YPL053C / KTR6

Probable mannosylphosphate transferase; involved in the synthesis of core oligosaccharides in protein glycosylation pathway; member of the KRE2/MNT1 mannosyltransferase family; KTR6 has a paralog, KRE2, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL053C / KTR6

Click on Significant Values for Screen Details ID:SGTC_166|Compound:k072-0058|FD-Score:5.16|P-value:7.37E-8 ID:SGTC_168|Compound:3970-0862|FD-Score:-3.10|P-value:7.36E-4 ID:SGTC_264|Compound:promethazine|FD-Score:3.82|P-value:5.12E-5 ID:SGTC_397|Compound:arbidol|FD-Score:3.27|P-value:4.36E-4 ID:SGTC_565|Compound:1418-0001|FD-Score:-3.23|P-value:4.67E-4 ID:SGTC_612|Compound:0302-0167|FD-Score:4.50|P-value:2.27E-6 ID:SGTC_684|Compound:1140-0066|FD-Score:3.13|P-value:7.37E-4 ID:SGTC_804|Compound:1595-0054|FD-Score:3.14|P-value:7.18E-4 ID:SGTC_934|Compound:2950-0684|FD-Score:3.42|P-value:2.51E-4 ID:SGTC_974|Compound:1326-0144|FD-Score:3.52|P-value:1.69E-4 ID:SGTC_1158|Compound:4092-0494|FD-Score:3.36|P-value:3.12E-4 ID:SGTC_1188|Compound:1403-0014|FD-Score:3.10|P-value:8.19E-4 ID:SGTC_1248|Compound:0469-0687|FD-Score:3.97|P-value:2.64E-5 ID:SGTC_1426|Compound:4048-4480|FD-Score:4.32|P-value:5.54E-6 ID:SGTC_1430|Compound:4049-0248|FD-Score:5.64|P-value:4.56E-9 ID:SGTC_1435|Compound:4092-0789|FD-Score:-3.81|P-value:4.72E-5 ID:SGTC_1831|Compound:st055328|FD-Score:3.54|P-value:1.57E-4 ID:SGTC_1849|Compound:st056239|FD-Score:5.43|P-value:1.57E-8 ID:SGTC_1851|Compound:st056236|FD-Score:6.31|P-value:6.58E-11 ID:SGTC_1858|Compound:4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione|FD-Score:4.09|P-value:1.57E-5 ID:SGTC_1867|Compound:st057372|FD-Score:3.25|P-value:4.68E-4 ID:SGTC_1958|Compound:st076513|FD-Score:3.46|P-value:2.16E-4 ID:SGTC_1962|Compound:st076595|FD-Score:5.56|P-value:7.48E-9 ID:SGTC_1970|Compound:st070122|FD-Score:3.45|P-value:2.27E-4 ID:SGTC_1971|Compound:st069429|FD-Score:6.11|P-value:2.43E-10 ID:SGTC_1973|Compound:st070275|FD-Score:3.57|P-value:1.41E-4 ID:SGTC_2017|Compound:5132927|FD-Score:7.08|P-value:2.70E-13 ID:SGTC_2056|Compound:5235370|FD-Score:3.29|P-value:4.06E-4 ID:SGTC_2058|Compound:5236698|FD-Score:-3.34|P-value:3.05E-4 ID:SGTC_2069|Compound:5228469|FD-Score:3.07|P-value:9.08E-4 ID:SGTC_2274|Compound:7947094|FD-Score:4.23|P-value:8.39E-6 ID:SGTC_2278|Compound:7948257|FD-Score:3.57|P-value:1.42E-4 ID:SGTC_2296|Compound:7971656|FD-Score:3.27|P-value:4.47E-4 ID:SGTC_2517|Compound:totarol|FD-Score:4.27|P-value:6.84E-6 ID:SGTC_2572|Compound:astragaloside iv|FD-Score:-3.45|P-value:2.05E-4 ID:SGTC_2580|Compound:diallyl disulphide|FD-Score:-3.13|P-value:6.63E-4 ID:SGTC_2585|Compound:alliin|FD-Score:3.73|P-value:7.25E-5 ID:SGTC_2587|Compound:piperic acid|FD-Score:-4.55|P-value:1.59E-6 ID:SGTC_2628|Compound:lathosterol|FD-Score:-3.11|P-value:7.15E-4 ID:SGTC_2749|Compound:bexarotene|FD-Score:4.95|P-value:2.29E-7 ID:SGTC_2833|Compound:9001315|FD-Score:3.47|P-value:2.08E-4 ID:SGTC_2836|Compound:9010338|FD-Score:-5.02|P-value:1.34E-7 ID:SGTC_2846|Compound:9008642|FD-Score:-4.30|P-value:5.23E-6 