YPL017C / IRC15

Microtubule associated protein; regulates microtubule dynamics; required for accurate meiotic chromosome segregation; null mutant displays large budded cells due to delayed mitotic progression, increased levels of spontaneous Rad52 foci

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL017C / IRC15

Click on Significant Values for Screen Details ID:SGTC_17|Compound:0960-0276|FD-Score:3.82|P-value:3.38E-4 ID:SGTC_20|Compound:0481-0013|FD-Score:3.52|P-value:8.68E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:4.28|P-value:6.92E-5 ID:SGTC_163|Compound:1327-0036|FD-Score:6.55|P-value:2.50E-9 ID:SGTC_187|Compound:1488-2104|FD-Score:3.86|P-value:2.95E-4 ID:SGTC_209|Compound:4077-0173|FD-Score:-3.76|P-value:3.56E-4 ID:SGTC_238|Compound:5hr heat shock (37°C) + nsc-638432|FD-Score:5.81|P-value:1.10E-7 ID:SGTC_239|Compound:5hr heat shock (37°C) + mitomycin C|FD-Score:4.64|P-value:1.78E-5 ID:SGTC_241|Compound:5hr heat shock (37°C) + cantharidin|FD-Score:11.10|P-value:1.77E-23 ID:SGTC_243|Compound:5hr heat shock (37°C) + splitomicin|FD-Score:4.73|P-value:1.26E-5 ID:SGTC_310|Compound:1273-0058|FD-Score:-4.30|P-value:5.36E-5 ID:SGTC_379|Compound:3970-0972|FD-Score:4.11|P-value:1.26E-4 ID:SGTC_408|Compound:cantharidin|FD-Score:4.54|P-value:2.65E-5 ID:SGTC_422|Compound:cantharidin|FD-Score:7.10|P-value:1.20E-10 ID:SGTC_514|Compound:4466-0038|FD-Score:9.57|P-value:6.22E-18 ID:SGTC_537|Compound:1334-0398|FD-Score:4.06|P-value:1.50E-4 ID:SGTC_546|Compound:peri-Naphthalide|FD-Score:3.73|P-value:4.47E-4 ID:SGTC_596|Compound:1155-0152|FD-Score:-3.80|P-value:3.13E-4 ID:SGTC_710|Compound:3448-4187|FD-Score:3.73|P-value:4.48E-4 ID:SGTC_863|Compound:0466-0191|FD-Score:3.90|P-value:2.56E-4 ID:SGTC_884|Compound:0851-0618|FD-Score:3.67|P-value:5.54E-4 ID:SGTC_916|Compound:4466-0038|FD-Score:5.65|P-value:2.37E-7 ID:SGTC_1090|Compound:efavirenz|FD-Score:3.50|P-value:9.29E-4 ID:SGTC_1106|Compound:tegaserod maleate|FD-Score:4.08|P-value:1.39E-4 ID:SGTC_1148|Compound:3909-7663|FD-Score:4.86|P-value:7.35E-6 ID:SGTC_1232|Compound:0279-0259|FD-Score:4.45|P-value:3.65E-5 ID:SGTC_1242|Compound:0402-0103|FD-Score:3.93|P-value:2.35E-4 ID:SGTC_1278|Compound:0874-0585|FD-Score:-3.87|P-value:2.48E-4 ID:SGTC_1521|Compound:st012942|FD-Score:4.39|P-value:4.69E-5 ID:SGTC_1589|Compound:2',5'-dimethoxyflavone|FD-Score:4.00|P-value:1.86E-4 ID:SGTC_1631|Compound:benzylvanillin|FD-Score:4.62|P-value:1.96E-5 ID:SGTC_1722|Compound:st034304|FD-Score:3.65|P-value:5.82E-4 ID:SGTC_1768|Compound:st044301|FD-Score:5.43|P-value:6.31E-7 ID:SGTC_1956|Compound:st077085|FD-Score:4.40|P-value:4.36E-5 ID:SGTC_1963|Compound:st076565|FD-Score:3.91|P-value:2.48E-4 ID:SGTC_1971|Compound:st069429|FD-Score:4.50|P-value:3.05E-5 ID:SGTC_2002|Compound:4023503|FD-Score:-3.91|P-value:2.15E-4 