YPL037C / EGD1

Subunit beta1 of the nascent polypeptide-associated complex (NAC) involved in protein targeting, associated with cytoplasmic ribosomes; enhances DNA binding of the Gal4p activator; homolog of human BTF3b

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL037C / EGD1

Click on Significant Values for Screen Details ID:SGTC_169|Compound:k015-0017|FD-Score:-4.65|P-value:6.16E-6 ID:SGTC_553|Compound:k007-0256|FD-Score:4.29|P-value:2.66E-5 ID:SGTC_609|Compound:0986-0026|FD-Score:3.52|P-value:4.46E-4 ID:SGTC_633|Compound:0437-0093|FD-Score:3.31|P-value:8.94E-4 ID:SGTC_705|Compound:1124-0212|FD-Score:3.90|P-value:1.17E-4 ID:SGTC_706|Compound:4262-0057|FD-Score:3.31|P-value:8.86E-4 ID:SGTC_720|Compound:r052-1644|FD-Score:3.57|P-value:3.86E-4 ID:SGTC_730|Compound:1436-0052|FD-Score:-3.39|P-value:7.30E-4 ID:SGTC_731|Compound:3966-0296|FD-Score:4.76|P-value:3.63E-6 ID:SGTC_774|Compound:k060-0086|FD-Score:4.35|P-value:2.04E-5 ID:SGTC_903|Compound:1134-0042|FD-Score:3.36|P-value:7.62E-4 ID:SGTC_1009|Compound:4106-0057|FD-Score:3.71|P-value:2.36E-4 ID:SGTC_1026|Compound:k007-1105|FD-Score:6.09|P-value:4.84E-9 ID:SGTC_1145|Compound:3546-0597|FD-Score:3.33|P-value:8.55E-4 ID:SGTC_1745|Compound:st081495|FD-Score:3.54|P-value:4.29E-4 ID:SGTC_1908|Compound:st060353|FD-Score:-3.29|P-value:9.99E-4 ID:SGTC_1963|Compound:st076565|FD-Score:3.58|P-value:3.70E-4 ID:SGTC_1974|Compound:st069448|FD-Score:-3.75|P-value:2.11E-4 ID:SGTC_1994|Compound:st072947|FD-Score:-3.39|P-value:7.31E-4 ID:SGTC_2068|Compound:5226020|FD-Score:3.47|P-value:5.40E-4 ID:SGTC_2122|Compound:5258151|FD-Score:3.49|P-value:4.98E-4 ID:SGTC_2389|Compound:9091542|FD-Score:-3.71|P-value:2.41E-4 ID:SGTC_2522|Compound:biochanin a|FD-Score:-3.63|P-value:3.19E-4 ID:SGTC_2532|Compound:xanthone|FD-Score:-3.53|P-value:4.52E-4 ID:SGTC_2626|Compound:ethyl orsellinate|FD-Score:4.33|P-value:2.21E-5 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.73|P-value:4.18E-6 ID:SGTC_2702|Compound:st077768|FD-Score:3.30|P-value:9.44E-4 ID:SGTC_2721|Compound:ifenprodil|FD-Score:3.33|P-value:8.47E-4 ID:SGTC_2917|Compound:7979103|FD-Score:3.75|P-value:2.06E-4 ID:SGTC_2920|Compound:7982904|FD-Score:-4.45|P-value:1.45E-5 ID:SGTC_2935|Compound:9038016|FD-Score:-3.96|P-value:9.93E-5 ID:SGTC_2944|Compound:9067346|FD-Score:3.74|P-value:2.13E-4 ID:SGTC_2946|Compound:9065502|FD-Score:-3.81|P-value:1.68E-4 ID:SGTC_3152|Compound:9099253|FD-Score:3.93|P-value:1.08E-4 ID:SGTC_3213|Compound:9129884|FD-Score:8.04|P-value:1.84E-14 ID:SGTC_3218|Compound:9131285|FD-Score:-3.90|P-value:1.24E-4 ID:SGTC_3219|Compound:9131112|FD-Score:-3.75|P-value:2.10E-4 ID:SGTC_3222|Compound:9128301|FD-Score:5.59|P-value:6.85E-8 ID:SGTC_3341|Compound:9147222|FD-Score:4.11|P-value:5.27E-5 ID:SGTC_169|Compound:k015-0017|FD-Score:-4.65|P-value:6.16E-6 ID:SGTC_553|Compound:k007-0256|FD-Score:4.29|P-value:2.66E-5 ID:SGTC_609|Compound:0986-0026|FD-Score:3.52|P-value:4.46E-4 ID:SGTC_633|Compound:0437-0093|FD-Score:3.31|P-value:8.94E-4 ID:SGTC_705|Compound:1124-0212|FD-Score:3.90|P-value:1.17E-4 ID:SGTC_706|Compound:4262-0057|FD-Score:3.31|P-value:8.86E-4 ID:SGTC_720|Compound:r052-1644|FD-Score:3.57|P-value:3.86E-4 ID:SGTC_730|Compound:1436-0052|FD-Score:-3.39|P-value:7.30E-4 ID:SGTC_731|Compound:3966-0296|FD-Score:4.76|P-value:3.63E-6 ID:SGTC_774|Compound:k060-0086|FD-Score:4.35|P-value:2.04E-5 ID:SGTC_903|Compound:1134-0042|FD-Score:3.36|P-value:7.62E-4 ID:SGTC_1009|Compound:4106-0057|FD-Score:3.71|P-value:2.36E-4 ID:SGTC_1026|Compound:k007-1105|FD-Score:6.09|P-value:4.84E-9 