YPL052W / OAZ1

Regulator of ornithine decarboxylase (Spe1p), antizyme that binds to Spe1p to stimulate ubiquitin-independent degradation by the proteasome; binding of polyamines to nascent Oaz1p during translation stimulates +1 ribosomal frameshifting, allowing translation of full-length Oaz1p

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL052W / OAZ1

Click on Significant Values for Screen Details ID:SGTC_92|Compound:0063-0024|FD-Score:3.01|P-value:8.11E-4 ID:SGTC_100|Compound:0086-0128|FD-Score:3.25|P-value:3.33E-4 ID:SGTC_145|Compound:3737-0113|FD-Score:3.78|P-value:3.65E-5 ID:SGTC_166|Compound:k072-0058|FD-Score:4.07|P-value:1.01E-5 ID:SGTC_184|Compound:1494-0393|FD-Score:6.12|P-value:6.74E-11 ID:SGTC_815|Compound:1582-0027|FD-Score:3.59|P-value:8.43E-5 ID:SGTC_826|Compound:1683-5028|FD-Score:-3.18|P-value:4.14E-4 ID:SGTC_936|Compound:3005-4620|FD-Score:3.44|P-value:1.55E-4 ID:SGTC_1053|Compound:3366-3204|FD-Score:5.81|P-value:5.64E-10 ID:SGTC_1206|Compound:3978-0017|FD-Score:-3.01|P-value:7.95E-4 ID:SGTC_1213|Compound:1315-0166|FD-Score:3.01|P-value:8.20E-4 ID:SGTC_1239|Compound:0337-0584|FD-Score:5.07|P-value:5.26E-8 ID:SGTC_1243|Compound:0416-0003|FD-Score:-4.44|P-value:1.55E-6 ID:SGTC_1245|Compound:0418-0076|FD-Score:3.16|P-value:4.56E-4 ID:SGTC_1246|Compound:0422-0085|FD-Score:-3.89|P-value:2.22E-5 ID:SGTC_1251|Compound:0490-5699|FD-Score:-3.54|P-value:1.01E-4 ID:SGTC_1293|Compound:1000-1278|FD-Score:3.25|P-value:3.28E-4 ID:SGTC_1369|Compound:1866-0067|FD-Score:-5.93|P-value:2.33E-10 ID:SGTC_1374|Compound:2889-5571|FD-Score:3.34|P-value:2.29E-4 ID:SGTC_1405|Compound:3909-7894|FD-Score:2.99|P-value:8.71E-4 ID:SGTC_1455|Compound:4262-0120|FD-Score:3.07|P-value:6.49E-4 ID:SGTC_1496|Compound:4469-0713|FD-Score:-3.21|P-value:3.74E-4 ID:SGTC_1511|Compound:0906-3109|FD-Score:3.38|P-value:1.95E-4 ID:SGTC_1651|Compound:st011928|FD-Score:3.16|P-value:4.59E-4 ID:SGTC_1749|Compound:st037932|FD-Score:3.13|P-value:5.20E-4 ID:SGTC_1891|Compound:st059073|FD-Score:3.41|P-value:1.76E-4 ID:SGTC_1901|Compound:st060216|FD-Score:3.64|P-value:6.75E-5 ID:SGTC_2394|Compound:5221648|FD-Score:-3.10|P-value:5.68E-4 ID:SGTC_2409|Compound:alverine citrate|FD-Score:-3.30|P-value:2.68E-4 ID:SGTC_2426|Compound:5582046|FD-Score:3.53|P-value:1.09E-4 ID:SGTC_2487|Compound:5918373|FD-Score:-3.11|P-value:5.45E-4 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:4.86|P-value:1.75E-7 ID:SGTC_2653|Compound:dihydrofissinolide|FD-Score:3.17|P-value:4.41E-4 ID:SGTC_2676|Compound:harmalol|FD-Score:-3.11|P-value:5.49E-4 ID:SGTC_2811|Compound:7967822|FD-Score:-3.90|P-value:2.09E-5 ID:SGTC_2970|Compound:9090938|FD-Score:-3.06|P-value:6.50E-4 ID:SGTC_3016|Compound:9080866|FD-Score:3.43|P-value:1.60E-4 ID:SGTC_3082|Compound:9117008|FD-Score:3.61|P-value:7.87E-5 ID:SGTC_3114|Compound:9122766|FD-Score:3.71|P-value:5.00E-5 ID:SGTC_3321|Compound:9137793|FD-Score:3.48|P-value:1.34E-4 ID:SGTC_3327|Compound:9140648|FD-Score:3.93|P-value:1.88E-5 ID:SGTC_92|Compound:0063-0024|FD-Score:3.01|P-value:8.11E-4 ID:SGTC_100|Compound:0086-0128|FD-Score:3.25|P-value:3.33E-4 ID:SGTC_145|Compound:3737-0113|FD-Score:3.78|P-value:3.65E-5 ID:SGTC_166|Compound:k072-0058|FD-Score:4.07|P-value:1.01E-5 ID:SGTC_184|Compound:1494-0393|FD-Score:6.12|P-value:6.74E-11 ID:SGTC_815|Compound:1582-0027|FD-Score:3.59|P-value:8.43E-5 ID:SGTC_826|Compound:1683-5028|FD-Score:-3.18|P-value:4.14E-4 