YPL062W_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YPL062W is not an essential gene; homozygous diploid mutant shows a decrease in glycogen accumulation

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL062W / YPL062W

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:-6.01|P-value:1.88E-8 ID:SGTC_61|Compound:0978-8327|FD-Score:4.18|P-value:7.42E-5 ID:SGTC_77|Compound:0828-0286|FD-Score:3.62|P-value:5.15E-4 ID:SGTC_120|Compound:rhodamine 6G|FD-Score:4.56|P-value:1.76E-5 ID:SGTC_127|Compound:0180-0333|FD-Score:3.87|P-value:2.21E-4 ID:SGTC_177|Compound:1327-0068|FD-Score:8.22|P-value:3.81E-14 ID:SGTC_227|Compound:fluconazole|FD-Score:6.18|P-value:9.53E-9 ID:SGTC_261|Compound:5-fluorouridine|FD-Score:3.73|P-value:3.65E-4 ID:SGTC_277|Compound:nystatin|FD-Score:4.24|P-value:6.00E-5 ID:SGTC_309|Compound:k408-0051|FD-Score:5.09|P-value:1.90E-6 ID:SGTC_363|Compound:0455-0021|FD-Score:4.41|P-value:3.12E-5 ID:SGTC_391|Compound:gliotoxin|FD-Score:12.00|P-value:5.84E-28 ID:SGTC_433|Compound:pimozide|FD-Score:4.46|P-value:2.60E-5 ID:SGTC_445|Compound:e6 berbamine|FD-Score:5.96|P-value:3.06E-8 ID:SGTC_447|Compound:ml7|FD-Score:3.65|P-value:4.65E-4 ID:SGTC_451|Compound:chloral hydrate|FD-Score:5.13|P-value:1.60E-6 ID:SGTC_528|Compound:3492-0019|FD-Score:3.86|P-value:2.32E-4 ID:SGTC_625|Compound:k213-0058|FD-Score:8.16|P-value:5.74E-14 ID:SGTC_673|Compound:1082-0474|FD-Score:6.78|P-value:3.48E-10 ID:SGTC_800|Compound:3448-7362|FD-Score:9.21|P-value:2.60E-17 ID:SGTC_804|Compound:1595-0054|FD-Score:-4.57|P-value:1.42E-5 ID:SGTC_841|Compound:0251-0215|FD-Score:5.17|P-value:1.35E-6 ID:SGTC_892|Compound:0929-0076|FD-Score:-4.03|P-value:1.09E-4 ID:SGTC_964|Compound:1287-0107|FD-Score:-3.63|P-value:4.39E-4 ID:SGTC_1134|Compound:3477-0009|FD-Score:7.89|P-value:3.50E-13 ID:SGTC_1249|Compound:0481-0015|FD-Score:4.22|P-value:6.39E-5 ID:SGTC_1252|Compound:0493-0875|FD-Score:4.62|P-value:1.38E-5 ID:SGTC_1317|Compound:1273-0028|FD-Score:5.46|P-value:3.61E-7 ID:SGTC_1374|Compound:2889-5571|FD-Score:3.80|P-value:2.84E-4 ID:SGTC_1425|Compound:4048-4433|FD-Score:4.22|P-value:6.46E-5 ID:SGTC_1495|Compound:4469-0029|FD-Score:3.74|P-value:3.49E-4 ID:SGTC_1608|Compound:st001473|FD-Score:4.33|P-value:4.22E-5 ID:SGTC_1624|Compound:st003710|FD-Score:6.06|P-value:1.86E-8 ID:SGTC_1655|Compound:st012546|FD-Score:-3.47|P-value:7.36E-4 ID:SGTC_1689|Compound:st020265|FD-Score:3.44|P-value:9.21E-4 ID:SGTC_1692|Compound:fluoroquinolonic acid|FD-Score:3.60|P-value:5.54E-4 ID:SGTC_1752|Compound:st044819|FD-Score:4.50|P-value:2.24E-5 ID:SGTC_1788|Compound:fluconazole|FD-Score:3.54|P-value:6.65E-4 ID:SGTC_1827|Compound:berberine|FD-Score:3.47|P-value:8.38E-4 ID:SGTC_1955|Compound:wogonin|FD-Score:-4.37|P-value:3.09E-5 ID:SGTC_1958|Compound:st076513|FD-Score:4.90|P-value:4.40E-6 ID:SGTC_1971|Compound:st069429|FD-Score:-3.40|P-value:9.00E-4 ID:SGTC_1974|Compound:st069448|FD-Score:3.52|P-value:7.14E-4 ID:SGTC_2040|Compound:5100729|FD-Score:3.79|P-value:2.94E-4 