YPL015C / HST2

Cytoplasmic member of the silencing information regulator 2 (Sir2) family of NAD(+)-dependent protein deacetylases; modulates nucleolar (rDNA) and telomeric silencing; possesses NAD(+)-dependent histone deacetylase activity in vitro; contains a nuclear export signal (NES); function regulated by its nuclear export

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL015C / HST2

Click on Significant Values for Screen Details ID:SGTC_317|Compound:4495-0002|FD-Score:3.56|P-value:5.76E-4 ID:SGTC_353|Compound:1988-1175|FD-Score:-3.79|P-value:2.78E-4 ID:SGTC_356|Compound:1634-0012|FD-Score:-4.43|P-value:2.74E-5 ID:SGTC_374|Compound:0880-0231|FD-Score:4.58|P-value:1.45E-5 ID:SGTC_386|Compound:1509-0011|FD-Score:-3.42|P-value:9.13E-4 ID:SGTC_550|Compound:4123-0385|FD-Score:3.52|P-value:6.44E-4 ID:SGTC_558|Compound:k064-0027|FD-Score:4.13|P-value:8.20E-5 ID:SGTC_616|Compound:4092-0450|FD-Score:-3.91|P-value:1.89E-4 ID:SGTC_700|Compound:3453-2283|FD-Score:3.42|P-value:8.91E-4 ID:SGTC_704|Compound:1310-0270|FD-Score:4.36|P-value:3.51E-5 ID:SGTC_721|Compound:1187-1332|FD-Score:-3.52|P-value:6.84E-4 ID:SGTC_733|Compound:4069-0007|FD-Score:3.54|P-value:6.11E-4 ID:SGTC_743|Compound:1275-0778|FD-Score:3.73|P-value:3.27E-4 ID:SGTC_959|Compound:1222-0044|FD-Score:3.92|P-value:1.75E-4 ID:SGTC_1019|Compound:4262-0212|FD-Score:-3.50|P-value:7.29E-4 ID:SGTC_1020|Compound:4335-0961|FD-Score:3.39|P-value:9.95E-4 ID:SGTC_1025|Compound:k007-0731|FD-Score:-5.17|P-value:1.24E-6 ID:SGTC_1122|Compound:capsaicin|FD-Score:-3.82|P-value:2.51E-4 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:-3.46|P-value:8.15E-4 ID:SGTC_1175|Compound:0741-0056|FD-Score:5.90|P-value:3.59E-8 ID:SGTC_1207|Compound:2099-0101|FD-Score:4.14|P-value:7.94E-5 ID:SGTC_1314|Compound:1222-0010|FD-Score:3.62|P-value:4.81E-4 ID:SGTC_1368|Compound:1852-0141|FD-Score:4.43|P-value:2.62E-5 ID:SGTC_1378|Compound:2093-0007|FD-Score:3.57|P-value:5.50E-4 ID:SGTC_1386|Compound:3228-0095|FD-Score:3.40|P-value:9.52E-4 ID:SGTC_1510|Compound:1123-0200|FD-Score:4.99|P-value:2.65E-6 ID:SGTC_1809|Compound:st050081|FD-Score:6.35|P-value:3.48E-9 ID:SGTC_1861|Compound:st057647|FD-Score:3.53|P-value:6.37E-4 ID:SGTC_2032|Compound:5185112|FD-Score:3.53|P-value:6.44E-4 ID:SGTC_2113|Compound:5491891|FD-Score:4.11|P-value:8.92E-5 ID:SGTC_2247|Compound:cerulenin|FD-Score:3.42|P-value:9.00E-4 ID:SGTC_2334|Compound:9017922|FD-Score:-3.87|P-value:2.14E-4 ID:SGTC_2350|Compound:9023895|FD-Score:4.20|P-value:6.40E-5 ID:SGTC_2358|Compound:9037157|FD-Score:-3.93|P-value:1.71E-4 ID:SGTC_2365|Compound:9042475|FD-Score:-3.57|P-value:5.73E-4 ID:SGTC_2553|Compound:4-methylesculetin|FD-Score:4.46|P-value:2.30E-5 ID:SGTC_2586|Compound:curcumin|FD-Score:5.87|P-value:4.24E-8 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:4.02|P-value:1.21E-4 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:4.81|P-value:5.73E-6 ID:SGTC_2690|Compound:usnic acid|FD-Score:5.54|P-value:2.11E-7 ID:SGTC_2725|Compound:haloperidol|FD-Score:3.58|P-value:5.43E-4 