YPL003W / ULA1

Protein that acts together with Uba3p to activate Rub1p before its conjugation to proteins (neddylation), which may play a role in protein degradation

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL003W / ULA1

Click on Significant Values for Screen Details ID:SGTC_35|Compound:0133-0054|FD-Score:-3.19|P-value:8.29E-4 ID:SGTC_45|Compound:0kpi-0036|FD-Score:3.71|P-value:1.33E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:4.21|P-value:1.70E-5 ID:SGTC_66|Compound:0109-0187|FD-Score:7.03|P-value:2.27E-12 ID:SGTC_97|Compound:0535-0701|FD-Score:3.24|P-value:7.19E-4 ID:SGTC_172|Compound:1112-0046|FD-Score:-5.57|P-value:2.06E-8 ID:SGTC_176|Compound:1486-1328|FD-Score:4.76|P-value:1.39E-6 ID:SGTC_202|Compound:3594-0513|FD-Score:3.65|P-value:1.64E-4 ID:SGTC_268|Compound:camptothecin|FD-Score:6.56|P-value:5.32E-11 ID:SGTC_280|Compound:3448-3607|FD-Score:3.55|P-value:2.40E-4 ID:SGTC_364|Compound:0083-0097|FD-Score:-3.75|P-value:1.10E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:5.05|P-value:3.39E-7 ID:SGTC_472|Compound:calcifediol|FD-Score:-3.50|P-value:2.85E-4 ID:SGTC_476|Compound:mead acid|FD-Score:-4.51|P-value:4.38E-6 ID:SGTC_538|Compound:2922-0838|FD-Score:-3.42|P-value:3.73E-4 ID:SGTC_907|Compound:3448-6986|FD-Score:4.61|P-value:2.80E-6 ID:SGTC_1102|Compound:cgs 12066b|FD-Score:3.92|P-value:5.80E-5 ID:SGTC_1707|Compound:st032323|FD-Score:4.70|P-value:1.90E-6 ID:SGTC_1733|Compound:st037357|FD-Score:4.11|P-value:2.65E-5 ID:SGTC_1831|Compound:st055328|FD-Score:-3.31|P-value:5.51E-4 ID:SGTC_1839|Compound:st053978|FD-Score:3.78|P-value:1.01E-4 ID:SGTC_1872|Compound:amphotericin b|FD-Score:3.61|P-value:1.88E-4 ID:SGTC_1901|Compound:st060216|FD-Score:3.44|P-value:3.53E-4 ID:SGTC_1925|Compound:st057770|FD-Score:-3.40|P-value:3.99E-4 ID:SGTC_1958|Compound:st076513|FD-Score:4.01|P-value:3.97E-5 ID:SGTC_2054|Compound:5233173|FD-Score:4.65|P-value:2.34E-6 ID:SGTC_2171|Compound:5739187|FD-Score:3.89|P-value:6.41E-5 ID:SGTC_2195|Compound:6536160|FD-Score:3.39|P-value:4.30E-4 ID:SGTC_2248|Compound:tofa|FD-Score:3.90|P-value:6.14E-5 ID:SGTC_2380|Compound:9035439|FD-Score:3.17|P-value:9.18E-4 ID:SGTC_2612|Compound:dictamnine|FD-Score:4.37|P-value:8.63E-6 ID:SGTC_2629|Compound:bisabolol|FD-Score:4.37|P-value:8.41E-6 ID:SGTC_2630|Compound:antimycin a|FD-Score:4.42|P-value:6.84E-6 ID:SGTC_2633|Compound:5,7-dihydroxyisoflavone|FD-Score:-3.91|P-value:5.81E-5 ID:SGTC_2640|Compound:pentamidine|FD-Score:5.96|P-value:2.19E-9 ID:SGTC_2795|Compound:7780010|FD-Score:-3.31|P-value:5.52E-4 ID:SGTC_2796|Compound:7949634|FD-Score:7.35|P-value:2.29E-13 ID:SGTC_2803|Compound:7707263|FD-Score:3.57|P-value:2.18E-4 ID:SGTC_2856|Compound:9022925|FD-Score:-4.47|P-value:5.29E-6 ID:SGTC_2907|Compound:7721985|FD-Score:4.50|P-value:4.84E-6 ID:SGTC_35|Compound:0133-0054|FD-Score:-3.19|P-value:8.29E-4 ID:SGTC_45|Compound:0kpi-0036|FD-Score:3.71|P-value:1.33E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:4.21|P-value:1.70E-5 ID:SGTC_66|Compound:0109-0187|FD-Score:7.03|P-value:2.27E-12 ID:SGTC_97|Compound:0535-0701|FD-Score:3.24|P-value:7.19E-4 ID:SGTC_172|Compound:1112-0046|FD-Score:-5.57|P-value:2.06E-8 ID:SGTC_176|Compound:1486-1328|FD-Score:4.76|P-value:1.39E-6 ID:SGTC_202|Compound:3594-0513|FD-Score:3.65|P-value:1.64E-4 ID:SGTC_268|Compound:camptothecin|FD-Score:6.56|P-value:5.32E-11 ID:SGTC_280|Compound:3448-3607|FD-Score:3.55|P-value:2.40E-4 ID:SGTC_364|Compound:0083-0097|FD-Score:-3.75|P-value:1.10E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:5.05|P-value:3.39E-7 ID:SGTC_472|Compound:calcifediol|FD-Score:-3.50|P-value:2.85E-4 ID:SGTC_476|Compound:mead acid|FD-Score:-4.51|P-value:4.38E-6 ID:SGTC_538|Compound:2922-0838|FD-Score:-3.42|P-value:3.73E-4 