YPL002C / SNF8

Component of the ESCRT-II complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; appears to be functionally related to SNF7; involved in glucose derepression

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL002C / SNF8

Click on Significant Values for Screen Details ID:SGTC_21|Compound:0849-0113|FD-Score:4.18|P-value:1.11E-4 ID:SGTC_68|Compound:0986-0284|FD-Score:-7.14|P-value:2.65E-10 ID:SGTC_102|Compound:gallobenzophenone|FD-Score:6.48|P-value:5.92E-9 ID:SGTC_117|Compound:lucigenin|FD-Score:5.54|P-value:5.24E-7 ID:SGTC_163|Compound:1327-0036|FD-Score:-4.75|P-value:1.86E-5 ID:SGTC_187|Compound:1488-2104|FD-Score:-3.71|P-value:6.64E-4 ID:SGTC_188|Compound:3229-0966|FD-Score:-4.85|P-value:1.28E-5 ID:SGTC_206|Compound:4546-0025|FD-Score:8.26|P-value:1.90E-13 ID:SGTC_207|Compound:4185-0010|FD-Score:-4.03|P-value:2.42E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:6.49|P-value:5.62E-9 ID:SGTC_227|Compound:fluconazole|FD-Score:5.66|P-value:3.05E-7 ID:SGTC_232|Compound:clozapine|FD-Score:5.13|P-value:2.98E-6 ID:SGTC_235|Compound:0330-0087|FD-Score:3.95|P-value:2.38E-4 ID:SGTC_301|Compound:4119-0100|FD-Score:8.32|P-value:1.33E-13 ID:SGTC_304|Compound:1310-0298|FD-Score:-6.00|P-value:9.25E-8 ID:SGTC_309|Compound:k408-0051|FD-Score:-4.34|P-value:8.43E-5 ID:SGTC_311|Compound:1315-0136|FD-Score:4.58|P-value:2.64E-5 ID:SGTC_313|Compound:3474-0040|FD-Score:5.07|P-value:3.86E-6 ID:SGTC_314|Compound:1671-0008|FD-Score:-5.12|P-value:4.45E-6 ID:SGTC_315|Compound:k915-0449|FD-Score:4.96|P-value:6.00E-6 ID:SGTC_328|Compound:k915-0120|FD-Score:6.81|P-value:1.00E-9 ID:SGTC_439|Compound:amiodarone|FD-Score:6.67|P-value:2.20E-9 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.81|P-value:4.82E-4 ID:SGTC_467|Compound:ro 31-8220|FD-Score:-4.08|P-value:2.07E-4 ID:SGTC_496|Compound:calpeptin|FD-Score:3.94|P-value:2.45E-4 ID:SGTC_576|Compound:1073-0113|FD-Score:7.10|P-value:2.08E-10 ID:SGTC_619|Compound:1652-1634|FD-Score:3.88|P-value:3.03E-4 ID:SGTC_637|Compound:1181-0519|FD-Score:5.05|P-value:4.21E-6 ID:SGTC_670|Compound:4204-0025|FD-Score:5.31|P-value:1.44E-6 ID:SGTC_720|Compound:r052-1644|FD-Score:3.52|P-value:9.21E-4 ID:SGTC_722|Compound:3534-0461|FD-Score:6.18|P-value:2.63E-8 ID:SGTC_733|Compound:4069-0007|FD-Score:7.16|P-value:1.50E-10 ID:SGTC_748|Compound:0136-0228|FD-Score:8.02|P-value:8.70E-13 ID:SGTC_751|Compound:0833-0568|FD-Score:-3.76|P-value:5.75E-4 ID:SGTC_768|Compound:0384-0033|FD-Score:4.62|P-value:2.30E-5 ID:SGTC_790|Compound:1575-0012|FD-Score:4.48|P-value:3.82E-5 ID:SGTC_813|Compound:k007-0158|FD-Score:3.91|P-value:2.76E-4 ID:SGTC_858|Compound:0438-0351|FD-Score:4.00|P-value:2.03E-4 ID:SGTC_888|Compound:0916-0002|FD-Score:8.17|P-value:3.40E-13 ID:SGTC_908|Compound:3448-7491|FD-Score:4.10|P-value:1.45E-4 ID:SGTC_955|Compound:1216-0110|FD-Score:3.69|P-value:5.50E-4 ID:SGTC_975|Compound:1335-0046|FD-Score:3.85|P-value:3.37E-4 ID:SGTC_1000|Compound:4048-0884|FD-Score:3.52|P-value:9.18E-4 ID:SGTC_1001|Compound:4048-4355|FD-Score:3.90|P-value:2.81E-4 ID:SGTC_1026|Compound:k007-1105|FD-Score:5.60|P-value:4.02E-7 