ID:SGTC_2238|Compound:6671620|FD-Score:-4.60|P-value:1.24E-5 ID:SGTC_2250|Compound:alverine citrate|FD-Score:-4.03|P-value:1.11E-4 ID:SGTC_2320|Compound:7373003|FD-Score:3.97|P-value:1.59E-4 ID:SGTC_2442|Compound:5158906|FD-Score:5.49|P-value:3.04E-7 ID:SGTC_2446|Compound:5162541|FD-Score:4.65|P-value:1.23E-5 ID:SGTC_2460|Compound:5552655|FD-Score:-4.11|P-value:8.32E-5 ID:SGTC_2461|Compound:5755302|FD-Score:3.69|P-value:4.07E-4 ID:SGTC_2482|Compound:5981709|FD-Score:3.84|P-value:2.45E-4 ID:SGTC_2549|Compound:cedrol|FD-Score:5.67|P-value:1.30E-7 ID:SGTC_2551|Compound:apiole|FD-Score:-4.36|P-value:3.18E-5 ID:SGTC_2552|Compound:juarezic acid|FD-Score:-4.41|P-value:2.63E-5 ID:SGTC_2553|Compound:4-methylesculetin|FD-Score:-6.82|P-value:2.19E-10 ID:SGTC_2554|Compound:13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one|FD-Score:-4.75|P-value:6.61E-6 ID:SGTC_2555|Compound:cholic acid|FD-Score:4.71|P-value:9.47E-6 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:8.50|P-value:5.31E-15 ID:SGTC_2646|Compound:retinol|FD-Score:4.10|P-value:1.00E-4 ID:SGTC_2647|Compound:atorvastatin|FD-Score:3.83|P-value:2.60E-4 ID:SGTC_2648|Compound:atorvastatin|FD-Score:5.47|P-value:3.38E-7 ID:SGTC_2679|Compound:rapamycin|FD-Score:-3.43|P-value:8.10E-4 ID:SGTC_2694|Compound:st077685|FD-Score:4.20|P-value:6.85E-5 ID:SGTC_2782|Compound:7736369|FD-Score:3.54|P-value:6.75E-4 ID:SGTC_2853|Compound:9015042|FD-Score:6.89|P-value:1.86E-10 ID:SGTC_2913|Compound:7966556|FD-Score:-3.91|P-value:1.66E-4 ID:SGTC_2971|Compound:9092186|FD-Score:3.42|P-value:9.65E-4 ID:SGTC_3002|Compound:9075603|FD-Score:4.00|P-value:1.45E-4 ID:SGTC_3126|Compound:9127922|FD-Score:3.73|P-value:3.61E-4 ID:SGTC_3254|Compound:9136651|FD-Score:3.97|P-value:1.56E-4 ID:SGTC_3304|Compound:9125678|FD-Score:4.59|P-value:1.55E-5 ID:SGTC_3317|Compound:9138495|FD-Score:4.13|P-value:9.11E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:-6.01|P-value:1.88E-8 ID:SGTC_61|Compound:0978-8327|FD-Score:4.18|P-value:7.42E-5 ID:SGTC_77|Compound:0828-0286|FD-Score:3.62|P-value:5.15E-4 ID:SGTC_120|Compound:rhodamine 6G|FD-Score:4.56|P-value:1.76E-5 ID:SGTC_127|Compound:0180-0333|FD-Score:3.87|P-value:2.21E-4 ID:SGTC_177|Compound:1327-0068|FD-Score:8.22|P-value:3.81E-14 ID:SGTC_227|Compound:fluconazole|FD-Score:6.18|P-value:9.53E-9 ID:SGTC_261|Compound:5-fluorouridine|FD-Score:3.73|P-value:3.65E-4 ID:SGTC_277|Compound:nystatin|FD-Score:4.24|P-value:6.00E-5 ID:SGTC_309|Compound:k408-0051|FD-Score:5.09|P-value:1.90E-6 ID:SGTC_363|Compound:0455-0021|FD-Score:4.41|P-value:3.12E-5 ID:SGTC_391|Compound:gliotoxin|FD-Score:12.00|P-value:5.84E-28 ID:SGTC_433|Compound:pimozide|FD-Score:4.46|P-value:2.60E-5 ID:SGTC_445|Compound:e6 berbamine|FD-Score:5.96|P-value:3.06E-8 ID:SGTC_447|Compound:ml7|FD-Score:3.65|P-value:4.65E-4 ID:SGTC_451|Compound:chloral hydrate|FD-Score:5.13|P-value:1.60E-6 ID:SGTC_528|Compound:3492-0019|FD-Score:3.86|P-value:2.32E-4 ID:SGTC_625|Compound:k213-0058|FD-Score:8.16|P-value:5.74E-14 