ID:SGTC_907|Compound:3448-6986|FD-Score:4.61|P-value:2.80E-6 ID:SGTC_1102|Compound:cgs 12066b|FD-Score:3.92|P-value:5.80E-5 ID:SGTC_1707|Compound:st032323|FD-Score:4.70|P-value:1.90E-6 ID:SGTC_1733|Compound:st037357|FD-Score:4.11|P-value:2.65E-5 ID:SGTC_1831|Compound:st055328|FD-Score:-3.31|P-value:5.51E-4 ID:SGTC_1839|Compound:st053978|FD-Score:3.78|P-value:1.01E-4 ID:SGTC_1872|Compound:amphotericin b|FD-Score:3.61|P-value:1.88E-4 ID:SGTC_1901|Compound:st060216|FD-Score:3.44|P-value:3.53E-4 ID:SGTC_1925|Compound:st057770|FD-Score:-3.40|P-value:3.99E-4 ID:SGTC_1958|Compound:st076513|FD-Score:4.01|P-value:3.97E-5 ID:SGTC_2054|Compound:5233173|FD-Score:4.65|P-value:2.34E-6 ID:SGTC_2171|Compound:5739187|FD-Score:3.89|P-value:6.41E-5 ID:SGTC_2195|Compound:6536160|FD-Score:3.39|P-value:4.30E-4 ID:SGTC_2248|Compound:tofa|FD-Score:3.90|P-value:6.14E-5 ID:SGTC_2380|Compound:9035439|FD-Score:3.17|P-value:9.18E-4 ID:SGTC_2612|Compound:dictamnine|FD-Score:4.37|P-value:8.63E-6 ID:SGTC_2629|Compound:bisabolol|FD-Score:4.37|P-value:8.41E-6 ID:SGTC_2630|Compound:antimycin a|FD-Score:4.42|P-value:6.84E-6 ID:SGTC_2633|Compound:5,7-dihydroxyisoflavone|FD-Score:-3.91|P-value:5.81E-5 ID:SGTC_2640|Compound:pentamidine|FD-Score:5.96|P-value:2.19E-9 ID:SGTC_2795|Compound:7780010|FD-Score:-3.31|P-value:5.52E-4 ID:SGTC_2796|Compound:7949634|FD-Score:7.35|P-value:2.29E-13 ID:SGTC_2803|Compound:7707263|FD-Score:3.57|P-value:2.18E-4 ID:SGTC_2856|Compound:9022925|FD-Score:-4.47|P-value:5.29E-6 ID:SGTC_2907|Compound:7721985|FD-Score:4.50|P-value:4.84E-6

Top fitness defect scores for YPL003W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2796 7949634 7.35 45.5 µM 2.29E-13 2 9.73E-14
2 SGTC_66 0109-0187 7.03 42.4 µM 2.27E-12 7 1.03E-12
3 SGTC_268 camptothecin 6.56 39.6 µM 5.32E-11 DNA damage response 23 2.68E-11
4 SGTC_2640 pentamidine 5.96 10.4 µM 2.19E-9 mitochondrial processes 7 1.23E-9
5 SGTC_431 k089-0097 5.05 107.0 µM 3.39E-7 iron homeostasis 11 2.24E-7
6 SGTC_176 1486-1328 4.76 72.8 µM 1.39E-6 34 9.55E-7
7 SGTC_1707 st032323 4.70 6.3 µM 1.90E-6 DNA damage response 39 1.32E-6
8 SGTC_2054 5233173 4.65 129.0 µM 2.34E-6 mitochondrial response to ROS 37 1.64E-6
9 SGTC_907 3448-6986 4.61 75.5 µM 2.80E-6 12 1.97E-6
10 SGTC_2907 7721985 4.50 69.9 µM 4.84E-6 11 3.46E-6
11 SGTC_2630 antimycin a 4.42 100.0 µM 6.84E-6 mitochondrial processes 24 4.95E-6
12 SGTC_2629 bisabolol 4.37 100.0 µM 8.41E-6 16 6.12E-6
13 SGTC_2612 dictamnine 4.37 15.5 µM 8.63E-6 RNA pol III & RNase P/MRP 33 6.29E-6
14 SGTC_58 0957-0393 4.21 9.0 µM 1.70E-5 cell wall 352 1.27E-5
15 SGTC_1733 st037357 4.11 54.9 µM 2.65E-5 60S ribosome export 22 2.00E-5
16 SGTC_1958 st076513 4.01 41.9 µM 3.97E-5 60S ribosome export 26 3.03E-5
17 SGTC_1102 cgs 12066b 3.92 26.1 µM 5.80E-5 endomembrane recycling 9 4.48E-5
18 SGTC_2248 tofa 3.90 1.1 µM 6.14E-5 sphingolipid biosynthesis & PDR1 40 4.75E-5
19 SGTC_2171 5739187 3.89 198.1 µM 6.41E-5 copper-dependent oxidative stress 18 4.97E-5
20 SGTC_1839 st053978 3.78 48.0 µM 1.01E-4 17 7.95E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.174 3.14E-24 YDL059C RAD59 hom Protein involved DNA double-strand break repair; repairs breaks in DNA during vegetative growth via recombination and single-strand annealing; anneals complementary single-stranded DNA; forms nuclear foci upon DNA replication stress; required for loading of Rad52p to DSBs; paralog of Rad52p
0.168 1.49E-22 YBR098W MMS4 hom Subunit of the structure-specific Mms4p-Mus81p endonuclease that cleaves branched DNA; involved in recombination, DNA repair, and joint molecule formation/resolution during meiotic recombination; phosphorylation of the non-catalytic subunit Mms4p by Cdc28p and Cdcp during mitotic cell cycle activates the function of Mms4p-Mus81p
