YPL018W / CTF19

Outer kinetochore protein, needed for accurate chromosome segregation; component of the kinetochore sub-complex COMA (Ctf19p, Okp1p, Mcm21p, Ame1p) that functions as a platform for kinetochore assembly; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-P and fission yeast fta2

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL018W / CTF19

Click on Significant Values for Screen Details ID:SGTC_190|Compound:3970-0790|FD-Score:-2.77|P-value:9.13E-4 ID:SGTC_195|Compound:4234-0266|FD-Score:3.64|P-value:9.04E-5 ID:SGTC_204|Compound:1543-0184|FD-Score:3.36|P-value:2.83E-4 ID:SGTC_331|Compound:k048-0133|FD-Score:3.32|P-value:3.25E-4 ID:SGTC_422|Compound:cantharidin|FD-Score:3.67|P-value:7.78E-5 ID:SGTC_424|Compound:splitomicin|FD-Score:-2.90|P-value:5.60E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:7.44|P-value:2.70E-15 ID:SGTC_553|Compound:k007-0256|FD-Score:3.52|P-value:1.50E-4 ID:SGTC_571|Compound:k831-0106|FD-Score:3.09|P-value:8.06E-4 ID:SGTC_580|Compound:1123-0028|FD-Score:6.34|P-value:1.58E-11 ID:SGTC_600|Compound:1495-0418|FD-Score:3.84|P-value:3.77E-5 ID:SGTC_724|Compound:3910-0327|FD-Score:3.15|P-value:6.36E-4 ID:SGTC_795|Compound:0685-0265|FD-Score:-3.20|P-value:1.70E-4 ID:SGTC_801|Compound:0866-0028|FD-Score:3.79|P-value:4.61E-5 ID:SGTC_843|Compound:0310-0051|FD-Score:3.34|P-value:3.05E-4 ID:SGTC_925|Compound:2064-1272|FD-Score:4.35|P-value:3.20E-6 ID:SGTC_992|Compound:3909-8734|FD-Score:3.49|P-value:1.64E-4 ID:SGTC_1005|Compound:4092-0690|FD-Score:4.92|P-value:1.55E-7 ID:SGTC_1044|Compound:1222-0021|FD-Score:3.39|P-value:2.46E-4 ID:SGTC_1051|Compound:3253-3903|FD-Score:-3.22|P-value:1.54E-4 ID:SGTC_1054|Compound:3429-0080|FD-Score:-2.76|P-value:9.40E-4 ID:SGTC_1055|Compound:3448-0672|FD-Score:-4.36|P-value:6.95E-7 ID:SGTC_1258|Compound:0671-0043|FD-Score:3.05|P-value:9.34E-4 ID:SGTC_1319|Compound:1306-0155|FD-Score:3.16|P-value:6.12E-4 ID:SGTC_1352|Compound:1496-0991|FD-Score:5.50|P-value:4.62E-9 ID:SGTC_1467|Compound:k284-1082|FD-Score:3.27|P-value:3.95E-4 ID:SGTC_1543|Compound:azetidyl-2-carboxylic acid|FD-Score:3.13|P-value:6.93E-4 ID:SGTC_1739|Compound:st037196|FD-Score:3.35|P-value:2.89E-4 ID:SGTC_1748|Compound:st037455|FD-Score:3.35|P-value:2.91E-4 ID:SGTC_1749|Compound:st037932|FD-Score:-4.98|P-value:2.05E-8 ID:SGTC_1761|Compound:st044296|FD-Score:4.00|P-value:1.79E-5 ID:SGTC_1762|Compound:st045503|FD-Score:3.40|P-value:2.44E-4 ID:SGTC_1893|Compound:st059353|FD-Score:-4.19|P-value:1.73E-6 ID:SGTC_2040|Compound:5100729|FD-Score:4.69|P-value:5.53E-7 ID:SGTC_2044|Compound:5102272|FD-Score:3.22|P-value:4.86E-4 ID:SGTC_2054|Compound:5233173|FD-Score:3.11|P-value:7.48E-4 ID:SGTC_2080|Compound:5212524|FD-Score:-2.84|P-value:6.91E-4 ID:SGTC_2082|Compound:5219693|FD-Score:3.81|P-value:4.31E-5 ID:SGTC_2161|Compound:5662504|FD-Score:3.93|P-value:2.43E-5 ID:SGTC_2377|Compound:9073351|FD-Score:3.49|P-value:1.70E-4 ID:SGTC_2393|Compound:9031399|FD-Score:3.40|P-value:2.45E-4 ID:SGTC_2401|Compound:5128683|FD-Score:-3.18|P-value:1.88E-4 ID:SGTC_2725|Compound:haloperidol|FD-Score:3.32|P-value:3.25E-4 