YPL007C / TFC8

One of six subunits of RNA polymerase III transcription initiation factor complex (TFIIIC); part of TFIIIC TauB domain that binds BoxB promoter sites of tRNA and other genes; linker between TauB and TauA domains; human homolog is TFIIIC-90

Zygosity: Heterozygous strain
fixedexpanded
Profile for YPL007C / TFC8

Click on Significant Values for Screen Details ID:SGTC_51|Compound:1013-0126|FD-Score:-3.60|P-value:1.58E-4 ID:SGTC_66|Compound:0109-0187|FD-Score:4.88|P-value:3.30E-7 ID:SGTC_69|Compound:0096-0274|FD-Score:4.09|P-value:1.50E-5 ID:SGTC_73|Compound:0327-0325|FD-Score:4.38|P-value:3.92E-6 ID:SGTC_106|Compound:0092-0003|FD-Score:4.07|P-value:1.57E-5 ID:SGTC_203|Compound:k066-0004|FD-Score:4.28|P-value:6.14E-6 ID:SGTC_307|Compound:1501-1223|FD-Score:5.71|P-value:3.07E-9 ID:SGTC_366|Compound:0181-0206|FD-Score:3.41|P-value:2.46E-4 ID:SGTC_480|Compound:am 92016|FD-Score:3.97|P-value:2.53E-5 ID:SGTC_505|Compound:gw-5074|FD-Score:3.07|P-value:8.19E-4 ID:SGTC_549|Compound:1661-1316|FD-Score:4.48|P-value:2.36E-6 ID:SGTC_571|Compound:k831-0106|FD-Score:-3.35|P-value:4.10E-4 ID:SGTC_774|Compound:k060-0086|FD-Score:-3.09|P-value:9.95E-4 ID:SGTC_780|Compound:0109-0199|FD-Score:3.32|P-value:3.33E-4 ID:SGTC_852|Compound:0418-0143|FD-Score:4.25|P-value:7.07E-6 ID:SGTC_1039|Compound:k821-0043|FD-Score:3.53|P-value:1.54E-4 ID:SGTC_1069|Compound:diphenylcyclopropenone|FD-Score:-3.26|P-value:5.63E-4 ID:SGTC_1080|Compound:nisoldipine|FD-Score:-3.35|P-value:4.11E-4 ID:SGTC_1173|Compound:0443-0020|FD-Score:3.07|P-value:8.36E-4 ID:SGTC_1205|Compound:4161-2785|FD-Score:-4.82|P-value:6.51E-7 ID:SGTC_1284|Compound:0929-0043|FD-Score:4.22|P-value:8.07E-6 ID:SGTC_1571|Compound:st070080|FD-Score:3.34|P-value:3.18E-4 ID:SGTC_1639|Compound:Lupinine o-methylbenzoicacid ester hydrochloride|FD-Score:3.21|P-value:5.00E-4 ID:SGTC_1676|Compound:st018489|FD-Score:5.50|P-value:1.05E-8 ID:SGTC_1688|Compound:st021091|FD-Score:4.58|P-value:1.46E-6 ID:SGTC_1728|Compound:st035614|FD-Score:-3.33|P-value:4.38E-4 ID:SGTC_1847|Compound:st056231|FD-Score:3.19|P-value:5.48E-4 ID:SGTC_1855|Compound:st056195|FD-Score:3.96|P-value:2.56E-5 ID:SGTC_1907|Compound:st060210|FD-Score:3.09|P-value:7.72E-4 ID:SGTC_1916|Compound:st067606|FD-Score:3.64|P-value:9.73E-5 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:4.24|P-value:7.35E-6 ID:SGTC_1980|Compound:st071811|FD-Score:3.63|P-value:1.03E-4 ID:SGTC_2050|Compound:5263056|FD-Score:-4.14|P-value:1.70E-5 ID:SGTC_2054|Compound:5233173|FD-Score:3.29|P-value:3.82E-4 ID:SGTC_2059|Compound:5238311|FD-Score:-4.70|P-value:1.23E-6 ID:SGTC_2084|Compound:5306078|FD-Score:4.35|P-value:4.58E-6 ID:SGTC_2085|Compound:5307070|FD-Score:6.28|P-value:8.01E-11 ID:SGTC_2091|Compound:4-phenylthiadiazole|FD-Score:-3.90|P-value:4.69E-5 ID:SGTC_2101|Compound:5377231|FD-Score:7.95|P-value:3.16E-16 ID:SGTC_2169|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:3.44|P-value:2.16E-4 ID:SGTC_2172|Compound:5754775|FD-Score:-5.09|P-value:1.58E-7 ID:SGTC_2178|Compound:5812956|FD-Score:-3.41|P-value:3.18E-4 ID:SGTC_2181|Compound:6316240|FD-Score:-3.31|P-value:4.65E-4 