YPL033C / SRL4

Protein of unknown function; involved in regulation of dNTP production; null mutant suppresses the lethality of lcd1 and rad53 mutations; expression is induced by Kar4p

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL033C / SRL4

Click on Significant Values for Screen Details ID:SGTC_5|Compound:0352-0601|FD-Score:-3.34|P-value:6.22E-5 ID:SGTC_14|Compound:0354-0009|FD-Score:-3.72|P-value:1.03E-5 ID:SGTC_15|Compound:0266-0086|FD-Score:-2.71|P-value:8.99E-4 ID:SGTC_27|Compound:0485-0001|FD-Score:-2.96|P-value:3.36E-4 ID:SGTC_135|Compound:0933-0004|FD-Score:3.35|P-value:9.62E-5 ID:SGTC_185|Compound:k048-0037|FD-Score:3.45|P-value:6.22E-5 ID:SGTC_195|Compound:4234-0266|FD-Score:-2.92|P-value:4.01E-4 ID:SGTC_203|Compound:k066-0004|FD-Score:3.40|P-value:7.88E-5 ID:SGTC_266|Compound:formosanin C|FD-Score:2.90|P-value:6.41E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:3.09|P-value:2.96E-4 ID:SGTC_558|Compound:k064-0027|FD-Score:3.43|P-value:6.81E-5 ID:SGTC_1144|Compound:3486-0183|FD-Score:-2.78|P-value:6.96E-4 ID:SGTC_1240|Compound:0356-0016|FD-Score:-3.62|P-value:1.66E-5 ID:SGTC_1284|Compound:0929-0043|FD-Score:3.11|P-value:2.81E-4 ID:SGTC_1292|Compound:0kpi-0043|FD-Score:-3.43|P-value:4.24E-5 ID:SGTC_1419|Compound:3993-2473|FD-Score:4.24|P-value:1.14E-6 ID:SGTC_1469|Compound:k284-2957|FD-Score:4.00|P-value:4.03E-6 ID:SGTC_1472|Compound:k841-0093|FD-Score:2.82|P-value:8.87E-4 ID:SGTC_1486|Compound:3970-0793|FD-Score:-3.20|P-value:1.21E-4 ID:SGTC_1495|Compound:4469-0029|FD-Score:5.69|P-value:9.50E-11 ID:SGTC_1657|Compound:st012939|FD-Score:-2.71|P-value:8.90E-4 ID:SGTC_1661|Compound:st013063|FD-Score:3.05|P-value:3.54E-4 ID:SGTC_1692|Compound:fluoroquinolonic acid|FD-Score:3.27|P-value:1.38E-4 ID:SGTC_1919|Compound:st067113|FD-Score:-2.88|P-value:4.63E-4 ID:SGTC_1942|Compound:st076330|FD-Score:3.16|P-value:2.20E-4 ID:SGTC_2052|Compound:5265182|FD-Score:3.45|P-value:6.17E-5 ID:SGTC_2088|Compound:5278280|FD-Score:3.13|P-value:2.50E-4 ID:SGTC_2255|Compound:7941087|FD-Score:3.01|P-value:4.11E-4 ID:SGTC_2569|Compound:tetrandrine|FD-Score:4.87|P-value:2.55E-8 ID:SGTC_2575|Compound:plumbagin|FD-Score:-2.83|P-value:5.59E-4 ID:SGTC_2576|Compound:guaiol|FD-Score:3.92|P-value:6.10E-6 ID:SGTC_2762|Compound:leflunomide|FD-Score:-2.93|P-value:3.76E-4 ID:SGTC_2767|Compound:sibutramine|FD-Score:3.23|P-value:1.67E-4 ID:SGTC_2772|Compound:vinpocetine|FD-Score:3.90|P-value:6.77E-6 ID:SGTC_2801|Compound:7907800|FD-Score:3.30|P-value:1.21E-4 ID:SGTC_3235|Compound:9132602|FD-Score:2.97|P-value:4.87E-4 ID:SGTC_5|Compound:0352-0601|FD-Score:-3.34|P-value:6.22E-5 ID:SGTC_14|Compound:0354-0009|FD-Score:-3.72|P-value:1.03E-5 ID:SGTC_15|Compound:0266-0086|FD-Score:-2.71|P-value:8.99E-4 ID:SGTC_27|Compound:0485-0001|FD-Score:-2.96|P-value:3.36E-4 ID:SGTC_135|Compound:0933-0004|FD-Score:3.35|P-value:9.62E-5 ID:SGTC_185|Compound:k048-0037|FD-Score:3.45|P-value:6.22E-5 ID:SGTC_195|Compound:4234-0266|FD-Score:-2.92|P-value:4.01E-4 ID:SGTC_203|Compound:k066-0004|FD-Score:3.40|P-value:7.88E-5 ID:SGTC_266|Compound:formosanin C|FD-Score:2.90|P-value:6.41E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:3.09|P-value:2.96E-4 ID:SGTC_558|Compound:k064-0027|FD-Score:3.43|P-value:6.81E-5 ID:SGTC_1144|Compound:3486-0183|FD-Score:-2.78|P-value:6.96E-4 ID:SGTC_1240|Compound:0356-0016|FD-Score:-3.62|P-value:1.66E-5 ID:SGTC_1284|Compound:0929-0043|FD-Score:3.11|P-value:2.81E-4 ID:SGTC_1292|Compound:0kpi-0043|FD-Score:-3.43|P-value:4.24E-5 ID:SGTC_1419|Compound:3993-2473|FD-Score:4.24|P-value:1.14E-6 ID:SGTC_1469|Compound:k284-2957|FD-Score:4.00|P-value:4.03E-6 ID:SGTC_1472|Compound:k841-0093|FD-Score:2.82|P-value:8.87E-4 ID:SGTC_1486|Compound:3970-0793|FD-Score:-3.20|P-value:1.21E-4 ID:SGTC_1495|Compound:4469-0029|FD-Score:5.69|P-value:9.50E-11 ID:SGTC_1657|Compound:st012939|FD-Score:-2.71|P-value:8.90E-4 ID:SGTC_1661|Compound:st013063|FD-Score:3.05|P-value:3.54E-4 ID:SGTC_1692|Compound:fluoroquinolonic acid|FD-Score:3.27|P-value:1.38E-4 ID:SGTC_1919|Compound:st067113|FD-Score:-2.88|P-value:4.63E-4 ID:SGTC_1942|Compound:st076330|FD-Score:3.16|P-value:2.20E-4 ID:SGTC_2052|Compound:5265182|FD-Score:3.45|P-value:6.17E-5 ID:SGTC_2088|Compound:5278280|FD-Score:3.13|P-value:2.50E-4 ID:SGTC_2255|Compound:7941087|FD-Score:3.01|P-value:4.11E-4 ID:SGTC_2569|Compound:tetrandrine|FD-Score:4.87|P-value:2.55E-8 ID:SGTC_2575|Compound:plumbagin|FD-Score:-2.83|P-value:5.59E-4 ID:SGTC_2576|Compound:guaiol|FD-Score:3.92|P-value:6.10E-6 ID:SGTC_2762|Compound:leflunomide|FD-Score:-2.93|P-value:3.76E-4 ID:SGTC_2767|Compound:sibutramine|FD-Score:3.23|P-value:1.67E-4 ID:SGTC_2772|Compound:vinpocetine|FD-Score:3.90|P-value:6.77E-6 ID:SGTC_2801|Compound:7907800|FD-Score:3.30|P-value:1.21E-4 ID:SGTC_3235|Compound:9132602|FD-Score:2.97|P-value:4.87E-4