ID:SGTC_2853|Compound:9015042|FD-Score:4.80|P-value:5.85E-6 ID:SGTC_2855|Compound:9016525|FD-Score:3.48|P-value:7.38E-4 ID:SGTC_2856|Compound:9022925|FD-Score:5.98|P-value:2.38E-8 ID:SGTC_2915|Compound:7971052|FD-Score:3.44|P-value:8.33E-4 ID:SGTC_2967|Compound:9089538|FD-Score:3.95|P-value:1.56E-4 ID:SGTC_2968|Compound:9090663|FD-Score:5.40|P-value:4.10E-7 ID:SGTC_2971|Compound:9092186|FD-Score:-3.48|P-value:7.61E-4 ID:SGTC_3047|Compound:9092122|FD-Score:-4.93|P-value:3.53E-6 ID:SGTC_3050|Compound:9093513|FD-Score:7.45|P-value:5.19E-12 ID:SGTC_3057|Compound:9095946|FD-Score:-4.54|P-value:1.76E-5 ID:SGTC_3063|Compound:1327-0034|FD-Score:3.79|P-value:2.67E-4 ID:SGTC_3206|Compound:9114350|FD-Score:3.41|P-value:9.12E-4 ID:SGTC_3237|Compound:9133362|FD-Score:-3.64|P-value:4.56E-4 ID:SGTC_3258|Compound:9138477|FD-Score:3.60|P-value:5.07E-4 ID:SGTC_3268|Compound:9137683|FD-Score:7.14|P-value:3.70E-11 ID:SGTC_3328|Compound:9140624|FD-Score:-3.42|P-value:9.39E-4 ID:SGTC_317|Compound:4495-0002|FD-Score:3.56|P-value:5.76E-4 ID:SGTC_353|Compound:1988-1175|FD-Score:-3.79|P-value:2.78E-4 ID:SGTC_356|Compound:1634-0012|FD-Score:-4.43|P-value:2.74E-5 ID:SGTC_374|Compound:0880-0231|FD-Score:4.58|P-value:1.45E-5 ID:SGTC_386|Compound:1509-0011|FD-Score:-3.42|P-value:9.13E-4 ID:SGTC_550|Compound:4123-0385|FD-Score:3.52|P-value:6.44E-4 ID:SGTC_558|Compound:k064-0027|FD-Score:4.13|P-value:8.20E-5 ID:SGTC_616|Compound:4092-0450|FD-Score:-3.91|P-value:1.89E-4 ID:SGTC_700|Compound:3453-2283|FD-Score:3.42|P-value:8.91E-4 ID:SGTC_704|Compound:1310-0270|FD-Score:4.36|P-value:3.51E-5 ID:SGTC_721|Compound:1187-1332|FD-Score:-3.52|P-value:6.84E-4 ID:SGTC_733|Compound:4069-0007|FD-Score:3.54|P-value:6.11E-4 ID:SGTC_743|Compound:1275-0778|FD-Score:3.73|P-value:3.27E-4 ID:SGTC_959|Compound:1222-0044|FD-Score:3.92|P-value:1.75E-4 ID:SGTC_1019|Compound:4262-0212|FD-Score:-3.50|P-value:7.29E-4 ID:SGTC_1020|Compound:4335-0961|FD-Score:3.39|P-value:9.95E-4 ID:SGTC_1025|Compound:k007-0731|FD-Score:-5.17|P-value:1.24E-6 ID:SGTC_1122|Compound:capsaicin|FD-Score:-3.82|P-value:2.51E-4 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:-3.46|P-value:8.15E-4 ID:SGTC_1175|Compound:0741-0056|FD-Score:5.90|P-value:3.59E-8 ID:SGTC_1207|Compound:2099-0101|FD-Score:4.14|P-value:7.94E-5 ID:SGTC_1314|Compound:1222-0010|FD-Score:3.62|P-value:4.81E-4 ID:SGTC_1368|Compound:1852-0141|FD-Score:4.43|P-value:2.62E-5 ID:SGTC_1378|Compound:2093-0007|FD-Score:3.57|P-value:5.50E-4 ID:SGTC_1386|Compound:3228-0095|FD-Score:3.40|P-value:9.52E-4 ID:SGTC_1510|Compound:1123-0200|FD-Score:4.99|P-value:2.65E-6 ID:SGTC_1809|Compound:st050081|FD-Score:6.35|P-value:3.48E-9 ID:SGTC_1861|Compound:st057647|FD-Score:3.53|P-value:6.37E-4 ID:SGTC_2032|Compound:5185112|FD-Score:3.53|P-value:6.44E-4 ID:SGTC_2113|Compound:5491891|FD-Score:4.11|P-value:8.92E-5 ID:SGTC_2247|Compound:cerulenin|FD-Score:3.42|P-value:9.00E-4 ID:SGTC_2334|Compound:9017922|FD-Score:-3.87|P-value:2.14E-4 ID:SGTC_2350|Compound:9023895|FD-Score:4.20|P-value:6.40E-5 