YPL010W / RET3

Zeta subunit of the coatomer complex (COPI), which coats Golgi-derived transport vesicles; involved in retrograde transport between Golgi and ER

Zygosity: Heterozygous strain
fixedexpanded
Profile for YPL010W / RET3

Click on Significant Values for Screen Details ID:SGTC_65|Compound:0798-0905|FD-Score:-6.08|P-value:1.66E-11 ID:SGTC_68|Compound:0986-0284|FD-Score:6.00|P-value:2.35E-11 ID:SGTC_75|Compound:0159-0059|FD-Score:-2.85|P-value:9.68E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:3.69|P-value:2.58E-5 ID:SGTC_144|Compound:4161-2749|FD-Score:4.33|P-value:1.02E-6 ID:SGTC_145|Compound:3737-0113|FD-Score:6.18|P-value:6.32E-12 ID:SGTC_218|Compound:alverine citrate|FD-Score:4.23|P-value:1.75E-6 ID:SGTC_236|Compound:1509-0011|FD-Score:3.36|P-value:1.10E-4 ID:SGTC_245|Compound:methotrexate|FD-Score:4.11|P-value:3.15E-6 ID:SGTC_251|Compound:melphalan|FD-Score:2.97|P-value:5.48E-4 ID:SGTC_256|Compound:clotrimazole|FD-Score:-3.06|P-value:4.36E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-5.22|P-value:6.36E-9 ID:SGTC_363|Compound:0455-0021|FD-Score:-4.14|P-value:3.32E-6 ID:SGTC_372|Compound:0155-0182|FD-Score:3.20|P-value:2.22E-4 ID:SGTC_505|Compound:gw-5074|FD-Score:3.13|P-value:2.94E-4 ID:SGTC_510|Compound:ag-490|FD-Score:-3.58|P-value:4.79E-5 ID:SGTC_622|Compound:1348-1566|FD-Score:3.23|P-value:1.93E-4 ID:SGTC_637|Compound:1181-0519|FD-Score:-2.93|P-value:7.33E-4 ID:SGTC_716|Compound:1683-5115|FD-Score:3.33|P-value:1.24E-4 ID:SGTC_733|Compound:4069-0007|FD-Score:2.96|P-value:5.68E-4 ID:SGTC_778|Compound:3456-2434|FD-Score:6.74|P-value:7.58E-14 ID:SGTC_779|Compound:1360-0071|FD-Score:4.02|P-value:5.09E-6 ID:SGTC_784|Compound:4579-0127|FD-Score:3.50|P-value:6.16E-5 ID:SGTC_787|Compound:4152-0075|FD-Score:-4.95|P-value:3.51E-8 ID:SGTC_1013|Compound:4112-3890|FD-Score:-3.04|P-value:4.74E-4 ID:SGTC_1072|Compound:oxiconazole|FD-Score:-3.40|P-value:1.06E-4 ID:SGTC_1141|Compound:3253-0389|FD-Score:3.09|P-value:3.37E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:5.18|P-value:6.53E-9 ID:SGTC_1162|Compound:k048-0130|FD-Score:2.91|P-value:6.75E-4 ID:SGTC_1281|Compound:0884-0031|FD-Score:-2.90|P-value:8.16E-4 ID:SGTC_1292|Compound:0kpi-0043|FD-Score:-3.03|P-value:4.96E-4 ID:SGTC_1307|Compound:1187-1599|FD-Score:3.09|P-value:3.44E-4 ID:SGTC_1335|Compound:1486-0900|FD-Score:-3.90|P-value:1.08E-5 ID:SGTC_1377|Compound:2944-0135|FD-Score:-3.85|P-value:1.38E-5 ID:SGTC_1519|Compound:esterone|FD-Score:3.00|P-value:4.84E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:4.55|P-value:2.94E-7 ID:SGTC_1622|Compound:st003707|FD-Score:-3.27|P-value:1.91E-4 ID:SGTC_1655|Compound:st012546|FD-Score:4.32|P-value:1.05E-6 ID:SGTC_1818|Compound:st052136|FD-Score:-3.75|P-value:2.25E-5 ID:SGTC_1861|Compound:st057647|FD-Score:3.76|P-value:1.86E-5 ID:SGTC_1872|Compound:amphotericin b|FD-Score:4.26|P-value:1.43E-6 ID:SGTC_1979|Compound:st071809|FD-Score:5.25|P-value:4.32E-9 ID:SGTC_1987|Compound:st072290|FD-Score:3.72|P-value:2.23E-5 ID:SGTC_2249|Compound:haloperidol|FD-Score:-3.27|P-value:1.88E-4 