YPL047W / SGF11

Integral subunit of SAGA histone acetyltransferase complex, regulates transcription of a subset of SAGA-regulated genes, required for the Ubp8p association with SAGA and for H2B deubiquitylation

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL047W / SGF11

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:5.00|P-value:2.67E-7 ID:SGTC_116|Compound:0155-0182|FD-Score:5.30|P-value:5.56E-8 ID:SGTC_141|Compound:0443-0274|FD-Score:7.08|P-value:6.85E-13 ID:SGTC_184|Compound:1494-0393|FD-Score:3.79|P-value:7.02E-5 ID:SGTC_241|Compound:5hr heat shock (37°C) + cantharidin|FD-Score:4.71|P-value:1.16E-6 ID:SGTC_268|Compound:camptothecin|FD-Score:4.35|P-value:6.38E-6 ID:SGTC_304|Compound:1310-0298|FD-Score:3.55|P-value:1.82E-4 ID:SGTC_312|Compound:4092-0653|FD-Score:3.78|P-value:7.55E-5 ID:SGTC_334|Compound:1502-1024|FD-Score:3.78|P-value:7.53E-5 ID:SGTC_351|Compound:caspofungin|FD-Score:3.47|P-value:2.45E-4 ID:SGTC_403|Compound:arphamenine a|FD-Score:4.29|P-value:8.54E-6 ID:SGTC_405|Compound:ebelactone b|FD-Score:3.46|P-value:2.53E-4 ID:SGTC_495|Compound:decylubiquinone|FD-Score:3.20|P-value:6.52E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:4.18|P-value:1.35E-5 ID:SGTC_526|Compound:4469-0568|FD-Score:-3.19|P-value:7.81E-4 ID:SGTC_548|Compound:1436-0017|FD-Score:3.11|P-value:8.93E-4 ID:SGTC_690|Compound:glyoxal|FD-Score:3.14|P-value:7.95E-4 ID:SGTC_777|Compound:1315-0167|FD-Score:6.87|P-value:3.12E-12 ID:SGTC_778|Compound:3456-2434|FD-Score:10.60|P-value:1.60E-26 ID:SGTC_780|Compound:0109-0199|FD-Score:5.74|P-value:4.36E-9 ID:SGTC_885|Compound:0865-0106|FD-Score:3.44|P-value:2.76E-4 ID:SGTC_890|Compound:0929-0006|FD-Score:-4.13|P-value:2.01E-5 ID:SGTC_898|Compound:1000-0849|FD-Score:3.44|P-value:2.79E-4 ID:SGTC_974|Compound:1326-0144|FD-Score:3.25|P-value:5.42E-4 ID:SGTC_1036|Compound:k216-0215|FD-Score:7.74|P-value:4.56E-15 ID:SGTC_1180|Compound:1193-0155|FD-Score:3.21|P-value:6.39E-4 ID:SGTC_1370|Compound:2001-0092|FD-Score:3.10|P-value:9.23E-4 ID:SGTC_1372|Compound:2752-0194|FD-Score:-3.21|P-value:7.21E-4 ID:SGTC_1445|Compound:4239-0156|FD-Score:4.18|P-value:1.39E-5 ID:SGTC_1630|Compound:st005209|FD-Score:-3.26|P-value:6.09E-4 ID:SGTC_1652|Compound:st011932|FD-Score:3.63|P-value:1.32E-4 ID:SGTC_1741|Compound:st038134|FD-Score:-5.06|P-value:2.42E-7 ID:SGTC_1742|Compound:st038235|FD-Score:3.09|P-value:9.66E-4 ID:SGTC_1893|Compound:st059353|FD-Score:3.91|P-value:4.41E-5 ID:SGTC_2040|Compound:5100729|FD-Score:4.47|P-value:3.76E-6 ID:SGTC_2054|Compound:5233173|FD-Score:8.27|P-value:6.13E-17 ID:SGTC_2082|Compound:5219693|FD-Score:-4.45|P-value:4.81E-6 ID:SGTC_2160|Compound:5660466|FD-Score:4.92|P-value:4.07E-7 ID:SGTC_2172|Compound:5754775|FD-Score:-3.56|P-value:2.04E-4 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:4.04|P-value:2.47E-5 ID:SGTC_2469|Compound:5655019|FD-Score:4.56|P-value:2.40E-6 ID:SGTC_2974|Compound:9094440|FD-Score:3.30|P-value:4.53E-4 