ID:SGTC_2282|Compound:7944268|FD-Score:-6.25|P-value:1.67E-10 ID:SGTC_2287|Compound:7945887|FD-Score:3.24|P-value:4.59E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:5.18|P-value:6.34E-8 ID:SGTC_2424|Compound:5537928|FD-Score:3.30|P-value:3.68E-4 ID:SGTC_2437|Compound:5741531|FD-Score:-4.18|P-value:1.39E-5 ID:SGTC_2452|Compound:5863136|FD-Score:3.49|P-value:1.78E-4 ID:SGTC_2572|Compound:astragaloside iv|FD-Score:-3.14|P-value:8.61E-4 ID:SGTC_2760|Compound:etidronate|FD-Score:4.14|P-value:1.18E-5 ID:SGTC_2795|Compound:7780010|FD-Score:3.90|P-value:3.36E-5 ID:SGTC_2798|Compound:7813637|FD-Score:3.30|P-value:3.65E-4 ID:SGTC_2800|Compound:7887935|FD-Score:4.34|P-value:4.80E-6 ID:SGTC_2850|Compound:9015429|FD-Score:4.30|P-value:5.61E-6 ID:SGTC_2871|Compound:9038510|FD-Score:-3.39|P-value:3.48E-4 ID:SGTC_3260|Compound:9137109|FD-Score:3.38|P-value:2.73E-4 ID:SGTC_51|Compound:1013-0126|FD-Score:-3.60|P-value:1.58E-4 ID:SGTC_66|Compound:0109-0187|FD-Score:4.88|P-value:3.30E-7 ID:SGTC_69|Compound:0096-0274|FD-Score:4.09|P-value:1.50E-5 ID:SGTC_73|Compound:0327-0325|FD-Score:4.38|P-value:3.92E-6 ID:SGTC_106|Compound:0092-0003|FD-Score:4.07|P-value:1.57E-5 ID:SGTC_203|Compound:k066-0004|FD-Score:4.28|P-value:6.14E-6 ID:SGTC_307|Compound:1501-1223|FD-Score:5.71|P-value:3.07E-9 ID:SGTC_366|Compound:0181-0206|FD-Score:3.41|P-value:2.46E-4 ID:SGTC_480|Compound:am 92016|FD-Score:3.97|P-value:2.53E-5 ID:SGTC_505|Compound:gw-5074|FD-Score:3.07|P-value:8.19E-4 ID:SGTC_549|Compound:1661-1316|FD-Score:4.48|P-value:2.36E-6 ID:SGTC_571|Compound:k831-0106|FD-Score:-3.35|P-value:4.10E-4 ID:SGTC_774|Compound:k060-0086|FD-Score:-3.09|P-value:9.95E-4 ID:SGTC_780|Compound:0109-0199|FD-Score:3.32|P-value:3.33E-4 ID:SGTC_852|Compound:0418-0143|FD-Score:4.25|P-value:7.07E-6 ID:SGTC_1039|Compound:k821-0043|FD-Score:3.53|P-value:1.54E-4 ID:SGTC_1069|Compound:diphenylcyclopropenone|FD-Score:-3.26|P-value:5.63E-4 ID:SGTC_1080|Compound:nisoldipine|FD-Score:-3.35|P-value:4.11E-4 ID:SGTC_1173|Compound:0443-0020|FD-Score:3.07|P-value:8.36E-4 ID:SGTC_1205|Compound:4161-2785|FD-Score:-4.82|P-value:6.51E-7 ID:SGTC_1284|Compound:0929-0043|FD-Score:4.22|P-value:8.07E-6 ID:SGTC_1571|Compound:st070080|FD-Score:3.34|P-value:3.18E-4 ID:SGTC_1639|Compound:Lupinine o-methylbenzoicacid ester hydrochloride|FD-Score:3.21|P-value:5.00E-4 ID:SGTC_1676|Compound:st018489|FD-Score:5.50|P-value:1.05E-8 ID:SGTC_1688|Compound:st021091|FD-Score:4.58|P-value:1.46E-6 ID:SGTC_1728|Compound:st035614|FD-Score:-3.33|P-value:4.38E-4 ID:SGTC_1847|Compound:st056231|FD-Score:3.19|P-value:5.48E-4 ID:SGTC_1855|Compound:st056195|FD-Score:3.96|P-value:2.56E-5 ID:SGTC_1907|Compound:st060210|FD-Score:3.09|P-value:7.72E-4 ID:SGTC_1916|Compound:st067606|FD-Score:3.64|P-value:9.73E-5 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:4.24|P-value:7.35E-6 ID:SGTC_1980|Compound:st071811|FD-Score:3.63|P-value:1.03E-4 ID:SGTC_2050|Compound:5263056|FD-Score:-4.14|P-value:1.70E-5 ID:SGTC_2054|Compound:5233173|FD-Score:3.29|P-value:3.82E-4 ID:SGTC_2059|Compound:5238311|FD-Score:-4.70|P-value:1.23E-6 ID:SGTC_2084|Compound:5306078|FD-Score:4.35|P-value:4.58E-6 