ID:SGTC_3065|Compound:9113888|FD-Score:3.39|P-value:2.46E-4 ID:SGTC_3068|Compound:9116768|FD-Score:3.32|P-value:3.27E-4 ID:SGTC_3137|Compound:9097352|FD-Score:3.78|P-value:4.74E-5 ID:SGTC_3155|Compound:9099265|FD-Score:-3.27|P-value:1.26E-4 ID:SGTC_3182|Compound:9108849|FD-Score:3.11|P-value:7.32E-4 ID:SGTC_3202|Compound:9113761|FD-Score:3.62|P-value:9.61E-5 ID:SGTC_3203|Compound:9113543|FD-Score:5.46|P-value:6.19E-9 ID:SGTC_3228|Compound:9131799|FD-Score:3.03|P-value:9.94E-4 ID:SGTC_3235|Compound:9132602|FD-Score:4.82|P-value:2.74E-7 ID:SGTC_3281|Compound:9140613|FD-Score:-2.97|P-value:4.32E-4 ID:SGTC_190|Compound:3970-0790|FD-Score:-2.77|P-value:9.13E-4 ID:SGTC_195|Compound:4234-0266|FD-Score:3.64|P-value:9.04E-5 ID:SGTC_204|Compound:1543-0184|FD-Score:3.36|P-value:2.83E-4 ID:SGTC_331|Compound:k048-0133|FD-Score:3.32|P-value:3.25E-4 ID:SGTC_422|Compound:cantharidin|FD-Score:3.67|P-value:7.78E-5 ID:SGTC_424|Compound:splitomicin|FD-Score:-2.90|P-value:5.60E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:7.44|P-value:2.70E-15 ID:SGTC_553|Compound:k007-0256|FD-Score:3.52|P-value:1.50E-4 ID:SGTC_571|Compound:k831-0106|FD-Score:3.09|P-value:8.06E-4 ID:SGTC_580|Compound:1123-0028|FD-Score:6.34|P-value:1.58E-11 ID:SGTC_600|Compound:1495-0418|FD-Score:3.84|P-value:3.77E-5 ID:SGTC_724|Compound:3910-0327|FD-Score:3.15|P-value:6.36E-4 ID:SGTC_795|Compound:0685-0265|FD-Score:-3.20|P-value:1.70E-4 ID:SGTC_801|Compound:0866-0028|FD-Score:3.79|P-value:4.61E-5 ID:SGTC_843|Compound:0310-0051|FD-Score:3.34|P-value:3.05E-4 ID:SGTC_925|Compound:2064-1272|FD-Score:4.35|P-value:3.20E-6 ID:SGTC_992|Compound:3909-8734|FD-Score:3.49|P-value:1.64E-4 ID:SGTC_1005|Compound:4092-0690|FD-Score:4.92|P-value:1.55E-7 ID:SGTC_1044|Compound:1222-0021|FD-Score:3.39|P-value:2.46E-4 ID:SGTC_1051|Compound:3253-3903|FD-Score:-3.22|P-value:1.54E-4 ID:SGTC_1054|Compound:3429-0080|FD-Score:-2.76|P-value:9.40E-4 ID:SGTC_1055|Compound:3448-0672|FD-Score:-4.36|P-value:6.95E-7 ID:SGTC_1258|Compound:0671-0043|FD-Score:3.05|P-value:9.34E-4 ID:SGTC_1319|Compound:1306-0155|FD-Score:3.16|P-value:6.12E-4 ID:SGTC_1352|Compound:1496-0991|FD-Score:5.50|P-value:4.62E-9 ID:SGTC_1467|Compound:k284-1082|FD-Score:3.27|P-value:3.95E-4 ID:SGTC_1543|Compound:azetidyl-2-carboxylic acid|FD-Score:3.13|P-value:6.93E-4 ID:SGTC_1739|Compound:st037196|FD-Score:3.35|P-value:2.89E-4 ID:SGTC_1748|Compound:st037455|FD-Score:3.35|P-value:2.91E-4 ID:SGTC_1749|Compound:st037932|FD-Score:-4.98|P-value:2.05E-8 ID:SGTC_1761|Compound:st044296|FD-Score:4.00|P-value:1.79E-5 ID:SGTC_1762|Compound:st045503|FD-Score:3.40|P-value:2.44E-4 ID:SGTC_1893|Compound:st059353|FD-Score:-4.19|P-value:1.73E-6 ID:SGTC_2040|Compound:5100729|FD-Score:4.69|P-value:5.53E-7 ID:SGTC_2044|Compound:5102272|FD-Score:3.22|P-value:4.86E-4 ID:SGTC_2054|Compound:5233173|FD-Score:3.11|P-value:7.48E-4 ID:SGTC_2080|Compound:5212524|FD-Score:-2.84|P-value:6.91E-4 ID:SGTC_2082|Compound:5219693|FD-Score:3.81|P-value:4.31E-5 ID:SGTC_2161|Compound:5662504|FD-Score:3.93|P-value:2.43E-5 