ID:SGTC_936|Compound:3005-4620|FD-Score:3.44|P-value:1.55E-4 ID:SGTC_1053|Compound:3366-3204|FD-Score:5.81|P-value:5.64E-10 ID:SGTC_1206|Compound:3978-0017|FD-Score:-3.01|P-value:7.95E-4 ID:SGTC_1213|Compound:1315-0166|FD-Score:3.01|P-value:8.20E-4 ID:SGTC_1239|Compound:0337-0584|FD-Score:5.07|P-value:5.26E-8 ID:SGTC_1243|Compound:0416-0003|FD-Score:-4.44|P-value:1.55E-6 ID:SGTC_1245|Compound:0418-0076|FD-Score:3.16|P-value:4.56E-4 ID:SGTC_1246|Compound:0422-0085|FD-Score:-3.89|P-value:2.22E-5 ID:SGTC_1251|Compound:0490-5699|FD-Score:-3.54|P-value:1.01E-4 ID:SGTC_1293|Compound:1000-1278|FD-Score:3.25|P-value:3.28E-4 ID:SGTC_1369|Compound:1866-0067|FD-Score:-5.93|P-value:2.33E-10 ID:SGTC_1374|Compound:2889-5571|FD-Score:3.34|P-value:2.29E-4 ID:SGTC_1405|Compound:3909-7894|FD-Score:2.99|P-value:8.71E-4 ID:SGTC_1455|Compound:4262-0120|FD-Score:3.07|P-value:6.49E-4 ID:SGTC_1496|Compound:4469-0713|FD-Score:-3.21|P-value:3.74E-4 ID:SGTC_1511|Compound:0906-3109|FD-Score:3.38|P-value:1.95E-4 ID:SGTC_1651|Compound:st011928|FD-Score:3.16|P-value:4.59E-4 ID:SGTC_1749|Compound:st037932|FD-Score:3.13|P-value:5.20E-4 ID:SGTC_1891|Compound:st059073|FD-Score:3.41|P-value:1.76E-4 ID:SGTC_1901|Compound:st060216|FD-Score:3.64|P-value:6.75E-5 ID:SGTC_2394|Compound:5221648|FD-Score:-3.10|P-value:5.68E-4 ID:SGTC_2409|Compound:alverine citrate|FD-Score:-3.30|P-value:2.68E-4 ID:SGTC_2426|Compound:5582046|FD-Score:3.53|P-value:1.09E-4 ID:SGTC_2487|Compound:5918373|FD-Score:-3.11|P-value:5.45E-4 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:4.86|P-value:1.75E-7 ID:SGTC_2653|Compound:dihydrofissinolide|FD-Score:3.17|P-value:4.41E-4 ID:SGTC_2676|Compound:harmalol|FD-Score:-3.11|P-value:5.49E-4 ID:SGTC_2811|Compound:7967822|FD-Score:-3.90|P-value:2.09E-5 ID:SGTC_2970|Compound:9090938|FD-Score:-3.06|P-value:6.50E-4 ID:SGTC_3016|Compound:9080866|FD-Score:3.43|P-value:1.60E-4 ID:SGTC_3082|Compound:9117008|FD-Score:3.61|P-value:7.87E-5 ID:SGTC_3114|Compound:9122766|FD-Score:3.71|P-value:5.00E-5 ID:SGTC_3321|Compound:9137793|FD-Score:3.48|P-value:1.34E-4 ID:SGTC_3327|Compound:9140648|FD-Score:3.93|P-value:1.88E-5

Top fitness defect scores for YPL052W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_184 1494-0393 6.12 24.7 µM 6.74E-11 15 4.54E-10
2 SGTC_1053 3366-3204 5.81 134.0 µM 5.64E-10 cell wall 11 3.14E-9
3 SGTC_1239 0337-0584 5.07 35.4 µM 5.26E-8 unfolded protein response 25 1.96E-7
4 SGTC_2538 3',7'-epoxycaryophyllan-6-one 4.86 100.0 µM 1.75E-7 12 5.86E-7
5 SGTC_166 k072-0058 4.07 166.4 µM 1.01E-5 DNA intercalators 31 2.38E-5
6 SGTC_3327 9140648 3.93 26.9 µM 1.88E-5 12 4.20E-5
7 SGTC_145 3737-0113 3.78 38.4 µM 3.65E-5 DNA intercalators 80 7.71E-5
8 SGTC_3114 9122766 3.71 49.5 µM 5.00E-5 22 1.03E-4
9 SGTC_1901 st060216 3.64 58.6 µM 6.75E-5 30 1.35E-4
10 SGTC_3082 9117008 3.61 49.5 µM 7.87E-5 24 1.55E-4
11 SGTC_815 1582-0027 3.59 36.9 µM 8.43E-5 41 1.65E-4
12 SGTC_2426 5582046 3.53 32.2 µM 1.09E-4 44 2.08E-4
13 SGTC_3321 9137793 3.48 26.8 µM 1.34E-4 cell wall 93 2.52E-4
14 SGTC_936 3005-4620 3.44 401.0 µM 1.55E-4 44 2.89E-4
15 SGTC_3016 9080866 3.43 49.5 µM 1.60E-4 42 2.98E-4
16 SGTC_1891 st059073 3.41 26.2 µM 1.76E-4 TSC3-RPN4 34 3.25E-4
17 SGTC_1511 0906-3109 3.38 28.5 µM 1.95E-4 excess fatty acid 76 3.57E-4
18 SGTC_1374 2889-5571 3.34 141.0 µM 2.29E-4 RSC complex & mRNA processing 69 4.13E-4
19 SGTC_1293 1000-1278 3.25 195.0 µM 3.28E-4 37 5.73E-4
