YPL014W_p

Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to the nucleus

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL014W / YPL014W

Click on Significant Values for Screen Details ID:SGTC_42|Compound:0133-0086|FD-Score:4.13|P-value:6.11E-5 ID:SGTC_48|Compound:0382-0018|FD-Score:-3.99|P-value:1.46E-4 ID:SGTC_160|Compound:3453-0671|FD-Score:-4.21|P-value:6.51E-5 ID:SGTC_161|Compound:4065-0411|FD-Score:5.94|P-value:1.85E-8 ID:SGTC_164|Compound:4100-3994|FD-Score:-8.27|P-value:2.00E-14 ID:SGTC_171|Compound:k064-0041|FD-Score:4.63|P-value:8.75E-6 ID:SGTC_180|Compound:1486-1293|FD-Score:3.52|P-value:5.32E-4 ID:SGTC_190|Compound:3970-0790|FD-Score:-3.64|P-value:4.81E-4 ID:SGTC_192|Compound:3455-0609|FD-Score:3.43|P-value:6.98E-4 ID:SGTC_194|Compound:1486-1323|FD-Score:-4.54|P-value:1.79E-5 ID:SGTC_195|Compound:4234-0266|FD-Score:-3.42|P-value:9.53E-4 ID:SGTC_204|Compound:1543-0184|FD-Score:3.41|P-value:7.55E-4 ID:SGTC_210|Compound:3551-0445|FD-Score:4.89|P-value:2.89E-6 ID:SGTC_496|Compound:calpeptin|FD-Score:5.24|P-value:6.00E-7 ID:SGTC_592|Compound:k241-0073|FD-Score:-4.95|P-value:3.35E-6 ID:SGTC_595|Compound:3909-8003|FD-Score:4.69|P-value:6.67E-6 ID:SGTC_749|Compound:1000-0129|FD-Score:5.08|P-value:1.23E-6 ID:SGTC_923|Compound:1900-2434|FD-Score:3.39|P-value:7.97E-4 ID:SGTC_953|Compound:1188-0045|FD-Score:3.60|P-value:3.97E-4 ID:SGTC_1246|Compound:0422-0085|FD-Score:4.14|P-value:5.95E-5 ID:SGTC_1298|Compound:1079-1278|FD-Score:-3.47|P-value:8.30E-4 ID:SGTC_1300|Compound:1094-0077|FD-Score:3.47|P-value:6.09E-4 ID:SGTC_1305|Compound:1181-0477|FD-Score:-3.94|P-value:1.74E-4 ID:SGTC_1457|Compound:k015-0032|FD-Score:6.13|P-value:7.10E-9 ID:SGTC_1508|Compound:1080-0625|FD-Score:4.05|P-value:8.41E-5 ID:SGTC_1594|Compound:piperine|FD-Score:3.81|P-value:1.99E-4 ID:SGTC_1683|Compound:st010134|FD-Score:3.53|P-value:5.15E-4 ID:SGTC_1726|Compound:st035556|FD-Score:3.52|P-value:5.24E-4 ID:SGTC_1745|Compound:st081495|FD-Score:3.39|P-value:7.94E-4 ID:SGTC_2066|Compound:5222451|FD-Score:3.76|P-value:2.34E-4 ID:SGTC_2165|Compound:5727197|FD-Score:3.78|P-value:2.21E-4 ID:SGTC_2246|Compound:7293507|FD-Score:3.46|P-value:6.38E-4 ID:SGTC_2433|Compound:5607874|FD-Score:-3.69|P-value:4.09E-4 ID:SGTC_2435|Compound:5706476|FD-Score:3.32|P-value:9.91E-4 ID:SGTC_2477|Compound:5967686|FD-Score:3.61|P-value:3.90E-4 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:-5.17|P-value:1.26E-6 ID:SGTC_2793|Compound:7325131|FD-Score:3.52|P-value:5.30E-4 ID:SGTC_2837|Compound:9008476|FD-Score:4.25|P-value:3.87E-5 ID:SGTC_3044|Compound:9093193|FD-Score:-3.63|P-value:4.96E-4 ID:SGTC_3077|Compound:9117319|FD-Score:3.63|P-value:3.71E-4 ID:SGTC_3178|Compound:9107506|FD-Score:-3.65|P-value:4.64E-4 ID:SGTC_3209|Compound:9113616|FD-Score:3.46|P-value:6.46E-4 ID:SGTC_42|Compound:0133-0086|FD-Score:4.13|P-value:6.11E-5 ID:SGTC_48|Compound:0382-0018|FD-Score:-3.99|P-value:1.46E-4 ID:SGTC_160|Compound:3453-0671|FD-Score:-4.21|P-value:6.51E-5 ID:SGTC_161|Compound:4065-0411|FD-Score:5.94|P-value:1.85E-8 ID:SGTC_164|Compound:4100-3994|FD-Score:-8.27|P-value:2.00E-14 ID:SGTC_171|Compound:k064-0041|FD-Score:4.63|P-value:8.75E-6 ID:SGTC_180|Compound:1486-1293|FD-Score:3.52|P-value:5.32E-4 ID:SGTC_190|Compound:3970-0790|FD-Score:-3.64|P-value:4.81E-4 ID:SGTC_192|Compound:3455-0609|FD-Score:3.43|P-value:6.98E-4 ID:SGTC_194|Compound:1486-1323|FD-Score:-4.54|P-value:1.79E-5 ID:SGTC_195|Compound:4234-0266|FD-Score:-3.42|P-value:9.53E-4 