YPL049C / DIG1

MAP kinase-responsive inhibitor of the Ste12p transcription factor, involved in the regulation of mating-specific genes and the invasive growth pathway; related regulators Dig1p and Dig2p bind to Ste12p

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL049C / DIG1

Click on Significant Values for Screen Details ID:SGTC_69|Compound:0096-0274|FD-Score:4.89|P-value:2.48E-6 ID:SGTC_128|Compound:0906-2981|FD-Score:3.98|P-value:1.04E-4 ID:SGTC_130|Compound:0136-0219|FD-Score:5.01|P-value:1.49E-6 ID:SGTC_138|Compound:0850-0259|FD-Score:-3.53|P-value:3.72E-4 ID:SGTC_238|Compound:5hr heat shock (37°C) + nsc-638432|FD-Score:3.91|P-value:1.37E-4 ID:SGTC_266|Compound:formosanin C|FD-Score:4.89|P-value:2.53E-6 ID:SGTC_528|Compound:3492-0019|FD-Score:4.72|P-value:5.41E-6 ID:SGTC_576|Compound:1073-0113|FD-Score:3.43|P-value:7.24E-4 ID:SGTC_587|Compound:k089-0003|FD-Score:3.87|P-value:1.59E-4 ID:SGTC_642|Compound:0335-0876|FD-Score:-3.37|P-value:6.35E-4 ID:SGTC_664|Compound:1222-0054|FD-Score:6.01|P-value:9.75E-9 ID:SGTC_684|Compound:1140-0066|FD-Score:3.73|P-value:2.65E-4 ID:SGTC_732|Compound:3970-1727|FD-Score:3.33|P-value:9.78E-4 ID:SGTC_779|Compound:1360-0071|FD-Score:3.42|P-value:7.51E-4 ID:SGTC_887|Compound:0885-0007|FD-Score:4.20|P-value:4.59E-5 ID:SGTC_946|Compound:3434-1334|FD-Score:5.53|P-value:1.22E-7 ID:SGTC_949|Compound:1165-0505|FD-Score:9.90|P-value:7.98E-21 ID:SGTC_951|Compound:1171-0579|FD-Score:3.82|P-value:1.90E-4 ID:SGTC_967|Compound:1306-0166|FD-Score:3.38|P-value:8.48E-4 ID:SGTC_992|Compound:3909-8734|FD-Score:3.44|P-value:6.97E-4 ID:SGTC_1050|Compound:3232-1156|FD-Score:3.70|P-value:2.87E-4 ID:SGTC_1063|Compound:disulfiram|FD-Score:3.71|P-value:2.84E-4 ID:SGTC_1072|Compound:oxiconazole|FD-Score:4.84|P-value:3.13E-6 ID:SGTC_1295|Compound:1013-0063|FD-Score:3.41|P-value:7.57E-4 ID:SGTC_1333|Compound:1482-0047|FD-Score:-3.47|P-value:4.56E-4 ID:SGTC_1340|Compound:1486-1359|FD-Score:3.58|P-value:4.44E-4 ID:SGTC_1480|Compound:1070-0044|FD-Score:4.65|P-value:7.14E-6 ID:SGTC_1537|Compound:2',6'-dihydroxyflavanone|FD-Score:4.36|P-value:2.43E-5 ID:SGTC_1585|Compound:2',4'-dihydroxychalcone|FD-Score:5.09|P-value:1.02E-6 ID:SGTC_1673|Compound:st016611|FD-Score:-4.41|P-value:1.36E-5 ID:SGTC_1678|Compound:st019265|FD-Score:-4.55|P-value:7.41E-6 ID:SGTC_1712|Compound:st032288|FD-Score:4.64|P-value:7.68E-6 ID:SGTC_1735|Compound:st034310|FD-Score:5.52|P-value:1.28E-7 ID:SGTC_1870|Compound:st057514|FD-Score:3.37|P-value:8.74E-4 ID:SGTC_1941|Compound:st076221|FD-Score:3.63|P-value:3.72E-4 ID:SGTC_1962|Compound:st076595|FD-Score:3.85|P-value:1.68E-4 ID:SGTC_1999|Compound:st074831|FD-Score:3.66|P-value:3.35E-4 ID:SGTC_2088|Compound:5278280|FD-Score:3.77|P-value:2.24E-4 ID:SGTC_2129|Compound:girgensonine|FD-Score:3.56|P-value:4.61E-4 ID:SGTC_2170|Compound:morpholine|FD-Score:3.64|P-value:3.52E-4 ID:SGTC_2307|Compound:7538926|FD-Score:5.09|P-value:1.01E-6 ID:SGTC_2308|Compound:7584454|FD-Score:5.60|P-value:8.23E-8 