YPL063W / TIM50

Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); acts as receptor for the TIM23 complex guiding incoming precursors from the TOM complex; may control the gating of the Tim23p-Tim17p channel

Zygosity: Heterozygous strain
fixedexpanded
Profile for YPL063W / TIM50

Click on Significant Values for Screen Details ID:SGTC_55|Compound:0767-0285|FD-Score:-3.69|P-value:6.43E-5 ID:SGTC_60|Compound:0986-0278|FD-Score:-3.35|P-value:2.63E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:5.38|P-value:2.21E-9 ID:SGTC_138|Compound:0850-0259|FD-Score:5.13|P-value:1.12E-8 ID:SGTC_263|Compound:alizarin|FD-Score:3.18|P-value:2.17E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:4.54|P-value:3.33E-7 ID:SGTC_459|Compound:nigericin|FD-Score:2.82|P-value:8.88E-4 ID:SGTC_611|Compound:3453-1652|FD-Score:3.52|P-value:5.28E-5 ID:SGTC_628|Compound:1636-0253|FD-Score:3.04|P-value:3.78E-4 ID:SGTC_673|Compound:1082-0474|FD-Score:4.82|P-value:6.81E-8 ID:SGTC_733|Compound:4069-0007|FD-Score:3.07|P-value:3.48E-4 ID:SGTC_825|Compound:1988-2224|FD-Score:3.49|P-value:6.04E-5 ID:SGTC_839|Compound:0122-0028|FD-Score:2.84|P-value:8.21E-4 ID:SGTC_909|Compound:3448-9333|FD-Score:-3.14|P-value:6.02E-4 ID:SGTC_973|Compound:1325-0077|FD-Score:3.61|P-value:3.57E-5 ID:SGTC_980|Compound:1473-0395|FD-Score:-3.63|P-value:8.52E-5 ID:SGTC_997|Compound:3996-0078|FD-Score:2.90|P-value:6.52E-4 ID:SGTC_1005|Compound:4092-0690|FD-Score:-3.61|P-value:9.18E-5 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.96|P-value:1.90E-5 ID:SGTC_1109|Compound:tnp00067|FD-Score:2.79|P-value:9.89E-4 ID:SGTC_1217|Compound:1183-1422|FD-Score:4.82|P-value:7.07E-8 ID:SGTC_1230|Compound:0170-0365|FD-Score:3.85|P-value:1.20E-5 ID:SGTC_1237|Compound:0330-0133|FD-Score:3.13|P-value:2.73E-4 ID:SGTC_1422|Compound:4031-0024|FD-Score:3.19|P-value:2.14E-4 ID:SGTC_1483|Compound:3453-0561|FD-Score:2.85|P-value:7.87E-4 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:2.83|P-value:8.37E-4 ID:SGTC_1595|Compound:6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin|FD-Score:3.21|P-value:1.96E-4 ID:SGTC_1604|Compound:st002052|FD-Score:-3.73|P-value:5.40E-5 ID:SGTC_1637|Compound:st007924|FD-Score:3.12|P-value:2.76E-4 ID:SGTC_1685|Compound:st024049|FD-Score:3.72|P-value:2.12E-5 ID:SGTC_1718|Compound:roemerine|FD-Score:-4.55|P-value:1.02E-6 ID:SGTC_1842|Compound:st055362|FD-Score:3.06|P-value:3.56E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.33|P-value:2.89E-4 ID:SGTC_2002|Compound:4023503|FD-Score:2.88|P-value:7.00E-4 ID:SGTC_2136|Compound:5328288|FD-Score:3.74|P-value:1.99E-5 ID:SGTC_2158|Compound:5657123|FD-Score:2.79|P-value:9.93E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:-3.51|P-value:1.41E-4 ID:SGTC_2323|Compound:6148992|FD-Score:-3.16|P-value:5.61E-4 ID:SGTC_2341|Compound:7987486|FD-Score:4.13|P-value:3.02E-6 ID:SGTC_2344|Compound:7990960|FD-Score:4.18|P-value:2.36E-6 ID:SGTC_2451|Compound:5856223|FD-Score:3.18|P-value:2.19E-4 ID:SGTC_2536|Compound:dehydroabietamide|FD-Score:3.28|P-value:1.49E-4 ID:SGTC_2577|Compound:2',4'-dihydroxy-4-methoxychalcone|FD-Score:-3.96|P-value:1.97E-5 ID:SGTC_2709|Compound:st078560|FD-Score:3.26|P-value:1.58E-4 ID:SGTC_3179|Compound:9107801|FD-Score:-3.03|P-value:9.03E-4 ID:SGTC_55|Compound:0767-0285|FD-Score:-3.69|P-value:6.43E-5 ID:SGTC_60|Compound:0986-0278|FD-Score:-3.35|P-value:2.63E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:5.38|P-value:2.21E-9 ID:SGTC_138|Compound:0850-0259|FD-Score:5.13|P-value:1.12E-8 ID:SGTC_263|Compound:alizarin|FD-Score:3.18|P-value:2.17E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:4.54|P-value:3.33E-7 ID:SGTC_459|Compound:nigericin|FD-Score:2.82|P-value:8.88E-4 ID:SGTC_611|Compound:3453-1652|FD-Score:3.52|P-value:5.28E-5 ID:SGTC_628|Compound:1636-0253|FD-Score:3.04|P-value:3.78E-4 ID:SGTC_673|Compound:1082-0474|FD-Score:4.82|P-value:6.81E-8 ID:SGTC_733|Compound:4069-0007|FD-Score:3.07|P-value:3.48E-4 ID:SGTC_825|Compound:1988-2224|FD-Score:3.49|P-value:6.04E-5 ID:SGTC_839|Compound:0122-0028|FD-Score:2.84|P-value:8.21E-4 ID:SGTC_909|Compound:3448-9333|FD-Score:-3.14|P-value:6.02E-4 ID:SGTC_973|Compound:1325-0077|FD-Score:3.61|P-value:3.57E-5 ID:SGTC_980|Compound:1473-0395|FD-Score:-3.63|P-value:8.52E-5 ID:SGTC_997|Compound:3996-0078|FD-Score:2.90|P-value:6.52E-4 ID:SGTC_1005|Compound:4092-0690|FD-Score:-3.61|P-value:9.18E-5 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.96|P-value:1.90E-5 ID:SGTC_1109|Compound:tnp00067|FD-Score:2.79|P-value:9.89E-4 ID:SGTC_1217|Compound:1183-1422|FD-Score:4.82|P-value:7.07E-8 ID:SGTC_1230|Compound:0170-0365|FD-Score:3.85|P-value:1.20E-5 ID:SGTC_1237|Compound:0330-0133|FD-Score:3.13|P-value:2.73E-4 ID:SGTC_1422|Compound:4031-0024|FD-Score:3.19|P-value:2.14E-4 ID:SGTC_1483|Compound:3453-0561|FD-Score:2.85|P-value:7.87E-4 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:2.83|P-value:8.37E-4 ID:SGTC_1595|Compound:6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin|FD-Score:3.21|P-value:1.96E-4 ID:SGTC_1604|Compound:st002052|FD-Score:-3.73|P-value:5.40E-5 ID:SGTC_1637|Compound:st007924|FD-Score:3.12|P-value:2.76E-4 ID:SGTC_1685|Compound:st024049|FD-Score:3.72|P-value:2.12E-5 ID:SGTC_1718|Compound:roemerine|FD-Score:-4.55|P-value:1.02E-6 ID:SGTC_1842|Compound:st055362|FD-Score:3.06|P-value:3.56E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.33|P-value:2.89E-4 ID:SGTC_2002|Compound:4023503|FD-Score:2.88|P-value:7.00E-4 ID:SGTC_2136|Compound:5328288|FD-Score:3.74|P-value:1.99E-5 ID:SGTC_2158|Compound:5657123|FD-Score:2.79|P-value:9.93E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:-3.51|P-value:1.41E-4 ID:SGTC_2323|Compound:6148992|FD-Score:-3.16|P-value:5.61E-4 ID:SGTC_2341|Compound:7987486|FD-Score:4.13|P-value:3.02E-6 ID:SGTC_2344|Compound:7990960|FD-Score:4.18|P-value:2.36E-6 ID:SGTC_2451|Compound:5856223|FD-Score:3.18|P-value:2.19E-4 ID:SGTC_2536|Compound:dehydroabietamide|FD-Score:3.28|P-value:1.49E-4 ID:SGTC_2577|Compound:2',4'-dihydroxy-4-methoxychalcone|FD-Score:-3.96|P-value:1.97E-5 ID:SGTC_2709|Compound:st078560|FD-Score:3.26|P-value:1.58E-4 ID:SGTC_3179|Compound:9107801|FD-Score:-3.03|P-value:9.03E-4

