YPL055C / LGE1

Protein of unknown function; null mutant forms abnormally large cells, and homozygous diploid null mutant displays delayed premeiotic DNA synthesis and reduced efficiency of meiotic nuclear division

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL055C / LGE1

Click on Significant Values for Screen Details ID:SGTC_7|Compound:0192-1582|FD-Score:4.40|P-value:2.44E-5 ID:SGTC_36|Compound:0335-0881|FD-Score:4.46|P-value:1.88E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:6.32|P-value:2.36E-9 ID:SGTC_64|Compound:000l-0018|FD-Score:3.64|P-value:3.90E-4 ID:SGTC_67|Compound:0335-0847|FD-Score:4.11|P-value:7.48E-5 ID:SGTC_86|Compound:0417-1630|FD-Score:3.98|P-value:1.18E-4 ID:SGTC_137|Compound:0438-0332|FD-Score:4.40|P-value:2.39E-5 ID:SGTC_138|Compound:0850-0259|FD-Score:3.61|P-value:4.44E-4 ID:SGTC_142|Compound:0335-0849|FD-Score:5.49|P-value:1.89E-7 ID:SGTC_158|Compound:k038-0087|FD-Score:4.76|P-value:5.34E-6 ID:SGTC_178|Compound:4092-0806|FD-Score:4.32|P-value:3.25E-5 ID:SGTC_293|Compound:4049-0273|FD-Score:3.75|P-value:2.70E-4 ID:SGTC_294|Compound:k038-0071|FD-Score:4.19|P-value:5.40E-5 ID:SGTC_305|Compound:1682-2595|FD-Score:6.11|P-value:7.54E-9 ID:SGTC_365|Compound:0121-0052|FD-Score:-3.36|P-value:7.80E-4 ID:SGTC_367|Compound:0335-0881|FD-Score:4.77|P-value:5.16E-6 ID:SGTC_397|Compound:arbidol|FD-Score:3.63|P-value:4.11E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:3.87|P-value:1.79E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:-3.53|P-value:4.49E-4 ID:SGTC_619|Compound:1652-1634|FD-Score:3.43|P-value:7.97E-4 ID:SGTC_642|Compound:0335-0876|FD-Score:5.82|P-value:3.54E-8 ID:SGTC_657|Compound:3534-0529|FD-Score:-3.63|P-value:3.19E-4 ID:SGTC_664|Compound:1222-0054|FD-Score:3.49|P-value:6.56E-4 ID:SGTC_683|Compound:panaxydol|FD-Score:3.70|P-value:3.18E-4 ID:SGTC_700|Compound:3453-2283|FD-Score:3.49|P-value:6.53E-4 ID:SGTC_721|Compound:1187-1332|FD-Score:5.21|P-value:7.24E-7 ID:SGTC_731|Compound:3966-0296|FD-Score:4.07|P-value:8.62E-5 ID:SGTC_790|Compound:1575-0012|FD-Score:3.64|P-value:3.90E-4 ID:SGTC_794|Compound:k038-0031|FD-Score:5.29|P-value:4.85E-7 ID:SGTC_819|Compound:1013-0258|FD-Score:4.31|P-value:3.44E-5 ID:SGTC_879|Compound:0831-1030|FD-Score:4.28|P-value:3.81E-5 ID:SGTC_918|Compound:glabranin|FD-Score:3.80|P-value:2.29E-4 ID:SGTC_1137|Compound:ixabepilone|FD-Score:3.95|P-value:1.34E-4 ID:SGTC_1151|Compound:3909-8316|FD-Score:4.79|P-value:4.79E-6 ID:SGTC_1154|Compound:4088-0362|FD-Score:4.84|P-value:3.89E-6 ID:SGTC_1173|Compound:0443-0020|FD-Score:6.87|P-value:9.90E-11 ID:SGTC_1179|Compound:1021-1431|FD-Score:4.10|P-value:7.64E-5 ID:SGTC_1247|Compound:0448-0043|FD-Score:7.03|P-value:3.71E-11 ID:SGTC_1250|Compound:0485-0349|FD-Score:-4.83|P-value:2.80E-6 ID:SGTC_1287|Compound:0971-0001|FD-Score:3.80|P-value:2.30E-4 