YPL001W / HAT1

Catalytic subunit of the Hat1p-Hat2p histone acetyltransferase complex that uses the cofactor acetyl coenzyme A, to acetylate free nuclear and cytoplasmic histone H4; involved in telomeric silencing and DNA double-strand break repair

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL001W / HAT1

Click on Significant Values for Screen Details ID:SGTC_127|Compound:0180-0333|FD-Score:-3.29|P-value:9.38E-4 ID:SGTC_282|Compound:k297-0036|FD-Score:-3.44|P-value:5.81E-4 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:3.92|P-value:1.15E-4 ID:SGTC_518|Compound:1021-0119|FD-Score:-3.56|P-value:3.87E-4 ID:SGTC_632|Compound:0781-2353|FD-Score:4.14|P-value:4.98E-5 ID:SGTC_996|Compound:3970-0799|FD-Score:5.07|P-value:9.61E-7 ID:SGTC_1045|Compound:1348-1485|FD-Score:3.75|P-value:2.12E-4 ID:SGTC_1046|Compound:2001-0062|FD-Score:4.99|P-value:1.41E-6 ID:SGTC_1052|Compound:3253-3998|FD-Score:3.35|P-value:8.36E-4 ID:SGTC_1353|Compound:1498-1206|FD-Score:3.43|P-value:6.32E-4 ID:SGTC_1446|Compound:4239-0190|FD-Score:-3.83|P-value:1.49E-4 ID:SGTC_1450|Compound:4112-4260|FD-Score:-3.75|P-value:1.98E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:3.85|P-value:1.49E-4 ID:SGTC_1463|Compound:k081-0032|FD-Score:3.63|P-value:3.27E-4 ID:SGTC_1485|Compound:3909-9022|FD-Score:3.40|P-value:6.97E-4 ID:SGTC_1486|Compound:3970-0793|FD-Score:3.43|P-value:6.50E-4 ID:SGTC_1681|Compound:tripelennamine|FD-Score:5.20|P-value:5.12E-7 ID:SGTC_1727|Compound:st034309|FD-Score:4.47|P-value:1.31E-5 ID:SGTC_1771|Compound:st048882|FD-Score:3.66|P-value:2.90E-4 ID:SGTC_1949|Compound:st076024|FD-Score:3.34|P-value:8.61E-4 ID:SGTC_2152|Compound:5568786|FD-Score:3.31|P-value:9.57E-4 ID:SGTC_2319|Compound:6033012|FD-Score:3.36|P-value:7.94E-4 ID:SGTC_2324|Compound:6149169|FD-Score:-3.91|P-value:1.11E-4 ID:SGTC_2328|Compound:6201408|FD-Score:5.40|P-value:1.92E-7 ID:SGTC_2612|Compound:dictamnine|FD-Score:3.62|P-value:3.39E-4 ID:SGTC_2775|Compound:cyproheptadine|FD-Score:3.34|P-value:8.72E-4 ID:SGTC_3303|Compound:9125618|FD-Score:-4.52|P-value:9.97E-6 ID:SGTC_127|Compound:0180-0333|FD-Score:-3.29|P-value:9.38E-4 ID:SGTC_282|Compound:k297-0036|FD-Score:-3.44|P-value:5.81E-4 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:3.92|P-value:1.15E-4 ID:SGTC_518|Compound:1021-0119|FD-Score:-3.56|P-value:3.87E-4 ID:SGTC_632|Compound:0781-2353|FD-Score:4.14|P-value:4.98E-5 ID:SGTC_996|Compound:3970-0799|FD-Score:5.07|P-value:9.61E-7 ID:SGTC_1045|Compound:1348-1485|FD-Score:3.75|P-value:2.12E-4 ID:SGTC_1046|Compound:2001-0062|FD-Score:4.99|P-value:1.41E-6 ID:SGTC_1052|Compound:3253-3998|FD-Score:3.35|P-value:8.36E-4 ID:SGTC_1353|Compound:1498-1206|FD-Score:3.43|P-value:6.32E-4 ID:SGTC_1446|Compound:4239-0190|FD-Score:-3.83|P-value:1.49E-4 ID:SGTC_1450|Compound:4112-4260|FD-Score:-3.75|P-value:1.98E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:3.85|P-value:1.49E-4 