YPL025C_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL025C / YPL025C

Click on Significant Values for Screen Details ID:SGTC_50|Compound:0929-0078|FD-Score:3.61|P-value:2.19E-4 ID:SGTC_54|Compound:0159-0055|FD-Score:-5.64|P-value:1.73E-8 ID:SGTC_145|Compound:3737-0113|FD-Score:3.23|P-value:8.27E-4 ID:SGTC_146|Compound:3448-8650|FD-Score:-7.25|P-value:6.81E-13 ID:SGTC_500|Compound:h-89|FD-Score:3.78|P-value:1.16E-4 ID:SGTC_535|Compound:2293-4129|FD-Score:-3.59|P-value:2.25E-4 ID:SGTC_542|Compound:3381-0244|FD-Score:4.68|P-value:2.59E-6 ID:SGTC_620|Compound:0109-0052|FD-Score:-3.63|P-value:1.90E-4 ID:SGTC_684|Compound:1140-0066|FD-Score:3.62|P-value:2.11E-4 ID:SGTC_759|Compound:3486-0358|FD-Score:-3.79|P-value:1.06E-4 ID:SGTC_1089|Compound:terbinafine|FD-Score:3.69|P-value:1.65E-4 ID:SGTC_1204|Compound:4049-0315|FD-Score:-3.87|P-value:7.52E-5 ID:SGTC_1266|Compound:0828-0227|FD-Score:3.37|P-value:5.27E-4 ID:SGTC_1374|Compound:2889-5571|FD-Score:-3.41|P-value:4.31E-4 ID:SGTC_1648|Compound:st011736|FD-Score:-3.23|P-value:7.73E-4 ID:SGTC_1700|Compound:st030840|FD-Score:-3.25|P-value:7.23E-4 ID:SGTC_1726|Compound:st035556|FD-Score:5.44|P-value:5.83E-8 ID:SGTC_1732|Compound:st034308|FD-Score:4.52|P-value:5.40E-6 ID:SGTC_1733|Compound:st037357|FD-Score:4.01|P-value:4.80E-5 ID:SGTC_1734|Compound:st037168|FD-Score:7.16|P-value:1.51E-12 ID:SGTC_1737|Compound:st035557|FD-Score:6.15|P-value:1.04E-9 ID:SGTC_1772|Compound:st048439|FD-Score:3.39|P-value:4.89E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:3.29|P-value:6.84E-4 ID:SGTC_1858|Compound:4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione|FD-Score:3.39|P-value:4.92E-4 ID:SGTC_1903|Compound:st060211|FD-Score:5.17|P-value:2.31E-7 ID:SGTC_1913|Compound:st060213|FD-Score:3.79|P-value:1.12E-4 ID:SGTC_1922|Compound:5578187|FD-Score:-3.89|P-value:7.12E-5 ID:SGTC_1931|Compound:st074438|FD-Score:4.95|P-value:7.10E-7 ID:SGTC_1933|Compound:st074711|FD-Score:3.61|P-value:2.19E-4 ID:SGTC_1955|Compound:wogonin|FD-Score:-3.73|P-value:1.31E-4 ID:SGTC_2195|Compound:6536160|FD-Score:3.36|P-value:5.44E-4 ID:SGTC_2394|Compound:5221648|FD-Score:3.51|P-value:3.22E-4 ID:SGTC_2409|Compound:alverine citrate|FD-Score:6.52|P-value:1.07E-10 ID:SGTC_2412|Compound:st077135|FD-Score:-5.74|P-value:9.89E-9 ID:SGTC_2415|Compound:st077333|FD-Score:-5.62|P-value:1.99E-8 ID:SGTC_2417|Compound:cerulenin|FD-Score:3.22|P-value:8.61E-4 ID:SGTC_2485|Compound:5633444|FD-Score:5.26|P-value:1.48E-7 ID:SGTC_2521|Compound:angolensin|FD-Score:3.64|P-value:1.97E-4 ID:SGTC_2536|Compound:dehydroabietamide|FD-Score:3.45|P-value:3.90E-4 ID:SGTC_2623|Compound:humulene|FD-Score:4.26|P-value:1.65E-5 ID:SGTC_2654|Compound:protoveratrine a|FD-Score:-3.86|P-value:7.82E-5 ID:SGTC_2659|Compound:sanguinarine|FD-Score:3.34|P-value:5.72E-4 ID:SGTC_2676|Compound:harmalol|FD-Score:-3.28|P-value:6.57E-4 ID:SGTC_2699|Compound:st077704|FD-Score:3.20|P-value:9.30E-4 