ID:SGTC_2377|Compound:9073351|FD-Score:3.49|P-value:1.70E-4 ID:SGTC_2393|Compound:9031399|FD-Score:3.40|P-value:2.45E-4 ID:SGTC_2401|Compound:5128683|FD-Score:-3.18|P-value:1.88E-4 ID:SGTC_2725|Compound:haloperidol|FD-Score:3.32|P-value:3.25E-4 ID:SGTC_3065|Compound:9113888|FD-Score:3.39|P-value:2.46E-4 ID:SGTC_3068|Compound:9116768|FD-Score:3.32|P-value:3.27E-4 ID:SGTC_3137|Compound:9097352|FD-Score:3.78|P-value:4.74E-5 ID:SGTC_3155|Compound:9099265|FD-Score:-3.27|P-value:1.26E-4 ID:SGTC_3182|Compound:9108849|FD-Score:3.11|P-value:7.32E-4 ID:SGTC_3202|Compound:9113761|FD-Score:3.62|P-value:9.61E-5 ID:SGTC_3203|Compound:9113543|FD-Score:5.46|P-value:6.19E-9 ID:SGTC_3228|Compound:9131799|FD-Score:3.03|P-value:9.94E-4 ID:SGTC_3235|Compound:9132602|FD-Score:4.82|P-value:2.74E-7 ID:SGTC_3281|Compound:9140613|FD-Score:-2.97|P-value:4.32E-4

Top fitness defect scores for YPL018W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_514 4466-0038 7.44 2.6 nM 2.70E-15 cell wall 51 5.17E-14
2 SGTC_580 1123-0028 6.34 41.0 µM 1.58E-11 DNA damage response 2 1.17E-10
3 SGTC_1352 1496-0991 5.50 99.0 µM 4.62E-9 tubulin folding & SWR complex 8 1.87E-8
4 SGTC_3203 9113543 5.46 49.5 µM 6.19E-9 7 2.44E-8
5 SGTC_1005 4092-0690 4.92 4.4 µM 1.55E-7 plasma membrane duress 15 4.38E-7
6 SGTC_3235 9132602 4.82 49.5 µM 2.74E-7 11 7.32E-7
7 SGTC_2040 5100729 4.69 123.0 µM 5.53E-7 27 1.38E-6
8 SGTC_925 2064-1272 4.35 59.6 µM 3.20E-6 17 6.70E-6
9 SGTC_1761 st044296 4.00 37.0 µM 1.79E-5 15 3.17E-5
10 SGTC_2161 5662504 3.93 8.5 µM 2.43E-5 tubulin folding & SWR complex 22 4.20E-5
11 SGTC_600 1495-0418 3.84 41.6 µM 3.77E-5 RPP1 & pyrimidine depletion 12 6.25E-5
12 SGTC_2082 5219693 3.81 150.0 µM 4.31E-5 RNA processing & uracil transport 32 7.05E-5
13 SGTC_801 0866-0028 3.79 10.1 µM 4.61E-5 33 7.50E-5
14 SGTC_3137 9097352 3.78 49.5 µM 4.74E-5 45 7.69E-5
15 SGTC_422 cantharidin 3.67 155.0 µM 7.78E-5 cell wall signaling 69 1.21E-4
16 SGTC_195 4234-0266 3.64 16.6 µM 9.04E-5 46 1.38E-4
17 SGTC_3202 9113761 3.62 49.5 µM 9.61E-5 60 1.46E-4
18 SGTC_553 k007-0256 3.52 45.7 µM 1.50E-4 heme biosynthesis & mitochondrial translocase 33 2.19E-4
19 SGTC_992 3909-8734 3.49 162.0 µM 1.64E-4 34 2.37E-4
20 SGTC_2377 9073351 3.49 62.6 µM 1.70E-4 ergosterol biosynthesis 34 2.45E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.156 1.18E-19 YMR121C RPL15B hom Ribosomal 60S subunit protein L15B; binds to 5.8 S rRNA; homologous to mammalian ribosomal protein L15, no bacterial homolog; RPL15B has a paralog, RPL15A, that arose from the whole genome duplication; relocalizes from nucleus to nucleolus upon DNA replication stress
0.155 1.39E-19 YMR036C MIH1 hom Protein tyrosine phosphatase involved in cell cycle control; regulates the phosphorylation state of Cdc28p; homolog of S. pombe cdc25
0.145 3.72E-17 YDR121W DPB4 hom Subunit of DNA pol epsilon and of ISW2 chromatin accessibility complex; involved in both chromosomal DNA replication and inheritance of telomeric silencing; stabilizes the interaction of Pol epsilon with primer-template DNA, positively affecting the processivity of the polymerase and exonuclease activities of Pol epsilon; interacts with extranucleosomal DNA and acts as anchor point for ISW2 complex that retains its position on DNA during nucleosome mobilization
