YPL065W / VPS28

Component of the ESCRT-I complex (Stp22p, Srn2p, Vps28p, and Mvb12p), which is involved in ubiquitin-dependent sorting of proteins into the endosome; conserved C-terminal domain interacts with ESCRT-III subunit Vps20p

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL065W / VPS28

Click on Significant Values for Screen Details ID:SGTC_40|Compound:0327-0103|FD-Score:-4.56|P-value:2.20E-5 ID:SGTC_45|Compound:0kpi-0036|FD-Score:3.64|P-value:5.27E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-7.61|P-value:4.53E-12 ID:SGTC_59|Compound:0330-0160|FD-Score:-3.50|P-value:8.61E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:3.84|P-value:2.77E-4 ID:SGTC_86|Compound:0417-1630|FD-Score:4.03|P-value:1.47E-4 ID:SGTC_102|Compound:gallobenzophenone|FD-Score:8.85|P-value:9.32E-16 ID:SGTC_117|Compound:lucigenin|FD-Score:10.50|P-value:1.54E-21 ID:SGTC_130|Compound:0136-0219|FD-Score:-3.52|P-value:8.23E-4 ID:SGTC_137|Compound:0438-0332|FD-Score:4.04|P-value:1.40E-4 ID:SGTC_146|Compound:3448-8650|FD-Score:5.18|P-value:1.58E-6 ID:SGTC_156|Compound:3474-0145|FD-Score:4.74|P-value:1.02E-5 ID:SGTC_163|Compound:1327-0036|FD-Score:-4.82|P-value:7.89E-6 ID:SGTC_188|Compound:3229-0966|FD-Score:-3.80|P-value:3.29E-4 ID:SGTC_206|Compound:4546-0025|FD-Score:6.76|P-value:6.31E-10 ID:SGTC_221|Compound:trifluoperazine|FD-Score:10.00|P-value:1.15E-19 ID:SGTC_227|Compound:fluconazole|FD-Score:8.48|P-value:1.32E-14 ID:SGTC_232|Compound:clozapine|FD-Score:6.19|P-value:1.34E-8 ID:SGTC_235|Compound:0330-0087|FD-Score:4.55|P-value:2.14E-5 ID:SGTC_301|Compound:4119-0100|FD-Score:7.22|P-value:4.26E-11 ID:SGTC_304|Compound:1310-0298|FD-Score:-5.63|P-value:2.29E-7 ID:SGTC_309|Compound:k408-0051|FD-Score:-4.28|P-value:6.28E-5 ID:SGTC_439|Compound:amiodarone|FD-Score:5.18|P-value:1.64E-6 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.88|P-value:2.56E-4 ID:SGTC_524|Compound:r073-0010|FD-Score:5.07|P-value:2.54E-6 ID:SGTC_525|Compound:k781-2675|FD-Score:8.29|P-value:4.85E-14 ID:SGTC_528|Compound:3492-0019|FD-Score:9.18|P-value:8.38E-17 ID:SGTC_568|Compound:1193-0097|FD-Score:4.49|P-value:2.67E-5 ID:SGTC_576|Compound:1073-0113|FD-Score:6.92|P-value:2.59E-10 ID:SGTC_601|Compound:0986-0029|FD-Score:-3.47|P-value:9.32E-4 ID:SGTC_637|Compound:1181-0519|FD-Score:3.90|P-value:2.29E-4 ID:SGTC_654|Compound:1124-0271|FD-Score:4.33|P-value:5.00E-5 ID:SGTC_670|Compound:4204-0025|FD-Score:3.61|P-value:5.86E-4 ID:SGTC_748|Compound:0136-0228|FD-Score:4.38|P-value:4.16E-5 ID:SGTC_768|Compound:0384-0033|FD-Score:4.18|P-value:8.59E-5 ID:SGTC_769|Compound:0302-0231|FD-Score:-3.76|P-value:3.74E-4 ID:SGTC_788|Compound:1182-0090|FD-Score:4.54|P-value:2.24E-5 ID:SGTC_813|Compound:k007-0158|FD-Score:4.65|P-value:1.44E-5 ID:SGTC_862|Compound:0452-0056|FD-Score:3.73|P-value:4.02E-4 ID:SGTC_978|Compound:1416-0512|FD-Score:3.65|P-value:5.12E-4 