ID:SGTC_204|Compound:1543-0184|FD-Score:3.41|P-value:7.55E-4 ID:SGTC_210|Compound:3551-0445|FD-Score:4.89|P-value:2.89E-6 ID:SGTC_496|Compound:calpeptin|FD-Score:5.24|P-value:6.00E-7 ID:SGTC_592|Compound:k241-0073|FD-Score:-4.95|P-value:3.35E-6 ID:SGTC_595|Compound:3909-8003|FD-Score:4.69|P-value:6.67E-6 ID:SGTC_749|Compound:1000-0129|FD-Score:5.08|P-value:1.23E-6 ID:SGTC_923|Compound:1900-2434|FD-Score:3.39|P-value:7.97E-4 ID:SGTC_953|Compound:1188-0045|FD-Score:3.60|P-value:3.97E-4 ID:SGTC_1246|Compound:0422-0085|FD-Score:4.14|P-value:5.95E-5 ID:SGTC_1298|Compound:1079-1278|FD-Score:-3.47|P-value:8.30E-4 ID:SGTC_1300|Compound:1094-0077|FD-Score:3.47|P-value:6.09E-4 ID:SGTC_1305|Compound:1181-0477|FD-Score:-3.94|P-value:1.74E-4 ID:SGTC_1457|Compound:k015-0032|FD-Score:6.13|P-value:7.10E-9 ID:SGTC_1508|Compound:1080-0625|FD-Score:4.05|P-value:8.41E-5 ID:SGTC_1594|Compound:piperine|FD-Score:3.81|P-value:1.99E-4 ID:SGTC_1683|Compound:st010134|FD-Score:3.53|P-value:5.15E-4 ID:SGTC_1726|Compound:st035556|FD-Score:3.52|P-value:5.24E-4 ID:SGTC_1745|Compound:st081495|FD-Score:3.39|P-value:7.94E-4 ID:SGTC_2066|Compound:5222451|FD-Score:3.76|P-value:2.34E-4 ID:SGTC_2165|Compound:5727197|FD-Score:3.78|P-value:2.21E-4 ID:SGTC_2246|Compound:7293507|FD-Score:3.46|P-value:6.38E-4 ID:SGTC_2433|Compound:5607874|FD-Score:-3.69|P-value:4.09E-4 ID:SGTC_2435|Compound:5706476|FD-Score:3.32|P-value:9.91E-4 ID:SGTC_2477|Compound:5967686|FD-Score:3.61|P-value:3.90E-4 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:-5.17|P-value:1.26E-6 ID:SGTC_2793|Compound:7325131|FD-Score:3.52|P-value:5.30E-4 ID:SGTC_2837|Compound:9008476|FD-Score:4.25|P-value:3.87E-5 ID:SGTC_3044|Compound:9093193|FD-Score:-3.63|P-value:4.96E-4 ID:SGTC_3077|Compound:9117319|FD-Score:3.63|P-value:3.71E-4 ID:SGTC_3178|Compound:9107506|FD-Score:-3.65|P-value:4.64E-4 ID:SGTC_3209|Compound:9113616|FD-Score:3.46|P-value:6.46E-4

Top fitness defect scores for YPL014W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1457 k015-0032 6.13 57.3 µM 7.10E-9 6 4.53E-10
2 SGTC_161 4065-0411 5.94 162.2 µM 1.85E-8 27 1.39E-9
3 SGTC_496 calpeptin 5.24 138.0 µM 6.00E-7 3 8.12E-8
4 SGTC_749 1000-0129 5.08 128.0 µM 1.23E-6 amide catabolism 4 1.87E-7
5 SGTC_210 3551-0445 4.89 56.8 µM 2.89E-6 38 5.08E-7
6 SGTC_595 3909-8003 4.69 73.7 µM 6.67E-6 6 1.35E-6
7 SGTC_171 k064-0041 4.63 9.7 µM 8.75E-6 heme requiring 19 1.85E-6
8 SGTC_2837 9008476 4.25 45.5 µM 3.87E-5 25 1.05E-5
9 SGTC_1246 0422-0085 4.14 105.0 µM 5.95E-5 26 1.72E-5
10 SGTC_42 0133-0086 4.13 60.6 µM 6.11E-5 25 1.78E-5
11 SGTC_1508 1080-0625 4.05 72.9 µM 8.41E-5 17 2.58E-5
12 SGTC_1594 piperine 3.81 70.1 µM 1.99E-4 16 7.01E-5
13 SGTC_2165 5727197 3.78 32.1 µM 2.21E-4 39 7.91E-5
14 SGTC_2066 5222451 3.76 176.0 µM 2.34E-4 heme biosynthesis & mitochondrial translocase 35 8.44E-5
15 SGTC_3077 9117319 3.63 49.5 µM 3.71E-4 23 1.44E-4
16 SGTC_2477 5967686 3.61 25.2 µM 3.90E-4 35 1.53E-4
17 SGTC_953 1188-0045 3.60 9.7 µM 3.97E-4 60S ribosome export 38 1.56E-4
18 SGTC_1683 st010134 3.53 710.0 nM 5.15E-4 47 2.11E-4
19 SGTC_1726 st035556 3.52 14.6 µM 5.24E-4 54 2.15E-4
20 SGTC_2793 7325131 3.52 81.8 µM 5.30E-4 23 2.18E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.110 1.58E-10 YGL214W_d YGL214W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; deletion mutation phenotype is likely due to the overlapping verified ORF SKI8/YGL213C