ID:SGTC_2802|Compound:7925815|FD-Score:4.54|P-value:5.00E-6 ID:SGTC_2885|Compound:9057732|FD-Score:4.04|P-value:4.23E-5 ID:SGTC_2906|Compound:7926292|FD-Score:3.19|P-value:9.57E-4 ID:SGTC_2927|Compound:9011802|FD-Score:-3.55|P-value:2.56E-4 ID:SGTC_2949|Compound:9072542|FD-Score:6.08|P-value:1.55E-9 ID:SGTC_3061|Compound:glucosamine|FD-Score:-4.25|P-value:1.61E-5 ID:SGTC_3083|Compound:9117465|FD-Score:3.45|P-value:3.97E-4 ID:SGTC_3193|Compound:9111931|FD-Score:5.88|P-value:5.14E-9 ID:SGTC_3200|Compound:9114385|FD-Score:3.28|P-value:7.10E-4 ID:SGTC_3265|Compound:9137266|FD-Score:6.24|P-value:6.14E-10 ID:SGTC_50|Compound:0929-0078|FD-Score:3.61|P-value:2.19E-4 ID:SGTC_54|Compound:0159-0055|FD-Score:-5.64|P-value:1.73E-8 ID:SGTC_145|Compound:3737-0113|FD-Score:3.23|P-value:8.27E-4 ID:SGTC_146|Compound:3448-8650|FD-Score:-7.25|P-value:6.81E-13 ID:SGTC_500|Compound:h-89|FD-Score:3.78|P-value:1.16E-4 ID:SGTC_535|Compound:2293-4129|FD-Score:-3.59|P-value:2.25E-4 ID:SGTC_542|Compound:3381-0244|FD-Score:4.68|P-value:2.59E-6 ID:SGTC_620|Compound:0109-0052|FD-Score:-3.63|P-value:1.90E-4 ID:SGTC_684|Compound:1140-0066|FD-Score:3.62|P-value:2.11E-4 ID:SGTC_759|Compound:3486-0358|FD-Score:-3.79|P-value:1.06E-4 ID:SGTC_1089|Compound:terbinafine|FD-Score:3.69|P-value:1.65E-4 ID:SGTC_1204|Compound:4049-0315|FD-Score:-3.87|P-value:7.52E-5 ID:SGTC_1266|Compound:0828-0227|FD-Score:3.37|P-value:5.27E-4 ID:SGTC_1374|Compound:2889-5571|FD-Score:-3.41|P-value:4.31E-4 ID:SGTC_1648|Compound:st011736|FD-Score:-3.23|P-value:7.73E-4 ID:SGTC_1700|Compound:st030840|FD-Score:-3.25|P-value:7.23E-4 ID:SGTC_1726|Compound:st035556|FD-Score:5.44|P-value:5.83E-8 ID:SGTC_1732|Compound:st034308|FD-Score:4.52|P-value:5.40E-6 ID:SGTC_1733|Compound:st037357|FD-Score:4.01|P-value:4.80E-5 ID:SGTC_1734|Compound:st037168|FD-Score:7.16|P-value:1.51E-12 ID:SGTC_1737|Compound:st035557|FD-Score:6.15|P-value:1.04E-9 ID:SGTC_1772|Compound:st048439|FD-Score:3.39|P-value:4.89E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:3.29|P-value:6.84E-4 ID:SGTC_1858|Compound:4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione|FD-Score:3.39|P-value:4.92E-4 ID:SGTC_1903|Compound:st060211|FD-Score:5.17|P-value:2.31E-7 ID:SGTC_1913|Compound:st060213|FD-Score:3.79|P-value:1.12E-4 ID:SGTC_1922|Compound:5578187|FD-Score:-3.89|P-value:7.12E-5 ID:SGTC_1931|Compound:st074438|FD-Score:4.95|P-value:7.10E-7 ID:SGTC_1933|Compound:st074711|FD-Score:3.61|P-value:2.19E-4 ID:SGTC_1955|Compound:wogonin|FD-Score:-3.73|P-value:1.31E-4 ID:SGTC_2195|Compound:6536160|FD-Score:3.36|P-value:5.44E-4 ID:SGTC_2394|Compound:5221648|FD-Score:3.51|P-value:3.22E-4 ID:SGTC_2409|Compound:alverine citrate|FD-Score:6.52|P-value:1.07E-10 ID:SGTC_2412|Compound:st077135|FD-Score:-5.74|P-value:9.89E-9 ID:SGTC_2415|Compound:st077333|FD-Score:-5.62|P-value:1.99E-8 ID:SGTC_2417|Compound:cerulenin|FD-Score:3.22|P-value:8.61E-4 