YPL029W / SUV3

ATP-dependent RNA helicase, component of the mitochondrial degradosome along with the RNase Dss1p; the degradosome associates with the ribosome and mediates RNA turnover; also required during splicing of the COX1 AI5_beta intron

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL029W / SUV3

Click on Significant Values for Screen Details ID:SGTC_10|Compound:0279-0212|FD-Score:6.69|P-value:9.44E-8 ID:SGTC_19|Compound:0279-0214|FD-Score:3.98|P-value:9.75E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:5.28|P-value:1.94E-5 ID:SGTC_63|Compound:0099-0242|FD-Score:8.08|P-value:1.55E-10 ID:SGTC_118|Compound:0083-0097|FD-Score:4.91|P-value:6.64E-5 ID:SGTC_165|Compound:k038-0023|FD-Score:-3.99|P-value:8.85E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:14.20|P-value:5.36E-29 ID:SGTC_177|Compound:1327-0068|FD-Score:4.90|P-value:6.91E-5 ID:SGTC_236|Compound:1509-0011|FD-Score:11.10|P-value:2.18E-18 ID:SGTC_255|Compound:tunicamycin|FD-Score:-4.21|P-value:4.84E-4 ID:SGTC_275|Compound:trichlorophene|FD-Score:11.80|P-value:1.62E-20 ID:SGTC_310|Compound:1273-0058|FD-Score:6.55|P-value:1.64E-7 ID:SGTC_526|Compound:4469-0568|FD-Score:4.00|P-value:9.22E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:-4.65|P-value:1.37E-4 ID:SGTC_629|Compound:3448-6466|FD-Score:4.10|P-value:7.11E-4 ID:SGTC_748|Compound:0136-0228|FD-Score:4.08|P-value:7.45E-4 ID:SGTC_767|Compound:0929-0023|FD-Score:5.28|P-value:2.00E-5 ID:SGTC_832|Compound:4083-0019|FD-Score:4.07|P-value:7.64E-4 ID:SGTC_843|Compound:0310-0051|FD-Score:-4.02|P-value:8.13E-4 ID:SGTC_849|Compound:0386-0493|FD-Score:4.74|P-value:1.12E-4 ID:SGTC_856|Compound:0433-0016|FD-Score:4.86|P-value:7.71E-5 ID:SGTC_875|Compound:0709-0210|FD-Score:-4.13|P-value:6.02E-4 ID:SGTC_967|Compound:1306-0166|FD-Score:4.33|P-value:3.80E-4 ID:SGTC_992|Compound:3909-8734|FD-Score:4.23|P-value:5.05E-4 ID:SGTC_998|Compound:3996-0085|FD-Score:4.27|P-value:4.50E-4 ID:SGTC_1036|Compound:k216-0215|FD-Score:5.30|P-value:1.85E-5 ID:SGTC_1125|Compound:tnp00248|FD-Score:5.61|P-value:6.19E-6 ID:SGTC_1133|Compound:3473-0247|FD-Score:4.56|P-value:1.96E-4 ID:SGTC_1240|Compound:0356-0016|FD-Score:4.06|P-value:7.92E-4 ID:SGTC_1450|Compound:4112-4260|FD-Score:-4.17|P-value:5.40E-4 ID:SGTC_1560|Compound:lithocholic acid|FD-Score:-4.18|P-value:5.33E-4 ID:SGTC_1604|Compound:st002052|FD-Score:-3.99|P-value:8.93E-4 ID:SGTC_1621|Compound:st003705|FD-Score:7.47|P-value:2.94E-9 ID:SGTC_1622|Compound:st003707|FD-Score:9.99|P-value:3.36E-15 ID:SGTC_1623|Compound:st003709|FD-Score:10.30|P-value:5.37E-16 ID:SGTC_1624|Compound:st003710|FD-Score:9.20|P-value:3.72E-13 ID:SGTC_1627|Compound:st003713|FD-Score:6.32|P-value:4.27E-7 ID:SGTC_1718|Compound:roemerine|FD-Score:-4.49|P-value:2.19E-4 