YPL034W_p

Putative protein of unknown function; YPL034W is not essential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL034W / YPL034W

Click on Significant Values for Screen Details ID:SGTC_35|Compound:0133-0054|FD-Score:-4.31|P-value:1.56E-5 ID:SGTC_40|Compound:0327-0103|FD-Score:4.52|P-value:7.37E-6 ID:SGTC_48|Compound:0382-0018|FD-Score:-4.00|P-value:5.53E-5 ID:SGTC_52|Compound:0329-0193|FD-Score:-5.00|P-value:6.68E-7 ID:SGTC_53|Compound:0973-0023|FD-Score:4.37|P-value:1.37E-5 ID:SGTC_55|Compound:0767-0285|FD-Score:4.71|P-value:3.10E-6 ID:SGTC_59|Compound:0330-0160|FD-Score:4.00|P-value:6.32E-5 ID:SGTC_105|Compound:0111-0055|FD-Score:-3.22|P-value:9.19E-4 ID:SGTC_117|Compound:lucigenin|FD-Score:5.21|P-value:2.91E-7 ID:SGTC_121|Compound:0557-0495|FD-Score:3.84|P-value:1.15E-4 ID:SGTC_146|Compound:3448-8650|FD-Score:-3.34|P-value:6.10E-4 ID:SGTC_159|Compound:3970-0959|FD-Score:-3.72|P-value:1.61E-4 ID:SGTC_163|Compound:1327-0036|FD-Score:7.45|P-value:4.11E-13 ID:SGTC_167|Compound:3672-0051|FD-Score:-3.97|P-value:6.31E-5 ID:SGTC_168|Compound:3970-0862|FD-Score:-3.37|P-value:5.64E-4 ID:SGTC_170|Compound:4197-0004|FD-Score:3.24|P-value:9.52E-4 ID:SGTC_176|Compound:1486-1328|FD-Score:4.71|P-value:3.09E-6 ID:SGTC_263|Compound:alizarin|FD-Score:3.25|P-value:9.35E-4 ID:SGTC_566|Compound:0958-0068|FD-Score:4.09|P-value:4.43E-5 ID:SGTC_587|Compound:k089-0003|FD-Score:3.72|P-value:1.82E-4 ID:SGTC_626|Compound:0214-0009|FD-Score:4.43|P-value:1.06E-5 ID:SGTC_725|Compound:1497-0963|FD-Score:3.31|P-value:7.68E-4 ID:SGTC_885|Compound:0865-0106|FD-Score:3.62|P-value:2.62E-4 ID:SGTC_902|Compound:1120-0002|FD-Score:-3.88|P-value:8.72E-5 ID:SGTC_967|Compound:1306-0166|FD-Score:3.55|P-value:3.39E-4 ID:SGTC_1035|Compound:k081-0041|FD-Score:4.12|P-value:3.93E-5 ID:SGTC_1044|Compound:1222-0021|FD-Score:3.38|P-value:6.06E-4 ID:SGTC_1080|Compound:nisoldipine|FD-Score:-3.27|P-value:7.80E-4 ID:SGTC_1156|Compound:4092-0367|FD-Score:3.33|P-value:7.24E-4 ID:SGTC_1180|Compound:1193-0155|FD-Score:-3.29|P-value:7.39E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:3.42|P-value:5.20E-4 ID:SGTC_1932|Compound:st074806|FD-Score:-3.94|P-value:6.91E-5 ID:SGTC_2012|Compound:4023501|FD-Score:-3.31|P-value:6.89E-4 ID:SGTC_2285|Compound:7945142|FD-Score:-3.92|P-value:7.67E-5 ID:SGTC_2294|Compound:7971431|FD-Score:4.39|P-value:1.28E-5 ID:SGTC_2399|Compound:5884133|FD-Score:3.53|P-value:3.65E-4 ID:SGTC_2411|Compound:st077133|FD-Score:3.54|P-value:3.43E-4 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:-3.53|P-value:3.22E-4 ID:SGTC_2729|Compound:fluphenazine|FD-Score:3.88|P-value:9.88E-5 ID:SGTC_2751|Compound:anetholtrithion|FD-Score:5.79|P-value:1.34E-8 ID:SGTC_2823|Compound:7987624|FD-Score:3.39|P-value:5.83E-4 ID:SGTC_2937|Compound:9044753|FD-Score:-3.25|P-value:8.43E-4 ID:SGTC_3071|Compound:9117417|FD-Score:5.02|P-value:7.42E-7 ID:SGTC_3194|Compound:9111903|FD-Score:3.35|P-value:6.64E-4 ID:SGTC_3233|Compound:9132340|FD-Score:3.78|P-value:1.46E-4 ID:SGTC_3337|Compound:9144342|FD-Score:3.66|P-value:2.29E-4 ID:SGTC_35|Compound:0133-0054|FD-Score:-4.31|P-value:1.56E-5 ID:SGTC_40|Compound:0327-0103|FD-Score:4.52|P-value:7.37E-6 ID:SGTC_48|Compound:0382-0018|FD-Score:-4.00|P-value:5.53E-5 ID:SGTC_52|Compound:0329-0193|FD-Score:-5.00|P-value:6.68E-7 ID:SGTC_53|Compound:0973-0023|FD-Score:4.37|P-value:1.37E-5 ID:SGTC_55|Compound:0767-0285|FD-Score:4.71|P-value:3.10E-6 ID:SGTC_59|Compound:0330-0160|FD-Score:4.00|P-value:6.32E-5 ID:SGTC_105|Compound:0111-0055|FD-Score:-3.22|P-value:9.19E-4 