YPL057C / SUR1

Mannosylinositol phosphorylceramide (MIPC) synthase catalytic subunit; forms a complex with regulatory subunit Csg2p; function in sphingolipid biosynthesis is overlapping with that of Csh1p; SUR1 has a paralog, CSH1, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL057C / SUR1

Click on Significant Values for Screen Details ID:SGTC_70|Compound:0141-0289|FD-Score:3.53|P-value:1.56E-4 ID:SGTC_168|Compound:3970-0862|FD-Score:-3.78|P-value:1.04E-4 ID:SGTC_206|Compound:4546-0025|FD-Score:4.95|P-value:2.42E-7 ID:SGTC_221|Compound:trifluoperazine|FD-Score:4.92|P-value:2.87E-7 ID:SGTC_232|Compound:clozapine|FD-Score:6.74|P-value:4.54E-12 ID:SGTC_266|Compound:formosanin C|FD-Score:27.10|P-value:9.10E-163 ID:SGTC_309|Compound:k408-0051|FD-Score:5.07|P-value:1.33E-7 ID:SGTC_312|Compound:4092-0653|FD-Score:-3.38|P-value:4.75E-4 ID:SGTC_314|Compound:1671-0008|FD-Score:-4.01|P-value:4.15E-5 ID:SGTC_352|Compound:k048-0007|FD-Score:4.04|P-value:1.93E-5 ID:SGTC_360|Compound:0957-0399|FD-Score:3.41|P-value:2.47E-4 ID:SGTC_425|Compound:3825-7017|FD-Score:5.39|P-value:2.30E-8 ID:SGTC_436|Compound:n,n-dimethylsphingosine|FD-Score:-4.02|P-value:4.03E-5 ID:SGTC_439|Compound:amiodarone|FD-Score:16.20|P-value:5.98E-60 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:5.18|P-value:7.10E-8 ID:SGTC_470|Compound:aa-861|FD-Score:12.40|P-value:3.03E-36 ID:SGTC_539|Compound:4859-0462|FD-Score:4.42|P-value:3.50E-6 ID:SGTC_570|Compound:0987-0065|FD-Score:3.88|P-value:3.79E-5 ID:SGTC_628|Compound:1636-0253|FD-Score:3.75|P-value:6.37E-5 ID:SGTC_649|Compound:1123-0311|FD-Score:-3.20|P-value:8.92E-4 ID:SGTC_664|Compound:1222-0054|FD-Score:7.03|P-value:6.01E-13 ID:SGTC_683|Compound:panaxydol|FD-Score:7.14|P-value:2.63E-13 ID:SGTC_798|Compound:1287-0182|FD-Score:3.17|P-value:5.87E-4 ID:SGTC_955|Compound:1216-0110|FD-Score:26.00|P-value:2.65E-150 ID:SGTC_1047|Compound:2043-3044|FD-Score:4.50|P-value:2.40E-6 ID:SGTC_1136|Compound:pergolide|FD-Score:3.98|P-value:2.43E-5 ID:SGTC_1173|Compound:0443-0020|FD-Score:4.20|P-value:9.29E-6 ID:SGTC_1174|Compound:0739-0097|FD-Score:-3.17|P-value:9.73E-4 ID:SGTC_1208|Compound:2323-2347|FD-Score:3.08|P-value:7.83E-4 ID:SGTC_1271|Compound:0832-2808|FD-Score:3.13|P-value:6.71E-4 ID:SGTC_1282|Compound:0886-0010|FD-Score:3.61|P-value:1.14E-4 ID:SGTC_1332|Compound:1480-0653|FD-Score:5.10|P-value:1.13E-7 ID:SGTC_1389|Compound:3405-0187|FD-Score:3.13|P-value:6.64E-4 ID:SGTC_1398|Compound:3558-0053|FD-Score:3.08|P-value:7.87E-4 ID:SGTC_1479|Compound:0549-0158|FD-Score:3.19|P-value:5.39E-4 ID:SGTC_1488|Compound:4013-0813|FD-Score:-3.37|P-value:4.87E-4 ID:SGTC_1534|Compound:6-azauridine|FD-Score:3.45|P-value:2.08E-4 ID:SGTC_1679|Compound:4130-1276|FD-Score:3.05|P-value:8.81E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:9.22|P-value:7.07E-21 ID:SGTC_1726|Compound:st035556|FD-Score:3.79|P-value:5.51E-5 ID:SGTC_1744|Compound:st037937|FD-Score:6.75|P-value:4.26E-12 ID:SGTC_1751|Compound:st044839|FD-Score:3.06|P-value:8.62E-4 ID:SGTC_1764|Compound:st044502|FD-Score:3.58|P-value:1.28E-4 ID:SGTC_1781|Compound:st038725|FD-Score:4.11|P-value:1.44E-5 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:3.85|P-value:4.35E-5 