YPL056C_p / LCL1

Putative protein of unknown function; deletion mutant is fluconazole resistant and has long chronological lifespan

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL056C / LCL1

Click on Significant Values for Screen Details ID:SGTC_55|Compound:0767-0285|FD-Score:5.07|P-value:1.62E-6 ID:SGTC_137|Compound:0438-0332|FD-Score:3.79|P-value:2.35E-4 ID:SGTC_146|Compound:3448-8650|FD-Score:-4.77|P-value:1.06E-5 ID:SGTC_158|Compound:k038-0087|FD-Score:6.68|P-value:5.08E-10 ID:SGTC_217|Compound:ketoconazole|FD-Score:-3.73|P-value:4.66E-4 ID:SGTC_256|Compound:clotrimazole|FD-Score:-4.43|P-value:4.10E-5 ID:SGTC_266|Compound:formosanin C|FD-Score:14.20|P-value:1.59E-38 ID:SGTC_304|Compound:1310-0298|FD-Score:5.58|P-value:1.58E-7 ID:SGTC_308|Compound:4092-1169|FD-Score:-3.70|P-value:5.27E-4 ID:SGTC_309|Compound:k408-0051|FD-Score:3.57|P-value:4.96E-4 ID:SGTC_312|Compound:4092-0653|FD-Score:-3.63|P-value:6.47E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:4.90|P-value:3.48E-6 ID:SGTC_683|Compound:panaxydol|FD-Score:5.57|P-value:1.64E-7 ID:SGTC_866|Compound:0495-0101|FD-Score:4.23|P-value:4.90E-5 ID:SGTC_890|Compound:0929-0006|FD-Score:3.76|P-value:2.61E-4 ID:SGTC_955|Compound:1216-0110|FD-Score:7.49|P-value:4.02E-12 ID:SGTC_1128|Compound:3448-9350|FD-Score:3.38|P-value:8.82E-4 ID:SGTC_1130|Compound:3454-2858|FD-Score:-4.00|P-value:1.95E-4 ID:SGTC_1325|Compound:1431-0015|FD-Score:3.97|P-value:1.30E-4 ID:SGTC_1495|Compound:4469-0029|FD-Score:-4.28|P-value:7.17E-5 ID:SGTC_1568|Compound:digitonin|FD-Score:4.02|P-value:1.07E-4 ID:SGTC_1588|Compound:farnesol|FD-Score:3.48|P-value:6.54E-4 ID:SGTC_1602|Compound:st001878|FD-Score:3.35|P-value:9.85E-4 ID:SGTC_1648|Compound:st011736|FD-Score:4.46|P-value:2.05E-5 ID:SGTC_1683|Compound:st010134|FD-Score:4.01|P-value:1.12E-4 ID:SGTC_1712|Compound:st032288|FD-Score:-3.69|P-value:5.28E-4 ID:SGTC_1748|Compound:st037455|FD-Score:-3.95|P-value:2.26E-4 ID:SGTC_1925|Compound:st057770|FD-Score:3.77|P-value:2.54E-4 ID:SGTC_1930|Compound:st074634|FD-Score:3.60|P-value:4.45E-4 ID:SGTC_1951|Compound:sophoraflavanone G|FD-Score:3.63|P-value:3.99E-4 ID:SGTC_2021|Compound:4019055|FD-Score:-4.63|P-value:1.88E-5 ID:SGTC_2314|Compound:7727897|FD-Score:4.03|P-value:1.02E-4 ID:SGTC_2362|Compound:9071156|FD-Score:-5.76|P-value:1.36E-7 ID:SGTC_2394|Compound:5221648|FD-Score:3.47|P-value:6.69E-4 ID:SGTC_2449|Compound:5812982|FD-Score:3.43|P-value:7.67E-4 ID:SGTC_2658|Compound:polymyxin b sulfate|FD-Score:4.83|P-value:4.69E-6 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.81|P-value:5.08E-6 ID:SGTC_2777|Compound:climbazole|FD-Score:-3.52|P-value:8.99E-4 ID:SGTC_2779|Compound:methotrexate|FD-Score:3.47|P-value:6.81E-4 ID:SGTC_2782|Compound:7736369|FD-Score:6.85|P-value:1.95E-10 ID:SGTC_2858|Compound:9025781|FD-Score:5.74|P-value:7.13E-8 ID:SGTC_2883|Compound:9059145|FD-Score:3.87|P-value:1.82E-4 