YPL061W / ALD6

Cytosolic aldehyde dehydrogenase, activated by Mg2+ and utilizes NADP+ as the preferred coenzyme; required for conversion of acetaldehyde to acetate; constitutively expressed; locates to the mitochondrial outer surface upon oxidative stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL061W / ALD6

Click on Significant Values for Screen Details ID:SGTC_63|Compound:0099-0242|FD-Score:5.13|P-value:2.46E-6 ID:SGTC_96|Compound:0929-0093|FD-Score:3.60|P-value:6.29E-4 ID:SGTC_115|Compound:0527-0192|FD-Score:4.68|P-value:1.52E-5 ID:SGTC_177|Compound:1327-0068|FD-Score:7.45|P-value:1.97E-11 ID:SGTC_202|Compound:3594-0513|FD-Score:3.68|P-value:4.93E-4 ID:SGTC_227|Compound:fluconazole|FD-Score:4.52|P-value:2.77E-5 ID:SGTC_283|Compound:0987-0079|FD-Score:3.45|P-value:9.88E-4 ID:SGTC_363|Compound:0455-0021|FD-Score:7.86|P-value:1.69E-12 ID:SGTC_371|Compound:0195-0006|FD-Score:-8.37|P-value:1.79E-13 ID:SGTC_391|Compound:gliotoxin|FD-Score:11.10|P-value:4.79E-23 ID:SGTC_445|Compound:e6 berbamine|FD-Score:6.07|P-value:3.51E-8 ID:SGTC_528|Compound:3492-0019|FD-Score:4.65|P-value:1.69E-5 ID:SGTC_625|Compound:k213-0058|FD-Score:5.90|P-value:7.76E-8 ID:SGTC_654|Compound:1124-0271|FD-Score:4.85|P-value:7.83E-6 ID:SGTC_673|Compound:1082-0474|FD-Score:4.04|P-value:1.51E-4 ID:SGTC_712|Compound:r015-0009|FD-Score:3.51|P-value:8.13E-4 ID:SGTC_753|Compound:1322-0200|FD-Score:5.51|P-value:4.72E-7 ID:SGTC_788|Compound:1182-0090|FD-Score:3.63|P-value:5.72E-4 ID:SGTC_789|Compound:1309-1135|FD-Score:4.22|P-value:8.19E-5 ID:SGTC_800|Compound:3448-7362|FD-Score:6.78|P-value:8.97E-10 ID:SGTC_830|Compound:4076-0286|FD-Score:3.48|P-value:8.92E-4 ID:SGTC_841|Compound:0251-0215|FD-Score:9.02|P-value:7.43E-16 ID:SGTC_847|Compound:0342-0274|FD-Score:3.84|P-value:2.97E-4 ID:SGTC_851|Compound:0394-0702|FD-Score:4.00|P-value:1.75E-4 ID:SGTC_862|Compound:0452-0056|FD-Score:3.72|P-value:4.32E-4 ID:SGTC_925|Compound:2064-1272|FD-Score:3.77|P-value:3.71E-4 ID:SGTC_1024|Compound:4507-0395|FD-Score:5.03|P-value:3.68E-6 ID:SGTC_1066|Compound:ketoconazole|FD-Score:3.95|P-value:2.03E-4 ID:SGTC_1258|Compound:0671-0043|FD-Score:3.75|P-value:3.93E-4 ID:SGTC_1317|Compound:1273-0028|FD-Score:7.20|P-value:8.56E-11 ID:SGTC_1365|Compound:1672-3266|FD-Score:3.89|P-value:2.48E-4 ID:SGTC_1374|Compound:2889-5571|FD-Score:4.49|P-value:3.08E-5 ID:SGTC_1495|Compound:4469-0029|FD-Score:4.02|P-value:1.64E-4 ID:SGTC_1497|Compound:4476-2978|FD-Score:3.95|P-value:2.05E-4 ID:SGTC_1506|Compound:4226-2149|FD-Score:5.71|P-value:1.93E-7 ID:SGTC_1513|Compound:0337-0559|FD-Score:-4.09|P-value:2.19E-4 ID:SGTC_1518|Compound:st038567|FD-Score:3.65|P-value:5.30E-4 ID:SGTC_1522|Compound:st012842|FD-Score:3.82|P-value:3.17E-4 ID:SGTC_1528|Compound:arabinosylhypoxanthine|FD-Score:5.84|P-value:1.05E-7 ID:SGTC_1548|Compound:st061468|FD-Score:-3.62|P-value:9.39E-4 ID:SGTC_1549|Compound:4'-methoxyflavonol|FD-Score:-3.74|P-value:6.54E-4 ID:SGTC_1552|Compound:6-methylflavone|FD-Score:5.25|P-value:1.48E-6 ID:SGTC_1565|Compound:sinapyl alcohol|FD-Score:-4.80|P-value:1.74E-5 ID:SGTC_1595|Compound:6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin|FD-Score:3.49|P-value:8.63E-4 