ID:SGTC_1786|Compound:berberine|FD-Score:3.68|P-value:8.68E-5 ID:SGTC_1787|Compound:fluconazole|FD-Score:-4.54|P-value:3.94E-6 ID:SGTC_1941|Compound:st076221|FD-Score:6.27|P-value:1.05E-10 ID:SGTC_2075|Compound:5212009|FD-Score:3.57|P-value:1.33E-4 ID:SGTC_2167|Compound:5876490|FD-Score:6.07|P-value:3.93E-10 ID:SGTC_2248|Compound:tofa|FD-Score:5.46|P-value:1.53E-8 ID:SGTC_2249|Compound:haloperidol|FD-Score:-4.52|P-value:4.38E-6 ID:SGTC_2267|Compound:7931562|FD-Score:-3.17|P-value:9.98E-4 ID:SGTC_2275|Compound:7947463|FD-Score:5.11|P-value:1.06E-7 ID:SGTC_2309|Compound:7664088|FD-Score:3.55|P-value:1.43E-4 ID:SGTC_2336|Compound:9001819|FD-Score:3.05|P-value:8.76E-4 ID:SGTC_2362|Compound:9071156|FD-Score:6.01|P-value:5.82E-10 ID:SGTC_2363|Compound:9053361|FD-Score:3.72|P-value:7.24E-5 ID:SGTC_2449|Compound:5812982|FD-Score:4.20|P-value:9.34E-6 ID:SGTC_2526|Compound:patulin|FD-Score:-3.54|P-value:2.65E-4 ID:SGTC_2562|Compound:3',7'-dimethoxyflavone|FD-Score:3.10|P-value:7.50E-4 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:3.68|P-value:8.55E-5 ID:SGTC_2576|Compound:guaiol|FD-Score:3.42|P-value:2.36E-4 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:3.83|P-value:4.64E-5 ID:SGTC_2581|Compound:avocatin a|FD-Score:3.07|P-value:8.14E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:9.78|P-value:3.16E-23 ID:SGTC_2651|Compound:1327-0036|FD-Score:6.10|P-value:3.28E-10 ID:SGTC_2658|Compound:polymyxin b sulfate|FD-Score:23.50|P-value:1.14E-123 ID:SGTC_2688|Compound:kanamycin b|FD-Score:5.83|P-value:1.75E-9 ID:SGTC_2701|Compound:st077767|FD-Score:6.66|P-value:8.16E-12 ID:SGTC_2736|Compound:butenafine|FD-Score:5.18|P-value:7.30E-8 ID:SGTC_2776|Compound:terbinafine|FD-Score:10.40|P-value:7.63E-26 ID:SGTC_2777|Compound:climbazole|FD-Score:-3.77|P-value:1.09E-4 ID:SGTC_2852|Compound:9023854|FD-Score:6.25|P-value:1.27E-10 ID:SGTC_2858|Compound:9025781|FD-Score:18.30|P-value:7.75E-76 ID:SGTC_2873|Compound:9040596|FD-Score:8.35|P-value:1.75E-17 ID:SGTC_2896|Compound:9052656|FD-Score:-5.58|P-value:1.88E-8 ID:SGTC_2939|Compound:9044578|FD-Score:-3.22|P-value:8.41E-4 ID:SGTC_3084|Compound:9116877|FD-Score:4.50|P-value:2.40E-6 ID:SGTC_3089|Compound:9117425|FD-Score:3.32|P-value:3.37E-4 ID:SGTC_3090|Compound:9117696|FD-Score:5.52|P-value:1.09E-8 ID:SGTC_3091|Compound:9116372|FD-Score:3.33|P-value:3.25E-4 ID:SGTC_3096|Compound:9117468|FD-Score:4.30|P-value:5.87E-6 ID:SGTC_3311|Compound:9131146|FD-Score:5.52|P-value:1.07E-8 ID:SGTC_70|Compound:0141-0289|FD-Score:3.53|P-value:1.56E-4 ID:SGTC_168|Compound:3970-0862|FD-Score:-3.78|P-value:1.04E-4 ID:SGTC_206|Compound:4546-0025|FD-Score:4.95|P-value:2.42E-7 ID:SGTC_221|Compound:trifluoperazine|FD-Score:4.92|P-value:2.87E-7 ID:SGTC_232|Compound:clozapine|FD-Score:6.74|P-value:4.54E-12 ID:SGTC_266|Compound:formosanin C|FD-Score:27.10|P-value:9.10E-163 ID:SGTC_309|Compound:k408-0051|FD-Score:5.07|P-value:1.33E-7 ID:SGTC_312|Compound:4092-0653|FD-Score:-3.38|P-value:4.75E-4 ID:SGTC_314|Compound:1671-0008|FD-Score:-4.01|P-value:4.15E-5 ID:SGTC_352|Compound:k048-0007|FD-Score:4.04|P-value:1.93E-5 ID:SGTC_360|Compound:0957-0399|FD-Score:3.41|P-value:2.47E-4 ID:SGTC_425|Compound:3825-7017|FD-Score:5.39|P-value:2.30E-8 