YPL051W / ARL3

GTPase of the Ras superfamily required to recruit Arl1p to the Golgi; similar to ADP-ribosylation factor

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL051W / ARL3

Click on Significant Values for Screen Details ID:SGTC_22|Compound:0964-0034|FD-Score:4.48|P-value:6.61E-5 ID:SGTC_56|Compound:0957-0365|FD-Score:3.86|P-value:4.95E-4 ID:SGTC_91|Compound:0417-1751|FD-Score:12.70|P-value:1.35E-27 ID:SGTC_98|Compound:0074-0023|FD-Score:4.41|P-value:8.40E-5 ID:SGTC_102|Compound:gallobenzophenone|FD-Score:3.90|P-value:4.47E-4 ID:SGTC_124|Compound:0136-0217|FD-Score:5.08|P-value:7.38E-6 ID:SGTC_132|Compound:0417-1715|FD-Score:4.26|P-value:1.40E-4 ID:SGTC_252|Compound:miconazole|FD-Score:-4.35|P-value:9.06E-5 ID:SGTC_263|Compound:alizarin|FD-Score:4.62|P-value:4.12E-5 ID:SGTC_291|Compound:4130-1278|FD-Score:5.82|P-value:3.30E-7 ID:SGTC_459|Compound:nigericin|FD-Score:4.00|P-value:3.26E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:7.65|P-value:3.14E-11 ID:SGTC_562|Compound:3772-2733|FD-Score:4.04|P-value:2.88E-4 ID:SGTC_605|Compound:1315-0399|FD-Score:4.05|P-value:2.79E-4 ID:SGTC_632|Compound:0781-2353|FD-Score:3.94|P-value:3.91E-4 ID:SGTC_653|Compound:0203-0016|FD-Score:3.95|P-value:3.75E-4 ID:SGTC_690|Compound:glyoxal|FD-Score:-3.71|P-value:6.98E-4 ID:SGTC_694|Compound:1315-0438|FD-Score:4.17|P-value:1.91E-4 ID:SGTC_696|Compound:1560-0013|FD-Score:4.26|P-value:1.42E-4 ID:SGTC_697|Compound:0508-1955|FD-Score:4.55|P-value:5.25E-5 ID:SGTC_726|Compound:3448-4391|FD-Score:3.82|P-value:5.64E-4 ID:SGTC_731|Compound:3966-0296|FD-Score:4.58|P-value:4.65E-5 ID:SGTC_736|Compound:0958-0254|FD-Score:4.25|P-value:1.47E-4 ID:SGTC_748|Compound:0136-0228|FD-Score:7.22|P-value:3.41E-10 ID:SGTC_770|Compound:0389-1121|FD-Score:3.85|P-value:5.18E-4 ID:SGTC_784|Compound:4579-0127|FD-Score:5.64|P-value:7.38E-7 ID:SGTC_841|Compound:0251-0215|FD-Score:4.30|P-value:1.25E-4 ID:SGTC_851|Compound:0394-0702|FD-Score:-3.76|P-value:6.00E-4 ID:SGTC_854|Compound:0422-0053|FD-Score:-3.92|P-value:3.70E-4 ID:SGTC_957|Compound:1187-1561|FD-Score:4.52|P-value:5.87E-5 ID:SGTC_970|Compound:1315-0089|FD-Score:3.90|P-value:4.43E-4 ID:SGTC_999|Compound:4022-0066|FD-Score:3.91|P-value:4.35E-4 ID:SGTC_1033|Compound:k072-0102|FD-Score:-3.89|P-value:4.05E-4 ID:SGTC_1062|Compound:mesoridazine|FD-Score:4.32|P-value:1.13E-4 ID:SGTC_1063|Compound:disulfiram|FD-Score:3.69|P-value:8.29E-4 ID:SGTC_1069|Compound:diphenylcyclopropenone|FD-Score:6.26|P-value:4.60E-8 ID:SGTC_1072|Compound:oxiconazole|FD-Score:-3.71|P-value:6.93E-4 ID:SGTC_1073|Compound:triclabendazole|FD-Score:14.70|P-value:1.81E-36 ID:SGTC_1084|Compound:voriconazole|FD-Score:-3.90|P-value:3.90E-4 ID:SGTC_1087|Compound:pterostilbene|FD-Score:3.92|P-value:4.22E-4 ID:SGTC_1112|Compound:tnp00069|FD-Score:5.20|P-value:4.50E-6 ID:SGTC_1280|Compound:0880-0253|FD-Score:4.16|P-value:1.96E-4 