ID:SGTC_2855|Compound:9016525|FD-Score:3.17|P-value:6.28E-4 ID:SGTC_2920|Compound:7982904|FD-Score:3.23|P-value:5.07E-4 ID:SGTC_2931|Compound:9014674|FD-Score:5.07|P-value:1.21E-7 ID:SGTC_2939|Compound:9044578|FD-Score:3.85|P-value:4.41E-5 ID:SGTC_3008|Compound:9078912|FD-Score:3.07|P-value:8.93E-4 ID:SGTC_3047|Compound:9092122|FD-Score:4.38|P-value:4.15E-6 ID:SGTC_3100|Compound:9120536|FD-Score:3.80|P-value:5.60E-5 ID:SGTC_3114|Compound:9122766|FD-Score:3.58|P-value:1.34E-4 ID:SGTC_3121|Compound:9125696|FD-Score:-3.07|P-value:8.15E-4 ID:SGTC_3137|Compound:9097352|FD-Score:3.51|P-value:1.75E-4 ID:SGTC_3205|Compound:9113483|FD-Score:3.25|P-value:4.72E-4 ID:SGTC_3212|Compound:9128307|FD-Score:3.64|P-value:1.09E-4 ID:SGTC_3251|Compound:9135047|FD-Score:3.64|P-value:1.07E-4 ID:SGTC_3252|Compound:9135871|FD-Score:3.21|P-value:5.55E-4 ID:SGTC_3283|Compound:9109332|FD-Score:4.57|P-value:1.66E-6 ID:SGTC_3286|Compound:9117135|FD-Score:-3.62|P-value:1.05E-4 ID:SGTC_166|Compound:k072-0058|FD-Score:5.16|P-value:7.37E-8 ID:SGTC_168|Compound:3970-0862|FD-Score:-3.10|P-value:7.36E-4 ID:SGTC_264|Compound:promethazine|FD-Score:3.82|P-value:5.12E-5 ID:SGTC_397|Compound:arbidol|FD-Score:3.27|P-value:4.36E-4 ID:SGTC_565|Compound:1418-0001|FD-Score:-3.23|P-value:4.67E-4 ID:SGTC_612|Compound:0302-0167|FD-Score:4.50|P-value:2.27E-6 ID:SGTC_684|Compound:1140-0066|FD-Score:3.13|P-value:7.37E-4 ID:SGTC_804|Compound:1595-0054|FD-Score:3.14|P-value:7.18E-4 ID:SGTC_934|Compound:2950-0684|FD-Score:3.42|P-value:2.51E-4 ID:SGTC_974|Compound:1326-0144|FD-Score:3.52|P-value:1.69E-4 ID:SGTC_1158|Compound:4092-0494|FD-Score:3.36|P-value:3.12E-4 ID:SGTC_1188|Compound:1403-0014|FD-Score:3.10|P-value:8.19E-4 ID:SGTC_1248|Compound:0469-0687|FD-Score:3.97|P-value:2.64E-5 ID:SGTC_1426|Compound:4048-4480|FD-Score:4.32|P-value:5.54E-6 ID:SGTC_1430|Compound:4049-0248|FD-Score:5.64|P-value:4.56E-9 ID:SGTC_1435|Compound:4092-0789|FD-Score:-3.81|P-value:4.72E-5 ID:SGTC_1831|Compound:st055328|FD-Score:3.54|P-value:1.57E-4 ID:SGTC_1849|Compound:st056239|FD-Score:5.43|P-value:1.57E-8 ID:SGTC_1851|Compound:st056236|FD-Score:6.31|P-value:6.58E-11 ID:SGTC_1858|Compound:4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione|FD-Score:4.09|P-value:1.57E-5 ID:SGTC_1867|Compound:st057372|FD-Score:3.25|P-value:4.68E-4 ID:SGTC_1958|Compound:st076513|FD-Score:3.46|P-value:2.16E-4 ID:SGTC_1962|Compound:st076595|FD-Score:5.56|P-value:7.48E-9 ID:SGTC_1970|Compound:st070122|FD-Score:3.45|P-value:2.27E-4 ID:SGTC_1971|Compound:st069429|FD-Score:6.11|P-value:2.43E-10 ID:SGTC_1973|Compound:st070275|FD-Score:3.57|P-value:1.41E-4 ID:SGTC_2017|Compound:5132927|FD-Score:7.08|P-value:2.70E-13 ID:SGTC_2056|Compound:5235370|FD-Score:3.29|P-value:4.06E-4 ID:SGTC_2058|Compound:5236698|FD-Score:-3.34|P-value:3.05E-4 ID:SGTC_2069|Compound:5228469|FD-Score:3.07|P-value:9.08E-4 ID:SGTC_2274|Compound:7947094|FD-Score:4.23|P-value:8.39E-6 ID:SGTC_2278|Compound:7948257|FD-Score:3.57|P-value:1.42E-4 ID:SGTC_2296|Compound:7971656|FD-Score:3.27|P-value:4.47E-4 