ID:SGTC_2358|Compound:9037157|FD-Score:-3.93|P-value:1.71E-4 ID:SGTC_2365|Compound:9042475|FD-Score:-3.57|P-value:5.73E-4 ID:SGTC_2553|Compound:4-methylesculetin|FD-Score:4.46|P-value:2.30E-5 ID:SGTC_2586|Compound:curcumin|FD-Score:5.87|P-value:4.24E-8 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:4.02|P-value:1.21E-4 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:4.81|P-value:5.73E-6 ID:SGTC_2690|Compound:usnic acid|FD-Score:5.54|P-value:2.11E-7 ID:SGTC_2725|Compound:haloperidol|FD-Score:3.58|P-value:5.43E-4 ID:SGTC_2853|Compound:9015042|FD-Score:4.80|P-value:5.85E-6 ID:SGTC_2855|Compound:9016525|FD-Score:3.48|P-value:7.38E-4 ID:SGTC_2856|Compound:9022925|FD-Score:5.98|P-value:2.38E-8 ID:SGTC_2915|Compound:7971052|FD-Score:3.44|P-value:8.33E-4 ID:SGTC_2967|Compound:9089538|FD-Score:3.95|P-value:1.56E-4 ID:SGTC_2968|Compound:9090663|FD-Score:5.40|P-value:4.10E-7 ID:SGTC_2971|Compound:9092186|FD-Score:-3.48|P-value:7.61E-4 ID:SGTC_3047|Compound:9092122|FD-Score:-4.93|P-value:3.53E-6 ID:SGTC_3050|Compound:9093513|FD-Score:7.45|P-value:5.19E-12 ID:SGTC_3057|Compound:9095946|FD-Score:-4.54|P-value:1.76E-5 ID:SGTC_3063|Compound:1327-0034|FD-Score:3.79|P-value:2.67E-4 ID:SGTC_3206|Compound:9114350|FD-Score:3.41|P-value:9.12E-4 ID:SGTC_3237|Compound:9133362|FD-Score:-3.64|P-value:4.56E-4 ID:SGTC_3258|Compound:9138477|FD-Score:3.60|P-value:5.07E-4 ID:SGTC_3268|Compound:9137683|FD-Score:7.14|P-value:3.70E-11 ID:SGTC_3328|Compound:9140624|FD-Score:-3.42|P-value:9.39E-4

Top fitness defect scores for YPL015C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3050 9093513 7.45 49.5 µM 5.19E-12 2 4.52E-14
2 SGTC_3268 9137683 7.14 49.5 µM 3.70E-11 1 4.74E-13
3 SGTC_1809 st050081 6.35 57.6 µM 3.48E-9 3 1.09E-10
4 SGTC_2856 9022925 5.98 19.5 µM 2.38E-8 4 1.09E-9
5 SGTC_1175 0741-0056 5.90 27.6 µM 3.59E-8 2 1.78E-9
6 SGTC_2586 curcumin 5.87 80.0 µM 4.24E-8 iron homeostasis 16 2.18E-9
7 SGTC_2690 usnic acid 5.54 100.0 µM 2.11E-7 8 1.48E-8
8 SGTC_2968 9090663 5.40 33.4 µM 4.10E-7 10 3.28E-8
9 SGTC_1510 1123-0200 4.99 71.5 µM 2.65E-6 25 3.04E-7
10 SGTC_2604 4'-hydroxychalcone 4.81 11.3 µM 5.73E-6 20 7.65E-7
11 SGTC_2853 9015042 4.80 58.4 µM 5.85E-6 14 7.85E-7
12 SGTC_374 0880-0231 4.58 82.3 µM 1.45E-5 iron homeostasis 15 2.32E-6
13 SGTC_2553 4-methylesculetin 4.46 85.1 µM 2.30E-5 9 4.01E-6
14 SGTC_1368 1852-0141 4.43 284.0 µM 2.62E-5 ERG2 30 4.68E-6
15 SGTC_704 1310-0270 4.36 142.0 µM 3.51E-5 25 6.65E-6
16 SGTC_2350 9023895 4.20 38.9 µM 6.40E-5 ergosterol biosynthesis 23 1.36E-5
17 SGTC_1207 2099-0101 4.14 141.0 µM 7.94E-5 15 1.76E-5
18 SGTC_558 k064-0027 4.13 21.3 µM 8.20E-5 DNA damage response 22 1.83E-5
19 SGTC_2113 5491891 4.11 107.0 µM 8.92E-5 TSC3-RPN4 15 2.02E-5
20 SGTC_2603 homopterocarpin 4.02 100.0 µM 1.21E-4 35 2.90E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.085 7.65E-7 YIL011W TIR3 hom Cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; expressed under anaerobic conditions and required for anaerobic growth