ID:SGTC_1299|Compound:1079-1439|FD-Score:3.72|P-value:7.57E-4 ID:SGTC_1306|Compound:1185-0270|FD-Score:18.30|P-value:8.99E-56 ID:SGTC_1313|Compound:1220-0047|FD-Score:5.58|P-value:9.68E-7 ID:SGTC_1326|Compound:1431-2094|FD-Score:-4.22|P-value:1.39E-4 ID:SGTC_1327|Compound:1436-0082|FD-Score:4.44|P-value:7.68E-5 ID:SGTC_1429|Compound:4049-0205|FD-Score:3.96|P-value:3.75E-4 ID:SGTC_1495|Compound:4469-0029|FD-Score:4.84|P-value:1.81E-5 ID:SGTC_1532|Compound:4',5'-dihydroxyflavone|FD-Score:6.49|P-value:1.49E-8 ID:SGTC_1581|Compound:himbacine|FD-Score:14.00|P-value:3.37E-33 ID:SGTC_1595|Compound:6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin|FD-Score:5.44|P-value:1.70E-6 ID:SGTC_1616|Compound:st002734|FD-Score:3.91|P-value:4.36E-4 ID:SGTC_1633|Compound:st005664|FD-Score:3.78|P-value:6.42E-4 ID:SGTC_1679|Compound:4130-1276|FD-Score:14.70|P-value:2.29E-36 ID:SGTC_1687|Compound:st020778|FD-Score:3.97|P-value:3.54E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:-4.32|P-value:1.01E-4 ID:SGTC_1724|Compound:st037281|FD-Score:6.45|P-value:1.84E-8 ID:SGTC_1745|Compound:st081495|FD-Score:-4.48|P-value:5.79E-5 ID:SGTC_1765|Compound:st044815|FD-Score:4.49|P-value:6.53E-5 ID:SGTC_1818|Compound:st052136|FD-Score:-4.28|P-value:1.13E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:5.22|P-value:4.19E-6 ID:SGTC_1897|Compound:st060201|FD-Score:3.65|P-value:9.37E-4 ID:SGTC_1915|Compound:st067105|FD-Score:3.69|P-value:8.34E-4 ID:SGTC_2041|Compound:5107442|FD-Score:6.45|P-value:1.85E-8 ID:SGTC_2053|Compound:5265679|FD-Score:4.17|P-value:1.90E-4 ID:SGTC_2122|Compound:5258151|FD-Score:5.26|P-value:3.57E-6 ID:SGTC_2133|Compound:5320837|FD-Score:3.80|P-value:5.96E-4 ID:SGTC_2140|Compound:5586273|FD-Score:5.16|P-value:5.30E-6 ID:SGTC_2142|Compound:5622915|FD-Score:4.24|P-value:1.50E-4 ID:SGTC_2242|Compound:6630449|FD-Score:16.20|P-value:3.44E-44 ID:SGTC_2289|Compound:7946404|FD-Score:3.91|P-value:4.35E-4 ID:SGTC_2291|Compound:7917025|FD-Score:12.20|P-value:1.01E-25 ID:SGTC_2322|Compound:7413319|FD-Score:5.04|P-value:8.45E-6 ID:SGTC_2363|Compound:9053361|FD-Score:5.18|P-value:4.97E-6 ID:SGTC_2389|Compound:9091542|FD-Score:4.17|P-value:1.90E-4 ID:SGTC_2393|Compound:9031399|FD-Score:-4.31|P-value:1.04E-4 ID:SGTC_2399|Compound:5884133|FD-Score:3.94|P-value:3.87E-4 ID:SGTC_2413|Compound:inermin|FD-Score:7.71|P-value:2.21E-11 ID:SGTC_2418|Compound:pentamidine|FD-Score:3.95|P-value:3.82E-4 ID:SGTC_2510|Compound:benzyl isothiocyanate|FD-Score:-4.15|P-value:1.77E-4 ID:SGTC_2511|Compound:berberine|FD-Score:-3.83|P-value:4.81E-4 ID:SGTC_2514|Compound:salinomycin|FD-Score:6.78|P-value:3.58E-9 ID:SGTC_2516|Compound:gossypol|FD-Score:5.14|P-value:5.74E-6 ID:SGTC_2543|Compound:pimpinellin|FD-Score:4.35|P-value:1.02E-4 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:12.10|P-value:2.55E-25 