ID:SGTC_1145|Compound:3546-0597|FD-Score:3.33|P-value:8.55E-4 ID:SGTC_1745|Compound:st081495|FD-Score:3.54|P-value:4.29E-4 ID:SGTC_1908|Compound:st060353|FD-Score:-3.29|P-value:9.99E-4 ID:SGTC_1963|Compound:st076565|FD-Score:3.58|P-value:3.70E-4 ID:SGTC_1974|Compound:st069448|FD-Score:-3.75|P-value:2.11E-4 ID:SGTC_1994|Compound:st072947|FD-Score:-3.39|P-value:7.31E-4 ID:SGTC_2068|Compound:5226020|FD-Score:3.47|P-value:5.40E-4 ID:SGTC_2122|Compound:5258151|FD-Score:3.49|P-value:4.98E-4 ID:SGTC_2389|Compound:9091542|FD-Score:-3.71|P-value:2.41E-4 ID:SGTC_2522|Compound:biochanin a|FD-Score:-3.63|P-value:3.19E-4 ID:SGTC_2532|Compound:xanthone|FD-Score:-3.53|P-value:4.52E-4 ID:SGTC_2626|Compound:ethyl orsellinate|FD-Score:4.33|P-value:2.21E-5 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.73|P-value:4.18E-6 ID:SGTC_2702|Compound:st077768|FD-Score:3.30|P-value:9.44E-4 ID:SGTC_2721|Compound:ifenprodil|FD-Score:3.33|P-value:8.47E-4 ID:SGTC_2917|Compound:7979103|FD-Score:3.75|P-value:2.06E-4 ID:SGTC_2920|Compound:7982904|FD-Score:-4.45|P-value:1.45E-5 ID:SGTC_2935|Compound:9038016|FD-Score:-3.96|P-value:9.93E-5 ID:SGTC_2944|Compound:9067346|FD-Score:3.74|P-value:2.13E-4 ID:SGTC_2946|Compound:9065502|FD-Score:-3.81|P-value:1.68E-4 ID:SGTC_3152|Compound:9099253|FD-Score:3.93|P-value:1.08E-4 ID:SGTC_3213|Compound:9129884|FD-Score:8.04|P-value:1.84E-14 ID:SGTC_3218|Compound:9131285|FD-Score:-3.90|P-value:1.24E-4 ID:SGTC_3219|Compound:9131112|FD-Score:-3.75|P-value:2.10E-4 ID:SGTC_3222|Compound:9128301|FD-Score:5.59|P-value:6.85E-8 ID:SGTC_3341|Compound:9147222|FD-Score:4.11|P-value:5.27E-5

Top fitness defect scores for YPL037C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3213 9129884 8.04 49.5 µM 1.84E-14 1 4.60E-16
2 SGTC_1026 k007-1105 6.09 30.6 µM 4.84E-9 ERAD & cell cycle 41 5.74E-10
3 SGTC_3222 9128301 5.59 49.5 µM 6.85E-8 60S ribosome export 7 1.13E-8
4 SGTC_731 3966-0296 4.76 387.0 µM 3.63E-6 6 9.70E-7
5 SGTC_2688 kanamycin b 4.73 96.7 µM 4.18E-6 calcium & mitochondrial duress 272 1.14E-6
6 SGTC_774 k060-0086 4.35 136.0 µM 2.04E-5 14 6.74E-6
7 SGTC_2626 ethyl orsellinate 4.33 100.0 µM 2.21E-5 26 7.37E-6
8 SGTC_553 k007-0256 4.29 45.7 µM 2.66E-5 heme biosynthesis & mitochondrial translocase 16 9.05E-6
9 SGTC_3341 9147222 4.11 25.9 µM 5.27E-5 RNA processing & uracil transport 13 1.95E-5
10 SGTC_3152 9099253 3.93 49.5 µM 1.08E-4 NEO1-PIK1 130 4.33E-5
11 SGTC_705 1124-0212 3.90 310.0 µM 1.17E-4 15 4.77E-5
12 SGTC_2917 7979103 3.75 53.8 µM 2.06E-4 35 8.98E-5
13 SGTC_2944 9067346 3.74 25.6 µM 2.13E-4 29 9.30E-5
14 SGTC_1009 4106-0057 3.71 9.9 µM 2.36E-4 19 1.04E-4
15 SGTC_1963 st076565 3.58 50.3 µM 3.70E-4 20 1.73E-4
16 SGTC_720 r052-1644 3.57 49.9 µM 3.86E-4 TSC3-RPN4 38 1.81E-4
17 SGTC_1745 st081495 3.54 74.0 µM 4.29E-4 RNA processing & uracil transport 91 2.04E-4
18 SGTC_609 0986-0026 3.52 86.3 µM 4.46E-4 calcium & mitochondrial duress 48 2.13E-4
19 SGTC_2122 5258151 3.49 111.7 µM 4.98E-4 39 2.40E-4
20 SGTC_2068 5226020 3.47 147.0 µM 5.40E-4 40 2.63E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.122 1.51E-12 YHR004C NEM1 hom Probable catalytic subunit of Nem1p-Spo7p phosphatase holoenzyme; regulates nuclear growth by controlling phospholipid biosynthesis, required for normal nuclear envelope morphology and sporulation; homolog of the human protein Dullard
0.116 1.87E-11 YKL061W_p BLI1_p hom Putative protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; green fluorescent protein (GFP)-fusion protein localizes to the endosome