ID:SGTC_2032|Compound:5185112|FD-Score:5.01|P-value:4.00E-6 ID:SGTC_2033|Compound:5192550|FD-Score:3.84|P-value:3.17E-4 ID:SGTC_2040|Compound:5100729|FD-Score:6.24|P-value:1.27E-8 ID:SGTC_2063|Compound:5246145|FD-Score:-4.42|P-value:3.53E-5 ID:SGTC_2065|Compound:5221596|FD-Score:4.59|P-value:2.12E-5 ID:SGTC_2075|Compound:5212009|FD-Score:-5.21|P-value:1.38E-6 ID:SGTC_2079|Compound:5212404|FD-Score:-3.53|P-value:7.43E-4 ID:SGTC_2131|Compound:toluylene red|FD-Score:-4.06|P-value:1.27E-4 ID:SGTC_2340|Compound:7987427|FD-Score:4.68|P-value:1.50E-5 ID:SGTC_2343|Compound:7990716|FD-Score:-4.12|P-value:1.05E-4 ID:SGTC_2377|Compound:9073351|FD-Score:-4.22|P-value:7.24E-5 ID:SGTC_2453|Compound:5731132|FD-Score:3.91|P-value:2.46E-4 ID:SGTC_2489|Compound:cantharidin|FD-Score:4.53|P-value:2.71E-5 ID:SGTC_2503|Compound:beta-caryophyllene alcohol|FD-Score:-3.71|P-value:4.16E-4 ID:SGTC_2561|Compound:acetosyringone|FD-Score:4.08|P-value:1.40E-4 ID:SGTC_2576|Compound:guaiol|FD-Score:4.15|P-value:1.08E-4 ID:SGTC_2584|Compound:androsterone|FD-Score:6.85|P-value:4.75E-10 ID:SGTC_2585|Compound:alliin|FD-Score:3.76|P-value:4.12E-4 ID:SGTC_2619|Compound:obliquin|FD-Score:4.65|P-value:1.68E-5 ID:SGTC_2640|Compound:pentamidine|FD-Score:3.88|P-value:2.73E-4 ID:SGTC_2737|Compound:bleomycin|FD-Score:3.72|P-value:4.60E-4 ID:SGTC_2776|Compound:terbinafine|FD-Score:3.84|P-value:3.19E-4 ID:SGTC_2809|Compound:7964133|FD-Score:-3.80|P-value:3.11E-4 ID:SGTC_2814|Compound:7977482|FD-Score:4.13|P-value:1.16E-4 ID:SGTC_2912|Compound:7964298|FD-Score:4.66|P-value:1.65E-5 ID:SGTC_2968|Compound:9090663|FD-Score:-3.85|P-value:2.63E-4 ID:SGTC_3110|Compound:9122132|FD-Score:-3.89|P-value:2.33E-4 ID:SGTC_3311|Compound:9131146|FD-Score:6.04|P-value:3.49E-8 ID:SGTC_3321|Compound:9137793|FD-Score:4.72|P-value:1.28E-5 ID:SGTC_17|Compound:0960-0276|FD-Score:3.82|P-value:3.38E-4 ID:SGTC_20|Compound:0481-0013|FD-Score:3.52|P-value:8.68E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:4.28|P-value:6.92E-5 ID:SGTC_163|Compound:1327-0036|FD-Score:6.55|P-value:2.50E-9 ID:SGTC_187|Compound:1488-2104|FD-Score:3.86|P-value:2.95E-4 ID:SGTC_209|Compound:4077-0173|FD-Score:-3.76|P-value:3.56E-4 ID:SGTC_238|Compound:5hr heat shock (37°C) + nsc-638432|FD-Score:5.81|P-value:1.10E-7 ID:SGTC_239|Compound:5hr heat shock (37°C) + mitomycin C|FD-Score:4.64|P-value:1.78E-5 ID:SGTC_241|Compound:5hr heat shock (37°C) + cantharidin|FD-Score:11.10|P-value:1.77E-23 ID:SGTC_243|Compound:5hr heat shock (37°C) + splitomicin|FD-Score:4.73|P-value:1.26E-5 ID:SGTC_310|Compound:1273-0058|FD-Score:-4.30|P-value:5.36E-5 ID:SGTC_379|Compound:3970-0972|FD-Score:4.11|P-value:1.26E-4 ID:SGTC_408|Compound:cantharidin|FD-Score:4.54|P-value:2.65E-5 ID:SGTC_422|Compound:cantharidin|FD-Score:7.10|P-value:1.20E-10 ID:SGTC_514|Compound:4466-0038|FD-Score:9.57|P-value:6.22E-18 