ID:SGTC_2580|Compound:diallyl disulphide|FD-Score:-4.00|P-value:2.83E-4 ID:SGTC_2586|Compound:curcumin|FD-Score:7.77|P-value:1.56E-11 ID:SGTC_2679|Compound:rapamycin|FD-Score:4.84|P-value:1.81E-5 ID:SGTC_2737|Compound:bleomycin|FD-Score:10.30|P-value:8.95E-19 ID:SGTC_2752|Compound:diclazuril|FD-Score:4.20|P-value:1.69E-4 ID:SGTC_2777|Compound:climbazole|FD-Score:-4.04|P-value:2.55E-4 ID:SGTC_2778|Compound:tioconazole|FD-Score:-4.85|P-value:1.53E-5 ID:SGTC_2782|Compound:7736369|FD-Score:4.49|P-value:6.45E-5 ID:SGTC_2833|Compound:9001315|FD-Score:3.90|P-value:4.43E-4 ID:SGTC_2845|Compound:9003024|FD-Score:3.82|P-value:5.59E-4 ID:SGTC_2858|Compound:9025781|FD-Score:6.19|P-value:6.22E-8 ID:SGTC_2867|Compound:9039098|FD-Score:4.37|P-value:9.63E-5 ID:SGTC_2884|Compound:9058502|FD-Score:7.55|P-value:5.73E-11 ID:SGTC_2890|Compound:9046729|FD-Score:11.60|P-value:1.53E-23 ID:SGTC_2896|Compound:9052656|FD-Score:4.02|P-value:3.04E-4 ID:SGTC_2923|Compound:7992654|FD-Score:4.35|P-value:1.06E-4 ID:SGTC_2942|Compound:9052777|FD-Score:5.30|P-value:3.02E-6 ID:SGTC_2943|Compound:9068529|FD-Score:5.89|P-value:2.52E-7 ID:SGTC_2944|Compound:9067346|FD-Score:-4.78|P-value:1.98E-5 ID:SGTC_2949|Compound:9072542|FD-Score:5.44|P-value:1.70E-6 ID:SGTC_3098|Compound:9119039|FD-Score:7.29|P-value:2.35E-10 ID:SGTC_3101|Compound:9120531|FD-Score:3.94|P-value:3.95E-4 ID:SGTC_3148|Compound:9097893|FD-Score:4.43|P-value:8.06E-5 ID:SGTC_3149|Compound:9097855|FD-Score:3.81|P-value:5.91E-4 ID:SGTC_3152|Compound:9099253|FD-Score:-4.80|P-value:1.82E-5 ID:SGTC_3166|Compound:9102297|FD-Score:4.93|P-value:1.30E-5 ID:SGTC_3213|Compound:9129884|FD-Score:-3.69|P-value:7.30E-4 ID:SGTC_3219|Compound:9131112|FD-Score:9.67|P-value:6.77E-17 ID:SGTC_3263|Compound:9137018|FD-Score:4.28|P-value:1.32E-4 ID:SGTC_3277|Compound:9138724|FD-Score:11.20|P-value:6.95E-22 ID:SGTC_3284|Compound:9108171|FD-Score:-3.73|P-value:6.64E-4 ID:SGTC_3302|Compound:9125395|FD-Score:-4.04|P-value:2.53E-4 ID:SGTC_3310|Compound:9130229|FD-Score:3.84|P-value:5.39E-4 ID:SGTC_3325|Compound:9138760|FD-Score:4.88|P-value:1.55E-5 ID:SGTC_22|Compound:0964-0034|FD-Score:4.48|P-value:6.61E-5 ID:SGTC_56|Compound:0957-0365|FD-Score:3.86|P-value:4.95E-4 ID:SGTC_91|Compound:0417-1751|FD-Score:12.70|P-value:1.35E-27 ID:SGTC_98|Compound:0074-0023|FD-Score:4.41|P-value:8.40E-5 ID:SGTC_102|Compound:gallobenzophenone|FD-Score:3.90|P-value:4.47E-4 ID:SGTC_124|Compound:0136-0217|FD-Score:5.08|P-value:7.38E-6 ID:SGTC_132|Compound:0417-1715|FD-Score:4.26|P-value:1.40E-4 ID:SGTC_252|Compound:miconazole|FD-Score:-4.35|P-value:9.06E-5 ID:SGTC_263|Compound:alizarin|FD-Score:4.62|P-value:4.12E-5 ID:SGTC_291|Compound:4130-1278|FD-Score:5.82|P-value:3.30E-7 ID:SGTC_459|Compound:nigericin|FD-Score:4.00|P-value:3.26E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:7.65|P-value:3.14E-11 