YPL044C_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene NOP4/YPL043W

Zygosity: Heterozygous strain
fixedexpanded
Profile for YPL044C / YPL044C

Click on Significant Values for Screen Details ID:SGTC_65|Compound:0798-0905|FD-Score:4.39|P-value:1.06E-6 ID:SGTC_118|Compound:0083-0097|FD-Score:3.07|P-value:4.64E-4 ID:SGTC_242|Compound:5hr heat shock (37°C) + 5-fluorouracil|FD-Score:4.53|P-value:5.05E-7 ID:SGTC_370|Compound:0180-0345|FD-Score:-3.48|P-value:7.12E-5 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:9.62|P-value:1.01E-25 ID:SGTC_432|Compound:NS 1619|FD-Score:3.22|P-value:2.61E-4 ID:SGTC_533|Compound:1222-0222|FD-Score:4.20|P-value:2.84E-6 ID:SGTC_610|Compound:4215-0184|FD-Score:5.28|P-value:5.66E-9 ID:SGTC_633|Compound:0437-0093|FD-Score:-3.51|P-value:6.26E-5 ID:SGTC_832|Compound:4083-0019|FD-Score:4.14|P-value:3.83E-6 ID:SGTC_1013|Compound:4112-3890|FD-Score:3.64|P-value:4.29E-5 ID:SGTC_1042|Compound:0350-0096|FD-Score:2.90|P-value:8.88E-4 ID:SGTC_1074|Compound:carmofur|FD-Score:5.27|P-value:5.88E-9 ID:SGTC_1077|Compound:5-fluorocytosine|FD-Score:3.97|P-value:9.06E-6 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.03|P-value:4.62E-4 ID:SGTC_1108|Compound:betulinic acid|FD-Score:3.00|P-value:6.21E-4 ID:SGTC_1247|Compound:0448-0043|FD-Score:2.93|P-value:7.96E-4 ID:SGTC_1262|Compound:0737-0114|FD-Score:3.65|P-value:4.01E-5 ID:SGTC_1292|Compound:0kpi-0043|FD-Score:3.04|P-value:5.27E-4 ID:SGTC_1353|Compound:1498-1206|FD-Score:-6.37|P-value:1.94E-12 ID:SGTC_1587|Compound:estradiol valerate|FD-Score:2.89|P-value:9.25E-4 ID:SGTC_1698|Compound:5-fluorocytosine|FD-Score:3.44|P-value:1.05E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:-2.83|P-value:9.77E-4 ID:SGTC_1789|Compound:tunicamycin|FD-Score:-2.99|P-value:5.36E-4 ID:SGTC_2125|Compound:5246583|FD-Score:3.09|P-value:4.35E-4 ID:SGTC_2134|Compound:5324836|FD-Score:3.74|P-value:2.68E-5 ID:SGTC_2455|Compound:5377712|FD-Score:-3.06|P-value:4.17E-4 ID:SGTC_2458|Compound:5808907|FD-Score:3.43|P-value:1.07E-4 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:-4.95|P-value:3.33E-8 ID:SGTC_2568|Compound:diosmetin|FD-Score:4.33|P-value:1.48E-6 ID:SGTC_2833|Compound:9001315|FD-Score:3.07|P-value:4.59E-4 ID:SGTC_2849|Compound:9019321|FD-Score:4.76|P-value:1.34E-7 ID:SGTC_2857|Compound:9024691|FD-Score:2.87|P-value:9.80E-4 ID:SGTC_2927|Compound:9011802|FD-Score:3.63|P-value:4.50E-5 ID:SGTC_2948|Compound:9070189|FD-Score:-2.94|P-value:6.39E-4 ID:SGTC_2971|Compound:9092186|FD-Score:-2.89|P-value:7.72E-4 ID:SGTC_3194|Compound:9111903|FD-Score:3.15|P-value:3.42E-4 ID:SGTC_3274|Compound:9138298|FD-Score:3.00|P-value:6.19E-4 ID:SGTC_65|Compound:0798-0905|FD-Score:4.39|P-value:1.06E-6 ID:SGTC_118|Compound:0083-0097|FD-Score:3.07|P-value:4.64E-4 ID:SGTC_242|Compound:5hr heat shock (37°C) + 5-fluorouracil|FD-Score:4.53|P-value:5.05E-7 ID:SGTC_370|Compound:0180-0345|FD-Score:-3.48|P-value:7.12E-5 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:9.62|P-value:1.01E-25 ID:SGTC_432|Compound:NS 1619|FD-Score:3.22|P-value:2.61E-4 ID:SGTC_533|Compound:1222-0222|FD-Score:4.20|P-value:2.84E-6 ID:SGTC_610|Compound:4215-0184|FD-Score:5.28|P-value:5.66E-9 