Top fitness defect scores for YPL063W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_103 0844-0104 5.38 51.8 µM 2.21E-9 ERAD & cell cycle 31 3.64E-8 0.00
2 SGTC_138 0850-0259 5.13 40.9 µM 1.12E-8 cell wall 39 1.48E-7 0.03
3 SGTC_673 1082-0474 4.82 110.0 µM 6.81E-8 RSC complex & mRNA processing 38 7.01E-7 0.03
4 SGTC_1217 1183-1422 4.82 255.0 µM 7.07E-8 1 7.24E-7 0.63
5 SGTC_431 k089-0097 4.54 107.0 µM 3.33E-7 iron homeostasis 9 2.75E-6 0.04
6 SGTC_2344 7990960 4.18 77.0 µM 2.36E-6 35 1.49E-5 0.06
7 SGTC_2341 7987486 4.13 176.7 µM 3.02E-6 5 1.83E-5 0.07
8 SGTC_1230 0170-0365 3.85 3.8 µM 1.20E-5 endomembrane recycling 25 6.01E-5 0.22
9 SGTC_2136 5328288 3.74 199.3 µM 1.99E-5 11 9.28E-5 0.20
10 SGTC_1685 st024049 3.72 53.1 µM 2.12E-5 TSC3-RPN4 2 9.80E-5 0.32
11 SGTC_973 1325-0077 3.61 65.9 µM 3.57E-5 2 1.54E-4 0.40
12 SGTC_611 3453-1652 3.52 23.7 µM 5.28E-5 29 2.15E-4 0.00
13 SGTC_825 1988-2224 3.49 89.6 µM 6.04E-5 cell wall signaling 11 2.41E-4 0.10
14 SGTC_2536 dehydroabietamide 3.28 32.0 µM 1.49E-4 9 5.25E-4 0.10
15 SGTC_2709 st078560 3.26 56.0 µM 1.58E-4 14 5.50E-4 0.02
16 SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 3.21 67.5 µM 1.96E-4 17 6.62E-4 0.04
17 SGTC_1422 4031-0024 3.19 15.5 µM 2.14E-4 iron homeostasis 18 7.15E-4 0.01
18 SGTC_263 alizarin 3.18 107.9 µM 2.17E-4 iron homeostasis 27 7.25E-4 0.04
19 SGTC_2451 5856223 3.18 45.7 µM 2.19E-4 17 7.28E-4 0.03
20 SGTC_1237 0330-0133 3.13 46.1 µM 2.73E-4 ergosterol biosynthesis 19 8.81E-4 0.04