ID:SGTC_537|Compound:1334-0398|FD-Score:4.06|P-value:1.50E-4 ID:SGTC_546|Compound:peri-Naphthalide|FD-Score:3.73|P-value:4.47E-4 ID:SGTC_596|Compound:1155-0152|FD-Score:-3.80|P-value:3.13E-4 ID:SGTC_710|Compound:3448-4187|FD-Score:3.73|P-value:4.48E-4 ID:SGTC_863|Compound:0466-0191|FD-Score:3.90|P-value:2.56E-4 ID:SGTC_884|Compound:0851-0618|FD-Score:3.67|P-value:5.54E-4 ID:SGTC_916|Compound:4466-0038|FD-Score:5.65|P-value:2.37E-7 ID:SGTC_1090|Compound:efavirenz|FD-Score:3.50|P-value:9.29E-4 ID:SGTC_1106|Compound:tegaserod maleate|FD-Score:4.08|P-value:1.39E-4 ID:SGTC_1148|Compound:3909-7663|FD-Score:4.86|P-value:7.35E-6 ID:SGTC_1232|Compound:0279-0259|FD-Score:4.45|P-value:3.65E-5 ID:SGTC_1242|Compound:0402-0103|FD-Score:3.93|P-value:2.35E-4 ID:SGTC_1278|Compound:0874-0585|FD-Score:-3.87|P-value:2.48E-4 ID:SGTC_1521|Compound:st012942|FD-Score:4.39|P-value:4.69E-5 ID:SGTC_1589|Compound:2',5'-dimethoxyflavone|FD-Score:4.00|P-value:1.86E-4 ID:SGTC_1631|Compound:benzylvanillin|FD-Score:4.62|P-value:1.96E-5 ID:SGTC_1722|Compound:st034304|FD-Score:3.65|P-value:5.82E-4 ID:SGTC_1768|Compound:st044301|FD-Score:5.43|P-value:6.31E-7 ID:SGTC_1956|Compound:st077085|FD-Score:4.40|P-value:4.36E-5 ID:SGTC_1963|Compound:st076565|FD-Score:3.91|P-value:2.48E-4 ID:SGTC_1971|Compound:st069429|FD-Score:4.50|P-value:3.05E-5 ID:SGTC_2002|Compound:4023503|FD-Score:-3.91|P-value:2.15E-4 ID:SGTC_2032|Compound:5185112|FD-Score:5.01|P-value:4.00E-6 ID:SGTC_2033|Compound:5192550|FD-Score:3.84|P-value:3.17E-4 ID:SGTC_2040|Compound:5100729|FD-Score:6.24|P-value:1.27E-8 ID:SGTC_2063|Compound:5246145|FD-Score:-4.42|P-value:3.53E-5 ID:SGTC_2065|Compound:5221596|FD-Score:4.59|P-value:2.12E-5 ID:SGTC_2075|Compound:5212009|FD-Score:-5.21|P-value:1.38E-6 ID:SGTC_2079|Compound:5212404|FD-Score:-3.53|P-value:7.43E-4 ID:SGTC_2131|Compound:toluylene red|FD-Score:-4.06|P-value:1.27E-4 ID:SGTC_2340|Compound:7987427|FD-Score:4.68|P-value:1.50E-5 ID:SGTC_2343|Compound:7990716|FD-Score:-4.12|P-value:1.05E-4 ID:SGTC_2377|Compound:9073351|FD-Score:-4.22|P-value:7.24E-5 ID:SGTC_2453|Compound:5731132|FD-Score:3.91|P-value:2.46E-4 ID:SGTC_2489|Compound:cantharidin|FD-Score:4.53|P-value:2.71E-5 ID:SGTC_2503|Compound:beta-caryophyllene alcohol|FD-Score:-3.71|P-value:4.16E-4 ID:SGTC_2561|Compound:acetosyringone|FD-Score:4.08|P-value:1.40E-4 ID:SGTC_2576|Compound:guaiol|FD-Score:4.15|P-value:1.08E-4 ID:SGTC_2584|Compound:androsterone|FD-Score:6.85|P-value:4.75E-10 ID:SGTC_2585|Compound:alliin|FD-Score:3.76|P-value:4.12E-4 ID:SGTC_2619|Compound:obliquin|FD-Score:4.65|P-value:1.68E-5 ID:SGTC_2640|Compound:pentamidine|FD-Score:3.88|P-value:2.73E-4 ID:SGTC_2737|Compound:bleomycin|FD-Score:3.72|P-value:4.60E-4 ID:SGTC_2776|Compound:terbinafine|FD-Score:3.84|P-value:3.19E-4 ID:SGTC_2809|Compound:7964133|FD-Score:-3.80|P-value:3.11E-4 ID:SGTC_2814|Compound:7977482|FD-Score:4.13|P-value:1.16E-4 ID:SGTC_2912|Compound:7964298|FD-Score:4.66|P-value:1.65E-5 ID:SGTC_2968|Compound:9090663|FD-Score:-3.85|P-value:2.63E-4 ID:SGTC_3110|Compound:9122132|FD-Score:-3.89|P-value:2.33E-4 ID:SGTC_3311|Compound:9131146|FD-Score:6.04|P-value:3.49E-8 ID:SGTC_3321|Compound:9137793|FD-Score:4.72|P-value:1.28E-5