ID:SGTC_1752|Compound:st044819|FD-Score:-4.25|P-value:4.35E-4 ID:SGTC_1754|Compound:st042065|FD-Score:-4.02|P-value:8.12E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:-4.61|P-value:1.52E-4 ID:SGTC_1815|Compound:st051655|FD-Score:-3.99|P-value:8.75E-4 ID:SGTC_1818|Compound:st052136|FD-Score:-4.13|P-value:6.03E-4 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:4.79|P-value:9.61E-5 ID:SGTC_1896|Compound:st058441|FD-Score:4.05|P-value:8.22E-4 ID:SGTC_2016|Compound:5121758|FD-Score:7.60|P-value:1.57E-9 ID:SGTC_2021|Compound:4019055|FD-Score:-7.58|P-value:1.50E-9 ID:SGTC_2062|Compound:5245942|FD-Score:4.14|P-value:6.43E-4 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:6.37|P-value:3.44E-7 ID:SGTC_2250|Compound:alverine citrate|FD-Score:5.73|P-value:4.03E-6 ID:SGTC_2326|Compound:6164455|FD-Score:4.83|P-value:8.56E-5 ID:SGTC_2418|Compound:pentamidine|FD-Score:4.17|P-value:5.92E-4 ID:SGTC_2473|Compound:5854593|FD-Score:-4.07|P-value:7.05E-4 ID:SGTC_2510|Compound:benzyl isothiocyanate|FD-Score:7.44|P-value:3.39E-9 ID:SGTC_2513|Compound:baicalein|FD-Score:4.51|P-value:2.22E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:-4.39|P-value:2.94E-4 ID:SGTC_2682|Compound:pyrogallin|FD-Score:5.23|P-value:2.34E-5 ID:SGTC_2729|Compound:fluphenazine|FD-Score:4.41|P-value:3.00E-4 ID:SGTC_2777|Compound:climbazole|FD-Score:-4.03|P-value:7.90E-4 ID:SGTC_2784|Compound:7567673|FD-Score:-4.83|P-value:7.75E-5 ID:SGTC_2823|Compound:7987624|FD-Score:4.33|P-value:3.77E-4 ID:SGTC_2858|Compound:9025781|FD-Score:-4.26|P-value:4.22E-4 ID:SGTC_2883|Compound:9059145|FD-Score:6.06|P-value:1.19E-6 ID:SGTC_2896|Compound:9052656|FD-Score:-7.79|P-value:5.62E-10 ID:SGTC_2939|Compound:9044578|FD-Score:-4.67|P-value:1.28E-4 ID:SGTC_3065|Compound:9113888|FD-Score:4.83|P-value:8.41E-5 ID:SGTC_3080|Compound:9117754|FD-Score:5.36|P-value:1.49E-5 ID:SGTC_3087|Compound:9117406|FD-Score:5.16|P-value:2.93E-5 ID:SGTC_3202|Compound:9113761|FD-Score:-6.66|P-value:9.37E-8 ID:SGTC_3219|Compound:9131112|FD-Score:-5.54|P-value:7.30E-6 ID:SGTC_3339|Compound:9145883|FD-Score:-5.28|P-value:1.76E-5 ID:SGTC_3343|Compound:9148379|FD-Score:-5.50|P-value:8.25E-6 ID:SGTC_3345|Compound:9148410|FD-Score:-4.95|P-value:5.29E-5 ID:SGTC_10|Compound:0279-0212|FD-Score:6.69|P-value:9.44E-8 ID:SGTC_19|Compound:0279-0214|FD-Score:3.98|P-value:9.75E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:5.28|P-value:1.94E-5 ID:SGTC_63|Compound:0099-0242|FD-Score:8.08|P-value:1.55E-10 ID:SGTC_118|Compound:0083-0097|FD-Score:4.91|P-value:6.64E-5 ID:SGTC_165|Compound:k038-0023|FD-Score:-3.99|P-value:8.85E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:14.20|P-value:5.36E-29 ID:SGTC_177|Compound:1327-0068|FD-Score:4.90|P-value:6.91E-5 