ID:SGTC_1044|Compound:1222-0021|FD-Score:6.91|P-value:6.03E-10 ID:SGTC_1130|Compound:3454-2858|FD-Score:5.27|P-value:1.67E-6 ID:SGTC_1142|Compound:3253-1408|FD-Score:4.91|P-value:7.31E-6 ID:SGTC_1165|Compound:k072-0275|FD-Score:3.97|P-value:2.25E-4 ID:SGTC_1194|Compound:1488-0194|FD-Score:3.85|P-value:3.34E-4 ID:SGTC_1394|Compound:3474-0001|FD-Score:5.78|P-value:1.81E-7 ID:SGTC_1428|Compound:4049-0204|FD-Score:-4.01|P-value:2.59E-4 ID:SGTC_1465|Compound:k213-0056|FD-Score:3.81|P-value:3.81E-4 ID:SGTC_1475|Compound:4092-1048|FD-Score:5.20|P-value:2.26E-6 ID:SGTC_1495|Compound:4469-0029|FD-Score:4.16|P-value:1.20E-4 ID:SGTC_1593|Compound:justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one|FD-Score:11.80|P-value:1.37E-25 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:-5.45|P-value:1.10E-6 ID:SGTC_1687|Compound:st020778|FD-Score:9.83|P-value:3.03E-18 ID:SGTC_1719|Compound:st032227|FD-Score:3.59|P-value:7.55E-4 ID:SGTC_1750|Compound:st081859|FD-Score:3.88|P-value:3.06E-4 ID:SGTC_1754|Compound:st042065|FD-Score:4.20|P-value:1.05E-4 ID:SGTC_1760|Compound:st045453|FD-Score:6.76|P-value:1.32E-9 ID:SGTC_1781|Compound:st038725|FD-Score:6.93|P-value:5.46E-10 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:4.24|P-value:8.96E-5 ID:SGTC_1788|Compound:fluconazole|FD-Score:6.45|P-value:6.68E-9 ID:SGTC_1803|Compound:st050068|FD-Score:3.89|P-value:2.96E-4 ID:SGTC_1873|Compound:rapamycin|FD-Score:5.22|P-value:2.13E-6 ID:SGTC_1877|Compound:wortmannin|FD-Score:5.25|P-value:1.85E-6 ID:SGTC_1884|Compound:5633444|FD-Score:10.50|P-value:1.26E-20 ID:SGTC_2006|Compound:4011487|FD-Score:7.94|P-value:1.48E-12 ID:SGTC_2016|Compound:5121758|FD-Score:7.40|P-value:3.77E-11 ID:SGTC_2027|Compound:5150920|FD-Score:4.45|P-value:4.26E-5 ID:SGTC_2036|Compound:5160441|FD-Score:6.27|P-value:1.71E-8 ID:SGTC_2077|Compound:5212015|FD-Score:3.58|P-value:7.80E-4 ID:SGTC_2322|Compound:7413319|FD-Score:7.30|P-value:6.66E-11 ID:SGTC_2526|Compound:patulin|FD-Score:4.56|P-value:2.81E-5 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:6.41|P-value:8.17E-9 ID:SGTC_2582|Compound:agaric acid|FD-Score:8.68|P-value:1.16E-14 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:11.80|P-value:1.80E-25 ID:SGTC_2619|Compound:obliquin|FD-Score:17.40|P-value:3.81E-53 ID:SGTC_2622|Compound:2-methoxyxanthone|FD-Score:-4.73|P-value:2.07E-5 ID:SGTC_2623|Compound:humulene|FD-Score:-4.35|P-value:8.08E-5 ID:SGTC_2647|Compound:atorvastatin|FD-Score:3.58|P-value:7.66E-4 ID:SGTC_2671|Compound:danthron|FD-Score:4.97|P-value:5.76E-6 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.97|P-value:2.24E-4 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:3.68|P-value:5.69E-4 ID:SGTC_2737|Compound:bleomycin|FD-Score:4.25|P-value:8.85E-5 ID:SGTC_2776|Compound:terbinafine|FD-Score:3.55|P-value:8.32E-4 ID:SGTC_2824|Compound:7998404|FD-Score:5.54|P-value:5.34E-7 ID:SGTC_2848|Compound:9016370|FD-Score:7.09|P-value:2.24E-10 ID:SGTC_2851|Compound:9015922|FD-Score:4.20|P-value:1.03E-4 ID:SGTC_2867|Compound:9039098|FD-Score:4.03|P-value:1.86E-4 