ID:SGTC_2889|Compound:9059656|FD-Score:3.79|P-value:2.36E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-11.30|P-value:1.07E-24 ID:SGTC_2964|Compound:9083345|FD-Score:3.55|P-value:5.16E-4 ID:SGTC_2996|Compound:9066192|FD-Score:4.69|P-value:8.08E-6 ID:SGTC_3029|Compound:9088683|FD-Score:4.69|P-value:8.20E-6 ID:SGTC_3143|Compound:9086658|FD-Score:3.69|P-value:3.34E-4 ID:SGTC_3212|Compound:9128307|FD-Score:3.69|P-value:3.36E-4 ID:SGTC_3243|Compound:9134147|FD-Score:3.54|P-value:5.47E-4 ID:SGTC_3311|Compound:9131146|FD-Score:4.99|P-value:2.30E-6 ID:SGTC_3356|Compound:9151811|FD-Score:3.44|P-value:7.37E-4 ID:SGTC_55|Compound:0767-0285|FD-Score:5.07|P-value:1.62E-6 ID:SGTC_137|Compound:0438-0332|FD-Score:3.79|P-value:2.35E-4 ID:SGTC_146|Compound:3448-8650|FD-Score:-4.77|P-value:1.06E-5 ID:SGTC_158|Compound:k038-0087|FD-Score:6.68|P-value:5.08E-10 ID:SGTC_217|Compound:ketoconazole|FD-Score:-3.73|P-value:4.66E-4 ID:SGTC_256|Compound:clotrimazole|FD-Score:-4.43|P-value:4.10E-5 ID:SGTC_266|Compound:formosanin C|FD-Score:14.20|P-value:1.59E-38 ID:SGTC_304|Compound:1310-0298|FD-Score:5.58|P-value:1.58E-7 ID:SGTC_308|Compound:4092-1169|FD-Score:-3.70|P-value:5.27E-4 ID:SGTC_309|Compound:k408-0051|FD-Score:3.57|P-value:4.96E-4 ID:SGTC_312|Compound:4092-0653|FD-Score:-3.63|P-value:6.47E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:4.90|P-value:3.48E-6 ID:SGTC_683|Compound:panaxydol|FD-Score:5.57|P-value:1.64E-7 ID:SGTC_866|Compound:0495-0101|FD-Score:4.23|P-value:4.90E-5 ID:SGTC_890|Compound:0929-0006|FD-Score:3.76|P-value:2.61E-4 ID:SGTC_955|Compound:1216-0110|FD-Score:7.49|P-value:4.02E-12 ID:SGTC_1128|Compound:3448-9350|FD-Score:3.38|P-value:8.82E-4 ID:SGTC_1130|Compound:3454-2858|FD-Score:-4.00|P-value:1.95E-4 ID:SGTC_1325|Compound:1431-0015|FD-Score:3.97|P-value:1.30E-4 ID:SGTC_1495|Compound:4469-0029|FD-Score:-4.28|P-value:7.17E-5 ID:SGTC_1568|Compound:digitonin|FD-Score:4.02|P-value:1.07E-4 ID:SGTC_1588|Compound:farnesol|FD-Score:3.48|P-value:6.54E-4 ID:SGTC_1602|Compound:st001878|FD-Score:3.35|P-value:9.85E-4 ID:SGTC_1648|Compound:st011736|FD-Score:4.46|P-value:2.05E-5 ID:SGTC_1683|Compound:st010134|FD-Score:4.01|P-value:1.12E-4 ID:SGTC_1712|Compound:st032288|FD-Score:-3.69|P-value:5.28E-4 ID:SGTC_1748|Compound:st037455|FD-Score:-3.95|P-value:2.26E-4 ID:SGTC_1925|Compound:st057770|FD-Score:3.77|P-value:2.54E-4 ID:SGTC_1930|Compound:st074634|FD-Score:3.60|P-value:4.45E-4 ID:SGTC_1951|Compound:sophoraflavanone G|FD-Score:3.63|P-value:3.99E-4 ID:SGTC_2021|Compound:4019055|FD-Score:-4.63|P-value:1.88E-5 ID:SGTC_2314|Compound:7727897|FD-Score:4.03|P-value:1.02E-4 ID:SGTC_2362|Compound:9071156|FD-Score:-5.76|P-value:1.36E-7 ID:SGTC_2394|Compound:5221648|FD-Score:3.47|P-value:6.69E-4 ID:SGTC_2449|Compound:5812982|FD-Score:3.43|P-value:7.67E-4 ID:SGTC_2658|Compound:polymyxin b sulfate|FD-Score:4.83|P-value:4.69E-6 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.81|P-value:5.08E-6 