ID:SGTC_1000|Compound:4048-0884|FD-Score:6.93|P-value:2.40E-10 ID:SGTC_1001|Compound:4048-4355|FD-Score:4.27|P-value:6.12E-5 ID:SGTC_1044|Compound:1222-0021|FD-Score:5.08|P-value:2.45E-6 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:5.19|P-value:1.55E-6 ID:SGTC_1130|Compound:3454-2858|FD-Score:6.66|P-value:1.09E-9 ID:SGTC_1165|Compound:k072-0275|FD-Score:6.36|P-value:5.37E-9 ID:SGTC_1174|Compound:0739-0097|FD-Score:4.96|P-value:4.05E-6 ID:SGTC_1239|Compound:0337-0584|FD-Score:5.06|P-value:2.66E-6 ID:SGTC_1266|Compound:0828-0227|FD-Score:-3.77|P-value:3.65E-4 ID:SGTC_1317|Compound:1273-0028|FD-Score:3.79|P-value:3.24E-4 ID:SGTC_1593|Compound:justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one|FD-Score:16.40|P-value:1.37E-49 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:-5.42|P-value:5.87E-7 ID:SGTC_1664|Compound:st014217|FD-Score:3.67|P-value:4.81E-4 ID:SGTC_1672|Compound:st016598|FD-Score:5.66|P-value:1.80E-7 ID:SGTC_1687|Compound:st020778|FD-Score:13.00|P-value:7.89E-32 ID:SGTC_1729|Compound:st035615|FD-Score:4.29|P-value:5.65E-5 ID:SGTC_1745|Compound:st081495|FD-Score:-3.79|P-value:3.48E-4 ID:SGTC_1750|Compound:st081859|FD-Score:7.64|P-value:3.43E-12 ID:SGTC_1754|Compound:st042065|FD-Score:5.17|P-value:1.69E-6 ID:SGTC_1760|Compound:st045453|FD-Score:8.08|P-value:2.00E-13 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:3.45|P-value:9.67E-4 ID:SGTC_1788|Compound:fluconazole|FD-Score:4.79|P-value:8.36E-6 ID:SGTC_1789|Compound:tunicamycin|FD-Score:4.01|P-value:1.58E-4 ID:SGTC_1800|Compound:st050079|FD-Score:5.39|P-value:6.46E-7 ID:SGTC_1801|Compound:st050089|FD-Score:5.58|P-value:2.63E-7 ID:SGTC_1803|Compound:st050068|FD-Score:8.68|P-value:3.23E-15 ID:SGTC_1804|Compound:st050076|FD-Score:4.04|P-value:1.41E-4 ID:SGTC_1818|Compound:st052136|FD-Score:3.74|P-value:3.91E-4 ID:SGTC_1827|Compound:berberine|FD-Score:6.04|P-value:2.85E-8 ID:SGTC_1829|Compound:berberine|FD-Score:4.05|P-value:1.33E-4 ID:SGTC_1830|Compound:st055982|FD-Score:3.99|P-value:1.65E-4 ID:SGTC_1831|Compound:st055328|FD-Score:8.37|P-value:2.81E-14 ID:SGTC_1844|Compound:rapamycin|FD-Score:8.72|P-value:2.41E-15 ID:SGTC_1884|Compound:5633444|FD-Score:6.91|P-value:2.70E-10 ID:SGTC_1949|Compound:st076024|FD-Score:-4.07|P-value:1.31E-4 ID:SGTC_1951|Compound:sophoraflavanone G|FD-Score:-3.66|P-value:5.31E-4 ID:SGTC_1952|Compound:st077036|FD-Score:4.92|P-value:4.89E-6 ID:SGTC_2016|Compound:5121758|FD-Score:3.62|P-value:5.61E-4 ID:SGTC_2027|Compound:5150920|FD-Score:5.35|P-value:7.74E-7 ID:SGTC_2054|Compound:5233173|FD-Score:3.84|P-value:2.77E-4 ID:SGTC_2130|Compound:NSC 7|FD-Score:4.36|P-value:4.43E-5 ID:SGTC_2134|Compound:5324836|FD-Score:-4.29|P-value:6.00E-5 ID:SGTC_2136|Compound:5328288|FD-Score:-3.52|P-value:8.15E-4 ID:SGTC_2183|Compound:6420625|FD-Score:4.16|P-value:9.06E-5 ID:SGTC_2196|Compound:6573537|FD-Score:3.63|P-value:5.49E-4 