ID:SGTC_2257|Compound:7960413|FD-Score:-3.63|P-value:3.96E-5 ID:SGTC_2293|Compound:7624732|FD-Score:-3.14|P-value:3.22E-4 ID:SGTC_2423|Compound:st077119|FD-Score:-2.97|P-value:6.31E-4 ID:SGTC_2426|Compound:5582046|FD-Score:6.71|P-value:9.48E-14 ID:SGTC_2489|Compound:cantharidin|FD-Score:2.87|P-value:8.05E-4 ID:SGTC_2577|Compound:2',4'-dihydroxy-4-methoxychalcone|FD-Score:-2.98|P-value:5.86E-4 ID:SGTC_2583|Compound:asiatic acid|FD-Score:3.97|P-value:6.40E-6 ID:SGTC_2584|Compound:androsterone|FD-Score:-3.05|P-value:4.52E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:-3.20|P-value:2.53E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:3.88|P-value:1.03E-5 ID:SGTC_2778|Compound:tioconazole|FD-Score:-3.44|P-value:9.04E-5 ID:SGTC_2864|Compound:9034755|FD-Score:-3.15|P-value:3.06E-4 ID:SGTC_2879|Compound:9041815|FD-Score:3.33|P-value:1.24E-4 ID:SGTC_3040|Compound:9091894|FD-Score:3.89|P-value:9.66E-6 ID:SGTC_3078|Compound:9116413|FD-Score:-3.08|P-value:4.05E-4 ID:SGTC_3123|Compound:9126162|FD-Score:-4.15|P-value:3.03E-6 ID:SGTC_3142|Compound:9086498|FD-Score:4.69|P-value:1.30E-7 ID:SGTC_3320|Compound:9137005|FD-Score:2.85|P-value:8.53E-4 ID:SGTC_65|Compound:0798-0905|FD-Score:-6.08|P-value:1.66E-11 ID:SGTC_68|Compound:0986-0284|FD-Score:6.00|P-value:2.35E-11 ID:SGTC_75|Compound:0159-0059|FD-Score:-2.85|P-value:9.68E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:3.69|P-value:2.58E-5 ID:SGTC_144|Compound:4161-2749|FD-Score:4.33|P-value:1.02E-6 ID:SGTC_145|Compound:3737-0113|FD-Score:6.18|P-value:6.32E-12 ID:SGTC_218|Compound:alverine citrate|FD-Score:4.23|P-value:1.75E-6 ID:SGTC_236|Compound:1509-0011|FD-Score:3.36|P-value:1.10E-4 ID:SGTC_245|Compound:methotrexate|FD-Score:4.11|P-value:3.15E-6 ID:SGTC_251|Compound:melphalan|FD-Score:2.97|P-value:5.48E-4 ID:SGTC_256|Compound:clotrimazole|FD-Score:-3.06|P-value:4.36E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-5.22|P-value:6.36E-9 ID:SGTC_363|Compound:0455-0021|FD-Score:-4.14|P-value:3.32E-6 ID:SGTC_372|Compound:0155-0182|FD-Score:3.20|P-value:2.22E-4 ID:SGTC_505|Compound:gw-5074|FD-Score:3.13|P-value:2.94E-4 ID:SGTC_510|Compound:ag-490|FD-Score:-3.58|P-value:4.79E-5 ID:SGTC_622|Compound:1348-1566|FD-Score:3.23|P-value:1.93E-4 ID:SGTC_637|Compound:1181-0519|FD-Score:-2.93|P-value:7.33E-4 ID:SGTC_716|Compound:1683-5115|FD-Score:3.33|P-value:1.24E-4 ID:SGTC_733|Compound:4069-0007|FD-Score:2.96|P-value:5.68E-4 ID:SGTC_778|Compound:3456-2434|FD-Score:6.74|P-value:7.58E-14 ID:SGTC_779|Compound:1360-0071|FD-Score:4.02|P-value:5.09E-6 ID:SGTC_784|Compound:4579-0127|FD-Score:3.50|P-value:6.16E-5 ID:SGTC_787|Compound:4152-0075|FD-Score:-4.95|P-value:3.51E-8 ID:SGTC_1013|Compound:4112-3890|FD-Score:-3.04|P-value:4.74E-4 ID:SGTC_1072|Compound:oxiconazole|FD-Score:-3.40|P-value:1.06E-4 ID:SGTC_1141|Compound:3253-0389|FD-Score:3.09|P-value:3.37E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:5.18|P-value:6.53E-9 ID:SGTC_1162|Compound:k048-0130|FD-Score:2.91|P-value:6.75E-4 ID:SGTC_1281|Compound:0884-0031|FD-Score:-2.90|P-value:8.16E-4 ID:SGTC_1292|Compound:0kpi-0043|FD-Score:-3.03|P-value:4.96E-4 