ID:SGTC_2873|Compound:9040596|FD-Score:4.23|P-value:9.45E-5 ID:SGTC_2928|Compound:9011484|FD-Score:3.53|P-value:9.05E-4 ID:SGTC_2950|Compound:9072895|FD-Score:3.65|P-value:6.30E-4 ID:SGTC_2965|Compound:9082772|FD-Score:4.15|P-value:1.24E-4 ID:SGTC_3089|Compound:9117425|FD-Score:3.83|P-value:3.52E-4 ID:SGTC_3110|Compound:9122132|FD-Score:6.48|P-value:5.97E-9 ID:SGTC_3113|Compound:9123498|FD-Score:4.71|P-value:1.65E-5 ID:SGTC_3119|Compound:9125183|FD-Score:5.06|P-value:4.00E-6 ID:SGTC_3143|Compound:9086658|FD-Score:-5.60|P-value:5.71E-7 ID:SGTC_3152|Compound:9099253|FD-Score:4.88|P-value:8.26E-6 ID:SGTC_21|Compound:0849-0113|FD-Score:4.18|P-value:1.11E-4 ID:SGTC_68|Compound:0986-0284|FD-Score:-7.14|P-value:2.65E-10 ID:SGTC_102|Compound:gallobenzophenone|FD-Score:6.48|P-value:5.92E-9 ID:SGTC_117|Compound:lucigenin|FD-Score:5.54|P-value:5.24E-7 ID:SGTC_163|Compound:1327-0036|FD-Score:-4.75|P-value:1.86E-5 ID:SGTC_187|Compound:1488-2104|FD-Score:-3.71|P-value:6.64E-4 ID:SGTC_188|Compound:3229-0966|FD-Score:-4.85|P-value:1.28E-5 ID:SGTC_206|Compound:4546-0025|FD-Score:8.26|P-value:1.90E-13 ID:SGTC_207|Compound:4185-0010|FD-Score:-4.03|P-value:2.42E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:6.49|P-value:5.62E-9 ID:SGTC_227|Compound:fluconazole|FD-Score:5.66|P-value:3.05E-7 ID:SGTC_232|Compound:clozapine|FD-Score:5.13|P-value:2.98E-6 ID:SGTC_235|Compound:0330-0087|FD-Score:3.95|P-value:2.38E-4 ID:SGTC_301|Compound:4119-0100|FD-Score:8.32|P-value:1.33E-13 ID:SGTC_304|Compound:1310-0298|FD-Score:-6.00|P-value:9.25E-8 ID:SGTC_309|Compound:k408-0051|FD-Score:-4.34|P-value:8.43E-5 ID:SGTC_311|Compound:1315-0136|FD-Score:4.58|P-value:2.64E-5 ID:SGTC_313|Compound:3474-0040|FD-Score:5.07|P-value:3.86E-6 ID:SGTC_314|Compound:1671-0008|FD-Score:-5.12|P-value:4.45E-6 ID:SGTC_315|Compound:k915-0449|FD-Score:4.96|P-value:6.00E-6 ID:SGTC_328|Compound:k915-0120|FD-Score:6.81|P-value:1.00E-9 ID:SGTC_439|Compound:amiodarone|FD-Score:6.67|P-value:2.20E-9 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.81|P-value:4.82E-4 ID:SGTC_467|Compound:ro 31-8220|FD-Score:-4.08|P-value:2.07E-4 ID:SGTC_496|Compound:calpeptin|FD-Score:3.94|P-value:2.45E-4 ID:SGTC_576|Compound:1073-0113|FD-Score:7.10|P-value:2.08E-10 ID:SGTC_619|Compound:1652-1634|FD-Score:3.88|P-value:3.03E-4 ID:SGTC_637|Compound:1181-0519|FD-Score:5.05|P-value:4.21E-6 ID:SGTC_670|Compound:4204-0025|FD-Score:5.31|P-value:1.44E-6 ID:SGTC_720|Compound:r052-1644|FD-Score:3.52|P-value:9.21E-4 ID:SGTC_722|Compound:3534-0461|FD-Score:6.18|P-value:2.63E-8 ID:SGTC_733|Compound:4069-0007|FD-Score:7.16|P-value:1.50E-10 ID:SGTC_748|Compound:0136-0228|FD-Score:8.02|P-value:8.70E-13 ID:SGTC_751|Compound:0833-0568|FD-Score:-3.76|P-value:5.75E-4 ID:SGTC_768|Compound:0384-0033|FD-Score:4.62|P-value:2.30E-5 ID:SGTC_790|Compound:1575-0012|FD-Score:4.48|P-value:3.82E-5 ID:SGTC_813|Compound:k007-0158|FD-Score:3.91|P-value:2.76E-4 ID:SGTC_858|Compound:0438-0351|FD-Score:4.00|P-value:2.03E-4 ID:SGTC_888|Compound:0916-0002|FD-Score:8.17|P-value:3.40E-13 ID:SGTC_908|Compound:3448-7491|FD-Score:4.10|P-value:1.45E-4 