ID:SGTC_1463|Compound:k081-0032|FD-Score:3.63|P-value:3.27E-4 ID:SGTC_1485|Compound:3909-9022|FD-Score:3.40|P-value:6.97E-4 ID:SGTC_1486|Compound:3970-0793|FD-Score:3.43|P-value:6.50E-4 ID:SGTC_1681|Compound:tripelennamine|FD-Score:5.20|P-value:5.12E-7 ID:SGTC_1727|Compound:st034309|FD-Score:4.47|P-value:1.31E-5 ID:SGTC_1771|Compound:st048882|FD-Score:3.66|P-value:2.90E-4 ID:SGTC_1949|Compound:st076024|FD-Score:3.34|P-value:8.61E-4 ID:SGTC_2152|Compound:5568786|FD-Score:3.31|P-value:9.57E-4 ID:SGTC_2319|Compound:6033012|FD-Score:3.36|P-value:7.94E-4 ID:SGTC_2324|Compound:6149169|FD-Score:-3.91|P-value:1.11E-4 ID:SGTC_2328|Compound:6201408|FD-Score:5.40|P-value:1.92E-7 ID:SGTC_2612|Compound:dictamnine|FD-Score:3.62|P-value:3.39E-4 ID:SGTC_2775|Compound:cyproheptadine|FD-Score:3.34|P-value:8.72E-4 ID:SGTC_3303|Compound:9125618|FD-Score:-4.52|P-value:9.97E-6

Top fitness defect scores for YPL001W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2328 6201408 5.40 200.0 µM 1.92E-7 6 3.30E-8
2 SGTC_1681 tripelennamine 5.20 100.0 µM 5.12E-7 6 9.93E-8
3 SGTC_996 3970-0799 5.07 1.8 µM 9.61E-7 51 2.02E-7
4 SGTC_1046 2001-0062 4.99 216.0 µM 1.41E-6 5 3.10E-7
5 SGTC_1727 st034309 4.47 9.9 µM 1.31E-5 21 3.83E-6
6 SGTC_632 0781-2353 4.14 4.7 µM 4.98E-5 Golgi 37 1.71E-5
7 SGTC_423 5-fluorouracil 3.92 457.0 µM 1.15E-4 exosome 23 4.39E-5
8 SGTC_1462 k081-0014 3.85 26.5 µM 1.49E-4 10 5.84E-5
9 SGTC_1045 1348-1485 3.75 165.0 µM 2.12E-4 37 8.70E-5
10 SGTC_1771 st048882 3.66 4.2 µM 2.90E-4 RPP1 & pyrimidine depletion 28 1.24E-4
11 SGTC_1463 k081-0032 3.63 34.1 µM 3.27E-4 10 1.41E-4
12 SGTC_2612 dictamnine 3.62 15.5 µM 3.39E-4 RNA pol III & RNase P/MRP 55 1.47E-4
13 SGTC_1353 1498-1206 3.43 8.1 µM 6.32E-4 mitochondrial response to ROS 80 2.96E-4
14 SGTC_1486 3970-0793 3.43 4.5 µM 6.50E-4 14 3.06E-4
15 SGTC_1485 3909-9022 3.40 254.0 µM 6.97E-4 RPP1 & pyrimidine depletion 20 3.31E-4
16 SGTC_2319 6033012 3.36 152.6 µM 7.94E-4 tubulin folding & SWR complex 44 3.83E-4
17 SGTC_1052 3253-3998 3.35 198.0 µM 8.36E-4 40 4.06E-4
18 SGTC_1949 st076024 3.34 69.1 µM 8.61E-4 49 4.20E-4
19 SGTC_2775 cyproheptadine 3.34 69.6 µM 8.72E-4 29 4.25E-4
20 SGTC_2152 5568786 3.31 200.0 µM 9.57E-4 29 4.73E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.203 1.39E-32 YML118W NGL3 hom 3'-5' exonuclease specific for poly-A RNAs; has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; similar to Ngl1p; NGL3 has a paralog, NGL2, that arose from the whole genome duplication
0.141 2.42E-16 YNL039W BDP1 het Essential subunit of RNA polymerase III transcription factor (TFIIIB), which is involved in transcription of genes encoding tRNAs, 5S rRNA, U6 snRNA, and other small RNAs
0.140 3.66E-16 YDR505C PSP1 hom Asn and gln rich protein of unknown function; high-copy suppressor of POL1 (DNA polymerase alpha) and partial suppressor of CDC2 (polymerase delta) and CDC6 (pre-RC loading factor) mutations; overexpression results in growth inhibition; PSP1 has a paralog, YLR177W, that arose from the whole genome duplication