20 SGTC_100 0086-0128 3.25 49.6 µM 3.33E-4 copper-dependent oxidative stress 91 5.81E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.159 2.09E-20 YML130C ERO1 het Thiol oxidase required for oxidative protein folding in the ER; essential for maintaining proper redox balance in ER; feedback regulation of Ero1p occurs via reduction and oxidation of Ero1p regulatory bonds; reduced Pdi1p activates Ero1p by direct reduction of Ero1p regulatory bonds; depletion of thiol substrates and accumulation of oxidized Pdi1p results in inactivation of Ero1p by both Pdi1p-mediated oxidation and autonomous oxidation of Ero1p regulatory bonds
0.155 1.47E-19 YFL032W_d YFL032W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene HAC1/YFL031W; YFL032W is not an essential gene
0.148 6.43E-18 YPL262W FUM1 hom Fumarase, converts fumaric acid to L-malic acid in the TCA cycle; cytosolic and mitochondrial distribution determined by the N-terminal targeting sequence, protein conformation, and status of glyoxylate shunt; phosphorylated in mitochondria
0.125 3.49E-13 YPL035C_d YPL035C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YPL034W; YPL035C is not an essential gene
0.104 1.82E-9 YMR001C-A_p YMR001C-A_p hom Putative protein of unknown function
0.103 2.64E-9 YDR250C_d YDR250C_d hom Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data
0.102 2.73E-9 YIL032C_d YIL032C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.102 2.97E-9 YGL175C SAE2 hom Endonuclease that processes hairpin DNA structures with the MRX complex; involved in meiotic and mitotic double-strand break repair; phosphorylated in response to DNA damage and required for normal resistance to DNA-damaging agents
0.102 3.54E-9 YLR132C USB1 het Putative phosphodiesterase specific for U6 snRNA 3' end modification; trims the 3' poly(u) tract to leave a terminal 3' phosphate; human homolog, hUSB1 (aka C16orf57) produces a 2',3' cyclic phosphate; mutations in hUSB1 are associated with a rare skin condition (OMIM 604173); essential protein that localizes to the nucleus and mitochondria; overexpression suppresses the respiratory defects of oxa1 and mtf2 mutants
0.101 4.50E-9 YHR149C SKG6 hom Integral membrane protein that localizes primarily to growing sites such as the bud tip or the cell periphery; potential Cdc28p substrate; Skg6p interacts with Zds1p and Zds2p
0.099 7.94E-9 YIL046W-A_p YIL046W-A_p hom Putative protein of unknown function; identified by expression profiling and mass spectrometry
0.096 2.43E-8 YNL075W IMP4 het Component of the SSU processome, which is required for pre-18S rRNA processing; interacts with Mpp10p; member of a superfamily of proteins that contain a sigma(70)-like motif and associate with RNAs
0.096 2.56E-8 YPL224C MMT2 hom Putative metal transporter involved in mitochondrial iron accumulation; closely related to Mmt1p
0.095 3.24E-8 YJL144W YJL144W hom Cytoplasmic hydrophilin essential in dessication-rehydration process; expression induced by osmotic stress, starvation and during stationary phase; protein abundance increases in response to DNA replication stress
0.095 3.45E-8 YMR044W IOC4 hom Member of a complex (Isw1b) with Isw1p and Ioc2p; interacts directly with H3K36me3 nucleosomes through its PWWP domain to recruit the Isw1b complex to open reading frames in a Set2p-dependent manner; Isw1b exhibits nucleosome-stimulated ATPase activity and acts within coding regions to coordinate transcription elongation with termination and processing