YPL005W / AEP3

Protein that may facilitate use of unformylated tRNA-Met in mitochondrial translation initiation; localized to the matrix face of the mitochondrial inner membrane; stabilizes the bicistronic AAP1-ATP6 mRNA

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL005W / AEP3

Click on Significant Values for Screen Details ID:SGTC_10|Compound:0279-0212|FD-Score:4.87|P-value:3.35E-6 ID:SGTC_19|Compound:0279-0214|FD-Score:3.58|P-value:4.33E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:-4.27|P-value:7.32E-5 ID:SGTC_120|Compound:rhodamine 6G|FD-Score:3.73|P-value:2.58E-4 ID:SGTC_167|Compound:3672-0051|FD-Score:3.32|P-value:9.69E-4 ID:SGTC_211|Compound:3455-0679|FD-Score:3.39|P-value:7.96E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:9.38|P-value:3.91E-18 ID:SGTC_275|Compound:trichlorophene|FD-Score:3.82|P-value:1.91E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:-3.49|P-value:9.97E-4 ID:SGTC_304|Compound:1310-0298|FD-Score:-3.63|P-value:6.56E-4 ID:SGTC_314|Compound:1671-0008|FD-Score:3.41|P-value:7.44E-4 ID:SGTC_339|Compound:3091-4833|FD-Score:-5.30|P-value:1.11E-6 ID:SGTC_341|Compound:1486-1430|FD-Score:4.63|P-value:8.90E-6 ID:SGTC_352|Compound:k048-0007|FD-Score:-8.37|P-value:2.67E-14 ID:SGTC_431|Compound:k089-0097|FD-Score:-7.18|P-value:5.93E-11 ID:SGTC_432|Compound:NS 1619|FD-Score:5.25|P-value:6.09E-7 ID:SGTC_444|Compound:curcumin|FD-Score:-4.65|P-value:1.71E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-7.37|P-value:1.80E-11 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:-4.17|P-value:1.02E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:-4.68|P-value:1.50E-5 ID:SGTC_568|Compound:1193-0097|FD-Score:-5.58|P-value:3.02E-7 ID:SGTC_671|Compound:0560-0003|FD-Score:3.45|P-value:6.54E-4 ID:SGTC_832|Compound:4083-0019|FD-Score:4.20|P-value:4.85E-5 ID:SGTC_908|Compound:3448-7491|FD-Score:5.67|P-value:8.53E-8 ID:SGTC_1017|Compound:4239-0030|FD-Score:3.50|P-value:5.48E-4 ID:SGTC_1068|Compound:loratadine|FD-Score:4.31|P-value:3.19E-5 ID:SGTC_1159|Compound:4092-0538|FD-Score:4.30|P-value:3.30E-5 ID:SGTC_1161|Compound:k007-0610|FD-Score:-3.67|P-value:5.67E-4 ID:SGTC_1242|Compound:0402-0103|FD-Score:4.52|P-value:1.43E-5 ID:SGTC_1247|Compound:0448-0043|FD-Score:4.54|P-value:1.30E-5 ID:SGTC_1332|Compound:1480-0653|FD-Score:3.56|P-value:4.53E-4 ID:SGTC_1371|Compound:2421-0008|FD-Score:4.98|P-value:2.06E-6 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:3.32|P-value:9.84E-4 ID:SGTC_1615|Compound:st002656|FD-Score:4.19|P-value:5.09E-5 ID:SGTC_1627|Compound:st003713|FD-Score:7.45|P-value:3.77E-12 ID:SGTC_1656|Compound:st012921|FD-Score:-4.04|P-value:1.65E-4 ID:SGTC_1695|Compound:st026914|FD-Score:5.06|P-value:1.47E-6 ID:SGTC_1705|Compound:st027868|FD-Score:3.57|P-value:4.45E-4 ID:SGTC_1707|Compound:st032323|FD-Score:-4.33|P-value:5.76E-5 ID:SGTC_1722|Compound:st034304|FD-Score:3.39|P-value:7.96E-4 ID:SGTC_1742|Compound:st038235|FD-Score:4.42|P-value:2.05E-5 ID:SGTC_1787|Compound:fluconazole|FD-Score:-3.62|P-value:6.64E-4 ID:SGTC_1834|Compound:st055981|FD-Score:4.43|P-value:2.05E-5 ID:SGTC_2203|Compound:7227154|FD-Score:3.74|P-value:2.50E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:5.26|P-value:5.88E-7 