ID:SGTC_1307|Compound:1187-1599|FD-Score:3.09|P-value:3.44E-4 ID:SGTC_1335|Compound:1486-0900|FD-Score:-3.90|P-value:1.08E-5 ID:SGTC_1377|Compound:2944-0135|FD-Score:-3.85|P-value:1.38E-5 ID:SGTC_1519|Compound:esterone|FD-Score:3.00|P-value:4.84E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:4.55|P-value:2.94E-7 ID:SGTC_1622|Compound:st003707|FD-Score:-3.27|P-value:1.91E-4 ID:SGTC_1655|Compound:st012546|FD-Score:4.32|P-value:1.05E-6 ID:SGTC_1818|Compound:st052136|FD-Score:-3.75|P-value:2.25E-5 ID:SGTC_1861|Compound:st057647|FD-Score:3.76|P-value:1.86E-5 ID:SGTC_1872|Compound:amphotericin b|FD-Score:4.26|P-value:1.43E-6 ID:SGTC_1979|Compound:st071809|FD-Score:5.25|P-value:4.32E-9 ID:SGTC_1987|Compound:st072290|FD-Score:3.72|P-value:2.23E-5 ID:SGTC_2249|Compound:haloperidol|FD-Score:-3.27|P-value:1.88E-4 ID:SGTC_2257|Compound:7960413|FD-Score:-3.63|P-value:3.96E-5 ID:SGTC_2293|Compound:7624732|FD-Score:-3.14|P-value:3.22E-4 ID:SGTC_2423|Compound:st077119|FD-Score:-2.97|P-value:6.31E-4 ID:SGTC_2426|Compound:5582046|FD-Score:6.71|P-value:9.48E-14 ID:SGTC_2489|Compound:cantharidin|FD-Score:2.87|P-value:8.05E-4 ID:SGTC_2577|Compound:2',4'-dihydroxy-4-methoxychalcone|FD-Score:-2.98|P-value:5.86E-4 ID:SGTC_2583|Compound:asiatic acid|FD-Score:3.97|P-value:6.40E-6 ID:SGTC_2584|Compound:androsterone|FD-Score:-3.05|P-value:4.52E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:-3.20|P-value:2.53E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:3.88|P-value:1.03E-5 ID:SGTC_2778|Compound:tioconazole|FD-Score:-3.44|P-value:9.04E-5 ID:SGTC_2864|Compound:9034755|FD-Score:-3.15|P-value:3.06E-4 ID:SGTC_2879|Compound:9041815|FD-Score:3.33|P-value:1.24E-4 ID:SGTC_3040|Compound:9091894|FD-Score:3.89|P-value:9.66E-6 ID:SGTC_3078|Compound:9116413|FD-Score:-3.08|P-value:4.05E-4 ID:SGTC_3123|Compound:9126162|FD-Score:-4.15|P-value:3.03E-6 ID:SGTC_3142|Compound:9086498|FD-Score:4.69|P-value:1.30E-7 ID:SGTC_3320|Compound:9137005|FD-Score:2.85|P-value:8.53E-4

Top fitness defect scores for YPL010W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_778 3456-2434 6.74 196.0 µM 7.58E-14 mitochondrial response to ROS 3 8.03E-12 1.69
2 SGTC_2426 5582046 6.71 32.2 µM 9.48E-14 1 9.69E-12 1.81
3 SGTC_145 3737-0113 6.18 38.4 µM 6.32E-12 DNA intercalators 16 3.26E-10 0.07
4 SGTC_68 0986-0284 6.00 82.8 µM 2.35E-11 2 9.79E-10 0.35
5 SGTC_1979 st071809 5.25 45.3 µM 4.32E-9 RPP1 & pyrimidine depletion 2 7.73E-8 0.60
6 SGTC_1161 k007-0610 5.18 110.0 µM 6.53E-9 ERAD & cell cycle 23 1.09E-7 0.06
7 SGTC_3142 9086498 4.69 49.5 µM 1.30E-7 iron homeostasis 34 1.34E-6 0.05
8 SGTC_1597 7-benzyloxygramine 4.55 47.5 µM 2.94E-7 calcium & mitochondrial duress 45 2.66E-6 0.01
9 SGTC_144 4161-2749 4.33 112.4 µM 1.02E-6 DNA intercalators 11 7.58E-6 0.18
10 SGTC_1655 st012546 4.32 55.1 µM 1.05E-6 4 7.77E-6 0.23
11 SGTC_1872 amphotericin b 4.26 148.0 nM 1.43E-6 RNA pol III & RNase P/MRP 19 1.00E-5 0.14
12 SGTC_218 alverine citrate 4.23 93.8 µM 1.75E-6 fatty acid desaturase (OLE1) 9 1.19E-5 0.43
13 SGTC_245 methotrexate 4.11 289.6 µM 3.15E-6 12 1.95E-5 0.08