ID:SGTC_2085|Compound:5307070|FD-Score:6.28|P-value:8.01E-11 ID:SGTC_2091|Compound:4-phenylthiadiazole|FD-Score:-3.90|P-value:4.69E-5 ID:SGTC_2101|Compound:5377231|FD-Score:7.95|P-value:3.16E-16 ID:SGTC_2169|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:3.44|P-value:2.16E-4 ID:SGTC_2172|Compound:5754775|FD-Score:-5.09|P-value:1.58E-7 ID:SGTC_2178|Compound:5812956|FD-Score:-3.41|P-value:3.18E-4 ID:SGTC_2181|Compound:6316240|FD-Score:-3.31|P-value:4.65E-4 ID:SGTC_2282|Compound:7944268|FD-Score:-6.25|P-value:1.67E-10 ID:SGTC_2287|Compound:7945887|FD-Score:3.24|P-value:4.59E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:5.18|P-value:6.34E-8 ID:SGTC_2424|Compound:5537928|FD-Score:3.30|P-value:3.68E-4 ID:SGTC_2437|Compound:5741531|FD-Score:-4.18|P-value:1.39E-5 ID:SGTC_2452|Compound:5863136|FD-Score:3.49|P-value:1.78E-4 ID:SGTC_2572|Compound:astragaloside iv|FD-Score:-3.14|P-value:8.61E-4 ID:SGTC_2760|Compound:etidronate|FD-Score:4.14|P-value:1.18E-5 ID:SGTC_2795|Compound:7780010|FD-Score:3.90|P-value:3.36E-5 ID:SGTC_2798|Compound:7813637|FD-Score:3.30|P-value:3.65E-4 ID:SGTC_2800|Compound:7887935|FD-Score:4.34|P-value:4.80E-6 ID:SGTC_2850|Compound:9015429|FD-Score:4.30|P-value:5.61E-6 ID:SGTC_2871|Compound:9038510|FD-Score:-3.39|P-value:3.48E-4 ID:SGTC_3260|Compound:9137109|FD-Score:3.38|P-value:2.73E-4

Top fitness defect scores for YPL007C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2101 5377231 7.95 179.2 µM 3.16E-16 1 9.34E-16 3.28
2 SGTC_2085 5307070 6.28 144.1 µM 8.01E-11 superoxide 1 1.67E-10 1.22
3 SGTC_307 1501-1223 5.71 22.3 µM 3.07E-9 1 5.78E-9 1.11
4 SGTC_1676 st018489 5.50 23.4 µM 1.05E-8 60S ribosome export 3 1.91E-8 0.84
5 SGTC_2405 ticlatone 5.18 3.5 µM 6.34E-8 11 1.09E-7 0.07
6 SGTC_66 0109-0187 4.88 42.4 µM 3.30E-7 5 5.41E-7 1.09
7 SGTC_1688 st021091 4.58 57.6 µM 1.46E-6 1 2.29E-6 0.61
8 SGTC_549 1661-1316 4.48 519.0 µM 2.36E-6 4 3.66E-6 0.25
9 SGTC_73 0327-0325 4.38 16.2 µM 3.92E-6 DNA damage response 2 5.97E-6 1.06
10 SGTC_2084 5306078 4.35 60.6 µM 4.58E-6 1 6.96E-6 0.33
11 SGTC_2800 7887935 4.34 81.8 µM 4.80E-6 RPP1 & pyrimidine depletion 6 7.27E-6 0.00
12 SGTC_2850 9015429 4.30 58.4 µM 5.61E-6 4 8.46E-6 0.29
13 SGTC_203 k066-0004 4.28 30.9 µM 6.14E-6 RSC & ERG11 10 9.23E-6 0.09
14 SGTC_852 0418-0143 4.25 439.0 µM 7.07E-6 calcium & mitochondrial duress 10 1.06E-5 0.03
15 SGTC_1926 methyl fluorone black 4.24 53.6 µM 7.35E-6 DNA intercalators 25 1.10E-5 0.08
16 SGTC_1284 0929-0043 4.22 16.0 µM 8.07E-6 3 1.20E-5 0.36
17 SGTC_2760 etidronate 4.14 98.0 µM 1.18E-5 5 1.74E-5 0.19
18 SGTC_69 0096-0274 4.09 206.7 µM 1.50E-5 mitochondrial processes 33 2.19E-5 0.09
19 SGTC_106 0092-0003 4.07 11.6 µM 1.57E-5 copper-dependent oxidative stress 6 2.30E-5 0.66
20 SGTC_480 am 92016 3.97 50.0 µM 2.53E-5 5 3.64E-5 0.01

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.143 8.60E-17 YOR282W_d YOR282W_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps essential, verified gene PLP2/YOR281C
0.104 1.41E-9 YPR157W_p TDA6_p hom Putative protein of unknown function; induced by treatment with 8-methoxypsoralen and UVA irradiation; null mutant is sensitive to expression of the top1-T722A allele