Top fitness defect scores for YPL033C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1495 4469-0029 5.69 237.0 µM 9.50E-11 61 6.33E-9
2 SGTC_2569 tetrandrine 4.87 100.0 µM 2.55E-8 7 5.44E-7
3 SGTC_1419 3993-2473 4.24 62.6 µM 1.14E-6 15 1.13E-5
4 SGTC_1469 k284-2957 4.00 126.0 µM 4.03E-6 8 3.12E-5
5 SGTC_2576 guaiol 3.92 23.1 µM 6.10E-6 20 4.35E-5
6 SGTC_2772 vinpocetine 3.90 57.1 µM 6.77E-6 26 4.73E-5
7 SGTC_2052 5265182 3.45 7.1 µM 6.17E-5 46 2.79E-4
8 SGTC_185 k048-0037 3.45 25.5 µM 6.22E-5 RSC & ERG11 19 2.81E-4
9 SGTC_558 k064-0027 3.43 21.3 µM 6.81E-5 DNA damage response 43 3.02E-4
10 SGTC_203 k066-0004 3.40 30.9 µM 7.88E-5 RSC & ERG11 34 3.40E-4
11 SGTC_135 0933-0004 3.35 26.4 µM 9.62E-5 60S ribosome export 44 4.00E-4
12 SGTC_2801 7907800 3.30 81.8 µM 1.21E-4 55 4.82E-4
13 SGTC_1692 fluoroquinolonic acid 3.27 71.0 µM 1.38E-4 20 5.35E-4
14 SGTC_2767 sibutramine 3.23 71.5 µM 1.67E-4 40 6.24E-4
15 SGTC_1942 st076330 3.16 65.2 µM 2.20E-4 53 7.79E-4
16 SGTC_2088 5278280 3.13 127.4 µM 2.50E-4 61 8.63E-4
17 SGTC_1284 0929-0043 3.11 16.0 µM 2.81E-4 63 9.48E-4
18 SGTC_431 k089-0097 3.09 107.0 µM 2.96E-4 iron homeostasis 92 9.90E-4
19 SGTC_1661 st013063 3.05 9.7 µM 3.54E-4 55 0.00114
20 SGTC_2255 7941087 3.01 197.4 µM 4.11E-4 77 0.00129