ID:SGTC_2200|Compound:6600604|FD-Score:4.16|P-value:9.01E-5 ID:SGTC_2250|Compound:alverine citrate|FD-Score:-3.88|P-value:2.52E-4 ID:SGTC_2289|Compound:7946404|FD-Score:5.19|P-value:1.57E-6 ID:SGTC_2322|Compound:7413319|FD-Score:4.80|P-value:8.03E-6 ID:SGTC_2389|Compound:9091542|FD-Score:4.43|P-value:3.42E-5 ID:SGTC_2485|Compound:5633444|FD-Score:5.94|P-value:4.75E-8 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:6.00|P-value:3.56E-8 ID:SGTC_2582|Compound:agaric acid|FD-Score:3.46|P-value:9.30E-4 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:6.07|P-value:2.51E-8 ID:SGTC_2619|Compound:obliquin|FD-Score:6.80|P-value:5.03E-10 ID:SGTC_2647|Compound:atorvastatin|FD-Score:3.99|P-value:1.69E-4 ID:SGTC_2648|Compound:atorvastatin|FD-Score:4.40|P-value:3.76E-5 ID:SGTC_2671|Compound:danthron|FD-Score:4.92|P-value:4.80E-6 ID:SGTC_2737|Compound:bleomycin|FD-Score:3.78|P-value:3.37E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:4.56|P-value:2.10E-5 ID:SGTC_2753|Compound:fluvastatin|FD-Score:4.60|P-value:1.75E-5 ID:SGTC_2776|Compound:terbinafine|FD-Score:3.55|P-value:7.02E-4 ID:SGTC_2851|Compound:9015922|FD-Score:4.28|P-value:5.94E-5 ID:SGTC_2910|Compound:7948405|FD-Score:4.18|P-value:8.55E-5 ID:SGTC_2912|Compound:7964298|FD-Score:6.50|P-value:2.58E-9 ID:SGTC_2925|Compound:9010536|FD-Score:4.11|P-value:1.10E-4 ID:SGTC_2928|Compound:9011484|FD-Score:4.71|P-value:1.15E-5 ID:SGTC_2965|Compound:9082772|FD-Score:5.73|P-value:1.29E-7 ID:SGTC_3033|Compound:9090887|FD-Score:4.49|P-value:2.71E-5 ID:SGTC_3037|Compound:9091026|FD-Score:5.22|P-value:1.37E-6 ID:SGTC_3128|Compound:9127691|FD-Score:5.05|P-value:2.82E-6 ID:SGTC_3152|Compound:9099253|FD-Score:4.47|P-value:2.98E-5 ID:SGTC_3266|Compound:9136860|FD-Score:-3.86|P-value:2.70E-4 ID:SGTC_3318|Compound:9139014|FD-Score:-3.65|P-value:5.42E-4 ID:SGTC_40|Compound:0327-0103|FD-Score:-4.56|P-value:2.20E-5 ID:SGTC_45|Compound:0kpi-0036|FD-Score:3.64|P-value:5.27E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-7.61|P-value:4.53E-12 ID:SGTC_59|Compound:0330-0160|FD-Score:-3.50|P-value:8.61E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:3.84|P-value:2.77E-4 ID:SGTC_86|Compound:0417-1630|FD-Score:4.03|P-value:1.47E-4 ID:SGTC_102|Compound:gallobenzophenone|FD-Score:8.85|P-value:9.32E-16 ID:SGTC_117|Compound:lucigenin|FD-Score:10.50|P-value:1.54E-21 ID:SGTC_130|Compound:0136-0219|FD-Score:-3.52|P-value:8.23E-4 ID:SGTC_137|Compound:0438-0332|FD-Score:4.04|P-value:1.40E-4 ID:SGTC_146|Compound:3448-8650|FD-Score:5.18|P-value:1.58E-6 ID:SGTC_156|Compound:3474-0145|FD-Score:4.74|P-value:1.02E-5 ID:SGTC_163|Compound:1327-0036|FD-Score:-4.82|P-value:7.89E-6 ID:SGTC_188|Compound:3229-0966|FD-Score:-3.80|P-value:3.29E-4 ID:SGTC_206|Compound:4546-0025|FD-Score:6.76|P-value:6.31E-10 ID:SGTC_221|Compound:trifluoperazine|FD-Score:10.00|P-value:1.15E-19 