ID:SGTC_633|Compound:0437-0093|FD-Score:-3.51|P-value:6.26E-5 ID:SGTC_832|Compound:4083-0019|FD-Score:4.14|P-value:3.83E-6 ID:SGTC_1013|Compound:4112-3890|FD-Score:3.64|P-value:4.29E-5 ID:SGTC_1042|Compound:0350-0096|FD-Score:2.90|P-value:8.88E-4 ID:SGTC_1074|Compound:carmofur|FD-Score:5.27|P-value:5.88E-9 ID:SGTC_1077|Compound:5-fluorocytosine|FD-Score:3.97|P-value:9.06E-6 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.03|P-value:4.62E-4 ID:SGTC_1108|Compound:betulinic acid|FD-Score:3.00|P-value:6.21E-4 ID:SGTC_1247|Compound:0448-0043|FD-Score:2.93|P-value:7.96E-4 ID:SGTC_1262|Compound:0737-0114|FD-Score:3.65|P-value:4.01E-5 ID:SGTC_1292|Compound:0kpi-0043|FD-Score:3.04|P-value:5.27E-4 ID:SGTC_1353|Compound:1498-1206|FD-Score:-6.37|P-value:1.94E-12 ID:SGTC_1587|Compound:estradiol valerate|FD-Score:2.89|P-value:9.25E-4 ID:SGTC_1698|Compound:5-fluorocytosine|FD-Score:3.44|P-value:1.05E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:-2.83|P-value:9.77E-4 ID:SGTC_1789|Compound:tunicamycin|FD-Score:-2.99|P-value:5.36E-4 ID:SGTC_2125|Compound:5246583|FD-Score:3.09|P-value:4.35E-4 ID:SGTC_2134|Compound:5324836|FD-Score:3.74|P-value:2.68E-5 ID:SGTC_2455|Compound:5377712|FD-Score:-3.06|P-value:4.17E-4 ID:SGTC_2458|Compound:5808907|FD-Score:3.43|P-value:1.07E-4 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:-4.95|P-value:3.33E-8 ID:SGTC_2568|Compound:diosmetin|FD-Score:4.33|P-value:1.48E-6 ID:SGTC_2833|Compound:9001315|FD-Score:3.07|P-value:4.59E-4 ID:SGTC_2849|Compound:9019321|FD-Score:4.76|P-value:1.34E-7 ID:SGTC_2857|Compound:9024691|FD-Score:2.87|P-value:9.80E-4 ID:SGTC_2927|Compound:9011802|FD-Score:3.63|P-value:4.50E-5 ID:SGTC_2948|Compound:9070189|FD-Score:-2.94|P-value:6.39E-4 ID:SGTC_2971|Compound:9092186|FD-Score:-2.89|P-value:7.72E-4 ID:SGTC_3194|Compound:9111903|FD-Score:3.15|P-value:3.42E-4 ID:SGTC_3274|Compound:9138298|FD-Score:3.00|P-value:6.19E-4

Top fitness defect scores for YPL044C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_423 5-fluorouracil 9.62 457.0 µM 1.01E-25 exosome 8 3.35E-22 2.32
2 SGTC_610 4215-0184 5.28 155.0 µM 5.66E-9 exosome 16 6.45E-8 0.32
3 SGTC_1074 carmofur 5.27 3.8 µM 5.88E-9 exosome 19 6.66E-8 0.50
4 SGTC_2849 9019321 4.76 13.0 µM 1.34E-7 2 9.65E-7 0.02
5 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.53 4.6 µM 5.05E-7 heat shock/prefoldin 18 3.02E-6 0.03
6 SGTC_65 0798-0905 4.39 35.0 µM 1.06E-6 calcium & mitochondrial duress 6 5.72E-6 0.14
7 SGTC_2568 diosmetin 4.33 100.0 µM 1.48E-6 4 7.59E-6 0.03
8 SGTC_533 1222-0222 4.20 6.7 µM 2.84E-6 PDR1 11 1.33E-5 0.20
9 SGTC_832 4083-0019 4.14 164.0 µM 3.83E-6 translation 25 1.72E-5 0.14
10 SGTC_1077 5-fluorocytosine 3.97 377.0 nM 9.06E-6 exosome 18 3.59E-5 0.24
11 SGTC_2134 5324836 3.74 1.5 µM 2.68E-5 4 9.12E-5 0.50
12 SGTC_1262 0737-0114 3.65 49.6 µM 4.01E-5 5 1.29E-4 0.02
13 SGTC_1013 4112-3890 3.64 241.0 µM 4.29E-5 TSC3-RPN4 9 1.37E-4 0.19
14 SGTC_2927 9011802 3.63 47.9 µM 4.50E-5 10 1.42E-4 0.08
15 SGTC_1698 5-fluorocytosine 3.44 1.1 µM 1.05E-4 exosome 19 2.96E-4 0.10
16 SGTC_2458 5808907 3.43 16.4 µM 1.07E-4 8 3.01E-4 0.06
17 SGTC_432 NS 1619 3.22 61.3 µM 2.61E-4 15 6.49E-4 0.10