0.110 1.49E-10 YLR186W EMG1 het Methyltransferase for rRNA; catalyzes methylation of the pseudouridine residue 1191 of 18S rRNA; member of the SPOUT methyltransferase family; required for maturation of 18S rRNA and for 40S ribosomal subunit production independently of methyltransferase activity; forms homodimers; human ortholog is mutated in Bowen-Conradi syndrome, and the equivalent mutation in yeast affects Emg1p dimerization and localization but not its methyltransferase activity
0.105 1.03E-9 YDR101C ARX1 hom Shuttling pre-60S factor; involved in the biogenesis of ribosomal large subunit biogenesis; interacts directly with Alb1; responsible for Tif6 recycling defects in absence of Rei1; associated with the ribosomal export complex
0.104 1.39E-9 YCR075W-A_p YCR075W-A_p hom Putative protein of unknown function; identified by homology to Ashbya gossypii; YCR075W-A has a paralog, YNR034W-A, that arose from the whole genome duplication
0.104 1.40E-9 YOL002C IZH2 hom Plasma membrane protein involved in zinc homeostasis and osmotin-induced apoptosis; transcription regulated by Zap1p, zinc and fatty acid levels; similar to mammalian adiponectins; deletion increases sensitivity to elevated zinc
0.096 2.37E-8 YDR238C SEC26 het Essential beta-coat protein of the COPI coatomer, involved in ER-to-Golgi protein trafficking and maintenance of normal ER morphology; shares 43% sequence identity with mammalian beta-coat protein (beta-COP)
0.096 2.97E-8 YEL022W GEA2 hom Guanine nucleotide exchange factor for ADP ribosylation factors (ARFs); involved in vesicular transport between the Golgi and ER, Golgi organization, and actin cytoskeleton organization; GEA2 has a paralog, GEA1, that arose from the whole genome duplication
0.088 2.89E-7 YPR152C URN1 hom Putative protein of unknown function containing WW and FF domains; overexpression causes accumulation of cells in G1 phase
0.084 1.04E-6 YDR372C VPS74 hom Golgi phosphatidylinositol-4-kinase effector and PtdIns4P sensor; interacts with the cytosolic domains of cis and medial glycosyltransferases, and in the PtdIns4P-bound state mediates the targeting of these enzymes to the Golgi; interacts with the catalytic domain of Sac1p, the major cellular PtdIns4P phosphatase, to direct dephosphosphorylation of the Golgi pool of PtdIns4P; tetramerization required for function; ortholog of human GOLPH3/GPP34/GMx33
0.084 1.16E-6 YDR451C YHP1 hom Homeobox transcriptional repressor; binds Mcm1p and early cell cycle box (ECB) elements of cell cycle regulated genes, thereby restricting ECB-mediated transcription to the M/G1 interval; YHP1 has a paralog, YOX1, that arose from the whole genome duplication
0.083 1.40E-6 YER084W_p YER084W_p hom Protein of unknown function; expressed at both mRNA and protein levels
0.083 1.61E-6 YKL176C LST4 hom Protein possibly involved in a post-Golgi secretory pathway; required for the transport of nitrogen-regulated amino acid permease Gap1p from the Golgi to the cell surface
0.082 1.83E-6 YBL075C SSA3 hom ATPase involved in protein folding and the response to stress; plays a role in SRP-dependent cotranslational protein-membrane targeting and translocation; member of the heat shock protein 70 (HSP70) family; localized to the cytoplasm; SSA3 has a paralog, SSA4, that arose from the whole genome duplication
0.082 1.87E-6 YGR202C PCT1 hom Cholinephosphate cytidylyltransferase; a rate-determining enzyme of the CDP-choline pathway for phosphatidylcholine synthesis, inhibited by Sec14p, activated upon lipid-binding; contains an element within the regulatory domain involved in both silencing and activation of enzymatic activity