0.128 8.22E-14 YDL099W BUG1 hom Cis-golgi localized protein involved in ER to Golgi transport; forms a complex with the mammalian GRASP65 homolog, Grh1p; mutants are compromised for the fusion of ER-derived vesicles with Golgi membranes
0.128 1.05E-13 YGL040C HEM2 het Aminolevulinate dehydratase, a homo-octameric enzyme, catalyzes the conversion of 5-aminolevulinate to porphobilinogen, the second step in heme biosynthesis; enzymatic activity is zinc-dependent; localizes to the cytoplasm and nucleus
0.127 1.26E-13 YGL222C EDC1 hom RNA-binding protein that activates mRNA decapping directly; binds to the mRNA substrate and enhances the activity of the decapping proteins Dcp1p and Dcp2p; has a role in translation during heat stress; protein becomes more abundant and forms cytoplasmic foci in response to DNA replication stress
0.125 3.85E-13 YOR037W CYC2 hom Mitochondrial peripheral inner membrane protein, contains a FAD cofactor in a domain exposed in the intermembrane space; exhibits redox activity in vitro; likely participates in ligation of heme to acytochromes c and c1 (Cyc1p and Cyt1p)
0.123 7.68E-13 YGL083W SCY1 hom Putative kinase, suppressor of GTPase mutant, similar to bovine rhodopsin kinase
0.120 2.67E-12 YGL205W POX1 hom Fatty-acyl coenzyme A oxidase, involved in the fatty acid beta-oxidation pathway; localized to the peroxisomal matrix
0.119 4.20E-12 YGL057C GEP7 hom Protein of unknown function; null mutant exhibits a respiratory growth defect and synthetic interactions with prohibitin (phb1) and gem1; authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.116 1.63E-11 YGL261C_p PAU11_p hom Putative protein of unknown function and member of the seripauperin multigene family encoded mainly in subtelomeric regions; mRNA expression appears to be regulated by SUT1 and UPC2
0.112 8.94E-11 YNR033W ABZ1 hom Para-aminobenzoate (PABA) synthase; has similarity to Escherichia coli PABA synthase components PabA and PabB; required for the synthesis of para-aminobenzoic acid, an important intermediate for folate and ubiquinone Q biosynthesis; protein abundance increases in response to DNA replication stress
0.109 2.76E-10 YDR325W YCG1 het Subunit of the condensin complex; required for establishment and maintenance of chromosome condensation, chromosome segregation and chromatin binding of the condensin complex; required for clustering of tRNA genes at the nucleolus; required for replication slow zone (RSZ) breakage following Mec1p inactivation
0.108 2.97E-10 YBR067C TIP1 hom Major cell wall mannoprotein with possible lipase activity; transcription is induced by heat- and cold-shock; member of the Srp1p/Tip1p family of serine-alanine-rich proteins
0.105 1.02E-9 YGR035C_p YGR035C_p hom Putative protein of unknown function, potential Cdc28p substrate; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance