YPL058C / PDR12

Plasma membrane ATP-binding cassette (ABC) transporter, weak-acid-inducible multidrug transporter required for weak organic acid resistance; induced by sorbate and benzoate and regulated by War1p; mutants exhibit sorbate hypersensitivity

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL058C / PDR12

Click on Significant Values for Screen Details ID:SGTC_92|Compound:0063-0024|FD-Score:3.33|P-value:4.46E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:5.05|P-value:2.39E-7 ID:SGTC_270|Compound:tamoxifen|FD-Score:-3.61|P-value:1.57E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:3.11|P-value:9.64E-4 ID:SGTC_397|Compound:arbidol|FD-Score:5.62|P-value:1.02E-8 ID:SGTC_421|Compound:streptovitacin|FD-Score:-3.57|P-value:1.82E-4 ID:SGTC_474|Compound:dl-dihydrosphingosine|FD-Score:-3.39|P-value:3.52E-4 ID:SGTC_500|Compound:h-89|FD-Score:3.14|P-value:8.71E-4 ID:SGTC_706|Compound:4262-0057|FD-Score:3.36|P-value:3.98E-4 ID:SGTC_856|Compound:0433-0016|FD-Score:3.41|P-value:3.41E-4 ID:SGTC_867|Compound:0518-0118|FD-Score:3.77|P-value:8.39E-5 ID:SGTC_896|Compound:0964-0007|FD-Score:-3.13|P-value:8.72E-4 ID:SGTC_1013|Compound:4112-3890|FD-Score:3.63|P-value:1.49E-4 ID:SGTC_1015|Compound:4130-4525|FD-Score:3.76|P-value:8.78E-5 ID:SGTC_1024|Compound:4507-0395|FD-Score:3.19|P-value:7.34E-4 ID:SGTC_1157|Compound:4092-0394|FD-Score:3.38|P-value:3.68E-4 ID:SGTC_1366|Compound:1683-0113|FD-Score:3.21|P-value:6.75E-4 ID:SGTC_1439|Compound:4092-1168|FD-Score:3.21|P-value:6.87E-4 ID:SGTC_1476|Compound:4112-3294|FD-Score:3.28|P-value:5.36E-4 ID:SGTC_1510|Compound:1123-0200|FD-Score:3.54|P-value:2.06E-4 ID:SGTC_1529|Compound:apigenin|FD-Score:-3.32|P-value:4.46E-4 ID:SGTC_1638|Compound:st008370|FD-Score:-3.41|P-value:3.24E-4 ID:SGTC_1691|Compound:st019933|FD-Score:4.76|P-value:1.03E-6 ID:SGTC_1699|Compound:st031318|FD-Score:5.44|P-value:2.87E-8 ID:SGTC_1707|Compound:st032323|FD-Score:3.93|P-value:4.38E-5 ID:SGTC_1822|Compound:st052468|FD-Score:3.82|P-value:7.06E-5 ID:SGTC_1855|Compound:st056195|FD-Score:3.51|P-value:2.36E-4 ID:SGTC_1868|Compound:st057644|FD-Score:3.76|P-value:8.86E-5 ID:SGTC_1968|Compound:st069590|FD-Score:4.35|P-value:7.24E-6 ID:SGTC_2095|Compound:5432005|FD-Score:5.12|P-value:1.64E-7 ID:SGTC_2271|Compound:7849410|FD-Score:-3.94|P-value:4.12E-5 ID:SGTC_2272|Compound:7805186|FD-Score:-3.21|P-value:6.61E-4 ID:SGTC_2321|Compound:7390090|FD-Score:-3.29|P-value:5.02E-4 ID:SGTC_2633|Compound:5,7-dihydroxyisoflavone|FD-Score:-3.37|P-value:3.80E-4 ID:SGTC_2757|Compound:clomiphene|FD-Score:3.34|P-value:4.28E-4 ID:SGTC_2815|Compound:7968870|FD-Score:4.16|P-value:1.63E-5 ID:SGTC_2906|Compound:7926292|FD-Score:5.74|P-value:5.16E-9 ID:SGTC_3025|Compound:9087895|FD-Score:6.07|P-value:6.84E-10 ID:SGTC_3128|Compound:9127691|FD-Score:4.31|P-value:8.49E-6 ID:SGTC_3148|Compound:9097893|FD-Score:-4.54|P-value:2.80E-6 ID:SGTC_3149|Compound:9097855|FD-Score:3.98|P-value:3.61E-5 ID:SGTC_92|Compound:0063-0024|FD-Score:3.33|P-value:4.46E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:5.05|P-value:2.39E-7 ID:SGTC_270|Compound:tamoxifen|FD-Score:-3.61|P-value:1.57E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:3.11|P-value:9.64E-4 