YPL042C / SSN3

Cyclin-dependent protein kinase, component of RNA polymerase II holoenzyme; involved in phosphorylation of the RNA polymerase II C-terminal domain; involved in glucose repression

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL042C / SSN3

Click on Significant Values for Screen Details ID:SGTC_86|Compound:0417-1630|FD-Score:6.32|P-value:5.51E-8 ID:SGTC_88|Compound:0180-0332|FD-Score:4.86|P-value:2.16E-5 ID:SGTC_89|Compound:0302-0250|FD-Score:4.53|P-value:6.99E-5 ID:SGTC_97|Compound:0535-0701|FD-Score:-3.90|P-value:5.32E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:-5.17|P-value:7.38E-6 ID:SGTC_174|Compound:3553-0389|FD-Score:6.13|P-value:1.30E-7 ID:SGTC_187|Compound:1488-2104|FD-Score:5.84|P-value:4.63E-7 ID:SGTC_198|Compound:3454-2873|FD-Score:-3.96|P-value:4.47E-4 ID:SGTC_268|Compound:camptothecin|FD-Score:3.95|P-value:4.52E-4 ID:SGTC_304|Compound:1310-0298|FD-Score:-4.79|P-value:2.98E-5 ID:SGTC_505|Compound:gw-5074|FD-Score:3.88|P-value:5.56E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:-3.79|P-value:7.36E-4 ID:SGTC_515|Compound:4092-1064|FD-Score:5.30|P-value:4.13E-6 ID:SGTC_524|Compound:r073-0010|FD-Score:-3.92|P-value:5.13E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:5.57|P-value:1.40E-6 ID:SGTC_682|Compound:0kpi-0099|FD-Score:12.80|P-value:2.20E-27 ID:SGTC_710|Compound:3448-4187|FD-Score:4.29|P-value:1.55E-4 ID:SGTC_892|Compound:0929-0076|FD-Score:3.70|P-value:9.30E-4 ID:SGTC_897|Compound:1000-0139|FD-Score:-4.28|P-value:1.66E-4 ID:SGTC_902|Compound:1120-0002|FD-Score:4.23|P-value:1.84E-4 ID:SGTC_1022|Compound:4477-0945|FD-Score:4.64|P-value:4.75E-5 ID:SGTC_1048|Compound:3161-0300|FD-Score:3.98|P-value:4.08E-4 ID:SGTC_1112|Compound:tnp00069|FD-Score:3.93|P-value:4.71E-4 ID:SGTC_1230|Compound:0170-0365|FD-Score:-3.73|P-value:8.92E-4 ID:SGTC_1231|Compound:0242-0792|FD-Score:5.10|P-value:8.88E-6 ID:SGTC_1291|Compound:0993-0025|FD-Score:4.08|P-value:3.04E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:4.12|P-value:2.68E-4 ID:SGTC_1604|Compound:st002052|FD-Score:-4.06|P-value:3.28E-4 ID:SGTC_1624|Compound:st003710|FD-Score:4.02|P-value:3.56E-4 ID:SGTC_1683|Compound:st010134|FD-Score:5.56|P-value:1.50E-6 ID:SGTC_1687|Compound:st020778|FD-Score:4.74|P-value:3.31E-5 ID:SGTC_1707|Compound:st032323|FD-Score:4.03|P-value:3.52E-4 ID:SGTC_1712|Compound:st032288|FD-Score:8.37|P-value:1.01E-12 ID:SGTC_1714|Compound:st033236|FD-Score:-4.37|P-value:1.26E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:-8.48|P-value:5.42E-13 ID:SGTC_1723|Compound:st034307|FD-Score:5.72|P-value:7.43E-7 ID:SGTC_1745|Compound:st081495|FD-Score:-4.00|P-value:4.03E-4 ID:SGTC_1800|Compound:st050079|FD-Score:5.33|P-value:3.73E-6 ID:SGTC_1801|Compound:st050089|FD-Score:5.44|P-value:2.42E-6 ID:SGTC_1803|Compound:st050068|FD-Score:7.18|P-value:7.81E-10 