ID:SGTC_1661|Compound:st013063|FD-Score:5.26|P-value:1.43E-6 ID:SGTC_1787|Compound:fluconazole|FD-Score:3.63|P-value:5.65E-4 ID:SGTC_1788|Compound:fluconazole|FD-Score:7.87|P-value:1.58E-12 ID:SGTC_1919|Compound:st067113|FD-Score:6.65|P-value:1.84E-9 ID:SGTC_2023|Compound:5144124|FD-Score:-3.81|P-value:5.32E-4 ID:SGTC_2129|Compound:girgensonine|FD-Score:3.80|P-value:3.39E-4 ID:SGTC_2289|Compound:7946404|FD-Score:7.63|P-value:6.88E-12 ID:SGTC_2325|Compound:6158266|FD-Score:3.68|P-value:4.84E-4 ID:SGTC_2422|Compound:chlorphenesin carbamate|FD-Score:3.69|P-value:4.79E-4 ID:SGTC_2446|Compound:5162541|FD-Score:4.39|P-value:4.51E-5 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:14.30|P-value:8.10E-37 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:-3.92|P-value:3.76E-4 ID:SGTC_2648|Compound:atorvastatin|FD-Score:4.77|P-value:1.05E-5 ID:SGTC_2661|Compound:dactinomycin|FD-Score:4.43|P-value:3.89E-5 ID:SGTC_2738|Compound:aclarubicin|FD-Score:3.46|P-value:9.65E-4 ID:SGTC_2753|Compound:fluvastatin|FD-Score:4.01|P-value:1.67E-4 ID:SGTC_2799|Compound:7812892|FD-Score:4.98|P-value:4.65E-6 ID:SGTC_2831|Compound:7999036|FD-Score:5.26|P-value:1.43E-6 ID:SGTC_2834|Compound:9001755|FD-Score:7.00|P-value:2.72E-10 ID:SGTC_2835|Compound:9006588|FD-Score:-4.70|P-value:2.52E-5 ID:SGTC_2854|Compound:9024559|FD-Score:4.16|P-value:9.92E-5 ID:SGTC_2859|Compound:9028643|FD-Score:3.81|P-value:3.28E-4 ID:SGTC_2910|Compound:7948405|FD-Score:4.12|P-value:1.15E-4 ID:SGTC_2921|Compound:7974240|FD-Score:4.70|P-value:1.38E-5 ID:SGTC_2989|Compound:9073649|FD-Score:5.93|P-value:6.97E-8 ID:SGTC_2991|Compound:9074669|FD-Score:-4.13|P-value:1.92E-4 ID:SGTC_3069|Compound:9117009|FD-Score:5.91|P-value:7.51E-8 ID:SGTC_3074|Compound:9116018|FD-Score:-5.64|P-value:5.45E-7 ID:SGTC_3076|Compound:9116187|FD-Score:4.59|P-value:2.12E-5 ID:SGTC_3131|Compound:9127911|FD-Score:-5.73|P-value:3.68E-7 ID:SGTC_3199|Compound:9111318|FD-Score:5.22|P-value:1.66E-6 ID:SGTC_3217|Compound:9129673|FD-Score:3.61|P-value:6.07E-4 ID:SGTC_3304|Compound:9125678|FD-Score:5.85|P-value:1.01E-7 ID:SGTC_3349|Compound:9149703|FD-Score:-3.64|P-value:9.06E-4 ID:SGTC_3355|Compound:9151058|FD-Score:-4.02|P-value:2.78E-4 ID:SGTC_63|Compound:0099-0242|FD-Score:5.13|P-value:2.46E-6 ID:SGTC_96|Compound:0929-0093|FD-Score:3.60|P-value:6.29E-4 ID:SGTC_115|Compound:0527-0192|FD-Score:4.68|P-value:1.52E-5 ID:SGTC_177|Compound:1327-0068|FD-Score:7.45|P-value:1.97E-11 ID:SGTC_202|Compound:3594-0513|FD-Score:3.68|P-value:4.93E-4 ID:SGTC_227|Compound:fluconazole|FD-Score:4.52|P-value:2.77E-5 ID:SGTC_283|Compound:0987-0079|FD-Score:3.45|P-value:9.88E-4 ID:SGTC_363|Compound:0455-0021|FD-Score:7.86|P-value:1.69E-12 ID:SGTC_371|Compound:0195-0006|FD-Score:-8.37|P-value:1.79E-13 ID:SGTC_391|Compound:gliotoxin|FD-Score:11.10|P-value:4.79E-23 ID:SGTC_445|Compound:e6 berbamine|FD-Score:6.07|P-value:3.51E-8 ID:SGTC_528|Compound:3492-0019|FD-Score:4.65|P-value:1.69E-5 ID:SGTC_625|Compound:k213-0058|FD-Score:5.90|P-value:7.76E-8 ID:SGTC_654|Compound:1124-0271|FD-Score:4.85|P-value:7.83E-6 ID:SGTC_673|Compound:1082-0474|FD-Score:4.04|P-value:1.51E-4 ID:SGTC_712|Compound:r015-0009|FD-Score:3.51|P-value:8.13E-4 