YPL039W_p

Putative protein of unknown function; YPL039W is not an essential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL039W / YPL039W

Click on Significant Values for Screen Details ID:SGTC_20|Compound:0481-0013|FD-Score:5.48|P-value:1.48E-7 ID:SGTC_516|Compound:3992-2719|FD-Score:3.49|P-value:5.44E-4 ID:SGTC_557|Compound:1315-0110|FD-Score:3.44|P-value:6.38E-4 ID:SGTC_802|Compound:4112-3352|FD-Score:4.43|P-value:1.68E-5 ID:SGTC_899|Compound:1083-0020|FD-Score:3.35|P-value:8.66E-4 ID:SGTC_906|Compound:1165-0455|FD-Score:3.68|P-value:2.84E-4 ID:SGTC_911|Compound:3456-4043|FD-Score:-3.53|P-value:4.78E-4 ID:SGTC_948|Compound:3448-0295|FD-Score:-4.53|P-value:1.10E-5 ID:SGTC_1057|Compound:3448-5381|FD-Score:3.97|P-value:1.03E-4 ID:SGTC_1239|Compound:0337-0584|FD-Score:3.70|P-value:2.64E-4 ID:SGTC_1245|Compound:0418-0076|FD-Score:-4.85|P-value:2.80E-6 ID:SGTC_1247|Compound:0448-0043|FD-Score:-5.58|P-value:8.60E-8 ID:SGTC_1249|Compound:0481-0015|FD-Score:3.54|P-value:4.67E-4 ID:SGTC_1257|Compound:0669-0121|FD-Score:3.44|P-value:6.53E-4 ID:SGTC_1601|Compound:4'-hydroxyflavanone|FD-Score:4.39|P-value:1.97E-5 ID:SGTC_1715|Compound:st032160|FD-Score:3.47|P-value:5.77E-4 ID:SGTC_1720|Compound:st037298|FD-Score:6.33|P-value:1.57E-9 ID:SGTC_1826|Compound:st055655|FD-Score:3.68|P-value:2.87E-4 ID:SGTC_1954|Compound:st077032|FD-Score:-3.37|P-value:7.91E-4 ID:SGTC_2006|Compound:4011487|FD-Score:3.83|P-value:1.71E-4 ID:SGTC_2240|Compound:6690706|FD-Score:3.33|P-value:9.08E-4 ID:SGTC_2260|Compound:7964312|FD-Score:4.34|P-value:2.48E-5 ID:SGTC_2262|Compound:9014885|FD-Score:-3.88|P-value:1.40E-4 ID:SGTC_2297|Compound:7971671|FD-Score:3.67|P-value:2.95E-4 ID:SGTC_2336|Compound:9001819|FD-Score:-4.38|P-value:2.05E-5 ID:SGTC_2337|Compound:9009472|FD-Score:-3.43|P-value:6.56E-4 ID:SGTC_2532|Compound:xanthone|FD-Score:3.86|P-value:1.53E-4 ID:SGTC_2592|Compound:piperlongumine|FD-Score:4.16|P-value:4.86E-5 ID:SGTC_2597|Compound:laccaic acid a|FD-Score:3.48|P-value:5.58E-4 ID:SGTC_2610|Compound:ononetin|FD-Score:-3.74|P-value:2.34E-4 ID:SGTC_2611|Compound:pyromycin|FD-Score:-3.97|P-value:1.03E-4 ID:SGTC_2612|Compound:dictamnine|FD-Score:3.43|P-value:6.67E-4 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:-3.58|P-value:3.96E-4 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:4.49|P-value:1.33E-5 ID:SGTC_2725|Compound:haloperidol|FD-Score:-3.67|P-value:2.91E-4 ID:SGTC_2755|Compound:lomerizine|FD-Score:4.97|P-value:1.66E-6 ID:SGTC_2759|Compound:disulfiram|FD-Score:-3.95|P-value:1.07E-4 ID:SGTC_2912|Compound:7964298|FD-Score:-5.55|P-value:1.03E-7 ID:SGTC_2984|Compound:9022109|FD-Score:-3.93|P-value:1.17E-4 ID:SGTC_3068|Compound:9116768|FD-Score:-3.35|P-value:8.61E-4 ID:SGTC_3089|Compound:9117425|FD-Score:3.64|P-value:3.30E-4 ID:SGTC_3104|Compound:9120930|FD-Score:4.25|P-value:3.45E-5 ID:SGTC_3110|Compound:9122132|FD-Score:-6.14|P-value:4.62E-9 ID:SGTC_3111|Compound:9122088|FD-Score:3.48|P-value:5.66E-4 ID:SGTC_3112|Compound:9123419|FD-Score:-6.23|P-value:2.70E-9 ID:SGTC_3264|Compound:9137442|FD-Score:5.37|P-value:2.55E-7 ID:SGTC_3322|Compound:9139058|FD-Score:3.94|P-value:1.15E-4 ID:SGTC_20|Compound:0481-0013|FD-Score:5.48|P-value:1.48E-7 ID:SGTC_516|Compound:3992-2719|FD-Score:3.49|P-value:5.44E-4 ID:SGTC_557|Compound:1315-0110|FD-Score:3.44|P-value:6.38E-4 ID:SGTC_802|Compound:4112-3352|FD-Score:4.43|P-value:1.68E-5 ID:SGTC_899|Compound:1083-0020|FD-Score:3.35|P-value:8.66E-4 ID:SGTC_906|Compound:1165-0455|FD-Score:3.68|P-value:2.84E-4 