ID:SGTC_562|Compound:3772-2733|FD-Score:4.04|P-value:2.88E-4 ID:SGTC_605|Compound:1315-0399|FD-Score:4.05|P-value:2.79E-4 ID:SGTC_632|Compound:0781-2353|FD-Score:3.94|P-value:3.91E-4 ID:SGTC_653|Compound:0203-0016|FD-Score:3.95|P-value:3.75E-4 ID:SGTC_690|Compound:glyoxal|FD-Score:-3.71|P-value:6.98E-4 ID:SGTC_694|Compound:1315-0438|FD-Score:4.17|P-value:1.91E-4 ID:SGTC_696|Compound:1560-0013|FD-Score:4.26|P-value:1.42E-4 ID:SGTC_697|Compound:0508-1955|FD-Score:4.55|P-value:5.25E-5 ID:SGTC_726|Compound:3448-4391|FD-Score:3.82|P-value:5.64E-4 ID:SGTC_731|Compound:3966-0296|FD-Score:4.58|P-value:4.65E-5 ID:SGTC_736|Compound:0958-0254|FD-Score:4.25|P-value:1.47E-4 ID:SGTC_748|Compound:0136-0228|FD-Score:7.22|P-value:3.41E-10 ID:SGTC_770|Compound:0389-1121|FD-Score:3.85|P-value:5.18E-4 ID:SGTC_784|Compound:4579-0127|FD-Score:5.64|P-value:7.38E-7 ID:SGTC_841|Compound:0251-0215|FD-Score:4.30|P-value:1.25E-4 ID:SGTC_851|Compound:0394-0702|FD-Score:-3.76|P-value:6.00E-4 ID:SGTC_854|Compound:0422-0053|FD-Score:-3.92|P-value:3.70E-4 ID:SGTC_957|Compound:1187-1561|FD-Score:4.52|P-value:5.87E-5 ID:SGTC_970|Compound:1315-0089|FD-Score:3.90|P-value:4.43E-4 ID:SGTC_999|Compound:4022-0066|FD-Score:3.91|P-value:4.35E-4 ID:SGTC_1033|Compound:k072-0102|FD-Score:-3.89|P-value:4.05E-4 ID:SGTC_1062|Compound:mesoridazine|FD-Score:4.32|P-value:1.13E-4 ID:SGTC_1063|Compound:disulfiram|FD-Score:3.69|P-value:8.29E-4 ID:SGTC_1069|Compound:diphenylcyclopropenone|FD-Score:6.26|P-value:4.60E-8 ID:SGTC_1072|Compound:oxiconazole|FD-Score:-3.71|P-value:6.93E-4 ID:SGTC_1073|Compound:triclabendazole|FD-Score:14.70|P-value:1.81E-36 ID:SGTC_1084|Compound:voriconazole|FD-Score:-3.90|P-value:3.90E-4 ID:SGTC_1087|Compound:pterostilbene|FD-Score:3.92|P-value:4.22E-4 ID:SGTC_1112|Compound:tnp00069|FD-Score:5.20|P-value:4.50E-6 ID:SGTC_1280|Compound:0880-0253|FD-Score:4.16|P-value:1.96E-4 ID:SGTC_1299|Compound:1079-1439|FD-Score:3.72|P-value:7.57E-4 ID:SGTC_1306|Compound:1185-0270|FD-Score:18.30|P-value:8.99E-56 ID:SGTC_1313|Compound:1220-0047|FD-Score:5.58|P-value:9.68E-7 ID:SGTC_1326|Compound:1431-2094|FD-Score:-4.22|P-value:1.39E-4 ID:SGTC_1327|Compound:1436-0082|FD-Score:4.44|P-value:7.68E-5 ID:SGTC_1429|Compound:4049-0205|FD-Score:3.96|P-value:3.75E-4 ID:SGTC_1495|Compound:4469-0029|FD-Score:4.84|P-value:1.81E-5 ID:SGTC_1532|Compound:4',5'-dihydroxyflavone|FD-Score:6.49|P-value:1.49E-8 ID:SGTC_1581|Compound:himbacine|FD-Score:14.00|P-value:3.37E-33 ID:SGTC_1595|Compound:6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin|FD-Score:5.44|P-value:1.70E-6 ID:SGTC_1616|Compound:st002734|FD-Score:3.91|P-value:4.36E-4 ID:SGTC_1633|Compound:st005664|FD-Score:3.78|P-value:6.42E-4 ID:SGTC_1679|Compound:4130-1276|FD-Score:14.70|P-value:2.29E-36 ID:SGTC_1687|Compound:st020778|FD-Score:3.97|P-value:3.54E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:-4.32|P-value:1.01E-4 