ID:SGTC_2517|Compound:totarol|FD-Score:4.27|P-value:6.84E-6 ID:SGTC_2572|Compound:astragaloside iv|FD-Score:-3.45|P-value:2.05E-4 ID:SGTC_2580|Compound:diallyl disulphide|FD-Score:-3.13|P-value:6.63E-4 ID:SGTC_2585|Compound:alliin|FD-Score:3.73|P-value:7.25E-5 ID:SGTC_2587|Compound:piperic acid|FD-Score:-4.55|P-value:1.59E-6 ID:SGTC_2628|Compound:lathosterol|FD-Score:-3.11|P-value:7.15E-4 ID:SGTC_2749|Compound:bexarotene|FD-Score:4.95|P-value:2.29E-7 ID:SGTC_2833|Compound:9001315|FD-Score:3.47|P-value:2.08E-4 ID:SGTC_2836|Compound:9010338|FD-Score:-5.02|P-value:1.34E-7 ID:SGTC_2846|Compound:9008642|FD-Score:-4.30|P-value:5.23E-6 ID:SGTC_2855|Compound:9016525|FD-Score:3.17|P-value:6.28E-4 ID:SGTC_2920|Compound:7982904|FD-Score:3.23|P-value:5.07E-4 ID:SGTC_2931|Compound:9014674|FD-Score:5.07|P-value:1.21E-7 ID:SGTC_2939|Compound:9044578|FD-Score:3.85|P-value:4.41E-5 ID:SGTC_3008|Compound:9078912|FD-Score:3.07|P-value:8.93E-4 ID:SGTC_3047|Compound:9092122|FD-Score:4.38|P-value:4.15E-6 ID:SGTC_3100|Compound:9120536|FD-Score:3.80|P-value:5.60E-5 ID:SGTC_3114|Compound:9122766|FD-Score:3.58|P-value:1.34E-4 ID:SGTC_3121|Compound:9125696|FD-Score:-3.07|P-value:8.15E-4 ID:SGTC_3137|Compound:9097352|FD-Score:3.51|P-value:1.75E-4 ID:SGTC_3205|Compound:9113483|FD-Score:3.25|P-value:4.72E-4 ID:SGTC_3212|Compound:9128307|FD-Score:3.64|P-value:1.09E-4 ID:SGTC_3251|Compound:9135047|FD-Score:3.64|P-value:1.07E-4 ID:SGTC_3252|Compound:9135871|FD-Score:3.21|P-value:5.55E-4 ID:SGTC_3283|Compound:9109332|FD-Score:4.57|P-value:1.66E-6 ID:SGTC_3286|Compound:9117135|FD-Score:-3.62|P-value:1.05E-4

Top fitness defect scores for YPL053C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2017 5132927 7.08 60.6 µM 2.70E-13 2 7.27E-13
2 SGTC_1851 st056236 6.31 18.9 µM 6.58E-11 2 1.43E-10
3 SGTC_1971 st069429 6.11 63.5 µM 2.43E-10 60S ribosome export 1 5.04E-10
4 SGTC_1430 4049-0248 5.64 69.1 µM 4.56E-9 4 8.45E-9
5 SGTC_1962 st076595 5.56 64.5 µM 7.48E-9 redox potentiating 9 1.36E-8
6 SGTC_1849 st056239 5.43 19.2 µM 1.57E-8 RPP1 & pyrimidine depletion 5 2.77E-8
7 SGTC_166 k072-0058 5.16 166.4 µM 7.37E-8 DNA intercalators 13 1.23E-7
8 SGTC_2931 9014674 5.07 55.7 µM 1.21E-7 5 1.98E-7
9 SGTC_2749 bexarotene 4.95 57.4 µM 2.29E-7 9 3.66E-7
10 SGTC_3283 9109332 4.57 35.8 µM 1.66E-6 DNA intercalators 6 2.47E-6
11 SGTC_612 0302-0167 4.50 22.4 µM 2.27E-6 copper-dependent oxidative stress 23 3.34E-6
12 SGTC_3047 9092122 4.38 49.5 µM 4.15E-6 12 5.97E-6
13 SGTC_1426 4048-4480 4.32 71.7 µM 5.54E-6 60S ribosome export 10 7.88E-6
14 SGTC_2517 totarol 4.27 10.0 µM 6.84E-6 15 9.66E-6
15 SGTC_2274 7947094 4.23 46.1 µM 8.39E-6 24 1.18E-5
16 SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 4.09 62.6 µM 1.57E-5 TSC3-RPN4 13 2.15E-5
17 SGTC_1248 0469-0687 3.97 58.6 µM 2.64E-5 30 3.55E-5
18 SGTC_2939 9044578 3.85 71.4 µM 4.41E-5 44 5.83E-5
19 SGTC_264 promethazine 3.82 12.5 mM 5.12E-5 DNA intercalators 57 6.73E-5