0.127 1.83E-13 YGL033W HOP2 hom Meiosis-specific protein that localizes to chromosomes, preventing synapsis between nonhomologous chromosomes and ensuring synapsis between homologs; complexes with Mnd1p to promote homolog pairing and meiotic double-strand break repair
0.123 7.87E-13 YOL003C PFA4 hom Palmitoyltransferase with autoacylation activity, required for palmitoylation of amino acid permeases containing a C-terminal Phe-Trp-Cys site; required for modification of Chs3p; member of the DHHC family of putative palmitoyltransferases
0.122 1.29E-12 YPR061C JID1 hom Probable Hsp40p co-chaperone, has a DnaJ-like domain and appears to be involved in ER-associated degradation of misfolded proteins containing a tightly folded cytoplasmic domain; inhibits replication of Brome mosaic virus in S. cerevisiae
0.121 1.88E-12 YBL085W BOI1 hom Protein implicated in polar growth; functionally redundant with Boi2p; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain; relocalizes from bud neck to cytoplasm upon DNA replication stress; BOI1 has a paralog, BOI2, that arose from the whole genome duplication
0.109 2.16E-10 YGR211W ZPR1 het Essential protein with two zinc fingers; present in the nucleus of growing cells but relocates to the cytoplasm in starved cells via a process mediated by Cpr1p; binds to translation elongation factor eEF-1 (Tef1p); relative distribution to the nucleus increases upon DNA replication stress
0.108 3.40E-10 YOR051C ETT1 hom Nuclear protein that inhibits replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts; deletion increases stop codon readthrough
0.103 2.53E-9 YLL032C YLL032C hom Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLL032C is not an essential gene
0.102 3.13E-9 YLR102C APC9 hom Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition
0.102 3.64E-9 YDR254W CHL4 hom Outer kinetochore protein required for chromosome stability; involved in new kinetochore assembly and sister chromatid cohesion; peripheral component of the Ctf19 kinetochore complex that interacts with Ctf19p, Ctf3p, Iml3p and Mif2p; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-N and fission yeast mis15
0.100 6.85E-9 YEL061C CIN8 hom Kinesin motor protein involved in mitotic spindle assembly and chromosome segregation
0.098 1.49E-8 YDR117C TMA64 hom Protein of unknown function that associates with ribosomes; has a putative RNA binding domain; in mammals the corresponding protein, eIF2D, has been shown to possess translation initiation factor activity
0.096 2.37E-8 YDR318W MCM21 hom Component of the kinetochore sub-complex COMA; COMA (Ctf19p, Okp1p, Mcm21p, Ame1p) bridges kinetochore subunits in contact with centromeric DNA with subunits bound to microtubules during kinetochore assembly; involved in minichromosome maintenance; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-O and fission yeast mal2