ID:SGTC_117|Compound:lucigenin|FD-Score:5.21|P-value:2.91E-7 ID:SGTC_121|Compound:0557-0495|FD-Score:3.84|P-value:1.15E-4 ID:SGTC_146|Compound:3448-8650|FD-Score:-3.34|P-value:6.10E-4 ID:SGTC_159|Compound:3970-0959|FD-Score:-3.72|P-value:1.61E-4 ID:SGTC_163|Compound:1327-0036|FD-Score:7.45|P-value:4.11E-13 ID:SGTC_167|Compound:3672-0051|FD-Score:-3.97|P-value:6.31E-5 ID:SGTC_168|Compound:3970-0862|FD-Score:-3.37|P-value:5.64E-4 ID:SGTC_170|Compound:4197-0004|FD-Score:3.24|P-value:9.52E-4 ID:SGTC_176|Compound:1486-1328|FD-Score:4.71|P-value:3.09E-6 ID:SGTC_263|Compound:alizarin|FD-Score:3.25|P-value:9.35E-4 ID:SGTC_566|Compound:0958-0068|FD-Score:4.09|P-value:4.43E-5 ID:SGTC_587|Compound:k089-0003|FD-Score:3.72|P-value:1.82E-4 ID:SGTC_626|Compound:0214-0009|FD-Score:4.43|P-value:1.06E-5 ID:SGTC_725|Compound:1497-0963|FD-Score:3.31|P-value:7.68E-4 ID:SGTC_885|Compound:0865-0106|FD-Score:3.62|P-value:2.62E-4 ID:SGTC_902|Compound:1120-0002|FD-Score:-3.88|P-value:8.72E-5 ID:SGTC_967|Compound:1306-0166|FD-Score:3.55|P-value:3.39E-4 ID:SGTC_1035|Compound:k081-0041|FD-Score:4.12|P-value:3.93E-5 ID:SGTC_1044|Compound:1222-0021|FD-Score:3.38|P-value:6.06E-4 ID:SGTC_1080|Compound:nisoldipine|FD-Score:-3.27|P-value:7.80E-4 ID:SGTC_1156|Compound:4092-0367|FD-Score:3.33|P-value:7.24E-4 ID:SGTC_1180|Compound:1193-0155|FD-Score:-3.29|P-value:7.39E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:3.42|P-value:5.20E-4 ID:SGTC_1932|Compound:st074806|FD-Score:-3.94|P-value:6.91E-5 ID:SGTC_2012|Compound:4023501|FD-Score:-3.31|P-value:6.89E-4 ID:SGTC_2285|Compound:7945142|FD-Score:-3.92|P-value:7.67E-5 ID:SGTC_2294|Compound:7971431|FD-Score:4.39|P-value:1.28E-5 ID:SGTC_2399|Compound:5884133|FD-Score:3.53|P-value:3.65E-4 ID:SGTC_2411|Compound:st077133|FD-Score:3.54|P-value:3.43E-4 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:-3.53|P-value:3.22E-4 ID:SGTC_2729|Compound:fluphenazine|FD-Score:3.88|P-value:9.88E-5 ID:SGTC_2751|Compound:anetholtrithion|FD-Score:5.79|P-value:1.34E-8 ID:SGTC_2823|Compound:7987624|FD-Score:3.39|P-value:5.83E-4 ID:SGTC_2937|Compound:9044753|FD-Score:-3.25|P-value:8.43E-4 ID:SGTC_3071|Compound:9117417|FD-Score:5.02|P-value:7.42E-7 ID:SGTC_3194|Compound:9111903|FD-Score:3.35|P-value:6.64E-4 ID:SGTC_3233|Compound:9132340|FD-Score:3.78|P-value:1.46E-4 ID:SGTC_3337|Compound:9144342|FD-Score:3.66|P-value:2.29E-4

Top fitness defect scores for YPL034W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_163 1327-0036 7.45 7.5 µM 4.11E-13 23 4.58E-14
2 SGTC_2751 anetholtrithion 5.79 17.2 µM 1.34E-8 6 3.42E-9
3 SGTC_117 lucigenin 5.21 22.1 µM 2.91E-7 redox potentiating 54 9.54E-8
4 SGTC_3071 9117417 5.02 49.5 µM 7.42E-7 fatty acid desaturase (OLE1) 9 2.62E-7
5 SGTC_176 1486-1328 4.71 72.8 µM 3.09E-6 36 1.22E-6
6 SGTC_55 0767-0285 4.71 6.6 µM 3.10E-6 32 1.23E-6
7 SGTC_40 0327-0103 4.52 19.8 µM 7.37E-6 17 3.12E-6
8 SGTC_626 0214-0009 4.43 33.0 µM 1.06E-5 copper-dependent oxidative stress 12 4.63E-6
9 SGTC_2294 7971431 4.39 200.0 µM 1.28E-5 7 5.65E-6
10 SGTC_53 0973-0023 4.37 40.0 µM 1.37E-5 RNA processing & uracil transport 10 6.08E-6
11 SGTC_1035 k081-0041 4.12 55.2 µM 3.93E-5 Golgi 18 1.90E-5
12 SGTC_566 0958-0068 4.09 16.5 µM 4.43E-5 RSC & ERG11 18 2.16E-5
13 SGTC_59 0330-0160 4.00 1.3 µM 6.32E-5 106 3.18E-5
14 SGTC_2729 fluphenazine 3.88 10.7 µM 9.88E-5 16 5.14E-5
15 SGTC_121 0557-0495 3.84 61.3 µM 1.15E-4 calcium & mitochondrial duress 61 6.07E-5
16 SGTC_3233 9132340 3.78 49.5 µM 1.46E-4 23 7.86E-5
17 SGTC_587 k089-0003 3.72 57.0 µM 1.82E-4 9 9.96E-5