ID:SGTC_2777|Compound:climbazole|FD-Score:-3.52|P-value:8.99E-4 ID:SGTC_2779|Compound:methotrexate|FD-Score:3.47|P-value:6.81E-4 ID:SGTC_2782|Compound:7736369|FD-Score:6.85|P-value:1.95E-10 ID:SGTC_2858|Compound:9025781|FD-Score:5.74|P-value:7.13E-8 ID:SGTC_2883|Compound:9059145|FD-Score:3.87|P-value:1.82E-4 ID:SGTC_2889|Compound:9059656|FD-Score:3.79|P-value:2.36E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-11.30|P-value:1.07E-24 ID:SGTC_2964|Compound:9083345|FD-Score:3.55|P-value:5.16E-4 ID:SGTC_2996|Compound:9066192|FD-Score:4.69|P-value:8.08E-6 ID:SGTC_3029|Compound:9088683|FD-Score:4.69|P-value:8.20E-6 ID:SGTC_3143|Compound:9086658|FD-Score:3.69|P-value:3.34E-4 ID:SGTC_3212|Compound:9128307|FD-Score:3.69|P-value:3.36E-4 ID:SGTC_3243|Compound:9134147|FD-Score:3.54|P-value:5.47E-4 ID:SGTC_3311|Compound:9131146|FD-Score:4.99|P-value:2.30E-6 ID:SGTC_3356|Compound:9151811|FD-Score:3.44|P-value:7.37E-4

Top fitness defect scores for YPL056C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature		Screen
Rank
Screen
P-value
1 SGTC_266 formosanin C 14.20 406.0 nM 1.59E-38 sphingolipid biosynthesis & PDR1 8 3.46E-46
2 SGTC_955 1216-0110 7.49 33.0 µM 4.02E-12 sphingolipid biosynthesis & PDR1 23 3.51E-14
3 SGTC_2782 7736369 6.85 71.4 µM 1.95E-10 3 3.78E-12
4 SGTC_158 k038-0087 6.68 26.4 µM 5.08E-10 ubiquinone biosynthesis & proteasome 59 1.20E-11
5 SGTC_2858 9025781 5.74 9.0 µM 7.13E-8 sphingolipid biosynthesis & PDR1 48 4.60E-9
6 SGTC_304 1310-0298 5.58 97.0 µM 1.58E-7 cell wall 24 1.20E-8
7 SGTC_683 panaxydol 5.57 45.0 µM 1.64E-7 sphingolipid biosynthesis & PDR1 17 1.25E-8
8 SGTC_55 0767-0285 5.07 6.6 µM 1.62E-6 25 1.94E-7
9 SGTC_3311 9131146 4.99 2.9 µM 2.30E-6 cell wall 83 2.97E-7
10 SGTC_457 grayanotoxin iii 4.90 135.0 µM 3.48E-6 30 4.86E-7
11 SGTC_2658 polymyxin b sulfate 4.83 77.0 µM 4.69E-6 NEO1 30 6.95E-7
12 SGTC_2688 kanamycin b 4.81 96.7 µM 5.08E-6 calcium & mitochondrial duress 266 7.66E-7
13 SGTC_2996 9066192 4.69 71.4 µM 8.08E-6 13 1.33E-6
14 SGTC_3029 9088683 4.69 49.5 µM 8.20E-6 14 1.36E-6
15 SGTC_1648 st011736 4.46 69.8 µM 2.05E-5 PDR1 5 4.06E-6
16 SGTC_866 0495-0101 4.23 262.0 µM 4.90E-5 60S ribosome export 11 1.15E-5
17 SGTC_2314 7727897 4.03 200.0 µM 1.02E-4 22 2.74E-5
18 SGTC_1568 digitonin 4.02 820.0 nM 1.07E-4 sphingolipid biosynthesis & PDR1 29 2.91E-5
19 SGTC_1683 st010134 4.01 710.0 nM 1.12E-4 26 3.06E-5
20 SGTC_1325 1431-0015 3.97 227.0 µM 1.30E-4 Golgi 19 3.66E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.398 5.08E-128 YPL057C SUR1 hom Mannosylinositol phosphorylceramide (MIPC) synthase catalytic subunit; forms a complex with regulatory subunit Csg2p; function in sphingolipid biosynthesis is overlapping with that of Csh1p; SUR1 has a paralog, CSH1, that arose from the whole genome duplication
0.334 1.88E-88 YMR102C_p YMR102C_p hom Protein of unknown function; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance; mutant shows increased resistance to azoles; YMR102C is not an essential gene
