YPL060W / MFM1

Mitochondrial inner membrane magnesium transporter, involved in maintenance of mitochondrial magnesium concentrations and membrane potential; indirectly affects splicing of group II introns; functionally and structurally related to Mrs2p

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL060W / MFM1

Click on Significant Values for Screen Details ID:SGTC_97|Compound:0535-0701|FD-Score:4.14|P-value:1.60E-4 ID:SGTC_335|Compound:4077-0256|FD-Score:-4.50|P-value:4.58E-5 ID:SGTC_393|Compound:acivicin|FD-Score:4.03|P-value:2.32E-4 ID:SGTC_512|Compound:prima-1|FD-Score:3.62|P-value:8.19E-4 ID:SGTC_551|Compound:k048-0028|FD-Score:3.86|P-value:3.97E-4 ID:SGTC_571|Compound:k831-0106|FD-Score:4.93|P-value:9.21E-6 ID:SGTC_684|Compound:1140-0066|FD-Score:-4.96|P-value:8.09E-6 ID:SGTC_792|Compound:4534-1957|FD-Score:-3.92|P-value:3.28E-4 ID:SGTC_904|Compound:1141-0088|FD-Score:4.39|P-value:6.77E-5 ID:SGTC_942|Compound:3253-1115|FD-Score:4.42|P-value:6.05E-5 ID:SGTC_946|Compound:3434-1334|FD-Score:4.06|P-value:2.09E-4 ID:SGTC_947|Compound:3447-0010|FD-Score:6.11|P-value:5.27E-8 ID:SGTC_955|Compound:1216-0110|FD-Score:5.63|P-value:4.85E-7 ID:SGTC_961|Compound:1252-1571|FD-Score:-3.97|P-value:2.77E-4 ID:SGTC_1095|Compound:3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran|FD-Score:3.66|P-value:7.24E-4 ID:SGTC_1283|Compound:0922-0125|FD-Score:5.39|P-value:1.35E-6 ID:SGTC_1288|Compound:0973-0013|FD-Score:5.47|P-value:1.00E-6 ID:SGTC_1307|Compound:1187-1599|FD-Score:9.15|P-value:9.06E-16 ID:SGTC_1321|Compound:1326-2144|FD-Score:4.38|P-value:6.98E-5 ID:SGTC_1356|Compound:1502-0781|FD-Score:3.79|P-value:4.92E-4 ID:SGTC_1537|Compound:2',6'-dihydroxyflavanone|FD-Score:3.78|P-value:5.03E-4 ID:SGTC_1540|Compound:guanosine|FD-Score:-3.80|P-value:4.79E-4 ID:SGTC_1765|Compound:st044815|FD-Score:3.85|P-value:4.03E-4 ID:SGTC_1766|Compound:st045414|FD-Score:4.00|P-value:2.56E-4 ID:SGTC_1887|Compound:st057648|FD-Score:-3.66|P-value:7.36E-4 ID:SGTC_1894|Compound:3',6'-dihydroxyflavone|FD-Score:4.34|P-value:8.13E-5 ID:SGTC_2110|Compound:5483698|FD-Score:-4.24|P-value:1.16E-4 ID:SGTC_2119|Compound:5528445|FD-Score:-4.27|P-value:1.04E-4 ID:SGTC_2368|Compound:9071271|FD-Score:4.78|P-value:1.63E-5 ID:SGTC_2400|Compound:5203494|FD-Score:3.57|P-value:9.57E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:3.60|P-value:8.64E-4 ID:SGTC_2512|Compound:diallyl trisulfide|FD-Score:5.12|P-value:4.30E-6 ID:SGTC_2553|Compound:4-methylesculetin|FD-Score:3.96|P-value:2.90E-4 ID:SGTC_2562|Compound:3',7'-dimethoxyflavone|FD-Score:3.60|P-value:8.82E-4 ID:SGTC_2580|Compound:diallyl disulphide|FD-Score:4.13|P-value:1.62E-4 ID:SGTC_2922|Compound:7999257|FD-Score:4.19|P-value:1.35E-4 ID:SGTC_3094|Compound:9117742|FD-Score:3.77|P-value:5.18E-4 ID:SGTC_97|Compound:0535-0701|FD-Score:4.14|P-value:1.60E-4 ID:SGTC_335|Compound:4077-0256|FD-Score:-4.50|P-value:4.58E-5 ID:SGTC_393|Compound:acivicin|FD-Score:4.03|P-value:2.32E-4 ID:SGTC_512|Compound:prima-1|FD-Score:3.62|P-value:8.19E-4 ID:SGTC_551|Compound:k048-0028|FD-Score:3.86|P-value:3.97E-4 ID:SGTC_571|Compound:k831-0106|FD-Score:4.93|P-value:9.21E-6 