14 SGTC_779 1360-0071 4.02 233.0 µM 5.09E-6 fatty acid desaturase (OLE1) 4 2.91E-5 0.11
15 SGTC_2583 asiatic acid 3.97 100.0 µM 6.40E-6 9 3.53E-5 0.08
16 SGTC_3040 9091894 3.89 49.5 µM 9.66E-6 DNA intercalators 10 4.99E-5 0.33
17 SGTC_2752 diclazuril 3.88 33.1 µM 1.03E-5 8 5.28E-5 0.09
18 SGTC_1861 st057647 3.76 17.4 µM 1.86E-5 7 8.65E-5 0.18
19 SGTC_1987 st072290 3.72 61.9 µM 2.23E-5 4 1.01E-4 0.43
20 SGTC_103 0844-0104 3.69 51.8 µM 2.58E-5 ERAD & cell cycle 54 1.14E-4 0.02

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.259 9.74E-53 YDR238C SEC26 het Essential beta-coat protein of the COPI coatomer, involved in ER-to-Golgi protein trafficking and maintenance of normal ER morphology; shares 43% sequence identity with mammalian beta-coat protein (beta-COP)
0.181 4.67E-26 YNL101W AVT4 hom Vacuolar transporter, exports large neutral amino acids from the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters
0.180 8.16E-26 YDL145C COP1 het Alpha subunit of COPI vesicle coatomer complex, which surrounds transport vesicles in the early secretory pathway
0.171 1.91E-23 YNL287W SEC21 het Gamma subunit of coatomer, a heptameric protein complex that together with Arf1p forms the COPI coat; involved in ER to Golgi transport of selective cargo
0.165 8.00E-22 YDL148C NOP14 het Nucleolar protein, forms a complex with Noc4p that mediates maturation and nuclear export of 40S ribosomal subunits; also present in the small subunit processome complex, which is required for processing of pre-18S rRNA
0.163 1.77E-21 YFR051C RET2 het Delta subunit of the coatomer complex (COPI), which coats Golgi-derived transport vesicles; involved in retrograde transport between Golgi and ER
0.156 1.23E-19 YGL118C_d YGL118C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.140 4.16E-16 YDR401W_d YDR401W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.137 1.99E-15 YNL313C EMW1 het Essential conserved protein with a role in cell wall integrity; contains six TPR (tetratricopeptide repeat) domains clustered in the C-terminal region; conditional mutant is suppressed by overexpression of GFA1; protein abundance increases in response to DNA replication stress
0.130 3.52E-14 YMR029C FAR8 hom Protein involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far3p, Far7p, Far9p, Far10p, and Far11p
0.127 1.52E-13 YDR186C YDR186C hom Putative protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.122 1.14E-12 YGL219C MDM34 hom Mitochondrial component of the ERMES complex that links the ER to mitochondria and may promote inter-organellar calcium and phospholipid exchange as well as coordinating mitochondrial DNA replication and growth
0.122 1.16E-12 YBR196C-B_p YBR196C-B_p hom Putative protein of unknown function; identified by expression profiling and mass spectrometry
0.122 1.47E-12 YBR167C POP7 het Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs
0.120 2.60E-12 YOR077W RTS2 het Basic zinc-finger protein, similar to human and mouse Kin17 proteins which are chromatin-associated proteins involved in UV response and DNA replication