ID:SGTC_673|Compound:1082-0474|FD-Score:6.78|P-value:3.48E-10 ID:SGTC_800|Compound:3448-7362|FD-Score:9.21|P-value:2.60E-17 ID:SGTC_804|Compound:1595-0054|FD-Score:-4.57|P-value:1.42E-5 ID:SGTC_841|Compound:0251-0215|FD-Score:5.17|P-value:1.35E-6 ID:SGTC_892|Compound:0929-0076|FD-Score:-4.03|P-value:1.09E-4 ID:SGTC_964|Compound:1287-0107|FD-Score:-3.63|P-value:4.39E-4 ID:SGTC_1134|Compound:3477-0009|FD-Score:7.89|P-value:3.50E-13 ID:SGTC_1249|Compound:0481-0015|FD-Score:4.22|P-value:6.39E-5 ID:SGTC_1252|Compound:0493-0875|FD-Score:4.62|P-value:1.38E-5 ID:SGTC_1317|Compound:1273-0028|FD-Score:5.46|P-value:3.61E-7 ID:SGTC_1374|Compound:2889-5571|FD-Score:3.80|P-value:2.84E-4 ID:SGTC_1425|Compound:4048-4433|FD-Score:4.22|P-value:6.46E-5 ID:SGTC_1495|Compound:4469-0029|FD-Score:3.74|P-value:3.49E-4 ID:SGTC_1608|Compound:st001473|FD-Score:4.33|P-value:4.22E-5 ID:SGTC_1624|Compound:st003710|FD-Score:6.06|P-value:1.86E-8 ID:SGTC_1655|Compound:st012546|FD-Score:-3.47|P-value:7.36E-4 ID:SGTC_1689|Compound:st020265|FD-Score:3.44|P-value:9.21E-4 ID:SGTC_1692|Compound:fluoroquinolonic acid|FD-Score:3.60|P-value:5.54E-4 ID:SGTC_1752|Compound:st044819|FD-Score:4.50|P-value:2.24E-5 ID:SGTC_1788|Compound:fluconazole|FD-Score:3.54|P-value:6.65E-4 ID:SGTC_1827|Compound:berberine|FD-Score:3.47|P-value:8.38E-4 ID:SGTC_1955|Compound:wogonin|FD-Score:-4.37|P-value:3.09E-5 ID:SGTC_1958|Compound:st076513|FD-Score:4.90|P-value:4.40E-6 ID:SGTC_1971|Compound:st069429|FD-Score:-3.40|P-value:9.00E-4 ID:SGTC_1974|Compound:st069448|FD-Score:3.52|P-value:7.14E-4 ID:SGTC_2040|Compound:5100729|FD-Score:3.79|P-value:2.94E-4 ID:SGTC_2238|Compound:6671620|FD-Score:-4.60|P-value:1.24E-5 ID:SGTC_2250|Compound:alverine citrate|FD-Score:-4.03|P-value:1.11E-4 ID:SGTC_2320|Compound:7373003|FD-Score:3.97|P-value:1.59E-4 ID:SGTC_2442|Compound:5158906|FD-Score:5.49|P-value:3.04E-7 ID:SGTC_2446|Compound:5162541|FD-Score:4.65|P-value:1.23E-5 ID:SGTC_2460|Compound:5552655|FD-Score:-4.11|P-value:8.32E-5 ID:SGTC_2461|Compound:5755302|FD-Score:3.69|P-value:4.07E-4 ID:SGTC_2482|Compound:5981709|FD-Score:3.84|P-value:2.45E-4 ID:SGTC_2549|Compound:cedrol|FD-Score:5.67|P-value:1.30E-7 ID:SGTC_2551|Compound:apiole|FD-Score:-4.36|P-value:3.18E-5 ID:SGTC_2552|Compound:juarezic acid|FD-Score:-4.41|P-value:2.63E-5 ID:SGTC_2553|Compound:4-methylesculetin|FD-Score:-6.82|P-value:2.19E-10 ID:SGTC_2554|Compound:13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one|FD-Score:-4.75|P-value:6.61E-6 ID:SGTC_2555|Compound:cholic acid|FD-Score:4.71|P-value:9.47E-6 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:8.50|P-value:5.31E-15 ID:SGTC_2646|Compound:retinol|FD-Score:4.10|P-value:1.00E-4 ID:SGTC_2647|Compound:atorvastatin|FD-Score:3.83|P-value:2.60E-4 ID:SGTC_2648|Compound:atorvastatin|FD-Score:5.47|P-value:3.38E-7 ID:SGTC_2679|Compound:rapamycin|FD-Score:-3.43|P-value:8.10E-4 ID:SGTC_2694|Compound:st077685|FD-Score:4.20|P-value:6.85E-5 ID:SGTC_2782|Compound:7736369|FD-Score:3.54|P-value:6.75E-4 