ID:SGTC_1812|Compound:st052057|FD-Score:4.00|P-value:3.83E-4 ID:SGTC_1877|Compound:wortmannin|FD-Score:11.00|P-value:1.32E-20 ID:SGTC_1937|Compound:st074714|FD-Score:-4.94|P-value:1.71E-5 ID:SGTC_1949|Compound:st076024|FD-Score:3.73|P-value:8.59E-4 ID:SGTC_2063|Compound:5246145|FD-Score:5.33|P-value:3.68E-6 ID:SGTC_2068|Compound:5226020|FD-Score:-3.71|P-value:9.31E-4 ID:SGTC_2078|Compound:5212016|FD-Score:-3.82|P-value:6.86E-4 ID:SGTC_2191|Compound:5911152|FD-Score:3.75|P-value:8.08E-4 ID:SGTC_2199|Compound:6590217|FD-Score:4.77|P-value:2.98E-5 ID:SGTC_2351|Compound:9026858|FD-Score:-3.89|P-value:5.47E-4 ID:SGTC_2540|Compound:epiandrosterone|FD-Score:6.33|P-value:5.14E-8 ID:SGTC_2544|Compound:sphondin|FD-Score:-4.44|P-value:9.89E-5 ID:SGTC_2575|Compound:plumbagin|FD-Score:3.78|P-value:7.38E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:-7.59|P-value:9.80E-11 ID:SGTC_2584|Compound:androsterone|FD-Score:-6.69|P-value:1.00E-8 ID:SGTC_2594|Compound:a-mangostin|FD-Score:-4.40|P-value:1.12E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:7.16|P-value:8.90E-10 ID:SGTC_2730|Compound:imipramine|FD-Score:3.91|P-value:5.08E-4 ID:SGTC_2751|Compound:anetholtrithion|FD-Score:-3.99|P-value:4.10E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:-4.68|P-value:4.31E-5 ID:SGTC_2759|Compound:disulfiram|FD-Score:-4.37|P-value:1.25E-4 ID:SGTC_2834|Compound:9001755|FD-Score:4.21|P-value:1.99E-4 ID:SGTC_2842|Compound:9000675|FD-Score:4.53|P-value:6.85E-5 ID:SGTC_3125|Compound:9127534|FD-Score:-4.66|P-value:4.73E-5 ID:SGTC_3128|Compound:9127691|FD-Score:4.45|P-value:9.13E-5 ID:SGTC_3138|Compound:9097216|FD-Score:4.04|P-value:3.42E-4 ID:SGTC_3219|Compound:9131112|FD-Score:-4.37|P-value:1.23E-4 ID:SGTC_3266|Compound:9136860|FD-Score:-6.43|P-value:3.41E-8 ID:SGTC_3328|Compound:9140624|FD-Score:-4.02|P-value:3.74E-4 ID:SGTC_3337|Compound:9144342|FD-Score:5.33|P-value:3.78E-6 ID:SGTC_86|Compound:0417-1630|FD-Score:6.32|P-value:5.51E-8 ID:SGTC_88|Compound:0180-0332|FD-Score:4.86|P-value:2.16E-5 ID:SGTC_89|Compound:0302-0250|FD-Score:4.53|P-value:6.99E-5 ID:SGTC_97|Compound:0535-0701|FD-Score:-3.90|P-value:5.32E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:-5.17|P-value:7.38E-6 ID:SGTC_174|Compound:3553-0389|FD-Score:6.13|P-value:1.30E-7 ID:SGTC_187|Compound:1488-2104|FD-Score:5.84|P-value:4.63E-7 ID:SGTC_198|Compound:3454-2873|FD-Score:-3.96|P-value:4.47E-4 ID:SGTC_268|Compound:camptothecin|FD-Score:3.95|P-value:4.52E-4 ID:SGTC_304|Compound:1310-0298|FD-Score:-4.79|P-value:2.98E-5 ID:SGTC_505|Compound:gw-5074|FD-Score:3.88|P-value:5.56E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:-3.79|P-value:7.36E-4 ID:SGTC_515|Compound:4092-1064|FD-Score:5.30|P-value:4.13E-6 ID:SGTC_524|Compound:r073-0010|FD-Score:-3.92|P-value:5.13E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:5.57|P-value:1.40E-6 