18 SGTC_3337 9144342 3.66 33.5 µM 2.29E-4 32 1.27E-4
19 SGTC_885 0865-0106 3.62 16.8 µM 2.62E-4 TSC3-RPN4 34 1.47E-4
20 SGTC_967 1306-0166 3.55 352.0 µM 3.39E-4 52 1.95E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.153 5.36E-19 YER052C HOM3 hom Aspartate kinase (L-aspartate 4-P-transferase); cytoplasmic enzyme that catalyzes the first step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis
0.140 3.10E-16 YBR068C BAP2 hom High-affinity leucine permease; functions as a branched-chain amino acid permease involved in uptake of leucine, isoleucine and valine; contains 12 predicted transmembrane domains; BAP2 has a paralog, BAP3, that arose from the whole genome duplication
0.133 1.08E-14 YIR008C PRI1 het Subunit of DNA primase, which is required for DNA synthesis and double-strand break repair
0.133 1.38E-14 YCR053W THR4 hom Threonine synthase, conserved protein that catalyzes formation of threonine from O-phosphohomoserine; expression is regulated by the GCN4-mediated general amino acid control pathway
0.122 1.23E-12 YGR193C PDX1 hom Dihydrolipoamide dehydrogenase (E3)-binding protein (E3BP) of the mitochondrial pyruvate dehydrogenase (PDH) complex, plays a structural role in the complex by binding and positioning E3 to the dihydrolipoamide acetyltransferase (E2) core
0.122 1.48E-12 YFL037W TUB2 het Beta-tubulin; associates with alpha-tubulin (Tub1p and Tub3p) to form tubulin dimer, which polymerizes to form microtubules; mutation in human ortholog is associated with congenital fibrosis of the extraocular muscles (CFEOM) with polymicrogyria
0.117 1.15E-11 YJR013W GPI14 het Glycosylphosphatidylinositol-alpha 1,4 mannosyltransferase I, involved in GPI anchor biosynthesis, requires Pbn1p for function; homolog of mammalian PIG-M
0.113 6.08E-11 YCL045C EMC1 hom Member of conserved endoplasmic reticulum membrane complex; involved in efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; interacts with Gal80p; homologous to worm H17B01.4/EMC-1, fly CG2943, and human KIAA0090
0.106 6.84E-10 YNL071W LAT1 hom Dihydrolipoamide acetyltransferase component (E2) of pyruvate dehydrogenase complex, which catalyzes the oxidative decarboxylation of pyruvate to acetyl-CoA
0.102 2.62E-9 YDR381W YRA1 het RNA binding protein required for export of poly(A)+ mRNA from the nucleus; proposed to couple mRNA export with 3' end processing via its interactions with Mex67p and Pcf11p; functionally redundant with Yra2p, another REF family member
0.100 6.87E-9 YBR049C REB1 het RNA polymerase I enhancer binding protein; DNA binding protein that binds to genes transcribed by both RNA polymerase I and RNA polymerase II; required for termination of RNA polymerase I transcription; REB1 has a paralog, NSI1, that arose from the whole genome duplication
0.095 3.03E-8 YOL138C RTC1 hom Subunit of the SEA (Seh1-associated) complex, a coatomer-related complex that associates dynamically with the vacuole; null mutation suppresses cdc13-1 temperature sensitivity; has N-terminal WD-40 repeats and a C-terminal RING motif
0.095 3.37E-8 YPR193C HPA2 hom Tetrameric histone acetyltransferase with similarity to Gcn5p, Hat1p, Elp3p, and Hpa3p; acetylates histones H3 and H4 in vitro and exhibits autoacetylation activity
0.092 8.04E-8 YIL022W TIM44 het Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); tethers the import motor and regulatory factors (PAM complex) to the translocation channel (Tim23p-Tim17p core complex)
0.092 1.06E-7 YMR007W_d YMR007W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data