ID:SGTC_753|Compound:1322-0200|FD-Score:5.51|P-value:4.72E-7 ID:SGTC_788|Compound:1182-0090|FD-Score:3.63|P-value:5.72E-4 ID:SGTC_789|Compound:1309-1135|FD-Score:4.22|P-value:8.19E-5 ID:SGTC_800|Compound:3448-7362|FD-Score:6.78|P-value:8.97E-10 ID:SGTC_830|Compound:4076-0286|FD-Score:3.48|P-value:8.92E-4 ID:SGTC_841|Compound:0251-0215|FD-Score:9.02|P-value:7.43E-16 ID:SGTC_847|Compound:0342-0274|FD-Score:3.84|P-value:2.97E-4 ID:SGTC_851|Compound:0394-0702|FD-Score:4.00|P-value:1.75E-4 ID:SGTC_862|Compound:0452-0056|FD-Score:3.72|P-value:4.32E-4 ID:SGTC_925|Compound:2064-1272|FD-Score:3.77|P-value:3.71E-4 ID:SGTC_1024|Compound:4507-0395|FD-Score:5.03|P-value:3.68E-6 ID:SGTC_1066|Compound:ketoconazole|FD-Score:3.95|P-value:2.03E-4 ID:SGTC_1258|Compound:0671-0043|FD-Score:3.75|P-value:3.93E-4 ID:SGTC_1317|Compound:1273-0028|FD-Score:7.20|P-value:8.56E-11 ID:SGTC_1365|Compound:1672-3266|FD-Score:3.89|P-value:2.48E-4 ID:SGTC_1374|Compound:2889-5571|FD-Score:4.49|P-value:3.08E-5 ID:SGTC_1495|Compound:4469-0029|FD-Score:4.02|P-value:1.64E-4 ID:SGTC_1497|Compound:4476-2978|FD-Score:3.95|P-value:2.05E-4 ID:SGTC_1506|Compound:4226-2149|FD-Score:5.71|P-value:1.93E-7 ID:SGTC_1513|Compound:0337-0559|FD-Score:-4.09|P-value:2.19E-4 ID:SGTC_1518|Compound:st038567|FD-Score:3.65|P-value:5.30E-4 ID:SGTC_1522|Compound:st012842|FD-Score:3.82|P-value:3.17E-4 ID:SGTC_1528|Compound:arabinosylhypoxanthine|FD-Score:5.84|P-value:1.05E-7 ID:SGTC_1548|Compound:st061468|FD-Score:-3.62|P-value:9.39E-4 ID:SGTC_1549|Compound:4'-methoxyflavonol|FD-Score:-3.74|P-value:6.54E-4 ID:SGTC_1552|Compound:6-methylflavone|FD-Score:5.25|P-value:1.48E-6 ID:SGTC_1565|Compound:sinapyl alcohol|FD-Score:-4.80|P-value:1.74E-5 ID:SGTC_1595|Compound:6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin|FD-Score:3.49|P-value:8.63E-4 ID:SGTC_1661|Compound:st013063|FD-Score:5.26|P-value:1.43E-6 ID:SGTC_1787|Compound:fluconazole|FD-Score:3.63|P-value:5.65E-4 ID:SGTC_1788|Compound:fluconazole|FD-Score:7.87|P-value:1.58E-12 ID:SGTC_1919|Compound:st067113|FD-Score:6.65|P-value:1.84E-9 ID:SGTC_2023|Compound:5144124|FD-Score:-3.81|P-value:5.32E-4 ID:SGTC_2129|Compound:girgensonine|FD-Score:3.80|P-value:3.39E-4 ID:SGTC_2289|Compound:7946404|FD-Score:7.63|P-value:6.88E-12 ID:SGTC_2325|Compound:6158266|FD-Score:3.68|P-value:4.84E-4 ID:SGTC_2422|Compound:chlorphenesin carbamate|FD-Score:3.69|P-value:4.79E-4 ID:SGTC_2446|Compound:5162541|FD-Score:4.39|P-value:4.51E-5 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:14.30|P-value:8.10E-37 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:-3.92|P-value:3.76E-4 ID:SGTC_2648|Compound:atorvastatin|FD-Score:4.77|P-value:1.05E-5 ID:SGTC_2661|Compound:dactinomycin|FD-Score:4.43|P-value:3.89E-5 ID:SGTC_2738|Compound:aclarubicin|FD-Score:3.46|P-value:9.65E-4 ID:SGTC_2753|Compound:fluvastatin|FD-Score:4.01|P-value:1.67E-4 ID:SGTC_2799|Compound:7812892|FD-Score:4.98|P-value:4.65E-6 ID:SGTC_2831|Compound:7999036|FD-Score:5.26|P-value:1.43E-6 ID:SGTC_2834|Compound:9001755|FD-Score:7.00|P-value:2.72E-10 ID:SGTC_2835|Compound:9006588|FD-Score:-4.70|P-value:2.52E-5 ID:SGTC_2854|Compound:9024559|FD-Score:4.16|P-value:9.92E-5 ID:SGTC_2859|Compound:9028643|FD-Score:3.81|P-value:3.28E-4 