ID:SGTC_955|Compound:1216-0110|FD-Score:3.69|P-value:5.50E-4 ID:SGTC_975|Compound:1335-0046|FD-Score:3.85|P-value:3.37E-4 ID:SGTC_1000|Compound:4048-0884|FD-Score:3.52|P-value:9.18E-4 ID:SGTC_1001|Compound:4048-4355|FD-Score:3.90|P-value:2.81E-4 ID:SGTC_1026|Compound:k007-1105|FD-Score:5.60|P-value:4.02E-7 ID:SGTC_1044|Compound:1222-0021|FD-Score:6.91|P-value:6.03E-10 ID:SGTC_1130|Compound:3454-2858|FD-Score:5.27|P-value:1.67E-6 ID:SGTC_1142|Compound:3253-1408|FD-Score:4.91|P-value:7.31E-6 ID:SGTC_1165|Compound:k072-0275|FD-Score:3.97|P-value:2.25E-4 ID:SGTC_1194|Compound:1488-0194|FD-Score:3.85|P-value:3.34E-4 ID:SGTC_1394|Compound:3474-0001|FD-Score:5.78|P-value:1.81E-7 ID:SGTC_1428|Compound:4049-0204|FD-Score:-4.01|P-value:2.59E-4 ID:SGTC_1465|Compound:k213-0056|FD-Score:3.81|P-value:3.81E-4 ID:SGTC_1475|Compound:4092-1048|FD-Score:5.20|P-value:2.26E-6 ID:SGTC_1495|Compound:4469-0029|FD-Score:4.16|P-value:1.20E-4 ID:SGTC_1593|Compound:justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one|FD-Score:11.80|P-value:1.37E-25 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:-5.45|P-value:1.10E-6 ID:SGTC_1687|Compound:st020778|FD-Score:9.83|P-value:3.03E-18 ID:SGTC_1719|Compound:st032227|FD-Score:3.59|P-value:7.55E-4 ID:SGTC_1750|Compound:st081859|FD-Score:3.88|P-value:3.06E-4 ID:SGTC_1754|Compound:st042065|FD-Score:4.20|P-value:1.05E-4 ID:SGTC_1760|Compound:st045453|FD-Score:6.76|P-value:1.32E-9 ID:SGTC_1781|Compound:st038725|FD-Score:6.93|P-value:5.46E-10 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:4.24|P-value:8.96E-5 ID:SGTC_1788|Compound:fluconazole|FD-Score:6.45|P-value:6.68E-9 ID:SGTC_1803|Compound:st050068|FD-Score:3.89|P-value:2.96E-4 ID:SGTC_1873|Compound:rapamycin|FD-Score:5.22|P-value:2.13E-6 ID:SGTC_1877|Compound:wortmannin|FD-Score:5.25|P-value:1.85E-6 ID:SGTC_1884|Compound:5633444|FD-Score:10.50|P-value:1.26E-20 ID:SGTC_2006|Compound:4011487|FD-Score:7.94|P-value:1.48E-12 ID:SGTC_2016|Compound:5121758|FD-Score:7.40|P-value:3.77E-11 ID:SGTC_2027|Compound:5150920|FD-Score:4.45|P-value:4.26E-5 ID:SGTC_2036|Compound:5160441|FD-Score:6.27|P-value:1.71E-8 ID:SGTC_2077|Compound:5212015|FD-Score:3.58|P-value:7.80E-4 ID:SGTC_2322|Compound:7413319|FD-Score:7.30|P-value:6.66E-11 ID:SGTC_2526|Compound:patulin|FD-Score:4.56|P-value:2.81E-5 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:6.41|P-value:8.17E-9 ID:SGTC_2582|Compound:agaric acid|FD-Score:8.68|P-value:1.16E-14 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:11.80|P-value:1.80E-25 ID:SGTC_2619|Compound:obliquin|FD-Score:17.40|P-value:3.81E-53 ID:SGTC_2622|Compound:2-methoxyxanthone|FD-Score:-4.73|P-value:2.07E-5 ID:SGTC_2623|Compound:humulene|FD-Score:-4.35|P-value:8.08E-5 ID:SGTC_2647|Compound:atorvastatin|FD-Score:3.58|P-value:7.66E-4 ID:SGTC_2671|Compound:danthron|FD-Score:4.97|P-value:5.76E-6 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.97|P-value:2.24E-4 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:3.68|P-value:5.69E-4 ID:SGTC_2737|Compound:bleomycin|FD-Score:4.25|P-value:8.85E-5 ID:SGTC_2776|Compound:terbinafine|FD-Score:3.55|P-value:8.32E-4 