ID:SGTC_2310|Compound:7668677|FD-Score:5.30|P-value:3.71E-7 ID:SGTC_2316|Compound:5844804|FD-Score:-3.66|P-value:2.38E-4 ID:SGTC_2373|Compound:9071805|FD-Score:5.21|P-value:5.62E-7 ID:SGTC_2382|Compound:9035899|FD-Score:6.29|P-value:2.02E-9 ID:SGTC_2481|Compound:5478948|FD-Score:5.55|P-value:1.08E-7 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:3.90|P-value:1.41E-4 ID:SGTC_2532|Compound:xanthone|FD-Score:7.76|P-value:1.81E-13 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:5.86|P-value:2.23E-8 ID:SGTC_2544|Compound:sphondin|FD-Score:5.91|P-value:1.65E-8 ID:SGTC_2613|Compound:3',4'-dimethoxydalbergione|FD-Score:-3.63|P-value:2.64E-4 ID:SGTC_2629|Compound:bisabolol|FD-Score:3.46|P-value:6.53E-4 ID:SGTC_2631|Compound:bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone|FD-Score:4.31|P-value:2.91E-5 ID:SGTC_2729|Compound:fluphenazine|FD-Score:-3.31|P-value:7.70E-4 ID:SGTC_2794|Compound:7785382|FD-Score:4.20|P-value:4.59E-5 ID:SGTC_2799|Compound:7812892|FD-Score:3.65|P-value:3.49E-4 ID:SGTC_2803|Compound:7707263|FD-Score:3.69|P-value:3.02E-4 ID:SGTC_2812|Compound:7970281|FD-Score:3.99|P-value:1.01E-4 ID:SGTC_2814|Compound:7977482|FD-Score:3.60|P-value:4.14E-4 ID:SGTC_2823|Compound:7987624|FD-Score:3.45|P-value:6.69E-4 ID:SGTC_2858|Compound:9025781|FD-Score:4.51|P-value:1.33E-5 ID:SGTC_2924|Compound:9010168|FD-Score:4.08|P-value:7.39E-5 ID:SGTC_2982|Compound:9019404|FD-Score:5.41|P-value:2.17E-7 ID:SGTC_3098|Compound:9119039|FD-Score:3.67|P-value:3.23E-4 ID:SGTC_3170|Compound:9103054|FD-Score:3.61|P-value:3.96E-4 ID:SGTC_3222|Compound:9128301|FD-Score:-3.24|P-value:9.92E-4 ID:SGTC_3265|Compound:9137266|FD-Score:-3.32|P-value:7.50E-4 ID:SGTC_3266|Compound:9136860|FD-Score:3.62|P-value:3.76E-4 ID:SGTC_3309|Compound:9129340|FD-Score:-4.21|P-value:3.07E-5 ID:SGTC_3311|Compound:9131146|FD-Score:7.36|P-value:2.87E-12 ID:SGTC_3326|Compound:9140064|FD-Score:6.22|P-value:3.08E-9 ID:SGTC_69|Compound:0096-0274|FD-Score:4.89|P-value:2.48E-6 ID:SGTC_128|Compound:0906-2981|FD-Score:3.98|P-value:1.04E-4 ID:SGTC_130|Compound:0136-0219|FD-Score:5.01|P-value:1.49E-6 ID:SGTC_138|Compound:0850-0259|FD-Score:-3.53|P-value:3.72E-4 ID:SGTC_238|Compound:5hr heat shock (37°C) + nsc-638432|FD-Score:3.91|P-value:1.37E-4 ID:SGTC_266|Compound:formosanin C|FD-Score:4.89|P-value:2.53E-6 ID:SGTC_528|Compound:3492-0019|FD-Score:4.72|P-value:5.41E-6 ID:SGTC_576|Compound:1073-0113|FD-Score:3.43|P-value:7.24E-4 ID:SGTC_587|Compound:k089-0003|FD-Score:3.87|P-value:1.59E-4 ID:SGTC_642|Compound:0335-0876|FD-Score:-3.37|P-value:6.35E-4 ID:SGTC_664|Compound:1222-0054|FD-Score:6.01|P-value:9.75E-9 ID:SGTC_684|Compound:1140-0066|FD-Score:3.73|P-value:2.65E-4 ID:SGTC_732|Compound:3970-1727|FD-Score:3.33|P-value:9.78E-4 ID:SGTC_779|Compound:1360-0071|FD-Score:3.42|P-value:7.51E-4 ID:SGTC_887|Compound:0885-0007|FD-Score:4.20|P-value:4.59E-5 ID:SGTC_946|Compound:3434-1334|FD-Score:5.53|P-value:1.22E-7 ID:SGTC_949|Compound:1165-0505|FD-Score:9.90|P-value:7.98E-21 ID:SGTC_951|Compound:1171-0579|FD-Score:3.82|P-value:1.90E-4 