ID:SGTC_684|Compound:1140-0066|FD-Score:-4.96|P-value:8.09E-6 ID:SGTC_792|Compound:4534-1957|FD-Score:-3.92|P-value:3.28E-4 ID:SGTC_904|Compound:1141-0088|FD-Score:4.39|P-value:6.77E-5 ID:SGTC_942|Compound:3253-1115|FD-Score:4.42|P-value:6.05E-5 ID:SGTC_946|Compound:3434-1334|FD-Score:4.06|P-value:2.09E-4 ID:SGTC_947|Compound:3447-0010|FD-Score:6.11|P-value:5.27E-8 ID:SGTC_955|Compound:1216-0110|FD-Score:5.63|P-value:4.85E-7 ID:SGTC_961|Compound:1252-1571|FD-Score:-3.97|P-value:2.77E-4 ID:SGTC_1095|Compound:3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran|FD-Score:3.66|P-value:7.24E-4 ID:SGTC_1283|Compound:0922-0125|FD-Score:5.39|P-value:1.35E-6 ID:SGTC_1288|Compound:0973-0013|FD-Score:5.47|P-value:1.00E-6 ID:SGTC_1307|Compound:1187-1599|FD-Score:9.15|P-value:9.06E-16 ID:SGTC_1321|Compound:1326-2144|FD-Score:4.38|P-value:6.98E-5 ID:SGTC_1356|Compound:1502-0781|FD-Score:3.79|P-value:4.92E-4 ID:SGTC_1537|Compound:2',6'-dihydroxyflavanone|FD-Score:3.78|P-value:5.03E-4 ID:SGTC_1540|Compound:guanosine|FD-Score:-3.80|P-value:4.79E-4 ID:SGTC_1765|Compound:st044815|FD-Score:3.85|P-value:4.03E-4 ID:SGTC_1766|Compound:st045414|FD-Score:4.00|P-value:2.56E-4 ID:SGTC_1887|Compound:st057648|FD-Score:-3.66|P-value:7.36E-4 ID:SGTC_1894|Compound:3',6'-dihydroxyflavone|FD-Score:4.34|P-value:8.13E-5 ID:SGTC_2110|Compound:5483698|FD-Score:-4.24|P-value:1.16E-4 ID:SGTC_2119|Compound:5528445|FD-Score:-4.27|P-value:1.04E-4 ID:SGTC_2368|Compound:9071271|FD-Score:4.78|P-value:1.63E-5 ID:SGTC_2400|Compound:5203494|FD-Score:3.57|P-value:9.57E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:3.60|P-value:8.64E-4 ID:SGTC_2512|Compound:diallyl trisulfide|FD-Score:5.12|P-value:4.30E-6 ID:SGTC_2553|Compound:4-methylesculetin|FD-Score:3.96|P-value:2.90E-4 ID:SGTC_2562|Compound:3',7'-dimethoxyflavone|FD-Score:3.60|P-value:8.82E-4 ID:SGTC_2580|Compound:diallyl disulphide|FD-Score:4.13|P-value:1.62E-4 ID:SGTC_2922|Compound:7999257|FD-Score:4.19|P-value:1.35E-4 ID:SGTC_3094|Compound:9117742|FD-Score:3.77|P-value:5.18E-4

Top fitness defect scores for YPL060W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1307 1187-1599 9.15 12.2 µM 9.06E-16 PDR1 1 2.94E-20
2 SGTC_947 3447-0010 6.11 211.0 µM 5.27E-8 2 4.85E-10
3 SGTC_955 1216-0110 5.63 33.0 µM 4.85E-7 sphingolipid biosynthesis & PDR1 35 8.92E-9
4 SGTC_1288 0973-0013 5.47 65.5 µM 1.00E-6 4 2.31E-8
5 SGTC_1283 0922-0125 5.39 16.4 µM 1.35E-6 5 3.43E-8
6 SGTC_2512 diallyl trisulfide 5.12 49.2 µM 4.30E-6 1 1.56E-7
7 SGTC_571 k831-0106 4.93 44.2 µM 9.21E-6 5 4.22E-7
8 SGTC_2368 9071271 4.78 200.0 µM 1.63E-5 12 8.91E-7
9 SGTC_942 3253-1115 4.42 227.0 µM 6.05E-5 19 4.94E-6
10 SGTC_904 1141-0088 4.39 396.0 µM 6.77E-5 10 5.72E-6
11 SGTC_1321 1326-2144 4.38 215.0 µM 6.98E-5 5 5.95E-6
12 SGTC_1894 3',6'-dihydroxyflavone 4.34 78.7 µM 8.13E-5 8 7.26E-6
13 SGTC_2922 7999257 4.19 32.5 µM 1.35E-4 10 1.40E-5
14 SGTC_97 0535-0701 4.14 19.1 µM 1.60E-4 60S ribosome export 12 1.75E-5
15 SGTC_2580 diallyl disulphide 4.13 81.4 µM 1.62E-4 20 1.78E-5
16 SGTC_946 3434-1334 4.06 87.4 µM 2.09E-4 29 2.48E-5
17 SGTC_393 acivicin 4.03 6.2 µM 2.32E-4 20 2.84E-5
18 SGTC_1766 st045414 4.00 44.8 µM 2.56E-4 RPP1 & pyrimidine depletion 26 3.23E-5