ID:SGTC_682|Compound:0kpi-0099|FD-Score:12.80|P-value:2.20E-27 ID:SGTC_710|Compound:3448-4187|FD-Score:4.29|P-value:1.55E-4 ID:SGTC_892|Compound:0929-0076|FD-Score:3.70|P-value:9.30E-4 ID:SGTC_897|Compound:1000-0139|FD-Score:-4.28|P-value:1.66E-4 ID:SGTC_902|Compound:1120-0002|FD-Score:4.23|P-value:1.84E-4 ID:SGTC_1022|Compound:4477-0945|FD-Score:4.64|P-value:4.75E-5 ID:SGTC_1048|Compound:3161-0300|FD-Score:3.98|P-value:4.08E-4 ID:SGTC_1112|Compound:tnp00069|FD-Score:3.93|P-value:4.71E-4 ID:SGTC_1230|Compound:0170-0365|FD-Score:-3.73|P-value:8.92E-4 ID:SGTC_1231|Compound:0242-0792|FD-Score:5.10|P-value:8.88E-6 ID:SGTC_1291|Compound:0993-0025|FD-Score:4.08|P-value:3.04E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:4.12|P-value:2.68E-4 ID:SGTC_1604|Compound:st002052|FD-Score:-4.06|P-value:3.28E-4 ID:SGTC_1624|Compound:st003710|FD-Score:4.02|P-value:3.56E-4 ID:SGTC_1683|Compound:st010134|FD-Score:5.56|P-value:1.50E-6 ID:SGTC_1687|Compound:st020778|FD-Score:4.74|P-value:3.31E-5 ID:SGTC_1707|Compound:st032323|FD-Score:4.03|P-value:3.52E-4 ID:SGTC_1712|Compound:st032288|FD-Score:8.37|P-value:1.01E-12 ID:SGTC_1714|Compound:st033236|FD-Score:-4.37|P-value:1.26E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:-8.48|P-value:5.42E-13 ID:SGTC_1723|Compound:st034307|FD-Score:5.72|P-value:7.43E-7 ID:SGTC_1745|Compound:st081495|FD-Score:-4.00|P-value:4.03E-4 ID:SGTC_1800|Compound:st050079|FD-Score:5.33|P-value:3.73E-6 ID:SGTC_1801|Compound:st050089|FD-Score:5.44|P-value:2.42E-6 ID:SGTC_1803|Compound:st050068|FD-Score:7.18|P-value:7.81E-10 ID:SGTC_1812|Compound:st052057|FD-Score:4.00|P-value:3.83E-4 ID:SGTC_1877|Compound:wortmannin|FD-Score:11.00|P-value:1.32E-20 ID:SGTC_1937|Compound:st074714|FD-Score:-4.94|P-value:1.71E-5 ID:SGTC_1949|Compound:st076024|FD-Score:3.73|P-value:8.59E-4 ID:SGTC_2063|Compound:5246145|FD-Score:5.33|P-value:3.68E-6 ID:SGTC_2068|Compound:5226020|FD-Score:-3.71|P-value:9.31E-4 ID:SGTC_2078|Compound:5212016|FD-Score:-3.82|P-value:6.86E-4 ID:SGTC_2191|Compound:5911152|FD-Score:3.75|P-value:8.08E-4 ID:SGTC_2199|Compound:6590217|FD-Score:4.77|P-value:2.98E-5 ID:SGTC_2351|Compound:9026858|FD-Score:-3.89|P-value:5.47E-4 ID:SGTC_2540|Compound:epiandrosterone|FD-Score:6.33|P-value:5.14E-8 ID:SGTC_2544|Compound:sphondin|FD-Score:-4.44|P-value:9.89E-5 ID:SGTC_2575|Compound:plumbagin|FD-Score:3.78|P-value:7.38E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:-7.59|P-value:9.80E-11 ID:SGTC_2584|Compound:androsterone|FD-Score:-6.69|P-value:1.00E-8 ID:SGTC_2594|Compound:a-mangostin|FD-Score:-4.40|P-value:1.12E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:7.16|P-value:8.90E-10 ID:SGTC_2730|Compound:imipramine|FD-Score:3.91|P-value:5.08E-4 ID:SGTC_2751|Compound:anetholtrithion|FD-Score:-3.99|P-value:4.10E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:-4.68|P-value:4.31E-5 