ID:SGTC_2406|Compound:ethylparaben|FD-Score:3.63|P-value:3.67E-4 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:-4.47|P-value:3.50E-5 ID:SGTC_2546|Compound:rhodinyl acetate|FD-Score:-3.96|P-value:2.18E-4 ID:SGTC_2551|Compound:apiole|FD-Score:-3.53|P-value:8.95E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:-3.98|P-value:2.00E-4 ID:SGTC_2727|Compound:riluzole|FD-Score:4.48|P-value:1.65E-5 ID:SGTC_2858|Compound:9025781|FD-Score:-5.10|P-value:2.65E-6 ID:SGTC_2885|Compound:9057732|FD-Score:4.81|P-value:4.26E-6 ID:SGTC_2896|Compound:9052656|FD-Score:-12.60|P-value:2.52E-30 ID:SGTC_2929|Compound:9013348|FD-Score:3.57|P-value:4.49E-4 ID:SGTC_2964|Compound:9083345|FD-Score:3.84|P-value:1.76E-4 ID:SGTC_2970|Compound:9090938|FD-Score:4.76|P-value:5.26E-6 ID:SGTC_2971|Compound:9092186|FD-Score:-4.00|P-value:1.92E-4 ID:SGTC_3018|Compound:9082602|FD-Score:3.55|P-value:4.72E-4 ID:SGTC_3266|Compound:9136860|FD-Score:-4.62|P-value:1.88E-5 ID:SGTC_3269|Compound:9137823|FD-Score:4.45|P-value:1.88E-5 ID:SGTC_3338|Compound:9144300|FD-Score:3.38|P-value:8.11E-4 ID:SGTC_3346|Compound:9158254|FD-Score:4.35|P-value:2.75E-5 ID:SGTC_10|Compound:0279-0212|FD-Score:4.87|P-value:3.35E-6 ID:SGTC_19|Compound:0279-0214|FD-Score:3.58|P-value:4.33E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:-4.27|P-value:7.32E-5 ID:SGTC_120|Compound:rhodamine 6G|FD-Score:3.73|P-value:2.58E-4 ID:SGTC_167|Compound:3672-0051|FD-Score:3.32|P-value:9.69E-4 ID:SGTC_211|Compound:3455-0679|FD-Score:3.39|P-value:7.96E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:9.38|P-value:3.91E-18 ID:SGTC_275|Compound:trichlorophene|FD-Score:3.82|P-value:1.91E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:-3.49|P-value:9.97E-4 ID:SGTC_304|Compound:1310-0298|FD-Score:-3.63|P-value:6.56E-4 ID:SGTC_314|Compound:1671-0008|FD-Score:3.41|P-value:7.44E-4 ID:SGTC_339|Compound:3091-4833|FD-Score:-5.30|P-value:1.11E-6 ID:SGTC_341|Compound:1486-1430|FD-Score:4.63|P-value:8.90E-6 ID:SGTC_352|Compound:k048-0007|FD-Score:-8.37|P-value:2.67E-14 ID:SGTC_431|Compound:k089-0097|FD-Score:-7.18|P-value:5.93E-11 ID:SGTC_432|Compound:NS 1619|FD-Score:5.25|P-value:6.09E-7 ID:SGTC_444|Compound:curcumin|FD-Score:-4.65|P-value:1.71E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-7.37|P-value:1.80E-11 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:-4.17|P-value:1.02E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:-4.68|P-value:1.50E-5 ID:SGTC_568|Compound:1193-0097|FD-Score:-5.58|P-value:3.02E-7 ID:SGTC_671|Compound:0560-0003|FD-Score:3.45|P-value:6.54E-4 ID:SGTC_832|Compound:4083-0019|FD-Score:4.20|P-value:4.85E-5 ID:SGTC_908|Compound:3448-7491|FD-Score:5.67|P-value:8.53E-8 ID:SGTC_1017|Compound:4239-0030|FD-Score:3.50|P-value:5.48E-4 ID:SGTC_1068|Compound:loratadine|FD-Score:4.31|P-value:3.19E-5 ID:SGTC_1159|Compound:4092-0538|FD-Score:4.30|P-value:3.30E-5 ID:SGTC_1161|Compound:k007-0610|FD-Score:-3.67|P-value:5.67E-4 ID:SGTC_1242|Compound:0402-0103|FD-Score:4.52|P-value:1.43E-5 ID:SGTC_1247|Compound:0448-0043|FD-Score:4.54|P-value:1.30E-5 ID:SGTC_1332|Compound:1480-0653|FD-Score:3.56|P-value:4.53E-4 