YPL012W / RRP12

Protein required for export of the ribosomal subunits; associates with the RNA components of the pre-ribosomes; has a role in nuclear import in association with Pse1p; contains HEAT-repeats

Zygosity: Heterozygous strain
fixedexpanded
Profile for YPL012W / RRP12

Click on Significant Values for Screen Details ID:SGTC_38|Compound:0929-0051|FD-Score:-8.92|P-value:2.44E-19 ID:SGTC_41|Compound:0478-0632|FD-Score:-8.45|P-value:1.45E-17 ID:SGTC_42|Compound:0133-0086|FD-Score:-5.83|P-value:2.68E-9 ID:SGTC_76|Compound:0433-0009|FD-Score:3.74|P-value:9.87E-5 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:3.75|P-value:9.25E-5 ID:SGTC_738|Compound:1315-0003|FD-Score:3.44|P-value:3.10E-4 ID:SGTC_812|Compound:4251-0442|FD-Score:3.19|P-value:7.45E-4 ID:SGTC_1169|Compound:aniline yellow|FD-Score:-3.64|P-value:1.32E-4 ID:SGTC_1244|Compound:0416-0015|FD-Score:3.22|P-value:6.70E-4 ID:SGTC_1466|Compound:k213-0079|FD-Score:3.18|P-value:7.64E-4 ID:SGTC_1753|Compound:st043925|FD-Score:3.27|P-value:5.65E-4 ID:SGTC_2008|Compound:4012253|FD-Score:-3.53|P-value:2.02E-4 ID:SGTC_2427|Compound:5545055|FD-Score:3.47|P-value:2.75E-4 ID:SGTC_2490|Compound:carminic acid|FD-Score:3.42|P-value:3.29E-4 ID:SGTC_2492|Compound:derrusnin|FD-Score:3.16|P-value:8.22E-4 ID:SGTC_2543|Compound:pimpinellin|FD-Score:-3.49|P-value:2.39E-4 ID:SGTC_2914|Compound:7968218|FD-Score:-3.52|P-value:2.09E-4 ID:SGTC_3090|Compound:9117696|FD-Score:-3.81|P-value:6.71E-5 ID:SGTC_3125|Compound:9127534|FD-Score:-3.39|P-value:3.45E-4 ID:SGTC_3147|Compound:9097027|FD-Score:3.90|P-value:5.01E-5 ID:SGTC_3217|Compound:9129673|FD-Score:3.42|P-value:3.27E-4 ID:SGTC_3326|Compound:9140064|FD-Score:3.57|P-value:1.87E-4 ID:SGTC_38|Compound:0929-0051|FD-Score:-8.92|P-value:2.44E-19 ID:SGTC_41|Compound:0478-0632|FD-Score:-8.45|P-value:1.45E-17 ID:SGTC_42|Compound:0133-0086|FD-Score:-5.83|P-value:2.68E-9 ID:SGTC_76|Compound:0433-0009|FD-Score:3.74|P-value:9.87E-5 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:3.75|P-value:9.25E-5 ID:SGTC_738|Compound:1315-0003|FD-Score:3.44|P-value:3.10E-4 ID:SGTC_812|Compound:4251-0442|FD-Score:3.19|P-value:7.45E-4 ID:SGTC_1169|Compound:aniline yellow|FD-Score:-3.64|P-value:1.32E-4 ID:SGTC_1244|Compound:0416-0015|FD-Score:3.22|P-value:6.70E-4 ID:SGTC_1466|Compound:k213-0079|FD-Score:3.18|P-value:7.64E-4 ID:SGTC_1753|Compound:st043925|FD-Score:3.27|P-value:5.65E-4 ID:SGTC_2008|Compound:4012253|FD-Score:-3.53|P-value:2.02E-4 ID:SGTC_2427|Compound:5545055|FD-Score:3.47|P-value:2.75E-4 ID:SGTC_2490|Compound:carminic acid|FD-Score:3.42|P-value:3.29E-4 ID:SGTC_2492|Compound:derrusnin|FD-Score:3.16|P-value:8.22E-4 ID:SGTC_2543|Compound:pimpinellin|FD-Score:-3.49|P-value:2.39E-4 ID:SGTC_2914|Compound:7968218|FD-Score:-3.52|P-value:2.09E-4 ID:SGTC_3090|Compound:9117696|FD-Score:-3.81|P-value:6.71E-5 ID:SGTC_3125|Compound:9127534|FD-Score:-3.39|P-value:3.45E-4 ID:SGTC_3147|Compound:9097027|FD-Score:3.90|P-value:5.01E-5 ID:SGTC_3217|Compound:9129673|FD-Score:3.42|P-value:3.27E-4 ID:SGTC_3326|Compound:9140064|FD-Score:3.57|P-value:1.87E-4