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.128 1.07E-13 YNL086W_p SNN1_p hom Putative protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; green fluorescent protein (GFP)-fusion protein localizes to endosomes
0.110 1.67E-10 YLR440C SEC39 het Component of the Dsl1p tethering complex that interacts with ER SNAREs Sec20p and Use1p; proposed to be involved in protein secretion; localizes to the ER and nuclear envelope
0.108 3.72E-10 YGR230W BNS1 hom Protein with some similarity to Spo12p; overexpression bypasses need for Spo12p, but not required for meiosis
0.105 9.20E-10 YGR227W DIE2 hom Dolichyl-phosphoglucose-dependent alpha-1,2 glucosyltransferase of the ER, functions in the pathway that synthesizes the dolichol-linked oligosaccharide precursor for N-linked protein glycosylation, has a role in regulation of ITR1 and INO1
0.099 1.05E-8 YKL095W YJU2 het Essential protein required for pre-mRNA splicing; associates transiently with the spliceosomal NTC (nineteen complex) and acts after Prp2p to promote the first catalytic reaction of splicing
0.084 1.19E-6 YIR036C_p IRC24_p hom Putative benzil reductase;(GFP)-fusion protein localizes to the cytoplasm and is induced by the DNA-damaging agent MMS; sequence similarity with short-chain dehydrogenase/reductases; null mutant has increased spontaneous Rad52p foci
0.083 1.70E-6 YEL068C_p YEL068C_p hom Protein of unknown function; expressed at both mRNA and protein levels
0.082 2.25E-6 YIL015W BAR1 hom Aspartyl protease secreted into the periplasmic space of mating type a cells, helps cells find mating partners, cleaves and inactivates alpha factor allowing cells to recover from alpha-factor-induced cell cycle arrest
0.080 3.15E-6 YDL085W NDE2 hom Mitochondrial external NADH dehydrogenase, catalyzes the oxidation of cytosolic NADH; Nde1p and Nde2p are involved in providing the cytosolic NADH to the mitochondrial respiratory chain
0.080 3.24E-6 YIL168W YIL168W hom Open reading frame, unlikely to produce a functional protein in S288C; in closely related species and other S. cerevisiae strain backgrounds YIL168W and adjacent ORF, YIL167W, constitute a single ORF encoding L-serine dehydratase
0.079 4.17E-6 YDR043C NRG1 hom Transcriptional repressor; recruits the Cyc8p-Tup1p complex to promoters; mediates glucose repression and negatively regulates a variety of processes including filamentous growth and alkaline pH response; NRG1 has a paralog, NRG2, that arose from the whole genome duplication
0.078 5.54E-6 YLR081W GAL2 hom Galactose permease, required for utilization of galactose; also able to transport glucose
0.078 6.06E-6 YKR024C DBP7 hom Putative ATP-dependent RNA helicase of the DEAD-box family involved in ribosomal biogenesis; essential for growth under anaerobic conditions
0.077 7.79E-6 YCL005W-A VMA9 hom Vacuolar H+ ATPase subunit e of the V-ATPase V0 subcomplex; essential for vacuolar acidification; interacts with the V-ATPase assembly factor Vma21p in the ER; involved in V0 biogenesis
0.074 2.02E-5 YHR105W YPT35 hom Endosomal protein of unknown function that contains a phox (PX) homology domain and binds to both phosphatidylinositol-3-phosphate (PtdIns(3)P) and proteins involved in ER-Golgi or vesicular transport