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.172 9.73E-24 YPR033C HTS1 het Cytoplasmic and mitochondrial histidine tRNA synthetase; efficient mitochondrial localization requires both a presequence and an amino-terminal sequence; mutations in human ortholog HARS2 are associated with Perrault syndrome
0.155 1.91E-19 YNL271C BNI1 hom Formin, nucleates the formation of linear actin filaments, involved in cell processes such as budding and mitotic spindle orientation which require the formation of polarized actin cables, functionally redundant with BNR1
0.151 1.75E-18 YDR501W PLM2 hom Putative transcription factor, contains Forkhead Associated domain; found associated with chromatin; target of SBF transcription factor; induced in response to DNA damaging agents and deletion of telomerase; PLM2 has a paralog, TOS4, that arose from the whole genome duplication
0.149 5.34E-18 YJL039C NUP192 het Essential subunit of the inner ring of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport; homologous to human NUP205
0.145 3.66E-17 YDR016C DAD1 het Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis
0.142 1.30E-16 YDR540C IRC4 hom Putative protein of unknown function; null mutant displays increased levels of spontaneous Rad52p foci; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus
0.140 4.20E-16 YDL148C NOP14 het Nucleolar protein, forms a complex with Noc4p that mediates maturation and nuclear export of 40S ribosomal subunits; also present in the small subunit processome complex, which is required for processing of pre-18S rRNA
0.139 7.40E-16 YML101C CUE4 hom Protein of unknown function; has a CUE domain that binds ubiquitin, which may facilitate intramolecular monoubiquitination; CUE4 has a paralog, CUE1, that arose from the whole genome duplication
0.128 1.23E-13 YAL051W OAF1 hom Oleate-activated transcription factor; acts alone and as a heterodimer with Pip2p; activates genes involved in beta-oxidation of fatty acids and peroxisome organization and biogenesis; OAF1 has a paralog, PIP2, that arose from the whole genome duplication
0.127 1.41E-13 YBL036C YBL036C hom Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS
0.127 1.45E-13 YER041W YEN1 hom Holliday junction resolvase; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation; homolog of human GEN1 and has similarity to S. cerevisiae endonuclease Rth1p
0.125 3.03E-13 YLR344W RPL26A hom Ribosomal 60S subunit protein L26A; binds to 5.8S rRNA; homologous to mammalian ribosomal protein L26 and bacterial L24; RPL26A has a paralog, RPL26B, that arose from the whole genome duplication
0.122 1.56E-12 YBR143C SUP45 het Polypeptide release factor (eRF1) in translation termination; mutant form acts as a recessive omnipotent suppressor; methylated by Mtq2p-Trm112p in ternary complex eRF1-eRF3-GTP; mutation of methylation site confers resistance to zymocin; has a role in cytokinesis through interaction with Mlc1p
0.120 2.78E-12 YLR232W_d YLR232W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene BNA5
0.120 3.20E-12 YDL007W RPT2 het One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; required for normal peptide hydrolysis by the core 20S particle