0.144 6.07E-17 YOL135C MED7 het Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation
0.123 8.53E-13 YLR135W SLX4 hom Endonuclease involved in processing DNA; acts during recombination and repair; cleaves branched structures in a complex with Slx1p; involved interstrand cross-link repair and in Rad1p/Rad10p-dependent removal of 3'-nonhomologous tails during DSBR via single-strand annealing; relative distribution to nuclear foci increases upon DNA replication stress
0.117 1.16E-11 YNL273W TOF1 hom Subunit of a replication-pausing checkpoint complex (Tof1p-Mrc1p-Csm3p) that acts at the stalled replication fork to promote sister chromatid cohesion after DNA damage, facilitating gap repair of damaged DNA; interacts with the MCM helicase
0.116 1.70E-11 YDR386W MUS81 hom Subunit of the structure-specific Mms4p-Mus81p endonuclease that cleaves branched DNA; involved in DNA repair, replication fork stability, and joint molecule formation/resolution during meiotic recombination; helix-hairpin-helix protein; phosphorylation of the non-catalytic subunit Mms4p by Cdc28p and Cdcp during mitotic cell cycle activates the function of Mms4p-Mus81p
0.112 7.08E-11 YMR048W CSM3 hom Replication fork associated factor; required for stable replication fork pausing; component of the DNA replication checkpoint pathway; required for accurate chromosome segregation during meiosis; forms nuclear foci upon DNA replication stress
0.110 2.02E-10 YNL221C POP1 het Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs; binds to the RPR1 RNA subunit in RNase P
0.106 6.20E-10 YDR075W PPH3 hom Catalytic subunit of protein phosphatase PP4 complex; active complex is composed of Pph3p and Psy2p, with Psy4p apparently providing additional substrate specificity in some cases; regulates recovery from the DNA damage checkpoint and also the gene conversion- and single-strand annealing-mediated pathways of meiotic double-strand break repair; involved in activation of Gln3p to alleviate nitrogen catabolite repression; Pph3p and Psy2p localize to foci on meiotic chromosomes
0.106 7.26E-10 YDR014W RAD61 hom Subunit of a complex (Scc3p, Pds5p, Rad61p) that inhibits sister chromatid cohesion; inhibited by Eco1p-acetylated cohesin subunits Smc3p and Mcd1p; related to the human Wapl protein that controls the association of cohesin with chromatin
0.105 1.00E-9 YDR460W TFB3 het Subunit of TFIIH and nucleotide excision repair factor 3 complexes, involved in transcription initiation, required for nucleotide excision repair; ring finger protein similar to mammalian CAK and TFIIH subunit
0.105 1.17E-9 YGL175C SAE2 hom Endonuclease that processes hairpin DNA structures with the MRX complex; involved in meiotic and mitotic double-strand break repair; phosphorylated in response to DNA damage and required for normal resistance to DNA-damaging agents
0.103 1.87E-9 YGL163C RAD54 hom DNA-dependent ATPase that stimulates strand exchange; modifies the topology of double-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; member of the SWI/SNF family; forms nuclear foci upon DNA replication stress
0.103 2.44E-9 YBL088C TEL1 hom Protein kinase primarily involved in telomere length regulation; contributes to cell cycle checkpoint control in response to DNA damage; functionally redundant with Mec1p; regulates P-body formation induced by replication stress; homolog of human ataxia-telangiectasia mutated (ATM) gene, the gene responsible for ataxia telangiectasia (AT) (OMIM 607585)
0.103 2.55E-9 YKL115C_d YKL115C_d hom Dubious open reading frame, unlikely to encode a protein; partially overlaps the verified gene PRR1