ID:SGTC_2853|Compound:9015042|FD-Score:6.89|P-value:1.86E-10 ID:SGTC_2913|Compound:7966556|FD-Score:-3.91|P-value:1.66E-4 ID:SGTC_2971|Compound:9092186|FD-Score:3.42|P-value:9.65E-4 ID:SGTC_3002|Compound:9075603|FD-Score:4.00|P-value:1.45E-4 ID:SGTC_3126|Compound:9127922|FD-Score:3.73|P-value:3.61E-4 ID:SGTC_3254|Compound:9136651|FD-Score:3.97|P-value:1.56E-4 ID:SGTC_3304|Compound:9125678|FD-Score:4.59|P-value:1.55E-5 ID:SGTC_3317|Compound:9138495|FD-Score:4.13|P-value:9.11E-5

Top fitness defect scores for YPL062W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_391 gliotoxin 12.00 8.3 µM 5.84E-28 5 2.49E-33
2 SGTC_800 3448-7362 9.21 155.0 µM 2.60E-17 translation 9 1.60E-20
3 SGTC_2566 crystal violet carbinol 8.50 226.0 nM 5.31E-15 5 9.53E-18
4 SGTC_177 1327-0068 8.22 8.4 µM 3.81E-14 13 1.02E-16
5 SGTC_625 k213-0058 8.16 121.0 µM 5.74E-14 translation 9 1.67E-16
6 SGTC_1134 3477-0009 7.89 42.5 µM 3.50E-13 4 1.46E-15
7 SGTC_2853 9015042 6.89 58.4 µM 1.86E-10 2 2.75E-12
8 SGTC_673 1082-0474 6.78 110.0 µM 3.48E-10 RSC complex & mRNA processing 18 5.85E-12
9 SGTC_227 fluconazole 6.18 33.5 µM 9.53E-9 azole & statin 39 3.12E-10
10 SGTC_1624 st003710 6.06 6.2 µM 1.86E-8 calcium & mitochondrial duress 11 6.97E-10
11 SGTC_445 e6 berbamine 5.96 66.0 µM 3.06E-8 NEO1-PIK1 32 1.26E-9
12 SGTC_2549 cedrol 5.67 20.9 µM 1.30E-7 2 7.19E-9
13 SGTC_2442 5158906 5.49 48.5 µM 3.04E-7 3 1.99E-8
14 SGTC_2648 atorvastatin 5.47 78.7 µM 3.38E-7 azole & statin 11 2.26E-8
15 SGTC_1317 1273-0028 5.46 910.0 nM 3.61E-7 azole & statin 31 2.44E-8
16 SGTC_841 0251-0215 5.17 91.2 µM 1.35E-6 51 1.18E-7
17 SGTC_451 chloral hydrate 5.13 100.0 µM 1.60E-6 25 1.45E-7
18 SGTC_309 k408-0051 5.09 1.5 µM 1.90E-6 23 1.79E-7
19 SGTC_1958 st076513 4.90 41.9 µM 4.40E-6 60S ribosome export 15 4.91E-7
20 SGTC_2555 cholic acid 4.71 100.0 µM 9.47E-6 8 1.23E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.369 8.56E-109 YPL061W ALD6 hom Cytosolic aldehyde dehydrogenase, activated by Mg2+ and utilizes NADP+ as the preferred coenzyme; required for conversion of acetaldehyde to acetate; constitutively expressed; locates to the mitochondrial outer surface upon oxidative stress
0.241 2.22E-45 YJR049C UTR1 hom ATP-NADH kinase; phosphorylates both NAD and NADH; active as a hexamer; enhances the activity of ferric reductase (Fre1p); UTR1 has a paralog, YEF1, that arose from the whole genome duplication
0.186 1.29E-27 YML081W TDA9 hom DNA-binding protein, putative transcription factor; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; null mutant is sensitive to expression of the top1-T722A allele; not an essential gene; TDA9 has a paralog, RSF2, that arose from the whole genome duplication
0.175 2.30E-24 YML075C HMG1 hom HMG-CoA reductase; catalyzes the conversion of HMG-CoA to mevalonate, which is a rate-limiting step in sterol biosynthesis; one of two isozymes; localizes to the nuclear envelope; overproduction induces the formation of karmellae; forms foci at the nuclear periphery upon DNA replication stress