ID:SGTC_2759|Compound:disulfiram|FD-Score:-4.37|P-value:1.25E-4 ID:SGTC_2834|Compound:9001755|FD-Score:4.21|P-value:1.99E-4 ID:SGTC_2842|Compound:9000675|FD-Score:4.53|P-value:6.85E-5 ID:SGTC_3125|Compound:9127534|FD-Score:-4.66|P-value:4.73E-5 ID:SGTC_3128|Compound:9127691|FD-Score:4.45|P-value:9.13E-5 ID:SGTC_3138|Compound:9097216|FD-Score:4.04|P-value:3.42E-4 ID:SGTC_3219|Compound:9131112|FD-Score:-4.37|P-value:1.23E-4 ID:SGTC_3266|Compound:9136860|FD-Score:-6.43|P-value:3.41E-8 ID:SGTC_3328|Compound:9140624|FD-Score:-4.02|P-value:3.74E-4 ID:SGTC_3337|Compound:9144342|FD-Score:5.33|P-value:3.78E-6

Top fitness defect scores for YPL042C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_682 0kpi-0099 12.80 17.0 µM 2.20E-27 3 5.76E-38
2 SGTC_1877 wortmannin 11.00 25.0 µM 1.32E-20 8 2.18E-28
3 SGTC_1712 st032288 8.37 53.4 µM 1.01E-12 calcium & mitochondrial duress 39 2.92E-17
4 SGTC_1803 st050068 7.18 52.4 µM 7.81E-10 NEO1-PIK1 52 3.40E-13
5 SGTC_2688 kanamycin b 7.16 96.7 µM 8.90E-10 calcium & mitochondrial duress 102 4.08E-13
6 SGTC_2540 epiandrosterone 6.33 100.0 µM 5.14E-8 19 1.22E-10
7 SGTC_86 0417-1630 6.32 471.9 µM 5.51E-8 ubiquinone biosynthesis & proteasome 83 1.35E-10
8 SGTC_174 3553-0389 6.13 74.3 µM 1.30E-7 3 4.49E-10
9 SGTC_187 1488-2104 5.84 32.7 µM 4.63E-7 calcium & mitochondrial duress 16 2.66E-9
10 SGTC_1723 st034307 5.72 2.5 µM 7.43E-7 mitochondrial processes 8 5.17E-9
11 SGTC_528 3492-0019 5.57 172.0 µM 1.40E-6 calcium & mitochondrial duress 135 1.26E-8
12 SGTC_1683 st010134 5.56 710.0 nM 1.50E-6 7 1.39E-8
13 SGTC_1801 st050089 5.44 28.4 µM 2.42E-6 NEO1-PIK1 57 2.71E-8
14 SGTC_2063 5246145 5.33 200.0 µM 3.68E-6 9 4.86E-8
15 SGTC_1800 st050079 5.33 29.1 µM 3.73E-6 NEO1-PIK1 64 4.95E-8
16 SGTC_3337 9144342 5.33 33.5 µM 3.78E-6 15 5.04E-8
17 SGTC_515 4092-1064 5.30 102.0 µM 4.13E-6 plasma membrane duress 32 5.70E-8
18 SGTC_1231 0242-0792 5.10 125.0 µM 8.88E-6 7 1.67E-7
19 SGTC_88 0180-0332 4.86 8.7 µM 2.16E-5 7 5.75E-7
20 SGTC_2199 6590217 4.77 200.0 µM 2.98E-5 mitochondrial processes 1 9.05E-7

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.344 9.92E-94 YDR443C SSN2 hom Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; required for stable association of Srb10p-Srb11p kinase; essential for transcriptional regulation
0.262 8.80E-54 YPR070W MED1 hom Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation
0.238 2.40E-44 YGR164W_d YGR164W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.223 4.38E-39 YJL164C TPK1 hom cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; inhibited by regulatory subunit Bcy1p in the absence of cAMP; regulates Whi3p; partially redundant with Tpk2p and Tpk3p; TPK1 has a paralog, TPK3, that arose from the whole genome duplication
0.217 5.00E-37 YDL019C OSH2 hom Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability
0.214 3.96E-36 YML126C ERG13 het 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) synthase, catalyzes the formation of HMG-CoA from acetyl-CoA and acetoacetyl-CoA; involved in the second step in mevalonate biosynthesis
0.199 2.82E-31 YJL165C HAL5 hom Putative protein kinase; overexpression increases sodium and lithium tolerance, whereas gene disruption increases cation and low pH sensitivity and impairs potassium uptake, suggesting a role in regulation of Trk1p and/or Trk2p transporters; HAL5 has a paralog, KKQ8, that arose from the whole genome duplication
0.187 9.45E-28 YDR442W_d YDR442W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.186 1.24E-27 YJL129C TRK1 hom Component of the Trk1p-Trk2p potassium transport system; 180 kDa high affinity potassium transporter; phosphorylated in vivo and interacts physically with the phosphatase Ppz1p, suggesting Trk1p acitivy is regulated by phosphorylation; TRK1 has a paralog, TRK2, that arose from the whole genome duplication
0.185 3.51E-27 YPL145C KES1 hom One of seven members of the yeast oxysterol binding protein family; involved in negative regulation of Sec14p-dependent Golgi complex secretory functions, peripheral membrane protein that localizes to the Golgi complex; KES1 has a paralog, HES1, that arose from the whole genome duplication
0.184 7.05E-27 YAL002W VPS8 hom Membrane-binding component of the CORVET complex; involved in endosomal vesicle tethering and fusion in the endosome to vacuole protein targeting pathway; interacts with Vps21p; contains RING finger motif
0.183 9.78E-27 YBL051C PIN4 hom Protein involved in G2/M phase progression and response to DNA damage, interacts with Rad53p; contains an RNA recognition motif, a nuclear localization signal, and several SQ/TQ cluster domains; hyperphosphorylated in response to DNA damage
0.179 1.11E-25 YIL105C SLM1 hom Phosphoinositide PI4,5P(2) binding protein, forms a complex with Slm2p; acts downstream of Mss4p in a pathway regulating actin cytoskeleton organization in response to stress; phosphorylated by the TORC2 complex; protein abundance increases in response to DNA replication stress; SLM1 has a paralog, SLM2, that arose from the whole genome duplication
0.179 1.13E-25 YGL035C MIG1 hom Transcription factor involved in glucose repression; sequence specific DNA binding protein containing two Cys2His2 zinc finger motifs; regulated by the SNF1 kinase and the GLC7 phosphatase; regulates filamentous growth along with Mig2p in response to glucose depletion
0.178 2.16E-25 YOL081W IRA2 hom GTPase-activating protein; negatively regulates RAS by converting it from the GTP- to the GDP-bound inactive form, required for reducing cAMP levels under nutrient limiting conditions; similar to human neurofibromin; IRA2 has a paralog, IRA1, that arose from the whole genome duplication