ID:SGTC_436|Compound:n,n-dimethylsphingosine|FD-Score:-4.02|P-value:4.03E-5 ID:SGTC_439|Compound:amiodarone|FD-Score:16.20|P-value:5.98E-60 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:5.18|P-value:7.10E-8 ID:SGTC_470|Compound:aa-861|FD-Score:12.40|P-value:3.03E-36 ID:SGTC_539|Compound:4859-0462|FD-Score:4.42|P-value:3.50E-6 ID:SGTC_570|Compound:0987-0065|FD-Score:3.88|P-value:3.79E-5 ID:SGTC_628|Compound:1636-0253|FD-Score:3.75|P-value:6.37E-5 ID:SGTC_649|Compound:1123-0311|FD-Score:-3.20|P-value:8.92E-4 ID:SGTC_664|Compound:1222-0054|FD-Score:7.03|P-value:6.01E-13 ID:SGTC_683|Compound:panaxydol|FD-Score:7.14|P-value:2.63E-13 ID:SGTC_798|Compound:1287-0182|FD-Score:3.17|P-value:5.87E-4 ID:SGTC_955|Compound:1216-0110|FD-Score:26.00|P-value:2.65E-150 ID:SGTC_1047|Compound:2043-3044|FD-Score:4.50|P-value:2.40E-6 ID:SGTC_1136|Compound:pergolide|FD-Score:3.98|P-value:2.43E-5 ID:SGTC_1173|Compound:0443-0020|FD-Score:4.20|P-value:9.29E-6 ID:SGTC_1174|Compound:0739-0097|FD-Score:-3.17|P-value:9.73E-4 ID:SGTC_1208|Compound:2323-2347|FD-Score:3.08|P-value:7.83E-4 ID:SGTC_1271|Compound:0832-2808|FD-Score:3.13|P-value:6.71E-4 ID:SGTC_1282|Compound:0886-0010|FD-Score:3.61|P-value:1.14E-4 ID:SGTC_1332|Compound:1480-0653|FD-Score:5.10|P-value:1.13E-7 ID:SGTC_1389|Compound:3405-0187|FD-Score:3.13|P-value:6.64E-4 ID:SGTC_1398|Compound:3558-0053|FD-Score:3.08|P-value:7.87E-4 ID:SGTC_1479|Compound:0549-0158|FD-Score:3.19|P-value:5.39E-4 ID:SGTC_1488|Compound:4013-0813|FD-Score:-3.37|P-value:4.87E-4 ID:SGTC_1534|Compound:6-azauridine|FD-Score:3.45|P-value:2.08E-4 ID:SGTC_1679|Compound:4130-1276|FD-Score:3.05|P-value:8.81E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:9.22|P-value:7.07E-21 ID:SGTC_1726|Compound:st035556|FD-Score:3.79|P-value:5.51E-5 ID:SGTC_1744|Compound:st037937|FD-Score:6.75|P-value:4.26E-12 ID:SGTC_1751|Compound:st044839|FD-Score:3.06|P-value:8.62E-4 ID:SGTC_1764|Compound:st044502|FD-Score:3.58|P-value:1.28E-4 ID:SGTC_1781|Compound:st038725|FD-Score:4.11|P-value:1.44E-5 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:3.85|P-value:4.35E-5 ID:SGTC_1786|Compound:berberine|FD-Score:3.68|P-value:8.68E-5 ID:SGTC_1787|Compound:fluconazole|FD-Score:-4.54|P-value:3.94E-6 ID:SGTC_1941|Compound:st076221|FD-Score:6.27|P-value:1.05E-10 ID:SGTC_2075|Compound:5212009|FD-Score:3.57|P-value:1.33E-4 ID:SGTC_2167|Compound:5876490|FD-Score:6.07|P-value:3.93E-10 ID:SGTC_2248|Compound:tofa|FD-Score:5.46|P-value:1.53E-8 ID:SGTC_2249|Compound:haloperidol|FD-Score:-4.52|P-value:4.38E-6 ID:SGTC_2267|Compound:7931562|FD-Score:-3.17|P-value:9.98E-4 ID:SGTC_2275|Compound:7947463|FD-Score:5.11|P-value:1.06E-7 ID:SGTC_2309|Compound:7664088|FD-Score:3.55|P-value:1.43E-4 ID:SGTC_2336|Compound:9001819|FD-Score:3.05|P-value:8.76E-4 ID:SGTC_2362|Compound:9071156|FD-Score:6.01|P-value:5.82E-10 ID:SGTC_2363|Compound:9053361|FD-Score:3.72|P-value:7.24E-5 ID:SGTC_2449|Compound:5812982|FD-Score:4.20|P-value:9.34E-6 ID:SGTC_2526|Compound:patulin|FD-Score:-3.54|P-value:2.65E-4 ID:SGTC_2562|Compound:3',7'-dimethoxyflavone|FD-Score:3.10|P-value:7.50E-4 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:3.68|P-value:8.55E-5 ID:SGTC_2576|Compound:guaiol|FD-Score:3.42|P-value:2.36E-4 