ID:SGTC_2910|Compound:7948405|FD-Score:4.12|P-value:1.15E-4 ID:SGTC_2921|Compound:7974240|FD-Score:4.70|P-value:1.38E-5 ID:SGTC_2989|Compound:9073649|FD-Score:5.93|P-value:6.97E-8 ID:SGTC_2991|Compound:9074669|FD-Score:-4.13|P-value:1.92E-4 ID:SGTC_3069|Compound:9117009|FD-Score:5.91|P-value:7.51E-8 ID:SGTC_3074|Compound:9116018|FD-Score:-5.64|P-value:5.45E-7 ID:SGTC_3076|Compound:9116187|FD-Score:4.59|P-value:2.12E-5 ID:SGTC_3131|Compound:9127911|FD-Score:-5.73|P-value:3.68E-7 ID:SGTC_3199|Compound:9111318|FD-Score:5.22|P-value:1.66E-6 ID:SGTC_3217|Compound:9129673|FD-Score:3.61|P-value:6.07E-4 ID:SGTC_3304|Compound:9125678|FD-Score:5.85|P-value:1.01E-7 ID:SGTC_3349|Compound:9149703|FD-Score:-3.64|P-value:9.06E-4 ID:SGTC_3355|Compound:9151058|FD-Score:-4.02|P-value:2.78E-4

Top fitness defect scores for YPL061W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2566 crystal violet carbinol 14.30 226.0 nM 8.10E-37 2 9.08E-47
2 SGTC_391 gliotoxin 11.10 8.3 µM 4.79E-23 8 5.32E-29
3 SGTC_841 0251-0215 9.02 91.2 µM 7.43E-16 18 9.54E-20
4 SGTC_1788 fluconazole 7.87 20.0 µM 1.58E-12 azole & statin 20 1.78E-15
5 SGTC_363 0455-0021 7.86 3.1 µM 1.69E-12 azole & statin 14 1.95E-15
6 SGTC_2289 7946404 7.63 165.1 µM 6.88E-12 19 1.18E-14
7 SGTC_177 1327-0068 7.45 8.4 µM 1.97E-11 16 4.51E-14
8 SGTC_1317 1273-0028 7.20 910.0 nM 8.56E-11 azole & statin 22 2.97E-13
9 SGTC_2834 9001755 7.00 58.4 µM 2.72E-10 5 1.30E-12
10 SGTC_800 3448-7362 6.78 155.0 µM 8.97E-10 translation 30 5.99E-12
11 SGTC_1919 st067113 6.65 52.3 µM 1.84E-9 TSC3-RPN4 6 1.50E-11
12 SGTC_445 e6 berbamine 6.07 66.0 µM 3.51E-8 NEO1-PIK1 31 6.48E-10
13 SGTC_2989 9073649 5.93 71.4 µM 6.97E-8 9 1.55E-9
14 SGTC_3069 9117009 5.91 49.5 µM 7.51E-8 60S ribosome export 2 1.71E-9
15 SGTC_625 k213-0058 5.90 121.0 µM 7.76E-8 translation 36 1.78E-9
16 SGTC_3304 9125678 5.85 46.1 µM 1.01E-7 13 2.49E-9
17 SGTC_1528 arabinosylhypoxanthine 5.84 74.6 µM 1.05E-7 5 2.63E-9
18 SGTC_1506 4226-2149 5.71 212.0 µM 1.93E-7 6 5.70E-9
19 SGTC_753 1322-0200 5.51 289.0 µM 4.72E-7 2 1.78E-8
20 SGTC_1661 st013063 5.26 9.7 µM 1.43E-6 10 7.29E-8

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.369 8.56E-109 YPL062W_d YPL062W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YPL062W is not an essential gene; homozygous diploid mutant shows a decrease in glycogen accumulation
0.263 2.63E-54 YJR049C UTR1 hom ATP-NADH kinase; phosphorylates both NAD and NADH; active as a hexamer; enhances the activity of ferric reductase (Fre1p); UTR1 has a paralog, YEF1, that arose from the whole genome duplication
0.218 1.59E-37 YML081W TDA9 hom DNA-binding protein, putative transcription factor; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; null mutant is sensitive to expression of the top1-T722A allele; not an essential gene; TDA9 has a paralog, RSF2, that arose from the whole genome duplication
0.182 2.47E-26 YML075C HMG1 hom HMG-CoA reductase; catalyzes the conversion of HMG-CoA to mevalonate, which is a rate-limiting step in sterol biosynthesis; one of two isozymes; localizes to the nuclear envelope; overproduction induces the formation of karmellae; forms foci at the nuclear periphery upon DNA replication stress