ID:SGTC_911|Compound:3456-4043|FD-Score:-3.53|P-value:4.78E-4 ID:SGTC_948|Compound:3448-0295|FD-Score:-4.53|P-value:1.10E-5 ID:SGTC_1057|Compound:3448-5381|FD-Score:3.97|P-value:1.03E-4 ID:SGTC_1239|Compound:0337-0584|FD-Score:3.70|P-value:2.64E-4 ID:SGTC_1245|Compound:0418-0076|FD-Score:-4.85|P-value:2.80E-6 ID:SGTC_1247|Compound:0448-0043|FD-Score:-5.58|P-value:8.60E-8 ID:SGTC_1249|Compound:0481-0015|FD-Score:3.54|P-value:4.67E-4 ID:SGTC_1257|Compound:0669-0121|FD-Score:3.44|P-value:6.53E-4 ID:SGTC_1601|Compound:4'-hydroxyflavanone|FD-Score:4.39|P-value:1.97E-5 ID:SGTC_1715|Compound:st032160|FD-Score:3.47|P-value:5.77E-4 ID:SGTC_1720|Compound:st037298|FD-Score:6.33|P-value:1.57E-9 ID:SGTC_1826|Compound:st055655|FD-Score:3.68|P-value:2.87E-4 ID:SGTC_1954|Compound:st077032|FD-Score:-3.37|P-value:7.91E-4 ID:SGTC_2006|Compound:4011487|FD-Score:3.83|P-value:1.71E-4 ID:SGTC_2240|Compound:6690706|FD-Score:3.33|P-value:9.08E-4 ID:SGTC_2260|Compound:7964312|FD-Score:4.34|P-value:2.48E-5 ID:SGTC_2262|Compound:9014885|FD-Score:-3.88|P-value:1.40E-4 ID:SGTC_2297|Compound:7971671|FD-Score:3.67|P-value:2.95E-4 ID:SGTC_2336|Compound:9001819|FD-Score:-4.38|P-value:2.05E-5 ID:SGTC_2337|Compound:9009472|FD-Score:-3.43|P-value:6.56E-4 ID:SGTC_2532|Compound:xanthone|FD-Score:3.86|P-value:1.53E-4 ID:SGTC_2592|Compound:piperlongumine|FD-Score:4.16|P-value:4.86E-5 ID:SGTC_2597|Compound:laccaic acid a|FD-Score:3.48|P-value:5.58E-4 ID:SGTC_2610|Compound:ononetin|FD-Score:-3.74|P-value:2.34E-4 ID:SGTC_2611|Compound:pyromycin|FD-Score:-3.97|P-value:1.03E-4 ID:SGTC_2612|Compound:dictamnine|FD-Score:3.43|P-value:6.67E-4 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:-3.58|P-value:3.96E-4 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:4.49|P-value:1.33E-5 ID:SGTC_2725|Compound:haloperidol|FD-Score:-3.67|P-value:2.91E-4 ID:SGTC_2755|Compound:lomerizine|FD-Score:4.97|P-value:1.66E-6 ID:SGTC_2759|Compound:disulfiram|FD-Score:-3.95|P-value:1.07E-4 ID:SGTC_2912|Compound:7964298|FD-Score:-5.55|P-value:1.03E-7 ID:SGTC_2984|Compound:9022109|FD-Score:-3.93|P-value:1.17E-4 ID:SGTC_3068|Compound:9116768|FD-Score:-3.35|P-value:8.61E-4 ID:SGTC_3089|Compound:9117425|FD-Score:3.64|P-value:3.30E-4 ID:SGTC_3104|Compound:9120930|FD-Score:4.25|P-value:3.45E-5 ID:SGTC_3110|Compound:9122132|FD-Score:-6.14|P-value:4.62E-9 ID:SGTC_3111|Compound:9122088|FD-Score:3.48|P-value:5.66E-4 ID:SGTC_3112|Compound:9123419|FD-Score:-6.23|P-value:2.70E-9 ID:SGTC_3264|Compound:9137442|FD-Score:5.37|P-value:2.55E-7 ID:SGTC_3322|Compound:9139058|FD-Score:3.94|P-value:1.15E-4

Top fitness defect scores for YPL039W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1720 st037298 6.33 9.5 µM 1.57E-9 10 1.23E-10
2 SGTC_20 0481-0013 5.48 4.9 µM 1.48E-7 6 2.16E-8
3 SGTC_3264 9137442 5.37 49.5 µM 2.55E-7 3 4.01E-8
4 SGTC_2755 lomerizine 4.97 42.7 µM 1.66E-6 11 3.38E-7
5 SGTC_2636 apigenin dimethyl ether 4.49 100.0 µM 1.33E-5 28 3.59E-6
6 SGTC_802 4112-3352 4.43 742.0 µM 1.68E-5 14 4.69E-6
7 SGTC_1601 4'-hydroxyflavanone 4.39 55.5 µM 1.97E-5 RPP1 & pyrimidine depletion 20 5.59E-6
8 SGTC_2260 7964312 4.34 200.0 µM 2.48E-5 7 7.27E-6
9 SGTC_3104 9120930 4.25 49.5 µM 3.45E-5 7 1.06E-5
10 SGTC_2592 piperlongumine 4.16 83.3 µM 4.86E-5 TSC3-RPN4 32 1.56E-5
11 SGTC_1057 3448-5381 3.97 134.0 µM 1.03E-4 calcium & mitochondrial duress 27 3.66E-5
12 SGTC_3322 9139058 3.94 2.1 µM 1.15E-4 cell wall 28 4.13E-5
13 SGTC_2532 xanthone 3.86 78.9 µM 1.53E-4 34 5.74E-5