19 SGTC_2553 4-methylesculetin 3.96 85.1 µM 2.90E-4 24 3.80E-5
20 SGTC_551 k048-0028 3.86 34.9 µM 3.97E-4 17 5.73E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.113 4.62E-11 YBR280C SAF1 hom F-Box protein involved in proteasome-dependent degradation of Aah1p during entry of cells into quiescence; interacts with Skp1
0.102 3.39E-9 YDL036C PUS9 hom Mitochondrial tRNA:pseudouridine synthase, catalyzes the formation of pseudouridine at position 32 in mitochondrial tRNAs; contains an N-terminal mitochondrial targeting sequence
0.093 7.46E-8 YOR282W_d YOR282W_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps essential, verified gene PLP2/YOR281C
0.091 1.14E-7 YOL126C MDH2 hom Cytoplasmic malate dehydrogenase, one of three isozymes that catalyze interconversion of malate and oxaloacetate; involved in the glyoxylate cycle and gluconeogenesis during growth on two-carbon compounds; interacts with Pck1p and Fbp1
0.080 3.27E-6 YNL236W SIN4 hom Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; contributes to both postive and negative transcriptional regulation; dispensible for basal transcription
0.078 6.15E-6 YDR219C MFB1 hom Mitochondria-associated F-box protein involved in maintenance of normal mitochondrial morphology; interacts with Skp1p through the F-box motif; preferentially localizes to the mother cell during budding
0.077 7.32E-6 YEL059C-A SOM1 hom Subunit of the mitochondrial inner membrane peptidase, which is required for maturation of mitochondrial proteins of the intermembrane space; Som1p facilitates cleavage of a subset of substrates; contains twin cysteine-x9-cysteine motifs
0.077 7.63E-6 YHR100C GEP4 hom Mitochondrial phosphatidylglycerophosphatase (PGP phosphatase), dephosphorylates phosphatidylglycerolphosphate to generate phosphatidylglycerol, an essential step during cardiolipin biosynthesis; null mutant is sensitive to tunicamycin, DTT
0.075 1.29E-5 YGR225W AMA1 hom Activator of meiotic anaphase promoting complex (APC/C); Cdc20p family member; required for initiation of spore wall assembly; required for Clb1p degradation during meiosis
0.074 1.74E-5 YER061C CEM1 hom Mitochondrial beta-keto-acyl synthase with possible role in fatty acid synthesis; required for mitochondrial respiration
0.074 1.75E-5 YDL104C QRI7 hom Highly conserved mitochondrial protein, essential for t6A modification of mitochondrial tRNAs that decode ANN codons; similar to Kae1p and E. coli YgjD, both of which are also required for tRNA t6A modification
0.074 1.86E-5 YOL050C_d YOL050C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps verified gene GAL11; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)
0.074 1.91E-5 YGL237C HAP2 hom Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences sufficient for both complex assembly and DNA binding
0.072 2.79E-5 YCL064C CHA1 hom Catabolic L-serine (L-threonine) deaminase, catalyzes the degradation of both L-serine and L-threonine; required to use serine or threonine as the sole nitrogen source, transcriptionally induced by serine and threonine
0.072 3.00E-5 YMR286W MRPL33 hom Mitochondrial ribosomal protein of the large subunit