ID:SGTC_236|Compound:1509-0011|FD-Score:11.10|P-value:2.18E-18 ID:SGTC_255|Compound:tunicamycin|FD-Score:-4.21|P-value:4.84E-4 ID:SGTC_275|Compound:trichlorophene|FD-Score:11.80|P-value:1.62E-20 ID:SGTC_310|Compound:1273-0058|FD-Score:6.55|P-value:1.64E-7 ID:SGTC_526|Compound:4469-0568|FD-Score:4.00|P-value:9.22E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:-4.65|P-value:1.37E-4 ID:SGTC_629|Compound:3448-6466|FD-Score:4.10|P-value:7.11E-4 ID:SGTC_748|Compound:0136-0228|FD-Score:4.08|P-value:7.45E-4 ID:SGTC_767|Compound:0929-0023|FD-Score:5.28|P-value:2.00E-5 ID:SGTC_832|Compound:4083-0019|FD-Score:4.07|P-value:7.64E-4 ID:SGTC_843|Compound:0310-0051|FD-Score:-4.02|P-value:8.13E-4 ID:SGTC_849|Compound:0386-0493|FD-Score:4.74|P-value:1.12E-4 ID:SGTC_856|Compound:0433-0016|FD-Score:4.86|P-value:7.71E-5 ID:SGTC_875|Compound:0709-0210|FD-Score:-4.13|P-value:6.02E-4 ID:SGTC_967|Compound:1306-0166|FD-Score:4.33|P-value:3.80E-4 ID:SGTC_992|Compound:3909-8734|FD-Score:4.23|P-value:5.05E-4 ID:SGTC_998|Compound:3996-0085|FD-Score:4.27|P-value:4.50E-4 ID:SGTC_1036|Compound:k216-0215|FD-Score:5.30|P-value:1.85E-5 ID:SGTC_1125|Compound:tnp00248|FD-Score:5.61|P-value:6.19E-6 ID:SGTC_1133|Compound:3473-0247|FD-Score:4.56|P-value:1.96E-4 ID:SGTC_1240|Compound:0356-0016|FD-Score:4.06|P-value:7.92E-4 ID:SGTC_1450|Compound:4112-4260|FD-Score:-4.17|P-value:5.40E-4 ID:SGTC_1560|Compound:lithocholic acid|FD-Score:-4.18|P-value:5.33E-4 ID:SGTC_1604|Compound:st002052|FD-Score:-3.99|P-value:8.93E-4 ID:SGTC_1621|Compound:st003705|FD-Score:7.47|P-value:2.94E-9 ID:SGTC_1622|Compound:st003707|FD-Score:9.99|P-value:3.36E-15 ID:SGTC_1623|Compound:st003709|FD-Score:10.30|P-value:5.37E-16 ID:SGTC_1624|Compound:st003710|FD-Score:9.20|P-value:3.72E-13 ID:SGTC_1627|Compound:st003713|FD-Score:6.32|P-value:4.27E-7 ID:SGTC_1718|Compound:roemerine|FD-Score:-4.49|P-value:2.19E-4 ID:SGTC_1752|Compound:st044819|FD-Score:-4.25|P-value:4.35E-4 ID:SGTC_1754|Compound:st042065|FD-Score:-4.02|P-value:8.12E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:-4.61|P-value:1.52E-4 ID:SGTC_1815|Compound:st051655|FD-Score:-3.99|P-value:8.75E-4 ID:SGTC_1818|Compound:st052136|FD-Score:-4.13|P-value:6.03E-4 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:4.79|P-value:9.61E-5 ID:SGTC_1896|Compound:st058441|FD-Score:4.05|P-value:8.22E-4 ID:SGTC_2016|Compound:5121758|FD-Score:7.60|P-value:1.57E-9 ID:SGTC_2021|Compound:4019055|FD-Score:-7.58|P-value:1.50E-9 ID:SGTC_2062|Compound:5245942|FD-Score:4.14|P-value:6.43E-4 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:6.37|P-value:3.44E-7 ID:SGTC_2250|Compound:alverine citrate|FD-Score:5.73|P-value:4.03E-6 ID:SGTC_2326|Compound:6164455|FD-Score:4.83|P-value:8.56E-5 ID:SGTC_2418|Compound:pentamidine|FD-Score:4.17|P-value:5.92E-4 