0.168 1.39E-22 YGR122W YGR122W hom Protein that may be involved in pH regulation; probable ortholog of A. nidulans PalC, which is involved in pH regulation and binds to the ESCRT-III complex; null mutant does not properly process Rim101p and has decreased resistance to rapamycin; GFP-fusion protein is cytoplasmic; relative distribution to cytoplasm increases upon DNA replication stress
0.160 1.49E-20 YMR154C RIM13 hom Calpain-like cysteine protease; involved in proteolytic activation of Rim101p in response to alkaline pH; localizes to punctate structures in alkaline conditions and in vps4 mutant; has similarity to A. nidulans palB
0.156 9.21E-20 YDR080W VPS41 hom Vacuolar membrane protein that is a subunit of the homotypic vacuole fusion and vacuole protein sorting (HOPS) complex; essential for membrane docking and fusion at the Golgi-to-endosome and endosome-to-vacuole stages of protein transport
0.147 1.06E-17 YLR153C ACS2 het Acetyl-coA synthetase isoform which, along with Acs1p, is the nuclear source of acetyl-coA for histone acetylation; mutants affect global transcription; required for growth on glucose; expressed under anaerobic conditions
0.143 7.77E-17 YPL195W APL5 hom Delta adaptin-like subunit of the clathrin associated protein complex (AP-3); functions in transport of alkaline phosphatase to the vacuole via the alternate pathway, suppressor of loss of casein kinase 1 function
0.138 1.25E-15 YDL119C_p YDL119C_p hom Putative mitochondrial transport protein; GFP-fusion protein is induced in response to the DNA-damaging agent MMS; the authentic, non-tagged protein is detected in purified mitochondria
0.135 4.61E-15 YGL169W SUA5 het Single-stranded telomeric DNA-binding protein, required for normal telomere length; null mutant lacks N6-threonylcarbamoyl adenosine (t6A) modification in the anticodon loop of ANN-decoding tRNA; member of conserved YrdC/Sua5 family
0.133 1.32E-14 YDL118W_d YDL118W_d hom Dubious open reading frame, unlikely to encode a protein; overlaps almost completely with YDL119C; mutations that would affect both YDL118W and YDL119C confer defective telomere maintenance and are synthetically sick or lethal with alpha-synuclein
0.127 1.50E-13 YDL192W ARF1 hom ADP-ribosylation factor; GTPase of the Ras superfamily involved in regulation of coated vesicle formation in intracellular trafficking within the Golgi; ARF1 has a paralog, ARF2, that arose from the whole genome duplication
0.127 1.73E-13 YJL024C APS3 hom Small subunit of the clathrin-associated adaptor complex AP-3; involved in vacuolar protein sorting; related to the sigma subunit of the mammalian clathrin AP-3 complex; suppressor of loss of casein kinase 1 function; protein abundance increases in response to DNA replication stress
0.126 2.59E-13 YJL188C_d BUD19_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 88% of ORF overlaps the verified gene RPL39; diploid mutant displays a weak budding pattern phenotype in a systematic assay