ID:SGTC_2824|Compound:7998404|FD-Score:5.54|P-value:5.34E-7 ID:SGTC_2848|Compound:9016370|FD-Score:7.09|P-value:2.24E-10 ID:SGTC_2851|Compound:9015922|FD-Score:4.20|P-value:1.03E-4 ID:SGTC_2867|Compound:9039098|FD-Score:4.03|P-value:1.86E-4 ID:SGTC_2873|Compound:9040596|FD-Score:4.23|P-value:9.45E-5 ID:SGTC_2928|Compound:9011484|FD-Score:3.53|P-value:9.05E-4 ID:SGTC_2950|Compound:9072895|FD-Score:3.65|P-value:6.30E-4 ID:SGTC_2965|Compound:9082772|FD-Score:4.15|P-value:1.24E-4 ID:SGTC_3089|Compound:9117425|FD-Score:3.83|P-value:3.52E-4 ID:SGTC_3110|Compound:9122132|FD-Score:6.48|P-value:5.97E-9 ID:SGTC_3113|Compound:9123498|FD-Score:4.71|P-value:1.65E-5 ID:SGTC_3119|Compound:9125183|FD-Score:5.06|P-value:4.00E-6 ID:SGTC_3143|Compound:9086658|FD-Score:-5.60|P-value:5.71E-7 ID:SGTC_3152|Compound:9099253|FD-Score:4.88|P-value:8.26E-6

Top fitness defect scores for YPL002C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2619 obliquin 17.40 87.9 µM 3.81E-53 cell wall 6 1.81E-68
2 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 11.80 54.9 µM 1.37E-25 redox potentiating 9 1.28E-32
3 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 11.80 70.0 µM 1.80E-25 redox potentiating 4 1.82E-32
4 SGTC_1884 5633444 10.50 25.0 µM 1.26E-20 redox potentiating 10 3.55E-26
5 SGTC_1687 st020778 9.83 55.4 µM 3.03E-18 51 4.39E-23
6 SGTC_2582 agaric acid 8.68 100.0 µM 1.16E-14 redox potentiating 90 1.95E-18
7 SGTC_301 4119-0100 8.32 24.5 µM 1.33E-13 NEO1 18 4.55E-17
8 SGTC_206 4546-0025 8.26 72.0 µM 1.90E-13 NEO1 18 7.23E-17
9 SGTC_888 0916-0002 8.17 7.0 µM 3.40E-13 NEO1 14 1.54E-16
10 SGTC_748 0136-0228 8.02 77.9 µM 8.70E-13 redox potentiating 19 5.19E-16
11 SGTC_2006 4011487 7.94 200.0 µM 1.48E-12 endomembrane recycling 31 1.03E-15
12 SGTC_2016 5121758 7.40 140.0 µM 3.77E-11 redox potentiating 9 6.81E-14
13 SGTC_2322 7413319 7.30 38.2 µM 6.66E-11 ERAD & cell cycle 44 1.42E-13
14 SGTC_733 4069-0007 7.16 56.1 µM 1.50E-10 ERAD & cell cycle 27 4.05E-13
15 SGTC_576 1073-0113 7.10 22.7 µM 2.08E-10 redox potentiating 11 6.20E-13
16 SGTC_2848 9016370 7.09 26.0 µM 2.24E-10 2 6.83E-13
17 SGTC_1781 st038725 6.93 66.3 µM 5.46E-10 NEO1 40 2.15E-12
18 SGTC_1044 1222-0021 6.91 1.8 µM 6.03E-10 heme biosynthesis & mitochondrial translocase 11 2.45E-12
19 SGTC_328 k915-0120 6.81 63.5 µM 1.00E-9 TSC3-RPN4 2 4.72E-12
20 SGTC_1760 st045453 6.76 10.4 µM 1.32E-9 NEO1-PIK1 70 6.76E-12

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.583 3.35E-305 YLR025W SNF7 hom One of four subunits of the endosomal sorting complex required for transport III (ESCRT-III); involved in the sorting of transmembrane proteins into the multivesicular body (MVB) pathway; recruited from the cytoplasm to endosomal membranes
0.556 6.86E-272 YPL065W VPS28 hom Component of the ESCRT-I complex (Stp22p, Srn2p, Vps28p, and Mvb12p), which is involved in ubiquitin-dependent sorting of proteins into the endosome; conserved C-terminal domain interacts with ESCRT-III subunit Vps20p