0.086 6.51E-7 YGR071C ENV11 hom Protein proposed to be involved in vacuolar functions; mutant shows defect in CPY processing and fragmented vacuoles; deletion mutant has increased glycogen accumulation and displays elongated buds; green fluorescent protein (GFP)-fusion protein localizes to the nucleus
0.085 8.55E-7 YKL206C ADD66 hom Protein involved in 20S proteasome assembly; forms a heterodimer with Pba1p that binds to proteasome precursors; similar to human PAC2 constituent of the PAC1-PAC2 complex involved in proteasome assembly
0.084 1.09E-6 YOR351C MEK1 hom Meiosis-specific serine/threonine protein kinase, functions in meiotic checkpoint, promotes recombination between homologous chromosomes by suppressing double strand break repair between sister chromatids
0.081 2.38E-6 YJL065C DLS1 hom Subunit of ISW2/yCHRAC chromatin accessibility complex; ISW2/yCHRAC also includes Itc1p, Isw2p, and Dpb4p; involved in inheritance of telomeric silencing; DLS1 has a paralog, DPB3, that arose from the whole genome duplication
0.080 3.57E-6 YPR152C URN1 hom Putative protein of unknown function containing WW and FF domains; overexpression causes accumulation of cells in G1 phase
0.078 5.83E-6 YMR181C_p YMR181C_p hom Protein of unknown function; mRNA transcribed as part of a bicistronic transcript with a predicted transcriptional repressor RGM1/YMR182C; mRNA is destroyed by nonsense-mediated decay (NMD); not an essential gene; YMR181C has a paralog, YPL229W, that arose from the whole genome duplication
0.077 8.81E-6 YEL006W YEA6 hom Putative mitochondrial NAD+ transporter, member of the mitochondrial carrier subfamily (see also YIA6); has putative human ortholog
0.076 1.12E-5 YOL101C IZH4 hom Membrane protein involved in zinc ion homeostasis; member of the four-protein IZH family; expression induced by fatty acids and altered zinc levels; deletion reduces sensitivity to excess zinc; possible role in sterol metabolism; protein increases in abundance and relocalizes from nucleus to ER upon DNA replication stress
0.074 1.66E-5 YMR285C NGL2 hom Protein involved in 5.8S rRNA processing; Ccr4p-like RNase required for correct 3'-end formation of 5.8S rRNA at site E; similar to Ngl1p; NGL2 has a paralog, NGL3, that arose from the whole genome duplication
0.074 1.78E-5 YBR035C PDX3 hom Pyridoxine (pyridoxamine) phosphate oxidase, has homologs in E. coli and Myxococcus xanthus; transcription is under the general control of nitrogen metabolism
0.074 1.86E-5 YNL069C RPL16B hom Ribosomal 60S subunit protein L16B; N-terminally acetylated, binds 5.8 S rRNA; transcriptionally regulated by Rap1p; homologous to mammalian ribosomal protein L13A and bacterial L13; RPL16B has a paralog, RPL16A, that arose from the whole genome duplication
0.072 3.25E-5 YBR237W PRP5 het RNA helicase in the DEAD-box family, necessary for prespliceosome formation, bridges U1 and U2 snRNPs and enables stable U2 snRNP association with intron RNA
0.071 4.17E-5 YER074W RPS24A hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S24, no bacterial homolog; RPS24A has a paralog, RPS24B, that arose from the whole genome duplication