ID:SGTC_1386|Compound:3228-0095|FD-Score:4.84|P-value:3.76E-6 ID:SGTC_1393|Compound:3470-5649|FD-Score:4.98|P-value:2.05E-6 ID:SGTC_1468|Compound:k284-1086|FD-Score:3.99|P-value:1.16E-4 ID:SGTC_1479|Compound:0549-0158|FD-Score:3.66|P-value:3.68E-4 ID:SGTC_1672|Compound:st016598|FD-Score:4.23|P-value:4.75E-5 ID:SGTC_1683|Compound:st010134|FD-Score:-5.38|P-value:2.16E-7 ID:SGTC_1694|Compound:st024011|FD-Score:5.59|P-value:1.17E-7 ID:SGTC_1714|Compound:st033236|FD-Score:4.02|P-value:1.02E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:-4.64|P-value:6.46E-6 ID:SGTC_1795|Compound:st049545|FD-Score:3.85|P-value:1.91E-4 ID:SGTC_1796|Compound:st049173|FD-Score:-3.28|P-value:9.81E-4 ID:SGTC_1849|Compound:st056239|FD-Score:4.13|P-value:6.88E-5 ID:SGTC_1909|Compound:st060837|FD-Score:5.68|P-value:7.41E-8 ID:SGTC_1934|Compound:st074720|FD-Score:6.50|P-value:8.66E-10 ID:SGTC_1941|Compound:st076221|FD-Score:3.41|P-value:8.30E-4 ID:SGTC_1983|Compound:st071813|FD-Score:5.48|P-value:1.98E-7 ID:SGTC_2019|Compound:4016004|FD-Score:3.66|P-value:3.68E-4 ID:SGTC_2085|Compound:5307070|FD-Score:-3.40|P-value:6.68E-4 ID:SGTC_2131|Compound:toluylene red|FD-Score:3.49|P-value:6.48E-4 ID:SGTC_2266|Compound:7929956|FD-Score:-3.48|P-value:5.28E-4 ID:SGTC_2312|Compound:7706453|FD-Score:3.53|P-value:5.69E-4 ID:SGTC_2351|Compound:9026858|FD-Score:3.85|P-value:1.93E-4 ID:SGTC_2365|Compound:9042475|FD-Score:5.15|P-value:9.43E-7 ID:SGTC_2486|Compound:5283202|FD-Score:4.91|P-value:2.77E-6 ID:SGTC_2651|Compound:1327-0036|FD-Score:6.18|P-value:5.25E-9 ID:SGTC_2679|Compound:rapamycin|FD-Score:-3.44|P-value:5.85E-4 ID:SGTC_2682|Compound:pyrogallin|FD-Score:3.57|P-value:4.98E-4 ID:SGTC_2691|Compound:st077356|FD-Score:3.42|P-value:8.13E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:4.87|P-value:3.41E-6 ID:SGTC_2789|Compound:5281112|FD-Score:5.54|P-value:1.47E-7 ID:SGTC_2858|Compound:9025781|FD-Score:10.50|P-value:9.02E-23 ID:SGTC_2917|Compound:7979103|FD-Score:-3.44|P-value:6.02E-4 ID:SGTC_2924|Compound:9010168|FD-Score:7.06|P-value:3.07E-11 ID:SGTC_3054|Compound:9094397|FD-Score:4.37|P-value:2.70E-5 ID:SGTC_3355|Compound:9151058|FD-Score:4.08|P-value:8.21E-5 ID:SGTC_7|Compound:0192-1582|FD-Score:4.40|P-value:2.44E-5 ID:SGTC_36|Compound:0335-0881|FD-Score:4.46|P-value:1.88E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:6.32|P-value:2.36E-9 ID:SGTC_64|Compound:000l-0018|FD-Score:3.64|P-value:3.90E-4 ID:SGTC_67|Compound:0335-0847|FD-Score:4.11|P-value:7.48E-5 ID:SGTC_86|Compound:0417-1630|FD-Score:3.98|P-value:1.18E-4 ID:SGTC_137|Compound:0438-0332|FD-Score:4.40|P-value:2.39E-5 ID:SGTC_138|Compound:0850-0259|FD-Score:3.61|P-value:4.44E-4 ID:SGTC_142|Compound:0335-0849|FD-Score:5.49|P-value:1.89E-7 ID:SGTC_158|Compound:k038-0087|FD-Score:4.76|P-value:5.34E-6 ID:SGTC_178|Compound:4092-0806|FD-Score:4.32|P-value:3.25E-5 