ID:SGTC_1724|Compound:st037281|FD-Score:6.45|P-value:1.84E-8 ID:SGTC_1745|Compound:st081495|FD-Score:-4.48|P-value:5.79E-5 ID:SGTC_1765|Compound:st044815|FD-Score:4.49|P-value:6.53E-5 ID:SGTC_1818|Compound:st052136|FD-Score:-4.28|P-value:1.13E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:5.22|P-value:4.19E-6 ID:SGTC_1897|Compound:st060201|FD-Score:3.65|P-value:9.37E-4 ID:SGTC_1915|Compound:st067105|FD-Score:3.69|P-value:8.34E-4 ID:SGTC_2041|Compound:5107442|FD-Score:6.45|P-value:1.85E-8 ID:SGTC_2053|Compound:5265679|FD-Score:4.17|P-value:1.90E-4 ID:SGTC_2122|Compound:5258151|FD-Score:5.26|P-value:3.57E-6 ID:SGTC_2133|Compound:5320837|FD-Score:3.80|P-value:5.96E-4 ID:SGTC_2140|Compound:5586273|FD-Score:5.16|P-value:5.30E-6 ID:SGTC_2142|Compound:5622915|FD-Score:4.24|P-value:1.50E-4 ID:SGTC_2242|Compound:6630449|FD-Score:16.20|P-value:3.44E-44 ID:SGTC_2289|Compound:7946404|FD-Score:3.91|P-value:4.35E-4 ID:SGTC_2291|Compound:7917025|FD-Score:12.20|P-value:1.01E-25 ID:SGTC_2322|Compound:7413319|FD-Score:5.04|P-value:8.45E-6 ID:SGTC_2363|Compound:9053361|FD-Score:5.18|P-value:4.97E-6 ID:SGTC_2389|Compound:9091542|FD-Score:4.17|P-value:1.90E-4 ID:SGTC_2393|Compound:9031399|FD-Score:-4.31|P-value:1.04E-4 ID:SGTC_2399|Compound:5884133|FD-Score:3.94|P-value:3.87E-4 ID:SGTC_2413|Compound:inermin|FD-Score:7.71|P-value:2.21E-11 ID:SGTC_2418|Compound:pentamidine|FD-Score:3.95|P-value:3.82E-4 ID:SGTC_2510|Compound:benzyl isothiocyanate|FD-Score:-4.15|P-value:1.77E-4 ID:SGTC_2511|Compound:berberine|FD-Score:-3.83|P-value:4.81E-4 ID:SGTC_2514|Compound:salinomycin|FD-Score:6.78|P-value:3.58E-9 ID:SGTC_2516|Compound:gossypol|FD-Score:5.14|P-value:5.74E-6 ID:SGTC_2543|Compound:pimpinellin|FD-Score:4.35|P-value:1.02E-4 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:12.10|P-value:2.55E-25 ID:SGTC_2580|Compound:diallyl disulphide|FD-Score:-4.00|P-value:2.83E-4 ID:SGTC_2586|Compound:curcumin|FD-Score:7.77|P-value:1.56E-11 ID:SGTC_2679|Compound:rapamycin|FD-Score:4.84|P-value:1.81E-5 ID:SGTC_2737|Compound:bleomycin|FD-Score:10.30|P-value:8.95E-19 ID:SGTC_2752|Compound:diclazuril|FD-Score:4.20|P-value:1.69E-4 ID:SGTC_2777|Compound:climbazole|FD-Score:-4.04|P-value:2.55E-4 ID:SGTC_2778|Compound:tioconazole|FD-Score:-4.85|P-value:1.53E-5 ID:SGTC_2782|Compound:7736369|FD-Score:4.49|P-value:6.45E-5 ID:SGTC_2833|Compound:9001315|FD-Score:3.90|P-value:4.43E-4 ID:SGTC_2845|Compound:9003024|FD-Score:3.82|P-value:5.59E-4 ID:SGTC_2858|Compound:9025781|FD-Score:6.19|P-value:6.22E-8 ID:SGTC_2867|Compound:9039098|FD-Score:4.37|P-value:9.63E-5 ID:SGTC_2884|Compound:9058502|FD-Score:7.55|P-value:5.73E-11 ID:SGTC_2890|Compound:9046729|FD-Score:11.60|P-value:1.53E-23 ID:SGTC_2896|Compound:9052656|FD-Score:4.02|P-value:3.04E-4 