YPL016W / SWI1

Subunit of the SWI/SNF chromatin remodeling complex; regulates transcription by remodeling chromatin; required for transcription of many genes, including ADH1, ADH2, GAL1, HO, INO1 and SUC2; can form the prion [SWI+]; human homolog ARID1A is a candidate tumor suppressor gene in breast cancer

Zygosity: Heterozygous strain
fixedexpanded
Profile for YPL016W / SWI1

Click on Significant Values for Screen Details ID:SGTC_116|Compound:0155-0182|FD-Score:-4.70|P-value:1.49E-5 ID:SGTC_147|Compound:4466-0538|FD-Score:3.95|P-value:2.48E-4 ID:SGTC_150|Compound:3970-0969|FD-Score:3.80|P-value:4.05E-4 ID:SGTC_171|Compound:k064-0041|FD-Score:4.10|P-value:1.48E-4 ID:SGTC_175|Compound:3793-3120|FD-Score:3.83|P-value:3.65E-4 ID:SGTC_362|Compound:0310-0100|FD-Score:5.15|P-value:2.78E-6 ID:SGTC_525|Compound:k781-2675|FD-Score:4.84|P-value:9.78E-6 ID:SGTC_661|Compound:1304-0007|FD-Score:3.66|P-value:6.26E-4 ID:SGTC_693|Compound:4161-2696|FD-Score:4.27|P-value:8.18E-5 ID:SGTC_863|Compound:0466-0191|FD-Score:4.51|P-value:3.46E-5 ID:SGTC_933|Compound:2914-0560|FD-Score:3.52|P-value:9.53E-4 ID:SGTC_1126|Compound:isoteolin|FD-Score:-3.66|P-value:5.71E-4 ID:SGTC_1590|Compound:st077108|FD-Score:4.18|P-value:1.13E-4 ID:SGTC_1604|Compound:st002052|FD-Score:3.51|P-value:9.81E-4 ID:SGTC_2090|Compound:5301565|FD-Score:3.55|P-value:8.89E-4 ID:SGTC_2094|Compound:5332512|FD-Score:-5.07|P-value:3.36E-6 ID:SGTC_2518|Compound:prenyletin|FD-Score:-3.50|P-value:9.43E-4 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:4.05|P-value:1.75E-4 ID:SGTC_2600|Compound:tangeritin|FD-Score:-3.96|P-value:2.16E-4 ID:SGTC_2722|Compound:naftopidil|FD-Score:3.52|P-value:9.64E-4 ID:SGTC_2802|Compound:7925815|FD-Score:-4.38|P-value:5.09E-5 ID:SGTC_2803|Compound:7707263|FD-Score:-3.74|P-value:4.51E-4 ID:SGTC_2818|Compound:7996756|FD-Score:8.40|P-value:5.84E-14 ID:SGTC_2822|Compound:7994718|FD-Score:4.45|P-value:4.31E-5 ID:SGTC_2824|Compound:7998404|FD-Score:8.67|P-value:9.55E-15 ID:SGTC_2935|Compound:9038016|FD-Score:-3.71|P-value:4.87E-4 ID:SGTC_2937|Compound:9044753|FD-Score:3.97|P-value:2.29E-4 ID:SGTC_2939|Compound:9044578|FD-Score:5.77|P-value:1.74E-7 ID:SGTC_2945|Compound:9067681|FD-Score:4.25|P-value:8.81E-5 ID:SGTC_2957|Compound:9076800|FD-Score:4.29|P-value:7.82E-5 ID:SGTC_2963|Compound:9082507|FD-Score:3.75|P-value:4.67E-4 ID:SGTC_3072|Compound:9116419|FD-Score:-3.72|P-value:4.71E-4 ID:SGTC_3152|Compound:9099253|FD-Score:3.51|P-value:9.74E-4 ID:SGTC_3282|Compound:9108498|FD-Score:-3.84|P-value:3.26E-4 ID:SGTC_3293|Compound:9120939|FD-Score:-3.82|P-value:3.50E-4 ID:SGTC_3311|Compound:9131146|FD-Score:4.50|P-value:3.64E-5 ID:SGTC_116|Compound:0155-0182|FD-Score:-4.70|P-value:1.49E-5 ID:SGTC_147|Compound:4466-0538|FD-Score:3.95|P-value:2.48E-4 ID:SGTC_150|Compound:3970-0969|FD-Score:3.80|P-value:4.05E-4 ID:SGTC_171|Compound:k064-0041|FD-Score:4.10|P-value:1.48E-4 ID:SGTC_175|Compound:3793-3120|FD-Score:3.83|P-value:3.65E-4 ID:SGTC_362|Compound:0310-0100|FD-Score:5.15|P-value:2.78E-6 ID:SGTC_525|Compound:k781-2675|FD-Score:4.84|P-value:9.78E-6 ID:SGTC_661|Compound:1304-0007|FD-Score:3.66|P-value:6.26E-4 ID:SGTC_693|Compound:4161-2696|FD-Score:4.27|P-value:8.18E-5 ID:SGTC_863|Compound:0466-0191|FD-Score:4.51|P-value:3.46E-5 ID:SGTC_933|Compound:2914-0560|FD-Score:3.52|P-value:9.53E-4 ID:SGTC_1126|Compound:isoteolin|FD-Score:-3.66|P-value:5.71E-4 ID:SGTC_1590|Compound:st077108|FD-Score:4.18|P-value:1.13E-4 ID:SGTC_1604|Compound:st002052|FD-Score:3.51|P-value:9.81E-4 ID:SGTC_2090|Compound:5301565|FD-Score:3.55|P-value:8.89E-4 ID:SGTC_2094|Compound:5332512|FD-Score:-5.07|P-value:3.36E-6 ID:SGTC_2518|Compound:prenyletin|FD-Score:-3.50|P-value:9.43E-4 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:4.05|P-value:1.75E-4 ID:SGTC_2600|Compound:tangeritin|FD-Score:-3.96|P-value:2.16E-4 ID:SGTC_2722|Compound:naftopidil|FD-Score:3.52|P-value:9.64E-4 ID:SGTC_2802|Compound:7925815|FD-Score:-4.38|P-value:5.09E-5 ID:SGTC_2803|Compound:7707263|FD-Score:-3.74|P-value:4.51E-4 ID:SGTC_2818|Compound:7996756|FD-Score:8.40|P-value:5.84E-14 ID:SGTC_2822|Compound:7994718|FD-Score:4.45|P-value:4.31E-5 ID:SGTC_2824|Compound:7998404|FD-Score:8.67|P-value:9.55E-15 ID:SGTC_2935|Compound:9038016|FD-Score:-3.71|P-value:4.87E-4 ID:SGTC_2937|Compound:9044753|FD-Score:3.97|P-value:2.29E-4 ID:SGTC_2939|Compound:9044578|FD-Score:5.77|P-value:1.74E-7 ID:SGTC_2945|Compound:9067681|FD-Score:4.25|P-value:8.81E-5 ID:SGTC_2957|Compound:9076800|FD-Score:4.29|P-value:7.82E-5 ID:SGTC_2963|Compound:9082507|FD-Score:3.75|P-value:4.67E-4 ID:SGTC_3072|Compound:9116419|FD-Score:-3.72|P-value:4.71E-4 ID:SGTC_3152|Compound:9099253|FD-Score:3.51|P-value:9.74E-4 ID:SGTC_3282|Compound:9108498|FD-Score:-3.84|P-value:3.26E-4 ID:SGTC_3293|Compound:9120939|FD-Score:-3.82|P-value:3.50E-4 ID:SGTC_3311|Compound:9131146|FD-Score:4.50|P-value:3.64E-5