Top fitness defect scores for YPL017C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_241 5hr heat shock (37°C) + cantharidin 11.10 155.4 µM 1.77E-23 cell wall signaling 10 6.43E-29
2 SGTC_514 4466-0038 9.57 2.6 nM 6.22E-18 cell wall 23 5.32E-22
3 SGTC_422 cantharidin 7.10 155.0 µM 1.20E-10 cell wall signaling 15 6.44E-13
4 SGTC_2584 androsterone 6.85 48.7 µM 4.75E-10 cell wall 42 3.57E-12
5 SGTC_163 1327-0036 6.55 7.5 µM 2.50E-9 38 2.82E-11
6 SGTC_2040 5100729 6.24 123.0 µM 1.27E-8 9 2.14E-10
7 SGTC_3311 9131146 6.04 2.9 µM 3.49E-8 cell wall 60 7.52E-10
8 SGTC_238 5hr heat shock (37°C) + nsc-638432 5.81 8.9 µM 1.10E-7 heat shock/prefoldin 17 3.15E-9
9 SGTC_916 4466-0038 5.65 42.0 nM 2.37E-7 cell wall 29 8.12E-9
10 SGTC_1768 st044301 5.43 37.2 µM 6.31E-7 4 2.75E-8
11 SGTC_2032 5185112 5.01 26.0 µM 4.00E-6 5 2.73E-7
12 SGTC_1148 3909-7663 4.86 27.7 µM 7.35E-6 3 5.81E-7
13 SGTC_243 5hr heat shock (37°C) + splitomicin 4.73 1.0 µM 1.26E-5 heat shock/prefoldin 29 1.14E-6
14 SGTC_3321 9137793 4.72 26.8 µM 1.28E-5 cell wall 51 1.15E-6
15 SGTC_2340 7987427 4.68 183.4 µM 1.50E-5 17 1.41E-6
16 SGTC_2912 7964298 4.66 10.9 µM 1.65E-5 cell wall 76 1.58E-6
17 SGTC_2619 obliquin 4.65 87.9 µM 1.68E-5 cell wall 108 1.62E-6
18 SGTC_239 5hr heat shock (37°C) + mitomycin C 4.64 819.4 µM 1.78E-5 heat shock/prefoldin 23 1.75E-6
19 SGTC_1631 benzylvanillin 4.62 81.9 µM 1.96E-5 Golgi 15 1.96E-6
20 SGTC_2065 5221596 4.59 34.3 µM 2.12E-5 9 2.17E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.297 1.75E-69 YLL032C YLL032C hom Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLL032C is not an essential gene
0.294 5.49E-68 YDR318W MCM21 hom Component of the kinetochore sub-complex COMA; COMA (Ctf19p, Okp1p, Mcm21p, Ame1p) bridges kinetochore subunits in contact with centromeric DNA with subunits bound to microtubules during kinetochore assembly; involved in minichromosome maintenance; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-O and fission yeast mal2
0.290 3.49E-66 YHR209W CRG1 hom S-AdoMet-dependent methyltransferase involved in lipid homeostasis; mediates resistance to a drug cantharidin
0.286 3.02E-64 YJL099W CHS6 hom Member of the ChAPs (Chs5p-Arf1p-binding proteins) family; part of the exomer complex that mediates export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane; CHS6 has a paralog, BCH2, that arose from the whole genome duplication