ID:SGTC_397|Compound:arbidol|FD-Score:5.62|P-value:1.02E-8 ID:SGTC_421|Compound:streptovitacin|FD-Score:-3.57|P-value:1.82E-4 ID:SGTC_474|Compound:dl-dihydrosphingosine|FD-Score:-3.39|P-value:3.52E-4 ID:SGTC_500|Compound:h-89|FD-Score:3.14|P-value:8.71E-4 ID:SGTC_706|Compound:4262-0057|FD-Score:3.36|P-value:3.98E-4 ID:SGTC_856|Compound:0433-0016|FD-Score:3.41|P-value:3.41E-4 ID:SGTC_867|Compound:0518-0118|FD-Score:3.77|P-value:8.39E-5 ID:SGTC_896|Compound:0964-0007|FD-Score:-3.13|P-value:8.72E-4 ID:SGTC_1013|Compound:4112-3890|FD-Score:3.63|P-value:1.49E-4 ID:SGTC_1015|Compound:4130-4525|FD-Score:3.76|P-value:8.78E-5 ID:SGTC_1024|Compound:4507-0395|FD-Score:3.19|P-value:7.34E-4 ID:SGTC_1157|Compound:4092-0394|FD-Score:3.38|P-value:3.68E-4 ID:SGTC_1366|Compound:1683-0113|FD-Score:3.21|P-value:6.75E-4 ID:SGTC_1439|Compound:4092-1168|FD-Score:3.21|P-value:6.87E-4 ID:SGTC_1476|Compound:4112-3294|FD-Score:3.28|P-value:5.36E-4 ID:SGTC_1510|Compound:1123-0200|FD-Score:3.54|P-value:2.06E-4 ID:SGTC_1529|Compound:apigenin|FD-Score:-3.32|P-value:4.46E-4 ID:SGTC_1638|Compound:st008370|FD-Score:-3.41|P-value:3.24E-4 ID:SGTC_1691|Compound:st019933|FD-Score:4.76|P-value:1.03E-6 ID:SGTC_1699|Compound:st031318|FD-Score:5.44|P-value:2.87E-8 ID:SGTC_1707|Compound:st032323|FD-Score:3.93|P-value:4.38E-5 ID:SGTC_1822|Compound:st052468|FD-Score:3.82|P-value:7.06E-5 ID:SGTC_1855|Compound:st056195|FD-Score:3.51|P-value:2.36E-4 ID:SGTC_1868|Compound:st057644|FD-Score:3.76|P-value:8.86E-5 ID:SGTC_1968|Compound:st069590|FD-Score:4.35|P-value:7.24E-6 ID:SGTC_2095|Compound:5432005|FD-Score:5.12|P-value:1.64E-7 ID:SGTC_2271|Compound:7849410|FD-Score:-3.94|P-value:4.12E-5 ID:SGTC_2272|Compound:7805186|FD-Score:-3.21|P-value:6.61E-4 ID:SGTC_2321|Compound:7390090|FD-Score:-3.29|P-value:5.02E-4 ID:SGTC_2633|Compound:5,7-dihydroxyisoflavone|FD-Score:-3.37|P-value:3.80E-4 ID:SGTC_2757|Compound:clomiphene|FD-Score:3.34|P-value:4.28E-4 ID:SGTC_2815|Compound:7968870|FD-Score:4.16|P-value:1.63E-5 ID:SGTC_2906|Compound:7926292|FD-Score:5.74|P-value:5.16E-9 ID:SGTC_3025|Compound:9087895|FD-Score:6.07|P-value:6.84E-10 ID:SGTC_3128|Compound:9127691|FD-Score:4.31|P-value:8.49E-6 ID:SGTC_3148|Compound:9097893|FD-Score:-4.54|P-value:2.80E-6 ID:SGTC_3149|Compound:9097855|FD-Score:3.98|P-value:3.61E-5

Top fitness defect scores for YPL058C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3025 9087895 6.07 49.5 µM 6.84E-10 PDR1 13 6.32E-10
2 SGTC_2906 7926292 5.74 26.4 µM 5.16E-9 5 4.80E-9
3 SGTC_397 arbidol 5.62 50.0 µM 1.02E-8 cell wall 4 9.54E-9
4 SGTC_1699 st031318 5.44 29.1 µM 2.87E-8 13 2.69E-8
5 SGTC_2095 5432005 5.12 200.0 µM 1.64E-7 3 1.55E-7
6 SGTC_173 1273-0061 5.05 2.7 µM 2.39E-7 mitochondrial stress 146 2.26E-7
7 SGTC_1691 st019933 4.76 84.6 µM 1.03E-6 6 9.77E-7
8 SGTC_1968 st069590 4.35 43.6 µM 7.24E-6 9 6.92E-6
9 SGTC_3128 9127691 4.31 49.5 µM 8.49E-6 17 8.12E-6
10 SGTC_2815 7968870 4.16 71.4 µM 1.63E-5 18 1.56E-5
11 SGTC_3149 9097855 3.98 49.5 µM 3.61E-5 Golgi 29 3.47E-5
12 SGTC_1707 st032323 3.93 6.3 µM 4.38E-5 DNA damage response 57 4.22E-5
13 SGTC_1822 st052468 3.82 42.0 µM 7.06E-5 13 6.80E-5