Top fitness defect scores for YPL016W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2824 7998404 8.67 52.0 µM 9.55E-15 1 2.23E-18 1.87
2 SGTC_2818 7996756 8.40 13.0 µM 5.84E-14 1 2.24E-17 2.52
3 SGTC_2939 9044578 5.77 71.4 µM 1.74E-7 2 3.92E-9 1.54
4 SGTC_362 0310-0100 5.15 9.0 µM 2.78E-6 RPP1 & pyrimidine depletion 5 1.32E-7 0.90
5 SGTC_525 k781-2675 4.84 26.7 µM 9.78E-6 redox potentiating 33 6.52E-7 0.15
6 SGTC_863 0466-0191 4.51 129.0 µM 3.46E-5 cell wall 19 3.24E-6 0.27
7 SGTC_3311 9131146 4.50 2.9 µM 3.64E-5 cell wall 16 3.45E-6 0.22
8 SGTC_2822 7994718 4.45 71.4 µM 4.31E-5 7 4.27E-6 0.70
9 SGTC_2957 9076800 4.29 11.5 µM 7.82E-5 2 9.09E-6 0.32
10 SGTC_693 4161-2696 4.27 114.0 µM 8.18E-5 2 9.62E-6 0.24
11 SGTC_2945 9067681 4.25 61.8 µM 8.81E-5 3 1.06E-5 0.07
12 SGTC_1590 st077108 4.18 57.8 µM 1.13E-4 4 1.44E-5 0.07
13 SGTC_171 k064-0041 4.10 9.7 µM 1.48E-4 heme requiring 14 2.03E-5 0.13
14 SGTC_2541 muurolladie-3-one 4.05 83.1 µM 1.75E-4 excess fatty acid 18 2.52E-5 0.17
15 SGTC_2937 9044753 3.97 11.3 µM 2.29E-4 60S ribosome export 8 3.53E-5 0.01
16 SGTC_147 4466-0538 3.95 29.2 µM 2.48E-4 ergosterol biosynthesis 8 3.91E-5 0.12
17 SGTC_175 3793-3120 3.83 23.7 µM 3.65E-4 9 6.38E-5 0.03
18 SGTC_150 3970-0969 3.80 77.2 µM 4.05E-4 18 7.27E-5 0.01
19 SGTC_2963 9082507 3.75 9.0 µM 4.67E-4 9 8.71E-5 0.04
20 SGTC_661 1304-0007 3.66 33.6 µM 6.26E-4 6 1.26E-4 0.01