ID:SGTC_2485|Compound:5633444|FD-Score:5.26|P-value:1.48E-7 ID:SGTC_2521|Compound:angolensin|FD-Score:3.64|P-value:1.97E-4 ID:SGTC_2536|Compound:dehydroabietamide|FD-Score:3.45|P-value:3.90E-4 ID:SGTC_2623|Compound:humulene|FD-Score:4.26|P-value:1.65E-5 ID:SGTC_2654|Compound:protoveratrine a|FD-Score:-3.86|P-value:7.82E-5 ID:SGTC_2659|Compound:sanguinarine|FD-Score:3.34|P-value:5.72E-4 ID:SGTC_2676|Compound:harmalol|FD-Score:-3.28|P-value:6.57E-4 ID:SGTC_2699|Compound:st077704|FD-Score:3.20|P-value:9.30E-4 ID:SGTC_2802|Compound:7925815|FD-Score:4.54|P-value:5.00E-6 ID:SGTC_2885|Compound:9057732|FD-Score:4.04|P-value:4.23E-5 ID:SGTC_2906|Compound:7926292|FD-Score:3.19|P-value:9.57E-4 ID:SGTC_2927|Compound:9011802|FD-Score:-3.55|P-value:2.56E-4 ID:SGTC_2949|Compound:9072542|FD-Score:6.08|P-value:1.55E-9 ID:SGTC_3061|Compound:glucosamine|FD-Score:-4.25|P-value:1.61E-5 ID:SGTC_3083|Compound:9117465|FD-Score:3.45|P-value:3.97E-4 ID:SGTC_3193|Compound:9111931|FD-Score:5.88|P-value:5.14E-9 ID:SGTC_3200|Compound:9114385|FD-Score:3.28|P-value:7.10E-4 ID:SGTC_3265|Compound:9137266|FD-Score:6.24|P-value:6.14E-10

Top fitness defect scores for YPL025C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1734 st037168 7.16 69.4 µM 1.51E-12 4 4.11E-13
2 SGTC_2409 alverine citrate 6.52 64.0 µM 1.07E-10 19 3.59E-11
3 SGTC_3265 9137266 6.24 49.5 µM 6.14E-10 1 2.25E-10
4 SGTC_1737 st035557 6.15 69.7 µM 1.04E-9 3 3.92E-10
5 SGTC_2949 9072542 6.08 2.2 µM 1.55E-9 TSC3-RPN4 6 5.95E-10
6 SGTC_3193 9111931 5.88 49.5 µM 5.14E-9 2 2.10E-9
7 SGTC_1726 st035556 5.44 14.6 µM 5.83E-8 15 2.69E-8
8 SGTC_2485 5633444 5.26 17.8 µM 1.48E-7 redox potentiating 21 7.17E-8
9 SGTC_1903 st060211 5.17 78.3 µM 2.31E-7 5 1.14E-7
10 SGTC_1931 st074438 4.95 57.1 µM 7.10E-7 5 3.71E-7
11 SGTC_542 3381-0244 4.68 89.3 µM 2.59E-6 22 1.44E-6
12 SGTC_2802 7925815 4.54 54.5 µM 5.00E-6 27 2.88E-6
13 SGTC_1732 st034308 4.52 51.8 µM 5.40E-6 17 3.12E-6
14 SGTC_2623 humulene 4.26 100.0 µM 1.65E-5 12 1.01E-5
15 SGTC_2885 9057732 4.04 52.0 µM 4.23E-5 12 2.71E-5
16 SGTC_1733 st037357 4.01 54.9 µM 4.80E-5 60S ribosome export 25 3.09E-5
17 SGTC_1913 st060213 3.79 96.1 µM 1.12E-4 35 7.51E-5
18 SGTC_500 h-89 3.78 112.0 µM 1.16E-4 cell wall signaling 33 7.80E-5
19 SGTC_1089 terbinafine 3.69 2.2 µM 1.65E-4 18 1.13E-4
20 SGTC_2521 angolensin 3.64 13.4 µM 1.97E-4 16 1.36E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.096 2.60E-8 YDR304C CPR5 hom Peptidyl-prolyl cis-trans isomerase (cyclophilin) of the endoplasmic reticulum, catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; transcriptionally induced in response to unfolded proteins in the ER
0.093 7.59E-8 YER121W_p YER121W_p hom Putative protein of unknown function; may be involved in phosphatase regulation and/or generation of precursor metabolites and energy