ID:SGTC_3054|Compound:9094397|FD-Score:-3.48|P-value:2.77E-4 ID:SGTC_3062|Compound:9077494|FD-Score:5.86|P-value:2.17E-9 ID:SGTC_3101|Compound:9120531|FD-Score:4.35|P-value:6.30E-6 ID:SGTC_3102|Compound:9121669|FD-Score:4.35|P-value:6.30E-6 ID:SGTC_3106|Compound:9121286|FD-Score:5.60|P-value:1.02E-8 ID:SGTC_3145|Compound:9085516|FD-Score:-3.75|P-value:9.82E-5 ID:SGTC_3168|Compound:9103419|FD-Score:-4.13|P-value:2.00E-5 ID:SGTC_3207|Compound:9114163|FD-Score:-3.78|P-value:8.70E-5 ID:SGTC_3247|Compound:9135149|FD-Score:3.19|P-value:6.72E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:5.00|P-value:2.67E-7 ID:SGTC_116|Compound:0155-0182|FD-Score:5.30|P-value:5.56E-8 ID:SGTC_141|Compound:0443-0274|FD-Score:7.08|P-value:6.85E-13 ID:SGTC_184|Compound:1494-0393|FD-Score:3.79|P-value:7.02E-5 ID:SGTC_241|Compound:5hr heat shock (37°C) + cantharidin|FD-Score:4.71|P-value:1.16E-6 ID:SGTC_268|Compound:camptothecin|FD-Score:4.35|P-value:6.38E-6 ID:SGTC_304|Compound:1310-0298|FD-Score:3.55|P-value:1.82E-4 ID:SGTC_312|Compound:4092-0653|FD-Score:3.78|P-value:7.55E-5 ID:SGTC_334|Compound:1502-1024|FD-Score:3.78|P-value:7.53E-5 ID:SGTC_351|Compound:caspofungin|FD-Score:3.47|P-value:2.45E-4 ID:SGTC_403|Compound:arphamenine a|FD-Score:4.29|P-value:8.54E-6 ID:SGTC_405|Compound:ebelactone b|FD-Score:3.46|P-value:2.53E-4 ID:SGTC_495|Compound:decylubiquinone|FD-Score:3.20|P-value:6.52E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:4.18|P-value:1.35E-5 ID:SGTC_526|Compound:4469-0568|FD-Score:-3.19|P-value:7.81E-4 ID:SGTC_548|Compound:1436-0017|FD-Score:3.11|P-value:8.93E-4 ID:SGTC_690|Compound:glyoxal|FD-Score:3.14|P-value:7.95E-4 ID:SGTC_777|Compound:1315-0167|FD-Score:6.87|P-value:3.12E-12 ID:SGTC_778|Compound:3456-2434|FD-Score:10.60|P-value:1.60E-26 ID:SGTC_780|Compound:0109-0199|FD-Score:5.74|P-value:4.36E-9 ID:SGTC_885|Compound:0865-0106|FD-Score:3.44|P-value:2.76E-4 ID:SGTC_890|Compound:0929-0006|FD-Score:-4.13|P-value:2.01E-5 ID:SGTC_898|Compound:1000-0849|FD-Score:3.44|P-value:2.79E-4 ID:SGTC_974|Compound:1326-0144|FD-Score:3.25|P-value:5.42E-4 ID:SGTC_1036|Compound:k216-0215|FD-Score:7.74|P-value:4.56E-15 ID:SGTC_1180|Compound:1193-0155|FD-Score:3.21|P-value:6.39E-4 ID:SGTC_1370|Compound:2001-0092|FD-Score:3.10|P-value:9.23E-4 ID:SGTC_1372|Compound:2752-0194|FD-Score:-3.21|P-value:7.21E-4 ID:SGTC_1445|Compound:4239-0156|FD-Score:4.18|P-value:1.39E-5 ID:SGTC_1630|Compound:st005209|FD-Score:-3.26|P-value:6.09E-4 ID:SGTC_1652|Compound:st011932|FD-Score:3.63|P-value:1.32E-4 ID:SGTC_1741|Compound:st038134|FD-Score:-5.06|P-value:2.42E-7 ID:SGTC_1742|Compound:st038235|FD-Score:3.09|P-value:9.66E-4 ID:SGTC_1893|Compound:st059353|FD-Score:3.91|P-value:4.41E-5 ID:SGTC_2040|Compound:5100729|FD-Score:4.47|P-value:3.76E-6 ID:SGTC_2054|Compound:5233173|FD-Score:8.27|P-value:6.13E-17 ID:SGTC_2082|Compound:5219693|FD-Score:-4.45|P-value:4.81E-6 ID:SGTC_2160|Compound:5660466|FD-Score:4.92|P-value:4.07E-7 ID:SGTC_2172|Compound:5754775|FD-Score:-3.56|P-value:2.04E-4 