0.085 8.16E-7 YDR042C_p YDR042C_p hom Putative protein of unknown function; expression is increased in ssu72-ts69 mutant
0.078 6.92E-6 YJL100W LSB6 hom Type II phosphatidylinositol 4-kinase that binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization
0.075 1.54E-5 YLR047C FRE8 hom Protein with sequence similarity to iron/copper reductases, involved in iron homeostasis; deletion mutant has iron deficiency/accumulation growth defects; expression increased in the absence of copper-responsive transcription factor Mac1p
0.072 2.68E-5 YDR050C TPI1 het Triose phosphate isomerase, abundant glycolytic enzyme; mRNA half-life is regulated by iron availability; transcription is controlled by activators Reb1p, Gcr1p, and Rap1p through binding sites in the 5' non-coding region; inhibition of Tpi1p activity by PEP (phosphoenolpyruvate) stimulates redox metabolism in respiring cells; E104D mutation in human TPI causes a rare autosomal disease
0.071 3.86E-5 YHR075C PPE1 hom Protein with carboxyl methyl esterase activity that may have a role in demethylation of the phosphoprotein phosphatase catalytic subunit; also identified as a small subunit mitochondrial ribosomal protein
0.070 4.75E-5 YJL067W_d YJL067W_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.070 5.08E-5 YCR068W ATG15 hom Lipase required for intravacuolar lysis of autophagic bodies and Cvt bodies; targeted to intravacuolar vesicles during autophagy via the multivesicular body (MVB) pathway
0.070 5.21E-5 YLR252W_d YLR252W_d hom Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified gene SYM1, a mitochondrial protein involved in ethanol metabolism
0.068 7.75E-5 YOR277C_d YOR277C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; almost completely overlaps the verified gene CAF20
0.068 8.18E-5 YCR027C RHB1 hom Putative Rheb-related GTPase involved in regulating canavanine resistance and arginine uptake; member of the Ras superfamily of G-proteins
0.068 8.58E-5 YLR092W SUL2 hom High affinity sulfate permease; sulfate uptake is mediated by specific sulfate transporters Sul1p and Sul2p, which control the concentration of endogenous activated sulfate intermediates
0.067 9.61E-5 YBL002W HTB2 hom Histone H2B, core histone protein required for chromatin assembly and chromosome function; nearly identical to HTB1; Rad6p-Bre1p-Lge1p mediated ubiquitination regulates transcriptional activation, meiotic DSB formation and H3 methylation
0.066 1.27E-4 YDR066C RTR2 hom Protein of unknown function; exhibits genetic interactions with Rtr1p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YDR066C is not an essential gene; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress; RTR2 has a paralog, RTR1, that arose from the whole genome duplication
0.066 1.33E-4 YJR100C AIM25 hom Putative protein of unknown function; non-tagged protein is detected in purified mitochondria in high-throughput studies; similar to murine NOR1; null mutant is viable and displays elevated frequency of mitochondrial genome loss