0.089 2.17E-7 YFR045W_p YFR045W_p hom Putative mitochondrial transport protein; null mutant is viable, exhibits decreased levels of chitin and normal resistance to calcofluor white
0.088 3.36E-7 YMR129W POM152 hom Glycoprotein subunit of the transmembrane ring of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport, NPC biogenesis and spindle pole body duplication; homologous to human NUP210
0.087 4.07E-7 YNL263C YIF1 het Integral membrane protein required for the fusion of ER-derived COPII transport vesicles with the Golgi; interacts with Yip1p and Yos1p; localizes to the Golgi, the ER, and COPII vesicles; homolog of human YIPF3
0.084 1.00E-6 YFR032C-B_p YFR032C-B_p hom Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
0.082 2.19E-6 YDL233W_p MFG1_p hom Regulator of filamentous growth; interacts with FLO11 promoter and regulates FLO11 expression; binds to transcription factors Flo8p and Mss11p; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YDL233W is not an essential gene
0.079 4.67E-6 YKL211C TRP3 hom Indole-3-glycerol-phosphate synthase; forms bifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp2p
0.075 1.27E-5 YHR076W PTC7 hom Type 2C protein phosphatase (PP2C); alternatively spliced to create two mRNA isoforms; protein from spliced form localizes to the mitochondria while the one from the unspliced form is localized to the nuclear envelope
0.075 1.39E-5 YEL056W HAT2 hom Subunit of the Hat1p-Hat2p histone acetyltransferase complex; required for high affinity binding of the complex to free histone H4, thereby enhancing Hat1p activity; similar to human RbAp46 and 48; has a role in telomeric silencing
0.073 2.20E-5 YDL058W USO1 het Essential protein involved in the vesicle-mediated ER to Golgi transport step of secretion; binds membranes and functions during vesicle docking to the Golgi; required for assembly of the ER-to-Golgi SNARE complex
0.073 2.42E-5 YBR045C GIP1 hom Meiosis-specific regulatory subunit of the Glc7p protein phosphatase, regulates spore wall formation and septin organization, required for expression of some late meiotic genes and for normal localization of Glc7p
0.072 3.27E-5 YBL078C ATG8 hom Component of autophagosomes and Cvt vesicles; unique ubiquitin-like protein whose conjugation target is the lipid phosphatidylethanolamine (PE); Atg8p-PE is anchored to membranes, is involved in phagophore expansion, and may mediate membrane fusion during autophagosome formation; deconjugation of Atg8p-PE is required for efficient autophagosome biogenesis
0.070 4.69E-5 YGR049W SCM4 hom Mitochondrial outer membrane protein of unknown function; predicted to have 4 transmembrane segments; import is mediated by Tom70p and Mim1p; interacts genetically with a cdc4 mutation
0.069 6.83E-5 YDR275W BSC2 hom Protein of unknown function; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression; BSC2 has a paralog, IRC23, that arose from the whole genome duplication