HIPHOP chemogenomics database
YPL039W_p 
Putative protein of unknown function; YPL039W is not an essential gene
Zygosity: Homozygous strain
fixedexpanded
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Top fitness defect scores for YPL039W deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.141 | 2.56E-16 | YDR032C | PST2 | hom | Protein with similarity to a family of flavodoxin-like proteins; induced by oxidative stress in a Yap1p dependent manner; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress; PST2 has a paralog, RFS1, that arose from the whole genome duplication |
| 0.110 | 1.66E-10 | YOR190W | SPR1 | hom | Sporulation-specific exo-1,3-beta-glucanase; contributes to ascospore thermoresistance |
| 0.083 | 1.45E-6 | YML130C | ERO1 | het | Thiol oxidase required for oxidative protein folding in the ER; essential for maintaining proper redox balance in ER; feedback regulation of Ero1p occurs via reduction and oxidation of Ero1p regulatory bonds; reduced Pdi1p activates Ero1p by direct reduction of Ero1p regulatory bonds; depletion of thiol substrates and accumulation of oxidized Pdi1p results in inactivation of Ero1p by both Pdi1p-mediated oxidation and autonomous oxidation of Ero1p regulatory bonds |
| 0.080 | 3.07E-6 | YBR142W | MAK5 | het | Essential nucleolar protein, putative DEAD-box RNA helicase required for maintenance of M1 dsRNA virus; involved in biogenesis of large (60S) ribosomal subunits |
| 0.080 | 3.13E-6 | YIL010W | DOT5 | hom | Nuclear thiol peroxidase which functions as an alkyl-hydroperoxide reductase during post-diauxic growth |
| 0.078 | 6.17E-6 | YOR003W | YSP3 | hom | Putative precursor to the subtilisin-like protease III |
| 0.077 | 8.82E-6 | YPR032W | SRO7 | hom | Effector of Rab GTPase Sec4p; forms a complex with Sec4p and t-SNARE Sec9p; involved in exocytosis and docking and fusion of post-Golgi vesicles with plasma membrane; homolog of Drosophila lgl tumor suppressor; SRO7 has a paralog, SRO77, that arose from the whole genome duplication |
| 0.076 | 9.89E-6 | YFL034C-A | RPL22B | hom | Ribosomal 60S subunit protein L22B; homologous to mammalian ribosomal protein L22, no bacterial homolog; RPL22B has a paralog, RPL22A, that arose from the whole genome duplication |
| 0.074 | 1.61E-5 | YER146W | LSM5 | het | Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA |
| 0.073 | 2.52E-5 | YJL162C | JJJ2 | hom | Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein |
| 0.072 | 2.65E-5 | YFL032W_d | YFL032W_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene HAC1/YFL031W; YFL032W is not an essential gene |
| 0.072 | 3.14E-5 | YEL016C | NPP2 | hom | Nucleotide pyrophosphatase/phosphodiesterase; mediates extracellular nucleotide phosphate hydrolysis along with Npp1p and Pho5p; activity and expression enhanced during conditions of phosphate starvation; NPP2 has a paralog, NPP1, that arose from the whole genome duplication |
| 0.071 | 3.49E-5 | YPL134C | ODC1 | hom | Mitochondrial inner membrane transporter, exports 2-oxoadipate and 2-oxoglutarate from the mitochondrial matrix to the cytosol for lysine and glutamate biosynthesis and lysine catabolism; suppresses, in multicopy, an fmc1 null mutation |
| 0.069 | 6.10E-5 | YDR370C | DXO1 | hom | Protein with decapping and 5′-3′ exoRNase activity; similar to Rai1p |
| 0.069 | 6.81E-5 | YER134C | YER134C | hom | Magnesium-dependent acid phosphatase, member of the haloacid dehalogenase superfamily; non-essential gene |