0.097 1.81E-8 YDR232W HEM1 het 5-aminolevulinate synthase, catalyzes the first step in the heme biosynthetic pathway; an N-terminal signal sequence is required for localization to the mitochondrial matrix; expression is regulated by Hap2p-Hap3p
0.092 9.55E-8 YLR451W LEU3 hom Zinc-knuckle transcription factor, repressor and activator; regulates genes involved in branched chain amino acid biosynthesis and ammonia assimilation; acts as a repressor in leucine-replete conditions and as an activator in the presence of alpha-isopropylmalate, an intermediate in leucine biosynthesis that accumulates during leucine starvation
0.087 4.10E-7 YBR225W_p YBR225W_p hom Putative protein of unknown function; non-essential gene identified in a screen for mutants affected in mannosylphophorylation of cell wall components
0.084 1.11E-6 YIR024C YIR024C hom Protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; interacts with Arh1p, a mitochondrial oxidoreductase; deletion mutant has a respiratory growth defect
0.077 8.77E-6 YBR186W PCH2 hom Nucleolar component of the pachytene checkpoint, which prevents chromosome segregation when recombination and chromosome synapsis are defective; also represses meiotic interhomolog recombination in the rDNA; required for meiotic double-stranded break formation
0.076 9.78E-6 YGL236C MTO1 hom Mitochondrial protein, forms a heterodimer complex with Mss1p that performs the 5-carboxymethylaminomethyl modification of the wobble uridine base in mitochondrial tRNAs; required for respiration in paromomycin-resistant 15S rRNA mutants
0.074 1.57E-5 YHR193C EGD2 hom Alpha subunit of the heteromeric nascent polypeptide-associated complex (NAC) involved in protein sorting and translocation, associated with cytoplasmic ribosomes
0.073 2.27E-5 YEL014C_d YEL014C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.072 3.35E-5 YNL129W NRK1 hom Nicotinamide riboside kinase, catalyzes the phosphorylation of nicotinamide riboside and nicotinic acid riboside in salvage pathways for NAD+ biosynthesis
0.071 4.09E-5 YML026C RPS18B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S18 and bacterial S13; RPS18B has a paralog, RPS18A, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
0.071 4.09E-5 YGL141W HUL5 hom Multiubiquitin chain assembly factor (E4); proteasome processivity factor that elongates polyUb chains on substrates, opposing Ubp6p, a branched polyubiquitin protease; required for retrograde transport of misfolded proteins during ERAD
0.070 5.34E-5 YFR033C QCR6 hom Subunit 6 of the ubiquinol cytochrome-c reductase complex; the complex, also known as the cytochrome bc(1) complex or Complex III, is a component of the mitochondrial inner membrane electron transport chain; highly acidic protein; required for maturation of cytochrome c1; may be loosely associated with the complex since it is easily released into the intermembrane space
0.069 6.74E-5 YLR418C CDC73 hom Component of the Paf1p complex; binds to and modulates the activity of RNA polymerases I and II; required for expression of certain genes, modification of some histones, and telomere maintenance; involved in transcription elongation as demonstrated by the G-less-based run-on (GLRO) assay; protein abundance increases in response to DNA replication stress
0.067 9.18E-5 YGL008C PMA1 het Plasma membrane H+-ATPase, pumps protons out of the cell; major regulator of cytoplasmic pH and plasma membrane potential; P2-type ATPase; Hsp30p plays a role in Pma1p regulation; interactions with Std1p appear to propagate [GAR+]