20 SGTC_3100 9120536 3.80 49.5 µM 5.60E-5 17 7.33E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.087 4.35E-7 YJR141W_p YJR141W_p het Essential protein of unknown function
0.086 6.76E-7 YGL001C ERG26 het C-3 sterol dehydrogenase, catalyzes the second of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis
0.085 7.84E-7 YPL167C REV3 hom Catalytic subunit of DNA polymerase zeta, involved in translesion synthesis during post-replication repair; required for mutagenesis induced by DNA damage; involved in double-strand break repair
0.085 7.94E-7 YFL022C FRS2 het Alpha subunit of cytoplasmic phenylalanyl-tRNA synthetase, forms a tetramer with Frs1p to form active enzyme; evolutionarily distant from mitochondrial phenylalanyl-tRNA synthetase based on protein sequence, but substrate binding is similar
0.079 4.34E-6 YMR168C CEP3 het Essential kinetochore protein, component of the CBF3 complex that binds the CDEIII region of the centromere; contains an N-terminal Zn2Cys6 type zinc finger domain, a C-terminal acidic domain, and a putative coiled coil dimerization domain
0.077 8.50E-6 YDR217C RAD9 hom DNA damage-dependent checkpoint protein; required for cell-cycle arrest in G1/S, intra-S, and G2/M; transmits checkpoint signal by activating Rad53p and Chk1p; hyperphosphorylated by Mec1p and Tel1p; multiple cyclin dependent kinase consensus sites and the C-terminal BRCT domain contribute to DNA damage checkpoint activation; potential Cdc28p substrate
0.075 1.29E-5 YLR184W_d YLR184W_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.075 1.39E-5 YDL054C MCH1 hom Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane; mutant is not deficient in monocarboxylate transport
0.074 1.88E-5 YBR141C_p YBR141C_p hom Putative S-adenosylmethionine-dependent methyltransferase; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; YBR141C is not an essential gene
0.073 2.51E-5 YMR166C_p YMR166C_p hom Predicted transporter of the mitochondrial inner membrane; has similarity to human mitochondrial ATP-Mg/Pi carriers; YMR166C is not an essential gene
0.072 2.84E-5 YOR133W EFT1 hom Elongation factor 2 (EF-2), also encoded by EFT2; catalyzes ribosomal translocation during protein synthesis; contains diphthamide, the unique posttranslationally modified histidine residue specifically ADP-ribosylated by diphtheria toxin; EFT1 has a paralog, EFT2, that arose from the whole genome duplication
0.072 3.11E-5 YEL032W MCM3 het Protein involved in DNA replication; component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex
0.071 3.99E-5 YMR289W ABZ2 hom Aminodeoxychorismate lyase (4-amino-4-deoxychorismate lyase), catalyzes the third step in para-aminobenzoic acid biosynthesis; involved in folic acid biosynthesis
0.070 4.94E-5 YLR413W_p YLR413W_p hom Putative protein of unknown function; YLR413W is not an essential gene
0.069 5.91E-5 YDR180W SCC2 het Subunit of cohesin loading factor (Scc2p-Scc4p), a complex required for loading of cohesin complexes onto chromosomes; involved in establishing sister chromatid cohesion during DSB repair via histone H2AX; evolutionarily-conserved adherin