YPL020C / ULP1

Protease that specifically cleaves Smt3p protein conjugates; required for cell cycle progression; associates with nucleoporins and may interact with septin rings during telophase; sequestered to the nucleolus under stress conditions

Zygosity: Heterozygous strain
fixedexpanded
Profile for YPL020C / ULP1

Click on Significant Values for Screen Details ID:SGTC_44|Compound:0929-0055|FD-Score:5.81|P-value:2.03E-7 ID:SGTC_101|Compound:0490-5701|FD-Score:4.35|P-value:7.38E-5 ID:SGTC_139|Compound:0099-0334|FD-Score:-3.77|P-value:4.66E-4 ID:SGTC_366|Compound:0181-0206|FD-Score:-3.61|P-value:7.82E-4 ID:SGTC_401|Compound:neomycin|FD-Score:3.74|P-value:5.54E-4 ID:SGTC_404|Compound:fumagillin|FD-Score:4.52|P-value:4.00E-5 ID:SGTC_531|Compound:3788-1495|FD-Score:4.66|P-value:2.38E-5 ID:SGTC_567|Compound:1080-0542|FD-Score:-3.66|P-value:6.64E-4 ID:SGTC_626|Compound:0214-0009|FD-Score:3.77|P-value:5.07E-4 ID:SGTC_1173|Compound:0443-0020|FD-Score:3.88|P-value:3.62E-4 ID:SGTC_1190|Compound:1486-1332|FD-Score:3.59|P-value:8.80E-4 ID:SGTC_1231|Compound:0242-0792|FD-Score:-3.89|P-value:3.25E-4 ID:SGTC_1246|Compound:0422-0085|FD-Score:-3.64|P-value:7.04E-4 ID:SGTC_1252|Compound:0493-0875|FD-Score:-4.39|P-value:5.84E-5 ID:SGTC_1825|Compound:st052143|FD-Score:-3.96|P-value:2.61E-4 ID:SGTC_2022|Compound:5136654|FD-Score:-3.57|P-value:8.72E-4 ID:SGTC_2051|Compound:5263410|FD-Score:3.86|P-value:3.89E-4 ID:SGTC_2163|Compound:5671233|FD-Score:5.30|P-value:1.85E-6 ID:SGTC_2464|Compound:5717415|FD-Score:3.62|P-value:8.00E-4 ID:SGTC_2607|Compound:solasodine|FD-Score:3.76|P-value:5.28E-4 ID:SGTC_3019|Compound:9081971|FD-Score:3.73|P-value:5.85E-4 ID:SGTC_44|Compound:0929-0055|FD-Score:5.81|P-value:2.03E-7 ID:SGTC_101|Compound:0490-5701|FD-Score:4.35|P-value:7.38E-5 ID:SGTC_139|Compound:0099-0334|FD-Score:-3.77|P-value:4.66E-4 ID:SGTC_366|Compound:0181-0206|FD-Score:-3.61|P-value:7.82E-4 ID:SGTC_401|Compound:neomycin|FD-Score:3.74|P-value:5.54E-4 ID:SGTC_404|Compound:fumagillin|FD-Score:4.52|P-value:4.00E-5 ID:SGTC_531|Compound:3788-1495|FD-Score:4.66|P-value:2.38E-5 ID:SGTC_567|Compound:1080-0542|FD-Score:-3.66|P-value:6.64E-4 ID:SGTC_626|Compound:0214-0009|FD-Score:3.77|P-value:5.07E-4 ID:SGTC_1173|Compound:0443-0020|FD-Score:3.88|P-value:3.62E-4 ID:SGTC_1190|Compound:1486-1332|FD-Score:3.59|P-value:8.80E-4 ID:SGTC_1231|Compound:0242-0792|FD-Score:-3.89|P-value:3.25E-4 ID:SGTC_1246|Compound:0422-0085|FD-Score:-3.64|P-value:7.04E-4 ID:SGTC_1252|Compound:0493-0875|FD-Score:-4.39|P-value:5.84E-5 ID:SGTC_1825|Compound:st052143|FD-Score:-3.96|P-value:2.61E-4 ID:SGTC_2022|Compound:5136654|FD-Score:-3.57|P-value:8.72E-4 ID:SGTC_2051|Compound:5263410|FD-Score:3.86|P-value:3.89E-4 ID:SGTC_2163|Compound:5671233|FD-Score:5.30|P-value:1.85E-6 ID:SGTC_2464|Compound:5717415|FD-Score:3.62|P-value:8.00E-4 ID:SGTC_2607|Compound:solasodine|FD-Score:3.76|P-value:5.28E-4 ID:SGTC_3019|Compound:9081971|FD-Score:3.73|P-value:5.85E-4