ID:SGTC_967|Compound:1306-0166|FD-Score:3.38|P-value:8.48E-4 ID:SGTC_992|Compound:3909-8734|FD-Score:3.44|P-value:6.97E-4 ID:SGTC_1050|Compound:3232-1156|FD-Score:3.70|P-value:2.87E-4 ID:SGTC_1063|Compound:disulfiram|FD-Score:3.71|P-value:2.84E-4 ID:SGTC_1072|Compound:oxiconazole|FD-Score:4.84|P-value:3.13E-6 ID:SGTC_1295|Compound:1013-0063|FD-Score:3.41|P-value:7.57E-4 ID:SGTC_1333|Compound:1482-0047|FD-Score:-3.47|P-value:4.56E-4 ID:SGTC_1340|Compound:1486-1359|FD-Score:3.58|P-value:4.44E-4 ID:SGTC_1480|Compound:1070-0044|FD-Score:4.65|P-value:7.14E-6 ID:SGTC_1537|Compound:2',6'-dihydroxyflavanone|FD-Score:4.36|P-value:2.43E-5 ID:SGTC_1585|Compound:2',4'-dihydroxychalcone|FD-Score:5.09|P-value:1.02E-6 ID:SGTC_1673|Compound:st016611|FD-Score:-4.41|P-value:1.36E-5 ID:SGTC_1678|Compound:st019265|FD-Score:-4.55|P-value:7.41E-6 ID:SGTC_1712|Compound:st032288|FD-Score:4.64|P-value:7.68E-6 ID:SGTC_1735|Compound:st034310|FD-Score:5.52|P-value:1.28E-7 ID:SGTC_1870|Compound:st057514|FD-Score:3.37|P-value:8.74E-4 ID:SGTC_1941|Compound:st076221|FD-Score:3.63|P-value:3.72E-4 ID:SGTC_1962|Compound:st076595|FD-Score:3.85|P-value:1.68E-4 ID:SGTC_1999|Compound:st074831|FD-Score:3.66|P-value:3.35E-4 ID:SGTC_2088|Compound:5278280|FD-Score:3.77|P-value:2.24E-4 ID:SGTC_2129|Compound:girgensonine|FD-Score:3.56|P-value:4.61E-4 ID:SGTC_2170|Compound:morpholine|FD-Score:3.64|P-value:3.52E-4 ID:SGTC_2307|Compound:7538926|FD-Score:5.09|P-value:1.01E-6 ID:SGTC_2308|Compound:7584454|FD-Score:5.60|P-value:8.23E-8 ID:SGTC_2310|Compound:7668677|FD-Score:5.30|P-value:3.71E-7 ID:SGTC_2316|Compound:5844804|FD-Score:-3.66|P-value:2.38E-4 ID:SGTC_2373|Compound:9071805|FD-Score:5.21|P-value:5.62E-7 ID:SGTC_2382|Compound:9035899|FD-Score:6.29|P-value:2.02E-9 ID:SGTC_2481|Compound:5478948|FD-Score:5.55|P-value:1.08E-7 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:3.90|P-value:1.41E-4 ID:SGTC_2532|Compound:xanthone|FD-Score:7.76|P-value:1.81E-13 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:5.86|P-value:2.23E-8 ID:SGTC_2544|Compound:sphondin|FD-Score:5.91|P-value:1.65E-8 ID:SGTC_2613|Compound:3',4'-dimethoxydalbergione|FD-Score:-3.63|P-value:2.64E-4 ID:SGTC_2629|Compound:bisabolol|FD-Score:3.46|P-value:6.53E-4 ID:SGTC_2631|Compound:bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone|FD-Score:4.31|P-value:2.91E-5 ID:SGTC_2729|Compound:fluphenazine|FD-Score:-3.31|P-value:7.70E-4 ID:SGTC_2794|Compound:7785382|FD-Score:4.20|P-value:4.59E-5 ID:SGTC_2799|Compound:7812892|FD-Score:3.65|P-value:3.49E-4 ID:SGTC_2803|Compound:7707263|FD-Score:3.69|P-value:3.02E-4 ID:SGTC_2812|Compound:7970281|FD-Score:3.99|P-value:1.01E-4 ID:SGTC_2814|Compound:7977482|FD-Score:3.60|P-value:4.14E-4 ID:SGTC_2823|Compound:7987624|FD-Score:3.45|P-value:6.69E-4 ID:SGTC_2858|Compound:9025781|FD-Score:4.51|P-value:1.33E-5 ID:SGTC_2924|Compound:9010168|FD-Score:4.08|P-value:7.39E-5 ID:SGTC_2982|Compound:9019404|FD-Score:5.41|P-value:2.17E-7 