ID:SGTC_227|Compound:fluconazole|FD-Score:8.48|P-value:1.32E-14 ID:SGTC_232|Compound:clozapine|FD-Score:6.19|P-value:1.34E-8 ID:SGTC_235|Compound:0330-0087|FD-Score:4.55|P-value:2.14E-5 ID:SGTC_301|Compound:4119-0100|FD-Score:7.22|P-value:4.26E-11 ID:SGTC_304|Compound:1310-0298|FD-Score:-5.63|P-value:2.29E-7 ID:SGTC_309|Compound:k408-0051|FD-Score:-4.28|P-value:6.28E-5 ID:SGTC_439|Compound:amiodarone|FD-Score:5.18|P-value:1.64E-6 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.88|P-value:2.56E-4 ID:SGTC_524|Compound:r073-0010|FD-Score:5.07|P-value:2.54E-6 ID:SGTC_525|Compound:k781-2675|FD-Score:8.29|P-value:4.85E-14 ID:SGTC_528|Compound:3492-0019|FD-Score:9.18|P-value:8.38E-17 ID:SGTC_568|Compound:1193-0097|FD-Score:4.49|P-value:2.67E-5 ID:SGTC_576|Compound:1073-0113|FD-Score:6.92|P-value:2.59E-10 ID:SGTC_601|Compound:0986-0029|FD-Score:-3.47|P-value:9.32E-4 ID:SGTC_637|Compound:1181-0519|FD-Score:3.90|P-value:2.29E-4 ID:SGTC_654|Compound:1124-0271|FD-Score:4.33|P-value:5.00E-5 ID:SGTC_670|Compound:4204-0025|FD-Score:3.61|P-value:5.86E-4 ID:SGTC_748|Compound:0136-0228|FD-Score:4.38|P-value:4.16E-5 ID:SGTC_768|Compound:0384-0033|FD-Score:4.18|P-value:8.59E-5 ID:SGTC_769|Compound:0302-0231|FD-Score:-3.76|P-value:3.74E-4 ID:SGTC_788|Compound:1182-0090|FD-Score:4.54|P-value:2.24E-5 ID:SGTC_813|Compound:k007-0158|FD-Score:4.65|P-value:1.44E-5 ID:SGTC_862|Compound:0452-0056|FD-Score:3.73|P-value:4.02E-4 ID:SGTC_978|Compound:1416-0512|FD-Score:3.65|P-value:5.12E-4 ID:SGTC_1000|Compound:4048-0884|FD-Score:6.93|P-value:2.40E-10 ID:SGTC_1001|Compound:4048-4355|FD-Score:4.27|P-value:6.12E-5 ID:SGTC_1044|Compound:1222-0021|FD-Score:5.08|P-value:2.45E-6 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:5.19|P-value:1.55E-6 ID:SGTC_1130|Compound:3454-2858|FD-Score:6.66|P-value:1.09E-9 ID:SGTC_1165|Compound:k072-0275|FD-Score:6.36|P-value:5.37E-9 ID:SGTC_1174|Compound:0739-0097|FD-Score:4.96|P-value:4.05E-6 ID:SGTC_1239|Compound:0337-0584|FD-Score:5.06|P-value:2.66E-6 ID:SGTC_1266|Compound:0828-0227|FD-Score:-3.77|P-value:3.65E-4 ID:SGTC_1317|Compound:1273-0028|FD-Score:3.79|P-value:3.24E-4 ID:SGTC_1593|Compound:justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one|FD-Score:16.40|P-value:1.37E-49 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:-5.42|P-value:5.87E-7 ID:SGTC_1664|Compound:st014217|FD-Score:3.67|P-value:4.81E-4 ID:SGTC_1672|Compound:st016598|FD-Score:5.66|P-value:1.80E-7 ID:SGTC_1687|Compound:st020778|FD-Score:13.00|P-value:7.89E-32 ID:SGTC_1729|Compound:st035615|FD-Score:4.29|P-value:5.65E-5 ID:SGTC_1745|Compound:st081495|FD-Score:-3.79|P-value:3.48E-4 ID:SGTC_1750|Compound:st081859|FD-Score:7.64|P-value:3.43E-12 ID:SGTC_1754|Compound:st042065|FD-Score:5.17|P-value:1.69E-6 ID:SGTC_1760|Compound:st045453|FD-Score:8.08|P-value:2.00E-13 