0.313 3.19E-77 YDR072C IPT1 hom Inositolphosphotransferase, involved in synthesis of mannose-(inositol-P)2-ceramide (M(IP)2C), the most abundant sphingolipid; can mutate to resistance to the antifungals syringomycin E and DmAMP1 and to K. lactis zymocin
0.244 1.68E-46 YDR326C YSP2 hom Protein involved in programmed cell death; mutant shows resistance to cell death induced by amiodarone or intracellular acidification; YSP2 has a paralog, YHR080C, that arose from the whole genome duplication
0.226 4.64E-40 YNL257C SIP3 hom Transcription cofactor; acts through interaction with DNA-bound Snf1p; C-terminal region has a putative leucine zipper motif; potential Cdc28p substrate; SIP3 has a paralog, YSP1, that arose from the whole genome duplication
0.224 2.82E-39 YBR036C CSG2 hom Endoplasmic reticulum membrane protein, required for mannosylation of inositolphosphorylceramide and for growth at high calcium concentrations; protein abundance increases in response to DNA replication stress
0.218 1.86E-37 YGR143W SKN1 hom Protein involved in sphingolipid biosynthesis; type II membrane protein with similarity to Kre6p
0.205 3.18E-33 YHR073W OSH3 hom Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability
0.186 1.50E-27 YLR055C SPT8 hom Subunit of the SAGA transcriptional regulatory complex but not present in SAGA-like complex SLIK/SALSA, required for SAGA-mediated inhibition at some promoters
0.180 8.34E-26 YGL066W SGF73 hom SAGA complex subunit; has a role in anchoring the deubiquitination module into SAGA and SLIK complexes; involved in preinitiation complex assembly at promoters; human ortholog ataxin-7 is associated with spinocerebellar ataxia diseases; mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay
0.171 1.78E-23 YNL229C URE2 hom Nitrogen catabolite repression transcriptional regulator that acts by inhibition of GLN3 transcription in good nitrogen source; has glutathione peroxidase activity and can mutate to acquire GST activity; altered form creates [URE3] prion
0.161 7.31E-21 YDR392W SPT3 hom Subunit of the SAGA and SAGA-like transcriptional regulatory complexes, interacts with Spt15p to activate transcription of some RNA polymerase II-dependent genes, also functions to inhibit transcription at some promoters
0.157 4.86E-20 YEL044W IES6 hom Protein that associates with the INO80 chromatin remodeling complex under low-salt conditions; human ortholog INO80C is a member of the human INO80 complex; implicated in DNA repair based on genetic interactions with RAD52 epistasis genes
0.151 1.29E-18 YNL027W CRZ1 hom Transcription factor, activates transcription of stress response genes; nuclear localization is positively regulated by calcineurin-mediated dephosphorylation; rapidly localizes to the nucleus under blue light stress
0.148 7.17E-18 YPR064W_d YPR064W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data