ID:SGTC_2473|Compound:5854593|FD-Score:-4.07|P-value:7.05E-4 ID:SGTC_2510|Compound:benzyl isothiocyanate|FD-Score:7.44|P-value:3.39E-9 ID:SGTC_2513|Compound:baicalein|FD-Score:4.51|P-value:2.22E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:-4.39|P-value:2.94E-4 ID:SGTC_2682|Compound:pyrogallin|FD-Score:5.23|P-value:2.34E-5 ID:SGTC_2729|Compound:fluphenazine|FD-Score:4.41|P-value:3.00E-4 ID:SGTC_2777|Compound:climbazole|FD-Score:-4.03|P-value:7.90E-4 ID:SGTC_2784|Compound:7567673|FD-Score:-4.83|P-value:7.75E-5 ID:SGTC_2823|Compound:7987624|FD-Score:4.33|P-value:3.77E-4 ID:SGTC_2858|Compound:9025781|FD-Score:-4.26|P-value:4.22E-4 ID:SGTC_2883|Compound:9059145|FD-Score:6.06|P-value:1.19E-6 ID:SGTC_2896|Compound:9052656|FD-Score:-7.79|P-value:5.62E-10 ID:SGTC_2939|Compound:9044578|FD-Score:-4.67|P-value:1.28E-4 ID:SGTC_3065|Compound:9113888|FD-Score:4.83|P-value:8.41E-5 ID:SGTC_3080|Compound:9117754|FD-Score:5.36|P-value:1.49E-5 ID:SGTC_3087|Compound:9117406|FD-Score:5.16|P-value:2.93E-5 ID:SGTC_3202|Compound:9113761|FD-Score:-6.66|P-value:9.37E-8 ID:SGTC_3219|Compound:9131112|FD-Score:-5.54|P-value:7.30E-6 ID:SGTC_3339|Compound:9145883|FD-Score:-5.28|P-value:1.76E-5 ID:SGTC_3343|Compound:9148379|FD-Score:-5.50|P-value:8.25E-6 ID:SGTC_3345|Compound:9148410|FD-Score:-4.95|P-value:5.29E-5

Top fitness defect scores for YPL029W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_173 1273-0061 14.20 2.7 µM 5.36E-29 mitochondrial stress 9 2.30E-46
2 SGTC_275 trichlorophene 11.80 5.7 µM 1.62E-20 mitochondrial stress 21 1.72E-32
3 SGTC_236 1509-0011 11.10 5.3 µM 2.18E-18 172 5.18E-29
4 SGTC_1623 st003709 10.30 20.3 µM 5.37E-16 calcium & mitochondrial duress 3 4.19E-25
5 SGTC_1622 st003707 9.99 19.4 µM 3.36E-15 calcium & mitochondrial duress 4 8.38E-24
6 SGTC_1624 st003710 9.20 6.2 µM 3.72E-13 calcium & mitochondrial duress 3 1.81E-20
7 SGTC_63 0099-0242 8.08 26.7 µM 1.55E-10 mitochondrial stress 10 3.37E-16
8 SGTC_2016 5121758 7.60 140.0 µM 1.57E-9 redox potentiating 7 1.45E-14
9 SGTC_1621 st003705 7.47 32.4 µM 2.94E-9 calcium & mitochondrial duress 2 4.06E-14
10 SGTC_2510 benzyl isothiocyanate 7.44 8.3 µM 3.39E-9 5 5.12E-14
11 SGTC_10 0279-0212 6.69 42.6 µM 9.44E-8 TRP & mitochondrial translation 19 1.14E-11
12 SGTC_310 1273-0058 6.55 1.1 µM 1.64E-7 mitochondrial stress 129 2.78E-11
13 SGTC_2232 chlorophetanol 6.37 41.5 µM 3.44E-7 TRP & mitochondrial translation 36 9.25E-11
14 SGTC_1627 st003713 6.32 25.6 µM 4.27E-7 calcium & mitochondrial duress 27 1.32E-10
15 SGTC_2883 9059145 6.06 45.5 µM 1.19E-6 1 6.93E-10
16 SGTC_2250 alverine citrate 5.73 130.0 µM 4.03E-6 59 4.99E-9
17 SGTC_1125 tnp00248 5.61 1.3 µM 6.19E-6 6 9.98E-9
18 SGTC_3080 9117754 5.36 49.5 µM 1.49E-5 4 4.12E-8