14 SGTC_2006 4011487 3.83 200.0 µM 1.71E-4 endomembrane recycling 84 6.50E-5
15 SGTC_1239 0337-0584 3.70 35.4 µM 2.64E-4 unfolded protein response 66 1.06E-4
16 SGTC_906 1165-0455 3.68 526.0 µM 2.84E-4 16 1.15E-4
17 SGTC_1826 st055655 3.68 41.6 µM 2.87E-4 ERG2 49 1.17E-4
18 SGTC_2297 7971671 3.67 152.3 µM 2.95E-4 RNA processing & uracil transport 37 1.21E-4
19 SGTC_3089 9117425 3.64 49.5 µM 3.30E-4 38 1.37E-4
20 SGTC_1249 0481-0015 3.54 10.2 µM 4.67E-4 37 2.03E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.141 2.56E-16 YDR032C PST2 hom Protein with similarity to a family of flavodoxin-like proteins; induced by oxidative stress in a Yap1p dependent manner; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress; PST2 has a paralog, RFS1, that arose from the whole genome duplication
0.110 1.66E-10 YOR190W SPR1 hom Sporulation-specific exo-1,3-beta-glucanase; contributes to ascospore thermoresistance
0.083 1.45E-6 YML130C ERO1 het Thiol oxidase required for oxidative protein folding in the ER; essential for maintaining proper redox balance in ER; feedback regulation of Ero1p occurs via reduction and oxidation of Ero1p regulatory bonds; reduced Pdi1p activates Ero1p by direct reduction of Ero1p regulatory bonds; depletion of thiol substrates and accumulation of oxidized Pdi1p results in inactivation of Ero1p by both Pdi1p-mediated oxidation and autonomous oxidation of Ero1p regulatory bonds
0.080 3.07E-6 YBR142W MAK5 het Essential nucleolar protein, putative DEAD-box RNA helicase required for maintenance of M1 dsRNA virus; involved in biogenesis of large (60S) ribosomal subunits
0.080 3.13E-6 YIL010W DOT5 hom Nuclear thiol peroxidase which functions as an alkyl-hydroperoxide reductase during post-diauxic growth
0.078 6.17E-6 YOR003W YSP3 hom Putative precursor to the subtilisin-like protease III
0.077 8.82E-6 YPR032W SRO7 hom Effector of Rab GTPase Sec4p; forms a complex with Sec4p and t-SNARE Sec9p; involved in exocytosis and docking and fusion of post-Golgi vesicles with plasma membrane; homolog of Drosophila lgl tumor suppressor; SRO7 has a paralog, SRO77, that arose from the whole genome duplication
0.076 9.89E-6 YFL034C-A RPL22B hom Ribosomal 60S subunit protein L22B; homologous to mammalian ribosomal protein L22, no bacterial homolog; RPL22B has a paralog, RPL22A, that arose from the whole genome duplication
0.074 1.61E-5 YER146W LSM5 het Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA
0.073 2.52E-5 YJL162C JJJ2 hom Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein
0.072 2.65E-5 YFL032W_d YFL032W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene HAC1/YFL031W; YFL032W is not an essential gene
0.072 3.14E-5 YEL016C NPP2 hom Nucleotide pyrophosphatase/phosphodiesterase; mediates extracellular nucleotide phosphate hydrolysis along with Npp1p and Pho5p; activity and expression enhanced during conditions of phosphate starvation; NPP2 has a paralog, NPP1, that arose from the whole genome duplication
0.071 3.49E-5 YPL134C ODC1 hom Mitochondrial inner membrane transporter, exports 2-oxoadipate and 2-oxoglutarate from the mitochondrial matrix to the cytosol for lysine and glutamate biosynthesis and lysine catabolism; suppresses, in multicopy, an fmc1 null mutation
0.069 6.10E-5 YDR370C DXO1 hom Protein with decapping and 5′-3′ exoRNase activity; similar to Rai1p
0.069 6.81E-5 YER134C YER134C hom Magnesium-dependent acid phosphatase, member of the haloacid dehalogenase superfamily; non-essential gene