ID:SGTC_1371|Compound:2421-0008|FD-Score:4.98|P-value:2.06E-6 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:3.32|P-value:9.84E-4 ID:SGTC_1615|Compound:st002656|FD-Score:4.19|P-value:5.09E-5 ID:SGTC_1627|Compound:st003713|FD-Score:7.45|P-value:3.77E-12 ID:SGTC_1656|Compound:st012921|FD-Score:-4.04|P-value:1.65E-4 ID:SGTC_1695|Compound:st026914|FD-Score:5.06|P-value:1.47E-6 ID:SGTC_1705|Compound:st027868|FD-Score:3.57|P-value:4.45E-4 ID:SGTC_1707|Compound:st032323|FD-Score:-4.33|P-value:5.76E-5 ID:SGTC_1722|Compound:st034304|FD-Score:3.39|P-value:7.96E-4 ID:SGTC_1742|Compound:st038235|FD-Score:4.42|P-value:2.05E-5 ID:SGTC_1787|Compound:fluconazole|FD-Score:-3.62|P-value:6.64E-4 ID:SGTC_1834|Compound:st055981|FD-Score:4.43|P-value:2.05E-5 ID:SGTC_2203|Compound:7227154|FD-Score:3.74|P-value:2.50E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:5.26|P-value:5.88E-7 ID:SGTC_2406|Compound:ethylparaben|FD-Score:3.63|P-value:3.67E-4 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:-4.47|P-value:3.50E-5 ID:SGTC_2546|Compound:rhodinyl acetate|FD-Score:-3.96|P-value:2.18E-4 ID:SGTC_2551|Compound:apiole|FD-Score:-3.53|P-value:8.95E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:-3.98|P-value:2.00E-4 ID:SGTC_2727|Compound:riluzole|FD-Score:4.48|P-value:1.65E-5 ID:SGTC_2858|Compound:9025781|FD-Score:-5.10|P-value:2.65E-6 ID:SGTC_2885|Compound:9057732|FD-Score:4.81|P-value:4.26E-6 ID:SGTC_2896|Compound:9052656|FD-Score:-12.60|P-value:2.52E-30 ID:SGTC_2929|Compound:9013348|FD-Score:3.57|P-value:4.49E-4 ID:SGTC_2964|Compound:9083345|FD-Score:3.84|P-value:1.76E-4 ID:SGTC_2970|Compound:9090938|FD-Score:4.76|P-value:5.26E-6 ID:SGTC_2971|Compound:9092186|FD-Score:-4.00|P-value:1.92E-4 ID:SGTC_3018|Compound:9082602|FD-Score:3.55|P-value:4.72E-4 ID:SGTC_3266|Compound:9136860|FD-Score:-4.62|P-value:1.88E-5 ID:SGTC_3269|Compound:9137823|FD-Score:4.45|P-value:1.88E-5 ID:SGTC_3338|Compound:9144300|FD-Score:3.38|P-value:8.11E-4 ID:SGTC_3346|Compound:9158254|FD-Score:4.35|P-value:2.75E-5

Top fitness defect scores for YPL005W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_236 1509-0011 9.38 5.3 µM 3.91E-18 207 3.36E-21
2 SGTC_1627 st003713 7.45 25.6 µM 3.77E-12 calcium & mitochondrial duress 17 4.79E-14
3 SGTC_908 3448-7491 5.67 47.7 µM 8.53E-8 mitochondrial stress 56 7.33E-9
4 SGTC_2250 alverine citrate 5.26 130.0 µM 5.88E-7 86 7.24E-8
5 SGTC_432 NS 1619 5.25 61.3 µM 6.09E-7 7 7.54E-8
6 SGTC_1695 st026914 5.06 34.5 µM 1.47E-6 2 2.13E-7
7 SGTC_1371 2421-0008 4.98 32.7 µM 2.06E-6 mitochondrial processes 15 3.20E-7
8 SGTC_10 0279-0212 4.87 42.6 µM 3.35E-6 TRP & mitochondrial translation 70 5.67E-7
9 SGTC_2885 9057732 4.81 52.0 µM 4.26E-6 6 7.54E-7
10 SGTC_2970 9090938 4.76 41.9 µM 5.26E-6 RNA processing & uracil transport 16 9.66E-7
11 SGTC_341 1486-1430 4.63 230.0 µM 8.90E-6 12 1.80E-6
12 SGTC_1247 0448-0043 4.54 5.8 µM 1.30E-5 ERG2 25 2.83E-6
13 SGTC_1242 0402-0103 4.52 60.1 µM 1.43E-5 18 3.15E-6
14 SGTC_2727 riluzole 4.48 51.8 µM 1.65E-5 mitochondrial processes 8 3.72E-6
15 SGTC_3269 9137823 4.45 49.5 µM 1.88E-5 60S ribosome export 11 4.35E-6
16 SGTC_1834 st055981 4.43 52.8 µM 2.05E-5 RPP1 & pyrimidine depletion 23 4.81E-6