14 SGTC_867 0518-0118 3.77 155.0 µM 8.39E-5 DNA intercalators 26 8.09E-5
15 SGTC_1015 4130-4525 3.76 82.0 µM 8.78E-5 60S ribosome export 28 8.47E-5
16 SGTC_1868 st057644 3.76 42.7 µM 8.86E-5 42 8.55E-5
17 SGTC_1013 4112-3890 3.63 241.0 µM 1.49E-4 TSC3-RPN4 45 1.44E-4
18 SGTC_1510 1123-0200 3.54 71.5 µM 2.06E-4 59 2.00E-4
19 SGTC_1855 st056195 3.51 39.6 µM 2.36E-4 60S ribosome export 29 2.28E-4
20 SGTC_856 0433-0016 3.41 11.3 µM 3.41E-4 23 3.31E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.106 6.29E-10 YHR190W ERG9 het Farnesyl-diphosphate farnesyl transferase (squalene synthase), joins two farnesyl pyrophosphate moieties to form squalene in the sterol biosynthesis pathway
0.100 6.25E-9 YOL135C MED7 het Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation
0.097 2.12E-8 YCR019W MAK32 hom Protein necessary for structural stability of L-A double-stranded RNA-containing particles
0.093 7.55E-8 YDL202W MRPL11 hom Mitochondrial ribosomal protein of the large subunit
0.087 4.59E-7 YOR374W ALD4 hom Mitochondrial aldehyde dehydrogenase, required for growth on ethanol and conversion of acetaldehyde to acetate; phosphorylated; activity is K+ dependent; utilizes NADP+ or NAD+ equally as coenzymes; expression is glucose repressed
0.081 2.32E-6 YPL204W HRR25 het Protein kinase involved in regulating diverse events including vesicular trafficking, DNA repair, and chromosome segregation; binds the CTD of RNA pol II; homolog of mammalian casein kinase 1delta (CK1delta)
0.075 1.45E-5 YDL059C RAD59 hom Protein involved DNA double-strand break repair; repairs breaks in DNA during vegetative growth via recombination and single-strand annealing; anneals complementary single-stranded DNA; forms nuclear foci upon DNA replication stress; required for loading of Rad52p to DSBs; paralog of Rad52p
0.075 1.50E-5 YNL203C_d YNL203C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.073 2.28E-5 YGL062W PYC1 hom Pyruvate carboxylase isoform; cytoplasmic enzyme that converts pyruvate to oxaloacetate; differentially regulated than isoform Pyc2p; mutations in the human homolog are associated with lactic acidosis; PYC1 has a paralog, PYC2, that arose from the whole genome duplication
0.073 2.37E-5 YPR040W TIP41 hom Protein that interacts with Tap42p, which regulates PP2A; component of the TOR (target of rapamycin) signaling pathway; protein abundance increases in response to DNA replication stress
0.071 3.46E-5 YBR247C ENP1 het Protein associated with U3 and U14 snoRNAs, required for pre-rRNA processing and 40S ribosomal subunit synthesis; localized in the nucleus and concentrated in the nucleolus
0.071 3.87E-5 YJR106W ECM27 hom Putative protein of unknown function; may play a role in cell wall biosynthesis, mutants are hypersensitive to Papulacandin B; null mutants have increased plasmid loss; displays a two-hybrid interaction with Pdr5p
0.070 5.37E-5 YHL004W MRP4 hom Mitochondrial ribosomal protein of the small subunit
0.067 9.85E-5 YLR122C_d YLR122C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR123C
0.067 1.05E-4 YEL020C_p YEL020C_p hom Protein of unknown function with low sequence identity to Pdc1p; mRNA identified as translated by ribosome profiling data