19 SGTC_1036 k216-0215 5.30 33.5 µM 1.85E-5 mitochondrial response to ROS 20 5.84E-8
20 SGTC_58 0957-0393 5.28 9.0 µM 1.94E-5 cell wall 257 6.30E-8

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.439 1.92E-158 YER050C RSM18 hom Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S18 ribosomal protein
0.438 3.31E-157 YPL040C ISM1 hom Mitochondrial isoleucyl-tRNA synthetase, null mutant is deficient in respiratory growth
0.416 1.68E-140 YDR296W MHR1 hom Protein involved in homologous recombination in mitochondria; required for recombination-dependent mtDNA partitioning; involved in stimulation of mitochondrial DNA replication in response to oxidative stress
0.409 2.11E-135 YDR194C MSS116 hom DEAD-box protein required for efficient splicing of mitochondrial Group I and II introns; non-polar RNA helicase that also facilities strand annealing
0.406 4.24E-133 YMR287C DSS1 hom 3'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs
0.405 1.66E-132 YEL050C RML2 hom Mitochondrial ribosomal protein of the large subunit, has similarity to E. coli L2 ribosomal protein; fat21 mutant allele causes inability to utilize oleate and may interfere with activity of the Adr1p transcription factor
0.401 1.67E-129 YDR298C ATP5 hom Subunit 5 of the stator stalk of mitochondrial F1F0 ATP synthase, which is an evolutionarily conserved enzyme complex required for ATP synthesis; homologous to bovine subunit OSCP (oligomycin sensitivity-conferring protein); phosphorylated
0.400 2.27E-129 YOL095C HMI1 hom Mitochondrial inner membrane localized ATP-dependent DNA helicase, required for the maintenance of the mitochondrial genome; not required for mitochondrial transcription; has homology to E. coli helicase uvrD
0.397 5.71E-127 YNL184C_p YNL184C_p hom Protein of unknown function; expressed at both mRNA and protein levels
0.390 1.46E-122 YNL081C SWS2 hom Putative mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S13 ribosomal protein; participates in controlling sporulation efficiency
0.390 2.23E-122 YGR215W RSM27 hom Mitochondrial ribosomal protein of the small subunit
0.390 2.55E-122 YMR072W ABF2 hom Mitochondrial DNA-binding protein involved in mitochondrial DNA replication and recombination, member of HMG1 DNA-binding protein family; activity may be regulated by protein kinase A phosphorylation
0.390 2.99E-122 YNL177C MRPL22 hom Mitochondrial ribosomal protein of the large subunit
0.382 3.30E-117 YBL038W MRPL16 hom Mitochondrial ribosomal protein of the large subunit
0.380 1.24E-115 YDL056W MBP1 hom Transcription factor involved in regulation of cell cycle progression from G1 to S phase, forms a complex with Swi6p that binds to MluI cell cycle box regulatory element in promoters of DNA synthesis genes