Top fitness defect scores for YPL012W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_3147 9097027 3.90 49.5 µM 5.01E-5 7 4.73E-5 0.00
2 SGTC_423 5-fluorouracil 3.75 457.0 µM 9.25E-5 exosome 31 8.77E-5 0.05
3 SGTC_76 0433-0009 3.74 400.3 µM 9.87E-5 10 9.36E-5 0.53
4 SGTC_3326 9140064 3.57 16.4 µM 1.87E-4 7 1.77E-4 0.16
5 SGTC_2427 5545055 3.47 42.8 µM 2.75E-4 11 2.61E-4 0.02
6 SGTC_738 1315-0003 3.44 72.4 µM 3.10E-4 9 2.95E-4 0.26
7 SGTC_3217 9129673 3.42 49.5 µM 3.27E-4 17 3.12E-4 0.01
8 SGTC_2490 carminic acid 3.42 95.4 µM 3.29E-4 11 3.14E-4 0.37
9 SGTC_1753 st043925 3.27 64.0 µM 5.65E-4 7 5.40E-4 0.03
10 SGTC_1244 0416-0015 3.22 52.5 µM 6.70E-4 ERG2 7 6.40E-4 0.10
11 SGTC_812 4251-0442 3.19 148.0 µM 7.45E-4 10 7.13E-4 0.10
12 SGTC_1466 k213-0079 3.18 57.5 µM 7.64E-4 22 7.30E-4 0.08
13 SGTC_2492 derrusnin 3.16 100.0 µM 8.22E-4 11 7.87E-4 0.00
14 SGTC_3346 9158254 3.07 43.6 µM 0.00113 29 0.00108 0.02
15 SGTC_701 4424-0219 3.04 185.0 µM 0.00124 calcium & mitochondrial duress 8 0.00119 0.02
16 SGTC_1193 1488-0126 3.04 41.5 µM 0.00124 12 0.00119 0.04
17 SGTC_877 0771-0151 2.88 33.1 µM 0.00210 12 0.00202 0.24
18 SGTC_2419 paclitaxel 2.83 166.5 µM 0.00243 19 0.00234 0.03
19 SGTC_524 r073-0010 2.82 27.8 µM 0.00252 36 0.00242 0.07
20 SGTC_924 2046-0044 2.80 21.3 µM 0.00263 23 0.00253 0.01

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.214 3.64E-36 YGR025W_d YGR025W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.159 1.73E-20 YGL156W AMS1 hom Vacuolar alpha mannosidase, involved in free oligosaccharide (fOS) degradation; delivered to the vacuole in a novel pathway separate from the secretory pathway
0.153 6.26E-19 YBR285W_p YBR285W_p hom Putative protein of unknown function; YBR285W is not an essential gene
0.146 1.69E-17 YGR012W YGR012W hom Putative cysteine synthase, localized to the mitochondrial outer membrane
0.139 5.00E-16 YGL151W NUT1 hom Component of the RNA polymerase II mediator complex, which is required for transcriptional activation and also has a role in basal transcription
0.134 5.85E-15 YGR008C STF2 hom Protein involved in resistance to dessication stress; Stf2p exhibits antioxidant properties, and its overexpression prevents ROS accumulation and apoptosis; binds to the F0 sector of mitochondrial F1F0 ATPase in vitro and is proposed to modulate the inhibitory action of Inh1p and Stf1p; protein abundance increases in response to DNA replication stress
0.131 2.75E-14 YMR041C ARA2 hom NAD-dependent arabinose dehydrogenase, involved in biosynthesis of dehydro-D-arabinono-1,4-lactone; similar to plant L-galactose dehydrogenase
0.125 3.03E-13 YIL028W_d YIL028W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.125 3.67E-13 YGL004C RPN14 hom Proteasome-interacting protein involved in the assembly of the base subcomplex of the 19S proteasome regulatory particle (RP); null mutants accumulate ubiquitinated Gcn4p and display decreased 26S proteasome stability; interacts with Rpt5p
0.111 1.19E-10 YOR239W ABP140 hom AdoMet-dependent tRNA methyltransferase and actin binding protein; C-terminal domain is responsible for 3-methylcytidine modification of residue 32 of the tRNA anticodon loop of tRNA-Thr and tRNA-Ser and contains an S-adenosylmethionine (AdoMet) binding motif; N-terminal actin binding sequence interacts with actin filaments and localizes to actin patches and cables; N- and C-terminal domains are encoded in separate ORFs that are translated into one protein via a +1 frameshift
0.107 4.72E-10 YLR105C SEN2 het Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p; Sen2p contains the active site for tRNA 5' splice site cleavage and has similarity to Sen34p and to Archaeal tRNA splicing endonuclease
0.106 8.57E-10 YLR287C_p YLR287C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR287C is not an essential gene
0.099 8.44E-9 YGL181W GTS1 hom Protein involved in Arf3p regulation and in transcription regulation; localizes to the nucleus and to endocytic patches; contains an N-terminal Zn-finger and ArfGAP homology domain, a C-terminal glutamine-rich region, and a UBA (ubiquitin associated) domain; gts1 mutations affect budding, cell size, heat tolerance, sporulation, life span, ultradian rhythms, endocytosis; expression oscillates in a pattern similar to metabolic oscillations
0.096 2.16E-8 YGL069C_d YGL069C_d het Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 92% of ORF overlaps the uncharacterized ORF YGL068W; deletion in cyr1 mutant results in loss of stress resistance
0.095 3.16E-8 YIL100W_d YIL100W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the dubious ORF YIL100C-A