ID:SGTC_2923|Compound:7992654|FD-Score:4.35|P-value:1.06E-4 ID:SGTC_2942|Compound:9052777|FD-Score:5.30|P-value:3.02E-6 ID:SGTC_2943|Compound:9068529|FD-Score:5.89|P-value:2.52E-7 ID:SGTC_2944|Compound:9067346|FD-Score:-4.78|P-value:1.98E-5 ID:SGTC_2949|Compound:9072542|FD-Score:5.44|P-value:1.70E-6 ID:SGTC_3098|Compound:9119039|FD-Score:7.29|P-value:2.35E-10 ID:SGTC_3101|Compound:9120531|FD-Score:3.94|P-value:3.95E-4 ID:SGTC_3148|Compound:9097893|FD-Score:4.43|P-value:8.06E-5 ID:SGTC_3149|Compound:9097855|FD-Score:3.81|P-value:5.91E-4 ID:SGTC_3152|Compound:9099253|FD-Score:-4.80|P-value:1.82E-5 ID:SGTC_3166|Compound:9102297|FD-Score:4.93|P-value:1.30E-5 ID:SGTC_3213|Compound:9129884|FD-Score:-3.69|P-value:7.30E-4 ID:SGTC_3219|Compound:9131112|FD-Score:9.67|P-value:6.77E-17 ID:SGTC_3263|Compound:9137018|FD-Score:4.28|P-value:1.32E-4 ID:SGTC_3277|Compound:9138724|FD-Score:11.20|P-value:6.95E-22 ID:SGTC_3284|Compound:9108171|FD-Score:-3.73|P-value:6.64E-4 ID:SGTC_3302|Compound:9125395|FD-Score:-4.04|P-value:2.53E-4 ID:SGTC_3310|Compound:9130229|FD-Score:3.84|P-value:5.39E-4 ID:SGTC_3325|Compound:9138760|FD-Score:4.88|P-value:1.55E-5

Top fitness defect scores for YPL051W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1306 1185-0270 18.30 9.0 µM 8.99E-56 Golgi 4 2.29E-75
2 SGTC_2242 6630449 16.20 61.3 µM 3.44E-44 Golgi 2 1.37E-59
3 SGTC_1073 triclabendazole 14.70 3.1 µM 1.81E-36 1 4.52E-49
4 SGTC_1679 4130-1276 14.70 6.7 µM 2.29E-36 Golgi 4 6.23E-49
5 SGTC_1581 himbacine 14.00 57.9 µM 3.37E-33 Golgi 1 1.28E-44
6 SGTC_91 0417-1751 12.70 58.4 µM 1.35E-27 Golgi 2 5.44E-37
7 SGTC_2291 7917025 12.20 104.3 µM 1.01E-25 iron homeostasis 4 1.94E-34
8 SGTC_2567 aureobasidin a 12.10 60.0 nM 2.55E-25 8 6.82E-34
9 SGTC_2890 9046729 11.60 58.4 µM 1.53E-23 Golgi 2 1.80E-31
10 SGTC_3277 9138724 11.20 49.5 µM 6.95E-22 Golgi 2 3.24E-29
11 SGTC_2737 bleomycin 10.30 30.5 nM 8.95E-19 Golgi 12 5.52E-25
12 SGTC_3219 9131112 9.67 49.5 µM 6.77E-17 Golgi 5 1.98E-22
13 SGTC_2586 curcumin 7.77 80.0 µM 1.56E-11 iron homeostasis 4 3.87E-15
14 SGTC_2413 inermin 7.71 26.1 µM 2.21E-11 10 6.19E-15
15 SGTC_528 3492-0019 7.65 172.0 µM 3.14E-11 calcium & mitochondrial duress 82 1.00E-14
16 SGTC_2884 9058502 7.55 52.0 µM 5.73E-11 1 2.26E-14
17 SGTC_3098 9119039 7.29 49.5 µM 2.35E-10 Golgi 4 1.53E-13
18 SGTC_748 0136-0228 7.22 77.9 µM 3.41E-10 redox potentiating 25 2.55E-13
19 SGTC_2514 salinomycin 6.78 42.7 µM 3.58E-9 12 6.19E-12
20 SGTC_1532 4',5'-dihydroxyflavone 6.49 78.7 µM 1.49E-8 Golgi 6 4.27E-11

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.554 7.04E-269 YJL004C SYS1 hom Integral membrane protein of the Golgi required for targeting of the Arf-like GTPase Arl3p to the Golgi; multicopy suppressor of ypt6 null mutation
0.466 8.36E-181 YBR164C ARL1 hom Soluble GTPase with a role in regulation of membrane traffic; regulates potassium influx; G protein of the Ras superfamily, similar to ADP-ribosylation factor