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:3.83|P-value:4.64E-5 ID:SGTC_2581|Compound:avocatin a|FD-Score:3.07|P-value:8.14E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:9.78|P-value:3.16E-23 ID:SGTC_2651|Compound:1327-0036|FD-Score:6.10|P-value:3.28E-10 ID:SGTC_2658|Compound:polymyxin b sulfate|FD-Score:23.50|P-value:1.14E-123 ID:SGTC_2688|Compound:kanamycin b|FD-Score:5.83|P-value:1.75E-9 ID:SGTC_2701|Compound:st077767|FD-Score:6.66|P-value:8.16E-12 ID:SGTC_2736|Compound:butenafine|FD-Score:5.18|P-value:7.30E-8 ID:SGTC_2776|Compound:terbinafine|FD-Score:10.40|P-value:7.63E-26 ID:SGTC_2777|Compound:climbazole|FD-Score:-3.77|P-value:1.09E-4 ID:SGTC_2852|Compound:9023854|FD-Score:6.25|P-value:1.27E-10 ID:SGTC_2858|Compound:9025781|FD-Score:18.30|P-value:7.75E-76 ID:SGTC_2873|Compound:9040596|FD-Score:8.35|P-value:1.75E-17 ID:SGTC_2896|Compound:9052656|FD-Score:-5.58|P-value:1.88E-8 ID:SGTC_2939|Compound:9044578|FD-Score:-3.22|P-value:8.41E-4 ID:SGTC_3084|Compound:9116877|FD-Score:4.50|P-value:2.40E-6 ID:SGTC_3089|Compound:9117425|FD-Score:3.32|P-value:3.37E-4 ID:SGTC_3090|Compound:9117696|FD-Score:5.52|P-value:1.09E-8 ID:SGTC_3091|Compound:9116372|FD-Score:3.33|P-value:3.25E-4 ID:SGTC_3096|Compound:9117468|FD-Score:4.30|P-value:5.87E-6 ID:SGTC_3311|Compound:9131146|FD-Score:5.52|P-value:1.07E-8

Top fitness defect scores for YPL057C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_266 formosanin C 27.10 406.0 nM 9.10E-163 sphingolipid biosynthesis & PDR1 2 9.67E-162
2 SGTC_955 1216-0110 26.00 33.0 µM 2.65E-150 sphingolipid biosynthesis & PDR1 2 2.54E-149
3 SGTC_2658 polymyxin b sulfate 23.50 77.0 µM 1.14E-123 NEO1 2 8.60E-123
4 SGTC_2858 9025781 18.30 9.0 µM 7.75E-76 sphingolipid biosynthesis & PDR1 8 3.60E-75
5 SGTC_439 amiodarone 16.20 34.4 µM 5.98E-60 NEO1-PIK1 4 2.30E-59
6 SGTC_470 aa-861 12.40 153.0 µM 3.03E-36 sphingolipid biosynthesis & PDR1 5 8.39E-36
7 SGTC_2776 terbinafine 10.40 19.9 µM 7.63E-26 cell wall signaling 11 1.77E-25
8 SGTC_2582 agaric acid 9.78 100.0 µM 3.16E-23 redox potentiating 68 6.98E-23
9 SGTC_1718 roemerine 9.22 11.9 µM 7.07E-21 redox potentiating 2 1.49E-20
10 SGTC_2873 9040596 8.35 71.4 µM 1.75E-17 5 3.44E-17
11 SGTC_683 panaxydol 7.14 45.0 µM 2.63E-13 sphingolipid biosynthesis & PDR1 8 4.69E-13
12 SGTC_664 1222-0054 7.03 14.9 µM 6.01E-13 sphingolipid biosynthesis & PDR1 11 1.06E-12
13 SGTC_1744 st037937 6.75 38.9 µM 4.26E-12 2 7.36E-12
14 SGTC_232 clozapine 6.74 119.0 µM 4.54E-12 NEO1 26 7.83E-12
15 SGTC_2701 st077767 6.66 14.7 µM 8.16E-12 11 1.40E-11
16 SGTC_1941 st076221 6.27 61.8 µM 1.05E-10 sphingolipid biosynthesis & PDR1 29 1.75E-10
17 SGTC_2852 9023854 6.25 52.0 µM 1.27E-10 6 2.11E-10
18 SGTC_2651 1327-0036 6.10 5.0 µM 3.28E-10 70 5.37E-10
19 SGTC_2167 5876490 6.07 200.0 µM 3.93E-10 3 6.42E-10
20 SGTC_2362 9071156 6.01 126.0 µM 5.82E-10 3 9.47E-10

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.573 3.51E-292 YDR072C IPT1 hom Inositolphosphotransferase, involved in synthesis of mannose-(inositol-P)2-ceramide (M(IP)2C), the most abundant sphingolipid; can mutate to resistance to the antifungals syringomycin E and DmAMP1 and to K. lactis zymocin