0.275 1.70E-59 YDR260C SWM1 hom Subunit of the anaphase-promoting complex, which is an E3 ubiquitin ligase that regulates the metaphase-anaphase transition and exit from mitosis; required for activation of the daughter-specific gene expression and spore wall maturation
0.252 8.64E-50 YBL085W BOI1 hom Protein implicated in polar growth; functionally redundant with Boi2p; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain; relocalizes from bud neck to cytoplasm upon DNA replication stress; BOI1 has a paralog, BOI2, that arose from the whole genome duplication
0.249 1.05E-48 YMR124W_p YMR124W_p hom Protein of unknown function; GFP-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; interacts with Crm1p in two-hybrid assay; YMR124W is not an essential gene; predicted to have a role in organelle organization
0.248 2.43E-48 YMR036C MIH1 hom Protein tyrosine phosphatase involved in cell cycle control; regulates the phosphorylation state of Cdc28p; homolog of S. pombe cdc25
0.237 3.04E-44 YJL095W BCK1 hom Mitogen-activated protein (MAP) kinase kinase kinase acting in the protein kinase C signaling pathway, which controls cell integrity; upon activation by Pkc1p phosphorylates downstream kinases Mkk1p and Mkk2p
0.224 2.61E-39 YJL159W HSP150 hom O-mannosylated heat shock protein; secreted and covalently attached to the cell wall via beta-1,3-glucan and disulfide bridges; required for cell wall stability; induced by heat shock, oxidative stress, and nitrogen limitation; HSP150 has a paralog, PIR3, that arose from the whole genome duplication
0.223 3.37E-39 YPR120C CLB5 hom B-type cyclin involved in DNA replication during S phase; activates Cdc28p to promote initiation of DNA synthesis; functions in formation of mitotic spindles along with Clb3p and Clb4p; most abundant during late G1 phase
0.221 2.68E-38 YDL203C ACK1 hom Protein that functions upstream of Pkc1p in the cell wall integrity pathway; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; non-tagged Ack1p is detected in purified mitochondria
0.213 8.24E-36 YLR027C AAT2 hom Cytosolic aspartate aminotransferase, involved in nitrogen metabolism; localizes to peroxisomes in oleate-grown cells
0.211 3.23E-35 YOL003C PFA4 hom Palmitoyltransferase with autoacylation activity, required for palmitoylation of amino acid permeases containing a C-terminal Phe-Trp-Cys site; required for modification of Chs3p; member of the DHHC family of putative palmitoyltransferases
0.209 4.20E-34 YHR030C SLT2 hom Serine/threonine MAP kinase; involved in regulating maintenance of cell wall integrity, progression through the cell cycle, and nuclear mRNA retention in heat shock; required for mitophagy and pexophagy; affects recruitment of mitochondria to the phagophore assembly site (PAS); regulated by the PKC1-mediated signaling pathway