ID:SGTC_3098|Compound:9119039|FD-Score:3.67|P-value:3.23E-4 ID:SGTC_3170|Compound:9103054|FD-Score:3.61|P-value:3.96E-4 ID:SGTC_3222|Compound:9128301|FD-Score:-3.24|P-value:9.92E-4 ID:SGTC_3265|Compound:9137266|FD-Score:-3.32|P-value:7.50E-4 ID:SGTC_3266|Compound:9136860|FD-Score:3.62|P-value:3.76E-4 ID:SGTC_3309|Compound:9129340|FD-Score:-4.21|P-value:3.07E-5 ID:SGTC_3311|Compound:9131146|FD-Score:7.36|P-value:2.87E-12 ID:SGTC_3326|Compound:9140064|FD-Score:6.22|P-value:3.08E-9

Top fitness defect scores for YPL049C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_949 1165-0505 9.90 146.0 µM 7.98E-21 2 1.99E-23
2 SGTC_2532 xanthone 7.76 78.9 µM 1.81E-13 3 4.14E-15
3 SGTC_3311 9131146 7.36 2.9 µM 2.87E-12 cell wall 40 9.44E-14
4 SGTC_2382 9035899 6.29 200.0 µM 2.02E-9 60S ribosome export 3 1.58E-10
5 SGTC_3326 9140064 6.22 16.4 µM 3.08E-9 6 2.54E-10
6 SGTC_664 1222-0054 6.01 14.9 µM 9.75E-9 sphingolipid biosynthesis & PDR1 16 9.34E-10
7 SGTC_2544 sphondin 5.91 68.5 µM 1.65E-8 RNA pol III & RNase P/MRP 6 1.70E-9
8 SGTC_2538 3',7'-epoxycaryophyllan-6-one 5.86 100.0 µM 2.23E-8 4 2.38E-9
9 SGTC_2308 7584454 5.60 197.6 µM 8.23E-8 4 1.04E-8
10 SGTC_2481 5478948 5.55 45.2 µM 1.08E-7 PDR1 10 1.43E-8
11 SGTC_946 3434-1334 5.53 87.4 µM 1.22E-7 6 1.63E-8
12 SGTC_1735 st034310 5.52 56.8 µM 1.28E-7 Golgi 6 1.73E-8
13 SGTC_2982 9019404 5.41 26.0 µM 2.17E-7 9 3.13E-8
14 SGTC_2310 7668677 5.30 200.0 µM 3.71E-7 9 5.75E-8
15 SGTC_2373 9071805 5.21 200.0 µM 5.62E-7 3 9.19E-8
16 SGTC_2307 7538926 5.09 6.3 µM 1.01E-6 17 1.78E-7
17 SGTC_1585 2',4'-dihydroxychalcone 5.09 10.4 µM 1.02E-6 12 1.80E-7
18 SGTC_130 0136-0219 5.01 337.7 µM 1.49E-6 10 2.78E-7
19 SGTC_69 0096-0274 4.89 206.7 µM 2.48E-6 mitochondrial processes 19 4.94E-7
20 SGTC_266 formosanin C 4.89 406.0 nM 2.53E-6 sphingolipid biosynthesis & PDR1 47 5.04E-7

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.114 3.05E-11 YMR237W BCH1 hom Member of the ChAPs family (Chs5p-Arf1p-binding proteins); members include Bch1p, Bch2p, Bud7p, and Chs6p; ChAPs family proteins form the exomer complex with Chs5p to mediate export of specific cargo proteins from the Golgi to the plasma membrane; may interact with ribosomes; protein abundance increases and forms cytoplasmic foci in response to DNA replication stress; BCH1 has a paralog, BUD7, that arose from the whole genome duplication
0.111 9.63E-11 YDR475C JIP4 hom Protein of unknown function; previously annotated as two separate ORFs, YDR474C and YDR475C, which were merged as a result of corrections to the systematic reference sequence
0.111 1.25E-10 YER119C-A_d YER119C-A_d hom Dubious open reading frame, not conserved in closely related Saccharomyces species; deletion mutation blocks replication of Brome mosaic virus in S. cerevisiae, but this is likely due to effects on the overlapping gene SCS2
0.107 4.60E-10 YMR102C_p YMR102C_p hom Protein of unknown function; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance; mutant shows increased resistance to azoles; YMR102C is not an essential gene