0.500 5.38E-212 YBR036C CSG2 hom Endoplasmic reticulum membrane protein, required for mannosylation of inositolphosphorylceramide and for growth at high calcium concentrations; protein abundance increases in response to DNA replication stress
0.398 5.08E-128 YPL056C_p LCL1_p hom Putative protein of unknown function; deletion mutant is fluconazole resistant and has long chronological lifespan
0.391 9.07E-123 YMR102C_p YMR102C_p hom Protein of unknown function; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance; mutant shows increased resistance to azoles; YMR102C is not an essential gene
0.318 7.94E-80 YDR326C YSP2 hom Protein involved in programmed cell death; mutant shows resistance to cell death induced by amiodarone or intracellular acidification; YSP2 has a paralog, YHR080C, that arose from the whole genome duplication
0.314 9.78E-78 YLR055C SPT8 hom Subunit of the SAGA transcriptional regulatory complex but not present in SAGA-like complex SLIK/SALSA, required for SAGA-mediated inhibition at some promoters
0.297 3.95E-69 YGR143W SKN1 hom Protein involved in sphingolipid biosynthesis; type II membrane protein with similarity to Kre6p
0.280 2.44E-61 YNL257C SIP3 hom Transcription cofactor; acts through interaction with DNA-bound Snf1p; C-terminal region has a putative leucine zipper motif; potential Cdc28p substrate; SIP3 has a paralog, YSP1, that arose from the whole genome duplication
0.269 1.05E-56 YJR059W PTK2 hom Putative serine/threonine protein kinase involved in regulation of ion transport across plasma membrane; enhances spermine uptake
0.259 2.11E-52 YDR392W SPT3 hom Subunit of the SAGA and SAGA-like transcriptional regulatory complexes, interacts with Spt15p to activate transcription of some RNA polymerase II-dependent genes, also functions to inhibit transcription at some promoters
0.256 1.69E-51 YOL050C_d YOL050C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps verified gene GAL11; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)
0.248 4.74E-48 YGL253W HXK2 hom Hexokinase isoenzyme 2; catalyzes phosphorylation of glucose in the cytosol; predominant hexokinase during growth on glucose; functions in the nucleus to repress expression of HXK1 and GLK1 and to induce expression of its own gene; phosphorylation/dephosphorylation at serine-14 by protein kinase Snf1p and protein phosphatase Glc7p-Reg1p regulates nucleocytoplasmic shuttling of Hxk2p; HXK2 has a paralog, HXK1, that arose from the whole genome duplication
0.246 1.87E-47 YKL190W CNB1 hom Calcineurin B; the regulatory subunit of calcineurin, a Ca++/calmodulin-regulated type 2B protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is encoded by CNA1 and/or CMP1; protein abundance increases in response to DNA replication stress
0.239 5.77E-45 YNL229C URE2 hom Nitrogen catabolite repression transcriptional regulator that acts by inhibition of GLN3 transcription in good nitrogen source; has glutathione peroxidase activity and can mutate to acquire GST activity; altered form creates [URE3] prion
0.228 6.40E-41 YNL027W CRZ1 hom Transcription factor, activates transcription of stress response genes; nuclear localization is positively regulated by calcineurin-mediated dephosphorylation; rapidly localizes to the nucleus under blue light stress