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:4.04|P-value:2.47E-5 ID:SGTC_2469|Compound:5655019|FD-Score:4.56|P-value:2.40E-6 ID:SGTC_2974|Compound:9094440|FD-Score:3.30|P-value:4.53E-4 ID:SGTC_3054|Compound:9094397|FD-Score:-3.48|P-value:2.77E-4 ID:SGTC_3062|Compound:9077494|FD-Score:5.86|P-value:2.17E-9 ID:SGTC_3101|Compound:9120531|FD-Score:4.35|P-value:6.30E-6 ID:SGTC_3102|Compound:9121669|FD-Score:4.35|P-value:6.30E-6 ID:SGTC_3106|Compound:9121286|FD-Score:5.60|P-value:1.02E-8 ID:SGTC_3145|Compound:9085516|FD-Score:-3.75|P-value:9.82E-5 ID:SGTC_3168|Compound:9103419|FD-Score:-4.13|P-value:2.00E-5 ID:SGTC_3207|Compound:9114163|FD-Score:-3.78|P-value:8.70E-5 ID:SGTC_3247|Compound:9135149|FD-Score:3.19|P-value:6.72E-4

Top fitness defect scores for YPL047W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_778 3456-2434 10.60 196.0 µM 1.60E-26 mitochondrial response to ROS 4 1.64E-26
2 SGTC_2054 5233173 8.27 129.0 µM 6.13E-17 mitochondrial response to ROS 6 6.47E-17
3 SGTC_1036 k216-0215 7.74 33.5 µM 4.56E-15 mitochondrial response to ROS 6 4.83E-15
4 SGTC_141 0443-0274 7.08 32.3 µM 6.85E-13 mitochondrial response to ROS 14 7.27E-13
5 SGTC_777 1315-0167 6.87 517.0 µM 3.12E-12 Golgi 2 3.32E-12
6 SGTC_3062 9077494 5.86 49.5 µM 2.17E-9 mitochondrial response to ROS 16 2.31E-9
7 SGTC_780 0109-0199 5.74 192.0 µM 4.36E-9 2 4.64E-9
8 SGTC_3106 9121286 5.60 49.5 µM 1.02E-8 3 1.09E-8
9 SGTC_116 0155-0182 5.30 31.8 µM 5.56E-8 mitochondrial response to ROS 36 5.92E-8
10 SGTC_58 0957-0393 5.00 9.0 µM 2.67E-7 cell wall 281 2.84E-7
11 SGTC_2160 5660466 4.92 132.9 µM 4.07E-7 60S ribosome export 4 4.33E-7
12 SGTC_241 5hr heat shock (37°C) + cantharidin 4.71 155.4 µM 1.16E-6 cell wall signaling 49 1.23E-6
13 SGTC_2469 5655019 4.56 90.8 µM 2.40E-6 16 2.55E-6
14 SGTC_2040 5100729 4.47 123.0 µM 3.76E-6 31 4.00E-6
15 SGTC_3102 9121669 4.35 49.5 µM 6.30E-6 5 6.69E-6
16 SGTC_3101 9120531 4.35 49.5 µM 6.30E-6 22 6.69E-6
17 SGTC_268 camptothecin 4.35 39.6 µM 6.38E-6 DNA damage response 58 6.77E-6
18 SGTC_403 arphamenine a 4.29 50.0 µM 8.54E-6 60S ribosome export 13 9.06E-6
19 SGTC_514 4466-0038 4.18 2.6 nM 1.35E-5 cell wall 138 1.44E-5
20 SGTC_1445 4239-0156 4.18 97.7 µM 1.39E-5 24 1.47E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.210 1.24E-34 YLR188W MDL1 hom Mitochondrial inner membrane half-type ATP-binding cassette (ABC) transporter, mediates export of peptides generated upon proteolysis of mitochondrial proteins, plays a role in the regulation of cellular resistance to oxidative stress
0.161 7.31E-21 YFL016C MDJ1 hom Co-chaperone that stimulates the ATPase activity of the HSP70 protein Ssc1p; involved in protein folding/refolding in the mitochodrial matrix; required for proteolysis of misfolded proteins; member of the HSP40 (DnaJ) family of chaperones
0.154 3.39E-19 YPL170W DAP1 hom Heme-binding protein involved in regulation of cytochrome P450 protein Erg11p; damage response protein, related to mammalian membrane progesterone receptors; mutations lead to defects in telomeres, mitochondria, and sterol synthesis