ID:SGTC_293|Compound:4049-0273|FD-Score:3.75|P-value:2.70E-4 ID:SGTC_294|Compound:k038-0071|FD-Score:4.19|P-value:5.40E-5 ID:SGTC_305|Compound:1682-2595|FD-Score:6.11|P-value:7.54E-9 ID:SGTC_365|Compound:0121-0052|FD-Score:-3.36|P-value:7.80E-4 ID:SGTC_367|Compound:0335-0881|FD-Score:4.77|P-value:5.16E-6 ID:SGTC_397|Compound:arbidol|FD-Score:3.63|P-value:4.11E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:3.87|P-value:1.79E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:-3.53|P-value:4.49E-4 ID:SGTC_619|Compound:1652-1634|FD-Score:3.43|P-value:7.97E-4 ID:SGTC_642|Compound:0335-0876|FD-Score:5.82|P-value:3.54E-8 ID:SGTC_657|Compound:3534-0529|FD-Score:-3.63|P-value:3.19E-4 ID:SGTC_664|Compound:1222-0054|FD-Score:3.49|P-value:6.56E-4 ID:SGTC_683|Compound:panaxydol|FD-Score:3.70|P-value:3.18E-4 ID:SGTC_700|Compound:3453-2283|FD-Score:3.49|P-value:6.53E-4 ID:SGTC_721|Compound:1187-1332|FD-Score:5.21|P-value:7.24E-7 ID:SGTC_731|Compound:3966-0296|FD-Score:4.07|P-value:8.62E-5 ID:SGTC_790|Compound:1575-0012|FD-Score:3.64|P-value:3.90E-4 ID:SGTC_794|Compound:k038-0031|FD-Score:5.29|P-value:4.85E-7 ID:SGTC_819|Compound:1013-0258|FD-Score:4.31|P-value:3.44E-5 ID:SGTC_879|Compound:0831-1030|FD-Score:4.28|P-value:3.81E-5 ID:SGTC_918|Compound:glabranin|FD-Score:3.80|P-value:2.29E-4 ID:SGTC_1137|Compound:ixabepilone|FD-Score:3.95|P-value:1.34E-4 ID:SGTC_1151|Compound:3909-8316|FD-Score:4.79|P-value:4.79E-6 ID:SGTC_1154|Compound:4088-0362|FD-Score:4.84|P-value:3.89E-6 ID:SGTC_1173|Compound:0443-0020|FD-Score:6.87|P-value:9.90E-11 ID:SGTC_1179|Compound:1021-1431|FD-Score:4.10|P-value:7.64E-5 ID:SGTC_1247|Compound:0448-0043|FD-Score:7.03|P-value:3.71E-11 ID:SGTC_1250|Compound:0485-0349|FD-Score:-4.83|P-value:2.80E-6 ID:SGTC_1287|Compound:0971-0001|FD-Score:3.80|P-value:2.30E-4 ID:SGTC_1386|Compound:3228-0095|FD-Score:4.84|P-value:3.76E-6 ID:SGTC_1393|Compound:3470-5649|FD-Score:4.98|P-value:2.05E-6 ID:SGTC_1468|Compound:k284-1086|FD-Score:3.99|P-value:1.16E-4 ID:SGTC_1479|Compound:0549-0158|FD-Score:3.66|P-value:3.68E-4 ID:SGTC_1672|Compound:st016598|FD-Score:4.23|P-value:4.75E-5 ID:SGTC_1683|Compound:st010134|FD-Score:-5.38|P-value:2.16E-7 ID:SGTC_1694|Compound:st024011|FD-Score:5.59|P-value:1.17E-7 ID:SGTC_1714|Compound:st033236|FD-Score:4.02|P-value:1.02E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:-4.64|P-value:6.46E-6 ID:SGTC_1795|Compound:st049545|FD-Score:3.85|P-value:1.91E-4 ID:SGTC_1796|Compound:st049173|FD-Score:-3.28|P-value:9.81E-4 ID:SGTC_1849|Compound:st056239|FD-Score:4.13|P-value:6.88E-5 ID:SGTC_1909|Compound:st060837|FD-Score:5.68|P-value:7.41E-8 ID:SGTC_1934|Compound:st074720|FD-Score:6.50|P-value:8.66E-10 ID:SGTC_1941|Compound:st076221|FD-Score:3.41|P-value:8.30E-4 ID:SGTC_1983|Compound:st071813|FD-Score:5.48|P-value:1.98E-7 