0.106 6.56E-10 YOR086C TCB1 hom Lipid-binding ER protein involved in ER-plasma membrane tethering; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PM phosphatidylinositol-4-phosphate (PI4P) levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; contains three calcium and lipid binding domains; non-tagged protein also localizes to mitochondria; C-termini of Tcb1p, Tcb2p and Tcb3p interact
0.105 1.14E-9 YPL057C SUR1 hom Mannosylinositol phosphorylceramide (MIPC) synthase catalytic subunit; forms a complex with regulatory subunit Csg2p; function in sphingolipid biosynthesis is overlapping with that of Csh1p; SUR1 has a paralog, CSH1, that arose from the whole genome duplication
0.105 1.26E-9 YDR326C YSP2 hom Protein involved in programmed cell death; mutant shows resistance to cell death induced by amiodarone or intracellular acidification; YSP2 has a paralog, YHR080C, that arose from the whole genome duplication
0.102 2.76E-9 YCL005W LDB16 hom Protein of unknown function; null mutants have decreased net negative cell surface charge; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; native protein is detected in purified mitochondria
0.101 4.24E-9 YKL046C DCW1 hom Putative mannosidase, GPI-anchored membrane protein required for cell wall biosynthesis in bud formation;homologous to Dfg5p
0.100 6.69E-9 YMR036C MIH1 hom Protein tyrosine phosphatase involved in cell cycle control; regulates the phosphorylation state of Cdc28p; homolog of S. pombe cdc25
0.097 1.56E-8 YNL229C URE2 hom Nitrogen catabolite repression transcriptional regulator that acts by inhibition of GLN3 transcription in good nitrogen source; has glutathione peroxidase activity and can mutate to acquire GST activity; altered form creates [URE3] prion
0.094 4.95E-8 YDL066W IDP1 hom Mitochondrial NADP-specific isocitrate dehydrogenase, catalyzes the oxidation of isocitrate to alpha-ketoglutarate; not required for mitochondrial respiration and may function to divert alpha-ketoglutarate to biosynthetic processes
0.093 7.06E-8 YPL243W SRP68 het Core component of the signal recognition particle (SRP) complex; SRP complex functions in targeting nascent secretory proteins to the endoplasmic reticulum (ER) membrane; relocalizes from cytoplasm to the nuclear periphery upon DNA replication stress
0.093 6.95E-8 YJL164C TPK1 hom cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; inhibited by regulatory subunit Bcy1p in the absence of cAMP; regulates Whi3p; partially redundant with Tpk2p and Tpk3p; TPK1 has a paralog, TPK3, that arose from the whole genome duplication
0.089 2.66E-7 YER120W SCS2 hom Integral ER membrane protein, regulates phospholipid metabolism; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PI4P levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; interacts with FFAT motif of Opi1p; involved in telomeric silencing; null shows inositol auxotrophy above 34 deg C; VAP homolog; SCS2 has a paralog, SCS22, that arose from the whole genome duplication