18 SGTC_3194 9111903 3.15 49.5 µM 3.42E-4 8 8.17E-4 0.01
19 SGTC_2125 5246583 3.09 200.0 µM 4.35E-4 tubulin folding & SWR complex 12 0.00101 0.03
20 SGTC_2833 9001315 3.07 45.5 µM 4.59E-4 amide catabolism 16 0.00106 0.01

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.471 1.58E-184 YGR195W SKI6 het Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp41p (EXOSC4)
0.397 9.31E-127 YDL111C RRP42 het Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp42p (EXOSC7)
0.388 4.11E-121 YPL043W NOP4 het Nucleolar protein, essential for processing and maturation of 27S pre-rRNA and large ribosomal subunit biogenesis; constituent of 66S pre-ribosomal particles; contains four RNA recognition motifs (RRMs)
0.380 9.80E-116 YKL172W EBP2 het Required for 25S rRNA maturation and 60S ribosomal subunit assembly; localizes to the nucleolus and in foci along nuclear periphery; constituent of 66S pre-ribosomal particles; cooperates with Rrs1p and Mps3p to mediate telomere clustering by binding Sir4p, but is not involved in telomere tethering
0.373 1.53E-111 YGR158C MTR3 het Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hMtr3p (EXOSC6)
0.369 1.31E-108 YPR142C_d YPR142C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RRP15, which is required for ribosomal RNA processing
0.313 5.74E-77 YOL021C DIS3 het Exosome core complex catalytic subunit; possesses both endonuclease and 3'-5' exonuclease activity; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase R and to human DIS3; protein abundance increases in response to DNA replication stress
0.302 1.42E-71 YPR143W RRP15 het Nucleolar protein, constituent of pre-60S ribosomal particles; required for proper processing of the 27S pre-rRNA at the A3 and B1 sites to yield mature 5.8S and 25S rRNAs
0.300 7.82E-71 YDR280W RRP45 het Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp45p (PM/SCL-75, EXOSC9); protein abundance increases in response to DNA replication stress
0.269 1.28E-56 YGR095C RRP46 het Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp46p (EXOSC5)
0.233 1.55E-42 YKL021C MAK11 het Protein involved in an early, nucleolar step of 60S ribosomal subunit biogenesis; essential for cell growth and replication of killer M1 dsRNA virus; contains four beta-transducin repeats
0.223 3.81E-39 YNL232W CSL4 het Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; predicted to contain an S1 RNA binding domain; has similarity to human hCsl4p (EXOSC1)
0.217 7.28E-37 YNL061W NOP2 het Probable RNA m(5)C methyltransferase, essential for processing and maturation of 27S pre-rRNA and large ribosomal subunit biogenesis; localized to the nucleolus; constituent of 66S pre-ribosomal particles
0.212 1.91E-35 YDR060W MAK21 het Constituent of 66S pre-ribosomal particles, required for large (60S) ribosomal subunit biogenesis; involved in nuclear export of pre-ribosomes; required for maintenance of dsRNA virus; homolog of human CAATT-binding protein
0.184 6.77E-27 YNL002C RLP7 het Nucleolar protein with similarity to large ribosomal subunit L7 proteins; constituent of 66S pre-ribosomal particles; plays an essential role in processing of precursors to the large ribosomal subunit RNAs