0.151 1.16E-18 YMR223W UBP8 hom Ubiquitin-specific protease that is a component of the SAGA (Spt-Ada-Gcn5-Acetyltransferase) acetylation complex; required for SAGA-mediated deubiquitination of histone H2B
0.151 1.17E-18 YDR335W MSN5 hom Karyopherin involved in nuclear import and export of proteins, including import of replication protein A and export of Swi6p, Far1p, and Pho4p; required for re-export of mature tRNAs after their retrograde import from the cytoplasm
0.149 3.44E-18 YGL252C RTG2 hom Sensor of mitochondrial dysfunction; regulates the subcellular location of Rtg1p and Rtg3p, transcriptional activators of the retrograde (RTG) and TOR pathways; Rtg2p is inhibited by the phosphorylated form of Mks1p
0.147 1.05E-17 YMR121C RPL15B hom Ribosomal 60S subunit protein L15B; binds to 5.8 S rRNA; homologous to mammalian ribosomal protein L15, no bacterial homolog; RPL15B has a paralog, RPL15A, that arose from the whole genome duplication; relocalizes from nucleus to nucleolus upon DNA replication stress
0.142 1.81E-16 YMR038C CCS1 hom Copper chaperone for superoxide dismutase Sod1p; involved in oxidative stress protection; Met-X-Cys-X2-Cys motif within the N-terminal portion is involved in insertion of copper into Sod1p under conditions of copper deprivation; protein abundance increases in response to DNA replication stress
0.141 2.20E-16 YER125W RSP5 het E3 ubiquitin ligase of the NEDD4 family; involved in regulating many cellular processes including MVB sorting, heat shock response, transcription, endocytosis, and ribosome stability; human homolog is involved in Liddle syndrome; mutant tolerates aneuploidy; ubiquitylates Sec23p
0.140 3.03E-16 YML012C-A_d YML012C-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene SEL1
0.139 6.91E-16 YOL003C PFA4 hom Palmitoyltransferase with autoacylation activity, required for palmitoylation of amino acid permeases containing a C-terminal Phe-Trp-Cys site; required for modification of Chs3p; member of the DHHC family of putative palmitoyltransferases
0.134 5.92E-15 YLL032C YLL032C hom Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLL032C is not an essential gene
0.133 9.36E-15 YER016W BIM1 hom Microtubule-binding protein that together with Kar9p makes up the cortical microtubule capture site and delays the exit from mitosis when the spindle is oriented abnormally
0.133 9.45E-15 YGL033W HOP2 hom Meiosis-specific protein that localizes to chromosomes, preventing synapsis between nonhomologous chromosomes and ensuring synapsis between homologs; complexes with Mnd1p to promote homolog pairing and meiotic double-strand break repair
0.127 1.31E-13 YML016C PPZ1 hom Serine/threonine protein phosphatase Z, isoform of Ppz2p; involved in regulation of potassium transport, which affects osmotic stability, cell cycle progression, and halotolerance