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:3.45|P-value:9.67E-4 ID:SGTC_1788|Compound:fluconazole|FD-Score:4.79|P-value:8.36E-6 ID:SGTC_1789|Compound:tunicamycin|FD-Score:4.01|P-value:1.58E-4 ID:SGTC_1800|Compound:st050079|FD-Score:5.39|P-value:6.46E-7 ID:SGTC_1801|Compound:st050089|FD-Score:5.58|P-value:2.63E-7 ID:SGTC_1803|Compound:st050068|FD-Score:8.68|P-value:3.23E-15 ID:SGTC_1804|Compound:st050076|FD-Score:4.04|P-value:1.41E-4 ID:SGTC_1818|Compound:st052136|FD-Score:3.74|P-value:3.91E-4 ID:SGTC_1827|Compound:berberine|FD-Score:6.04|P-value:2.85E-8 ID:SGTC_1829|Compound:berberine|FD-Score:4.05|P-value:1.33E-4 ID:SGTC_1830|Compound:st055982|FD-Score:3.99|P-value:1.65E-4 ID:SGTC_1831|Compound:st055328|FD-Score:8.37|P-value:2.81E-14 ID:SGTC_1844|Compound:rapamycin|FD-Score:8.72|P-value:2.41E-15 ID:SGTC_1884|Compound:5633444|FD-Score:6.91|P-value:2.70E-10 ID:SGTC_1949|Compound:st076024|FD-Score:-4.07|P-value:1.31E-4 ID:SGTC_1951|Compound:sophoraflavanone G|FD-Score:-3.66|P-value:5.31E-4 ID:SGTC_1952|Compound:st077036|FD-Score:4.92|P-value:4.89E-6 ID:SGTC_2016|Compound:5121758|FD-Score:3.62|P-value:5.61E-4 ID:SGTC_2027|Compound:5150920|FD-Score:5.35|P-value:7.74E-7 ID:SGTC_2054|Compound:5233173|FD-Score:3.84|P-value:2.77E-4 ID:SGTC_2130|Compound:NSC 7|FD-Score:4.36|P-value:4.43E-5 ID:SGTC_2134|Compound:5324836|FD-Score:-4.29|P-value:6.00E-5 ID:SGTC_2136|Compound:5328288|FD-Score:-3.52|P-value:8.15E-4 ID:SGTC_2183|Compound:6420625|FD-Score:4.16|P-value:9.06E-5 ID:SGTC_2196|Compound:6573537|FD-Score:3.63|P-value:5.49E-4 ID:SGTC_2200|Compound:6600604|FD-Score:4.16|P-value:9.01E-5 ID:SGTC_2250|Compound:alverine citrate|FD-Score:-3.88|P-value:2.52E-4 ID:SGTC_2289|Compound:7946404|FD-Score:5.19|P-value:1.57E-6 ID:SGTC_2322|Compound:7413319|FD-Score:4.80|P-value:8.03E-6 ID:SGTC_2389|Compound:9091542|FD-Score:4.43|P-value:3.42E-5 ID:SGTC_2485|Compound:5633444|FD-Score:5.94|P-value:4.75E-8 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:6.00|P-value:3.56E-8 ID:SGTC_2582|Compound:agaric acid|FD-Score:3.46|P-value:9.30E-4 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:6.07|P-value:2.51E-8 ID:SGTC_2619|Compound:obliquin|FD-Score:6.80|P-value:5.03E-10 ID:SGTC_2647|Compound:atorvastatin|FD-Score:3.99|P-value:1.69E-4 ID:SGTC_2648|Compound:atorvastatin|FD-Score:4.40|P-value:3.76E-5 ID:SGTC_2671|Compound:danthron|FD-Score:4.92|P-value:4.80E-6 ID:SGTC_2737|Compound:bleomycin|FD-Score:3.78|P-value:3.37E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:4.56|P-value:2.10E-5 ID:SGTC_2753|Compound:fluvastatin|FD-Score:4.60|P-value:1.75E-5 ID:SGTC_2776|Compound:terbinafine|FD-Score:3.55|P-value:7.02E-4 ID:SGTC_2851|Compound:9015922|FD-Score:4.28|P-value:5.94E-5 ID:SGTC_2910|Compound:7948405|FD-Score:4.18|P-value:8.55E-5 ID:SGTC_2912|Compound:7964298|FD-Score:6.50|P-value:2.58E-9 ID:SGTC_2925|Compound:9010536|FD-Score:4.11|P-value:1.10E-4 