0.179 1.53E-25 YMR154C RIM13 hom Calpain-like cysteine protease; involved in proteolytic activation of Rim101p in response to alkaline pH; localizes to punctate structures in alkaline conditions and in vps4 mutant; has similarity to A. nidulans palB
0.177 4.18E-25 YGR122W YGR122W hom Protein that may be involved in pH regulation; probable ortholog of A. nidulans PalC, which is involved in pH regulation and binds to the ESCRT-III complex; null mutant does not properly process Rim101p and has decreased resistance to rapamycin; GFP-fusion protein is cytoplasmic; relative distribution to cytoplasm increases upon DNA replication stress
0.166 2.91E-22 YJL024C APS3 hom Small subunit of the clathrin-associated adaptor complex AP-3; involved in vacuolar protein sorting; related to the sigma subunit of the mammalian clathrin AP-3 complex; suppressor of loss of casein kinase 1 function; protein abundance increases in response to DNA replication stress
0.149 3.23E-18 YBR288C APM3 hom Mu3-like subunit of the clathrin associated protein complex (AP-3); functions in transport of alkaline phosphatase to the vacuole via the alternate pathway
0.148 5.92E-18 YNL294C RIM21 hom pH sensor molecule, component of the RIM101 pathway; has a role in cell wall construction and alkaline pH response; is glycosylated and phosphorylated; interacts with Dfg16p and Rim9p to form a pH-sensing complex; localization to the plasma membrane is dependent on Dfg16p and Rim9p; has similarity to A. nidulans PalH
0.147 1.30E-17 YLR359W ADE13 het Adenylosuccinate lyase, catalyzes two steps in the 'de novo' purine nucleotide biosynthetic pathway; expression is repressed by adenine and activated by Bas1p and Pho2p; mutations in human ortholog ADSL cause adenylosuccinase deficiency
0.145 3.62E-17 YLR153C ACS2 het Acetyl-coA synthetase isoform which, along with Acs1p, is the nuclear source of acetyl-coA for histone acetylation; mutants affect global transcription; required for growth on glucose; expressed under anaerobic conditions
0.140 3.20E-16 YDR080W VPS41 hom Vacuolar membrane protein that is a subunit of the homotypic vacuole fusion and vacuole protein sorting (HOPS) complex; essential for membrane docking and fusion at the Golgi-to-endosome and endosome-to-vacuole stages of protein transport
0.137 1.41E-15 YGL045W RIM8 hom Protein involved in proteolytic activation of Rim101p in response to alkaline pH; interacts with ESCRT-1 subunits Stp22p and Vps28p; essential for anaerobic growth; member of the arrestin-related trafficking adaptor family
0.133 1.21E-14 YDL118W_d YDL118W_d hom Dubious open reading frame, unlikely to encode a protein; overlaps almost completely with YDL119C; mutations that would affect both YDL118W and YDL119C confer defective telomere maintenance and are synthetically sick or lethal with alpha-synuclein
0.131 2.60E-14 YMR063W RIM9 hom Plasma membrane protein of unknown function; involved in the proteolytic activation of Rim101p in response to alkaline pH; interacts with Rim21p and Dfg16p to form a pH-sensing complex in the Rim101 pathway and is required to maintain Rim21p levels; has similarity to A. nidulans PalI;