ID:SGTC_2019|Compound:4016004|FD-Score:3.66|P-value:3.68E-4 ID:SGTC_2085|Compound:5307070|FD-Score:-3.40|P-value:6.68E-4 ID:SGTC_2131|Compound:toluylene red|FD-Score:3.49|P-value:6.48E-4 ID:SGTC_2266|Compound:7929956|FD-Score:-3.48|P-value:5.28E-4 ID:SGTC_2312|Compound:7706453|FD-Score:3.53|P-value:5.69E-4 ID:SGTC_2351|Compound:9026858|FD-Score:3.85|P-value:1.93E-4 ID:SGTC_2365|Compound:9042475|FD-Score:5.15|P-value:9.43E-7 ID:SGTC_2486|Compound:5283202|FD-Score:4.91|P-value:2.77E-6 ID:SGTC_2651|Compound:1327-0036|FD-Score:6.18|P-value:5.25E-9 ID:SGTC_2679|Compound:rapamycin|FD-Score:-3.44|P-value:5.85E-4 ID:SGTC_2682|Compound:pyrogallin|FD-Score:3.57|P-value:4.98E-4 ID:SGTC_2691|Compound:st077356|FD-Score:3.42|P-value:8.13E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:4.87|P-value:3.41E-6 ID:SGTC_2789|Compound:5281112|FD-Score:5.54|P-value:1.47E-7 ID:SGTC_2858|Compound:9025781|FD-Score:10.50|P-value:9.02E-23 ID:SGTC_2917|Compound:7979103|FD-Score:-3.44|P-value:6.02E-4 ID:SGTC_2924|Compound:9010168|FD-Score:7.06|P-value:3.07E-11 ID:SGTC_3054|Compound:9094397|FD-Score:4.37|P-value:2.70E-5 ID:SGTC_3355|Compound:9151058|FD-Score:4.08|P-value:8.21E-5

Top fitness defect scores for YPL055C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2858 9025781 10.50 9.0 µM 9.02E-23 sphingolipid biosynthesis & PDR1 19 4.15E-26
2 SGTC_2924 9010168 7.06 62.8 µM 3.07E-11 cell wall signaling 5 8.51E-13
3 SGTC_1247 0448-0043 7.03 5.8 µM 3.71E-11 ERG2 5 1.06E-12
4 SGTC_1173 0443-0020 6.87 122.0 µM 9.90E-11 TSC3-RPN4 7 3.29E-12
5 SGTC_1934 st074720 6.50 32.6 µM 8.66E-10 13 4.02E-11
6 SGTC_58 0957-0393 6.32 9.0 µM 2.36E-9 cell wall 191 1.28E-10
7 SGTC_2651 1327-0036 6.18 5.0 µM 5.25E-9 68 3.21E-10
8 SGTC_305 1682-2595 6.11 20.8 µM 7.54E-9 RNA processing & uracil transport 4 4.88E-10
9 SGTC_642 0335-0876 5.82 158.0 µM 3.54E-8 ubiquinone biosynthesis & proteasome 12 2.91E-9
10 SGTC_1909 st060837 5.68 51.5 µM 7.41E-8 21 6.83E-9
11 SGTC_1694 st024011 5.59 44.9 µM 1.17E-7 ERG2 12 1.16E-8
12 SGTC_2789 5281112 5.54 71.4 µM 1.47E-7 10 1.51E-8
13 SGTC_142 0335-0849 5.49 62.7 µM 1.89E-7 ubiquinone biosynthesis & proteasome 74 2.01E-8
14 SGTC_1983 st071813 5.48 46.9 µM 1.98E-7 RPP1 & pyrimidine depletion 3 2.13E-8
15 SGTC_794 k038-0031 5.29 316.0 µM 4.85E-7 ubiquinone biosynthesis & proteasome 73 5.98E-8
16 SGTC_721 1187-1332 5.21 279.0 µM 7.24E-7 cell wall signaling 5 9.49E-8
17 SGTC_2365 9042475 5.15 200.0 µM 9.43E-7 13 1.29E-7
18 SGTC_1393 3470-5649 4.98 58.2 µM 2.05E-6 60S ribosome export 5 3.16E-7
19 SGTC_2486 5283202 4.91 22.4 µM 2.77E-6 21 4.46E-7
20 SGTC_2752 diclazuril 4.87 33.1 µM 3.41E-6 79 5.68E-7