17 SGTC_1742 st038235 4.42 28.9 µM 2.05E-5 mitochondrial stress 100 4.83E-6
18 SGTC_3346 9158254 4.35 43.6 µM 2.75E-5 6 6.82E-6
19 SGTC_1068 loratadine 4.31 26.9 µM 3.19E-5 16 8.10E-6
20 SGTC_1159 4092-0538 4.30 61.2 µM 3.30E-5 19 8.46E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.364 1.51E-105 YDR462W MRPL28 hom Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress
0.362 5.08E-104 YML061C PIF1 hom DNA helicase; exists in a nuclear form that acts as a catalytic inhibitor of telomerase; and as a mitochondrial form involved in repair and recombination of mitochondrial DNA; mutations affect zinc and iron homeostasis; regulated by Rad53p-dependent phosphorylation in rho0 cells
0.356 1.01E-100 YDR268W MSW1 hom Mitochondrial tryptophanyl-tRNA synthetase
0.351 5.54E-98 YDR296W MHR1 hom Protein involved in homologous recombination in mitochondria; required for recombination-dependent mtDNA partitioning; involved in stimulation of mitochondrial DNA replication in response to oxidative stress
0.349 8.32E-97 YDR194C MSS116 hom DEAD-box protein required for efficient splicing of mitochondrial Group I and II introns; non-polar RNA helicase that also facilities strand annealing
0.344 7.98E-94 YNL184C_p YNL184C_p hom Protein of unknown function; expressed at both mRNA and protein levels
0.343 4.86E-93 YDL056W MBP1 hom Transcription factor involved in regulation of cell cycle progression from G1 to S phase, forms a complex with Swi6p that binds to MluI cell cycle box regulatory element in promoters of DNA synthesis genes
0.341 8.28E-92 YPR100W MRPL51 hom Mitochondrial ribosomal protein of the large subunit
0.339 5.80E-91 YEL050C RML2 hom Mitochondrial ribosomal protein of the large subunit, has similarity to E. coli L2 ribosomal protein; fat21 mutant allele causes inability to utilize oleate and may interfere with activity of the Adr1p transcription factor
0.338 3.38E-90 YGL064C MRH4 hom Mitochondrial ATP-dependent RNA helicase of the DEAD-box family, plays an essential role in mitochondrial function
0.332 8.55E-87 YER050C RSM18 hom Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S18 ribosomal protein
0.331 2.41E-86 YLR270W DCS1 hom Non-essential hydrolase involved in mRNA decapping; activates Xrn1p; may function in a feedback mechanism to regulate deadenylation, contains pyrophosphatase activity and a HIT (histidine triad) motif; interacts with neutral trehalase Nth1p; required for growth on glycerol medium; protein abundance increases in response to DNA replication stress
0.327 1.59E-84 YMR193W MRPL24 hom Mitochondrial ribosomal protein of the large subunit; two mitochondrial ribosomal proteins, YmL14 and YmL24, have been assigned to the same gene
0.327 3.07E-84 YBL090W MRP21 hom Mitochondrial ribosomal protein of the small subunit; MRP21 exhibits genetic interactions with mutations in the COX2 and COX3 mRNA 5'-untranslated leader sequences
0.327 3.74E-84 YOL095C HMI1 hom Mitochondrial inner membrane localized ATP-dependent DNA helicase, required for the maintenance of the mitochondrial genome; not required for mitochondrial transcription; has homology to E. coli helicase uvrD