INO1 hom Inositol-3-phosphate synthase, involved in synthesis of inositol phosphates and inositol-containing phospholipids; transcription is coregulated with other phospholipid biosynthetic genes by Ino2p and Ino4p, which bind the UASINO DNA element
0.102 2.93E-9 YNL334C SNO2 hom Protein of unknown function, nearly identical to Sno3p; expression is induced before the diauxic shift and also in the absence of thiamin
0.100 6.41E-9 YGR100W MDR1 hom Cytoplasmic GTPase-activating protein for Ypt/Rab transport GTPases Ypt6p, Ypt31p and Sec4p; involved in recycling of internalized proteins and regulation of Golgi secretory function
0.090 1.65E-7 YAR047C_d YAR047C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.078 6.34E-6 YOR149C SMP3 het Alpha 1,2-mannosyltransferase involved in glycosyl phosphatidyl inositol (GPI) biosynthesis; required for addition of the fourth, side branching mannose to the GPI core structure
0.078 6.58E-6 YHR159W_p TDA11_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; potential Cdc28p substrate; null mutant is sensitive to expression of the top1-T722A allele
0.075 1.23E-5 YER002W NOP16 hom Constituent of 66S pre-ribosomal particles, involved in 60S ribosomal subunit biogenesis
0.075 1.26E-5 YHL022C SPO11 hom Meiosis-specific protein that initiates meiotic recombination by catalyzing the formation of double-strand breaks in DNA via a transesterification reaction; required for homologous chromosome pairing and synaptonemal complex formation
0.075 1.33E-5 YMR144W_p YMR144W_p hom Putative protein of unknown function; localized to the nucleus; YMR144W is not an essential gene
0.074 1.84E-5 YKL026C GPX1 hom Phospholipid hydroperoxide glutathione peroxidase induced by glucose starvation that protects cells from phospholipid hydroperoxides and nonphospholipid peroxides during oxidative stress
0.071 3.55E-5 YGR065C VHT1 het High-affinity plasma membrane H+-biotin (vitamin H) symporter; mutation results in fatty acid auxotrophy; 12 transmembrane domain containing major facilitator subfamily member; mRNA levels negatively regulated by iron deprivation and biotin
0.071 3.57E-5 YKR012C_d YKR012C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene PRY2
0.071 4.07E-5 YPL174C NIP100 hom Large subunit of the dynactin complex, which is involved in partitioning the mitotic spindle between mother and daughter cells; putative ortholog of mammalian p150(glued)
0.070 4.47E-5 YNL221C POP1 het Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs; binds to the RPR1 RNA subunit in RNase P