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.271 2.12E-57 YML034C-A_d YML034C-A_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.255 7.74E-51 YPR064W_d YPR064W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.251 3.18E-49 YNL111C CYB5 hom Cytochrome b5, involved in the sterol and lipid biosynthesis pathways; acts as an electron donor to support sterol C5-6 desaturation
0.247 1.05E-47 YOR254C SEC63 het Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
0.238 2.06E-44 YPR065W ROX1 hom Heme-dependent repressor of hypoxic genes; mediates aerobic transcriptional repression of hypoxia induced genes such as COX5b and CYC7; repressor function regulated through decreased promoter occupancy in response to oxidative stress; contains an HMG domain that is responsible for DNA bending activity; involved in the hyperosmotic stress resistance
0.236 8.63E-44 YBR275C RIF1 hom Protein that binds to the Rap1p C-terminus and acts synergistically with Rif2p to help control telomere length and establish telomeric silencing; deletion results in telomere elongation
0.235 2.51E-43 YJL193W_p YJL193W_p hom Putative protein of unknown function, predicted to encode a triose phosphate transporter subfamily member based on phylogenetic analysis; similar to YOR307C/SLY41; deletion mutant has a respiratory growth defect
0.234 5.95E-43 YMR110C HFD1 hom Hexadecenal dehydrogenase; involved in the conversion of sphingosine 1-phosphate breakdown product hexadecenal to hexadecenoic acid; located in the mitochondrial outer membrane and also in lipid particles; has similarity to ALDH3A2, a human fatty aldehyde dehydrogenase (FALDH) mutated in Sjogren-Larsson syndrome, a neurocutaneous disorder
0.230 2.61E-41 YML034W SRC1 hom Inner nuclear membrane protein; functions in regulation of subtelomeric genes and is linked to TREX (transcription export) factors; SRC1 produces 2 splice variant proteins with different functions; alternative splicing of SRC1 pre-mRNA is promoted by Hub1p; mutant has aneuploidy tolerance
0.219 7.58E-38 YDR537C_d YDR537C_d hom Dubious open reading frame unlikely to encode a protein, almost completely overlaps verified ORF PAD1/YDR538W
0.217 5.64E-37 YNR042W_d YNR042W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene COQ2
0.214 4.47E-36 YPL153C RAD53 het Protein kinase, required for cell-cycle arrest in response to DNA damage; activated by trans autophosphorylation when interacting with hyperphosphorylated Rad9p; also interacts with ARS1 and plays a role in initiation of DNA replication
0.212 2.25E-35 YPR146C_d YPR146C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.210 7.68E-35 YMR015C ERG5 hom C-22 sterol desaturase, a cytochrome P450 enzyme that catalyzes the formation of the C-22(23) double bond in the sterol side chain in ergosterol biosynthesis; may be a target of azole antifungal drugs
0.203 2.08E-32 YJL155C FBP26 hom Fructose-2,6-bisphosphatase, required for glucose metabolism; protein abundance increases in response to DNA replication stress