Top fitness defect scores for YPL020C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_44 0929-0055 5.81 61.2 µM 2.03E-7 2 3.18E-9 0.90
2 SGTC_2163 5671233 5.30 125.0 µM 1.85E-6 6 5.64E-8 0.09
3 SGTC_531 3788-1495 4.66 174.0 µM 2.38E-5 unfolded protein response 5 1.55E-6 0.27
4 SGTC_404 fumagillin 4.52 50.0 µM 4.00E-5 1 3.04E-6 0.26
5 SGTC_101 0490-5701 4.35 117.5 µM 7.38E-5 3 6.72E-6 0.04
6 SGTC_1173 0443-0020 3.88 122.0 µM 3.62E-4 TSC3-RPN4 4 5.26E-5 0.14
7 SGTC_2051 5263410 3.86 176.0 µM 3.89E-4 7 5.76E-5 0.06
8 SGTC_626 0214-0009 3.77 33.0 µM 5.07E-4 copper-dependent oxidative stress 4 8.12E-5 0.30
9 SGTC_2607 solasodine 3.76 47.4 µM 5.28E-4 14 8.56E-5 0.02
10 SGTC_401 neomycin 3.74 50.0 µM 5.54E-4 4 9.10E-5 0.52
11 SGTC_3019 9081971 3.73 49.5 µM 5.85E-4 5 9.76E-5 0.16
12 SGTC_2464 5717415 3.62 7.7 µM 8.00E-4 4 1.46E-4 0.25
13 SGTC_1190 1486-1332 3.59 13.0 µM 8.80E-4 7 1.65E-4 0.05
14 SGTC_2422 chlorphenesin carbamate 3.51 384.2 µM 0.00111 10 2.22E-4 0.23
15 SGTC_526 4469-0568 3.45 170.0 µM 0.00131 azole & statin 9 2.77E-4 0.07
16 SGTC_1775 st081588 3.44 35.2 µM 0.00134 60S ribosome export 14 2.86E-4 0.01
17 SGTC_260 nsc-65238 3.33 4.0 µM 0.00188 endomembrane recycling 8 4.39E-4 0.15
18 SGTC_359 0081-0058 3.31 15.9 µM 0.00199 60S ribosome export 26 4.72E-4 0.04
19 SGTC_2058 5236698 3.25 133.0 µM 0.00234 9 5.83E-4 0.13
20 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 3.24 44.4 nM 0.00241 DNA damage response 14 6.04E-4 0.05

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.161 7.74E-21 YPL022W RAD1 hom Single-stranded DNA endonuclease (with Rad10p), cleaves single-stranded DNA during nucleotide excision repair and double-strand break repair; subunit of Nucleotide Excision Repair Factor 1 (NEF1); homolog of human XPF protein
0.128 1.24E-13 YMR201C RAD14 hom Protein that recognizes and binds damaged DNA during nucleotide excision repair; subunit of Nucleotide Excision Repair Factor 1 (NEF1); contains zinc finger motif; homolog of human XPA protein
0.118 6.17E-12 YML095C RAD10 hom Single-stranded DNA endonuclease (with Rad1p), cleaves single-stranded DNA during nucleotide excision repair and double-strand break repair; subunit of Nucleotide Excision Repair Factor 1 (NEF1); homolog of human ERCC1 protein
0.114 2.96E-11 YOR373W NUD1 het Component of the spindle pole body outer plaque; acts through the mitotic exit network to specify asymmetric spindle pole body inheritance
0.112 7.42E-11 YGR258C RAD2 hom Single-stranded DNA endonuclease, cleaves single-stranded DNA during nucleotide excision repair to excise damaged DNA; subunit of Nucleotide Excision Repair Factor 3 (NEF3); homolog of human XPG protein
0.110 1.51E-10 YMR004W MVP1 hom Protein required for sorting proteins to the vacuole; Mvp1p and Vps1p act in concert to promote membrane traffic to the vacuole; participates in transcription initiation and/or early elongation of specific genes; interacts with foot domain of RNA polymerase II; deletion results in abnormal CTD-Ser5 phosphorylation of RNA polymerase II at specific promoter regions; protein abundance increases in response to DNA replication stress
0.105 1.04E-9 YOR151C RPB2 het RNA polymerase II second largest subunit B150, part of central core; similar to bacterial beta subunit
0.101 3.89E-9 YGL058W RAD6 hom Ubiquitin-conjugating enzyme (E2), involved in postreplication repair (as a heterodimer with Rad18p), DSBR and checkpoint control (as a heterodimer with Bre1p), ubiquitin-mediated N-end rule protein degradation (as a heterodimer with Ubr1p
0.101 5.36E-9 YPR177C_d YPR177C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the 5' end of the essential PRP4 gene encoding a component of the U4/U6-U5 snRNP complex
0.092 9.23E-8 YIL166C_p YIL166C_p hom Putative protein with similarity to the allantoate permease (Dal5p) subfamily of the major facilitator superfamily; mRNA expression is elevated by sulfur limitation; YIL166C is a non-essential gene
0.088 3.83E-7 YEL040W UTR2 hom Chitin transglycosylase that functions in the transfer of chitin to beta(1-6) and beta(1-3) glucans in the cell wall; similar to and functionally redundant with Crh1; glycosylphosphatidylinositol (GPI)-anchored protein localized to bud neck
0.087 4.41E-7 YPL274W SAM3 hom High-affinity S-adenosylmethionine permease, required for utilization of S-adenosylmethionine as a sulfur source; has similarity to S-methylmethionine permease Mmp1p
0.084 1.26E-6 YKR091W SRL3 hom Cytoplasmic protein that, when overexpressed, suppresses the lethality of a rad53 null mutation; potential Cdc28p substrate
0.082 2.10E-6 YOR186W_p YOR186W_p hom Putative protein of unknown function; proper regulation of expression during heat stress is sphingolipid-dependent; YOR186W has a paralog, YLR297W, that arose from the whole genome duplication
0.080 3.24E-6 YLR432W IMD3 hom Inosine monophosphate dehydrogenase, catalyzes the first step of GMP biosynthesis, member of a four-gene family in S. cerevisiae, constitutively expressed