0.544 1.32E-257 YLR417W VPS36 hom Component of the ESCRT-II complex; contains the GLUE (GRAM Like Ubiquitin binding in EAP45) domain which is involved in interactions with ESCRT-I and ubiquitin-dependent sorting of proteins into the endosome
0.527 1.62E-239 YJR102C VPS25 hom Component of the ESCRT-II complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome
0.505 1.40E-216 YMR077C VPS20 hom Myristoylated subunit of ESCRTIII, the endosomal sorting complex required for transport of transmembrane proteins into the multivesicular body pathway to the lysosomal/vacuolar lumen; cytoplasmic protein recruited to endosomal membranes
0.479 1.88E-192 YCL008C STP22 hom Component of the ESCRT-I complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; homologous to the mouse and human Tsg101 tumor susceptibility gene; mutants exhibit a Class E Vps phenotype
0.359 1.08E-102 YDR456W NHX1 hom Na+/H+ and K+/H+ exchanger, required for intracellular sequestration of Na+ and K+; located in the vacuole and late endosome compartments; required for osmotolerance to acute hypertonic shock and for vacuolar fusion
0.356 9.60E-101 YDR455C_d YDR455C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YDR456W
0.348 5.18E-96 YDR323C PEP7 hom Multivalent adaptor protein that facilitates vesicle-mediated vacuolar protein sorting by ensuring high-fidelity vesicle docking and fusion, which are essential for targeting of vesicles to the endosome; required for vacuole inheritance
0.341 2.73E-92 YPR173C VPS4 hom AAA-ATPase involved in multivesicular body (MVB) protein sorting, ATP-bound Vps4p localizes to endosomes and catalyzes ESCRT-III disassembly and membrane release; ATPase activity is activated by Vta1p; regulates cellular sterol metabolism
0.329 1.48E-85 YGL045W RIM8 hom Protein involved in proteolytic activation of Rim101p in response to alkaline pH; interacts with ESCRT-1 subunits Stp22p and Vps28p; essential for anaerobic growth; member of the arrestin-related trafficking adaptor family
0.326 4.64E-84 YLR119W SRN2 hom Component of the ESCRT-I complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; suppressor of rna1-1 mutation; may be involved in RNA export from nucleus
0.324 7.45E-83 YNL294C RIM21 hom pH sensor molecule, component of the RIM101 pathway; has a role in cell wall construction and alkaline pH response; is glycosylated and phosphorylated; interacts with Dfg16p and Rim9p to form a pH-sensing complex; localization to the plasma membrane is dependent on Dfg16p and Rim9p; has similarity to A. nidulans PalH
0.321 3.38E-81 YOR036W PEP12 hom Target membrane receptor (t-SNARE) for vesicular intermediates traveling between the Golgi apparatus and the vacuole; controls entry of biosynthetic, endocytic, and retrograde traffic into the prevacuolar compartment; syntaxin
0.318 1.42E-79 YJL053W PEP8 hom Vacuolar protein component of the retromer; forms part of the multimeric membrane-associated retromer complex involved in vacuolar protein sorting along with Vps35p, Vps29p, Vps17p, and Vps5p; essential for endosome-to-Golgi retrograde protein transport; interacts with Ypt7p; protein abundance increases in response to DNA replication stress