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.129 6.48E-14 YER147C SCC4 het Subunit of cohesin loading factor (Scc2p-Scc4p), a complex required for the loading of cohesin complexes onto chromosomes; involved in establishing sister chromatid cohesion during double-strand break repair via phosphorylated histone H2AX
0.122 1.23E-12 YDR503C LPP1 hom Lipid phosphate phosphatase, catalyzes Mg(2+)-independent dephosphorylation of phosphatidic acid (PA), lysophosphatidic acid, and diacylglycerol pyrophosphate; involved in control of the cellular levels of phosphatidylinositol and PA
0.118 7.98E-12 YDL066W IDP1 hom Mitochondrial NADP-specific isocitrate dehydrogenase, catalyzes the oxidation of isocitrate to alpha-ketoglutarate; not required for mitochondrial respiration and may function to divert alpha-ketoglutarate to biosynthetic processes
0.115 2.19E-11 YNR040W_p YNR040W_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.111 1.16E-10 YBR120C CBP6 hom Mitochondrial protein required for translation of the COB mRNA; forms a complex with Cbp3p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex
0.109 2.07E-10 YDR149C_d YDR149C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps the verified gene NUM1; null mutation blocks anaerobic growth
0.108 3.81E-10 YPL179W PPQ1 hom Putative protein serine/threonine phosphatase; null mutation enhances efficiency of translational suppressors
0.104 1.34E-9 YKL035W UGP1 het UDP-glucose pyrophosphorylase (UGPase); catalyses the reversible formation of UDP-Glc from glucose 1-phosphate and UTP, involved in a wide variety of metabolic pathways, expression modulated by Pho85p through Pho4p; UGP1 has a paralog, YHL012W, that arose from the whole genome duplication
0.099 8.64E-9 YBR298C MAL31 hom Maltose permease, high-affinity maltose transporter (alpha-glucoside transporter); encoded in the MAL3 complex locus; member of the 12 transmembrane domain superfamily of sugar transporters; functional in genomic reference strain S288C
0.097 1.80E-8 YNL314W DAL82 hom Positive regulator of allophanate inducible genes; binds a dodecanucleotide sequence upstream of all genes that are induced by allophanate; contains an UISALL DNA-binding, a transcriptional activation, and a coiled-coil domain
0.094 4.46E-8 YBL006C LDB7 hom Component of the RSC chromatin remodeling complex; interacts with Rsc3p, Rsc30p, Npl6p, and Htl1p to form a module important for a broad range of RSC functions
0.094 4.86E-8 YJL099W CHS6 hom Member of the ChAPs (Chs5p-Arf1p-binding proteins) family; part of the exomer complex that mediates export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane; CHS6 has a paralog, BCH2, that arose from the whole genome duplication
0.091 1.38E-7 YHR176W FMO1 hom Flavin-containing monooxygenase, localized to the cytoplasmic face of the ER membrane; catalyzes oxidation of biological thiols to maintain the ER redox buffer ratio for correct folding of disulfide-bonded proteins
0.090 1.71E-7 YDL213C NOP6 hom rRNA-binding protein required for 40S ribosomal subunit biogenesis; contains an RNA recognition motif (RRM); hydrophilin essential to overcome the stress of the desiccation-rehydration process; NOP6 may be a fungal-specific gene as no homologs have been yet identified in higher eukaryotes
0.087 3.86E-7 YCL005W LDB16 hom Protein of unknown function; null mutants have decreased net negative cell surface charge; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; native protein is detected in purified mitochondria