0.339 5.19E-91 YML071C COG8 hom Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
0.297 5.07E-69 YGL005C COG7 hom Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
0.282 1.26E-62 YMR079W SEC14 het Phosphatidylinositol/phosphatidylcholine transfer protein; involved in regulating PtdIns, PtdCho, and ceramide metabolism, products of which regulate intracellular transport and UPR; has a role in localization of lipid raft proteins; functionally homologous to mammalian PITPs
0.278 1.82E-60 YDR108W TRS85 hom Subunit of TRAPPIII (transport protein particle), a multimeric guanine nucleotide-exchange factor for Ypt1p, required for membrane expansion during autophagy and the CVT pathway; directs Ypt1p to the PAS; late post-replication meiotic role
0.250 4.61E-49 YNL041C COG6 hom Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
0.234 4.64E-43 YEL053C MAK10 hom Non-catalytic subunit of N-terminal acetyltransferase of the NatC type, required for replication of dsRNA virus; expression is glucose-repressible
0.218 1.92E-37 YKR019C IRS4 hom EH domain-containing protein; involved in regulating phosphatidylinositol 4,5-bisphosphate levels and autophagy; Irs4p and Tax4p bind and activate the PtdIns phosphatase Inp51p; Irs4p and Tax4p are involved in localizing Atg17p to the PAS; IRS4 has a paralog, TAX4, that arose from the whole genome duplication
0.206 1.70E-33 YDR320C SWA2 hom Auxilin-like protein involved in vesicular transport; clathrin-binding protein required for uncoating of clathrin-coated vesicles
0.202 4.22E-32 YDR202C RAV2 hom Subunit of RAVE (Rav1p, Rav2p, Skp1p), a complex that associates with the V1 domain of the vacuolar membrane (H+)-ATPase (V-ATPase) and promotes assembly and reassembly of the holoenzyme
0.194 7.89E-30 YGL212W VAM7 hom Vacuolar SNARE protein; functions with Vam3p in vacuolar protein trafficking; has an N-terminal PX domain (phosphoinositide-binding module) that binds PtdIns-3-P and mediates membrane binding; SNAP-25 homolog; protein abundance increases in response to DNA replication stress
0.193 1.36E-29 YOL146W PSF3 het Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication origins and implicated in assembly of the DNA replication machinery
0.193 1.80E-29 YJR033C RAV1 hom Subunit of the RAVE complex (Rav1p, Rav2p, Skp1p), which promotes assembly of the V-ATPase holoenzyme; required for transport between the early and late endosome/PVC and for localization of TGN membrane proteins; potential Cdc28p substrate
0.189 2.00E-28 YGL095C VPS45 hom Protein of the Sec1p/Munc-18 family, essential for vacuolar protein sorting; required for the function of Pep12p and the early endosome/late Golgi SNARE Tlg2p; essential for fusion of Golgi-derived vesicles with the prevacuolar compartment