ID:SGTC_2928|Compound:9011484|FD-Score:4.71|P-value:1.15E-5 ID:SGTC_2965|Compound:9082772|FD-Score:5.73|P-value:1.29E-7 ID:SGTC_3033|Compound:9090887|FD-Score:4.49|P-value:2.71E-5 ID:SGTC_3037|Compound:9091026|FD-Score:5.22|P-value:1.37E-6 ID:SGTC_3128|Compound:9127691|FD-Score:5.05|P-value:2.82E-6 ID:SGTC_3152|Compound:9099253|FD-Score:4.47|P-value:2.98E-5 ID:SGTC_3266|Compound:9136860|FD-Score:-3.86|P-value:2.70E-4 ID:SGTC_3318|Compound:9139014|FD-Score:-3.65|P-value:5.42E-4

Top fitness defect scores for YPL065W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 16.40 54.9 µM 1.37E-49 redox potentiating 3 5.23E-61
2 SGTC_1687 st020778 13.00 55.4 µM 7.89E-32 29 5.45E-39
3 SGTC_117 lucigenin 10.50 22.1 µM 1.54E-21 redox potentiating 7 3.03E-26
4 SGTC_221 trifluoperazine 10.00 10.3 µM 1.15E-19 NEO1-PIK1 59 6.32E-24
5 SGTC_528 3492-0019 9.18 172.0 µM 8.38E-17 calcium & mitochondrial duress 50 2.21E-20
6 SGTC_102 gallobenzophenone 8.85 83.6 µM 9.32E-16 redox potentiating 4 4.36E-19
7 SGTC_1844 rapamycin 8.72 4.0 nM 2.41E-15 47 1.41E-18
8 SGTC_1803 st050068 8.68 52.4 µM 3.23E-15 NEO1-PIK1 30 2.02E-18
9 SGTC_227 fluconazole 8.48 33.5 µM 1.32E-14 azole & statin 22 1.16E-17
10 SGTC_1831 st055328 8.37 12.0 µM 2.81E-14 heme biosynthesis & mitochondrial translocase 2 2.95E-17
11 SGTC_525 k781-2675 8.29 26.7 µM 4.85E-14 redox potentiating 10 5.78E-17
12 SGTC_1760 st045453 8.08 10.4 µM 2.00E-13 NEO1-PIK1 51 3.34E-16
13 SGTC_1750 st081859 7.64 2.4 µM 3.43E-12 endomembrane recycling 77 1.12E-14
14 SGTC_301 4119-0100 7.22 24.5 µM 4.26E-11 NEO1 27 2.51E-13
15 SGTC_1000 4048-0884 6.93 8.7 µM 2.40E-10 copper-dependent oxidative stress 5 2.12E-12
16 SGTC_576 1073-0113 6.92 22.7 µM 2.59E-10 redox potentiating 12 2.34E-12
17 SGTC_1884 5633444 6.91 25.0 µM 2.70E-10 redox potentiating 23 2.45E-12
18 SGTC_2619 obliquin 6.80 87.9 µM 5.03E-10 cell wall 63 5.29E-12
19 SGTC_206 4546-0025 6.76 72.0 µM 6.31E-10 NEO1 28 7.00E-12
20 SGTC_1130 3454-2858 6.66 15.9 µM 1.09E-9 NEO1 32 1.37E-11

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.640 0 YLR417W VPS36 hom Component of the ESCRT-II complex; contains the GLUE (GRAM Like Ubiquitin binding in EAP45) domain which is involved in interactions with ESCRT-I and ubiquitin-dependent sorting of proteins into the endosome
0.638 0 YJR102C VPS25 hom Component of the ESCRT-II complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome
0.599 0 YLR025W SNF7 hom One of four subunits of the endosomal sorting complex required for transport III (ESCRT-III); involved in the sorting of transmembrane proteins into the multivesicular body (MVB) pathway; recruited from the cytoplasm to endosomal membranes
0.584 1.05E-306 YCL008C STP22 hom Component of the ESCRT-I complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; homologous to the mouse and human Tsg101 tumor susceptibility gene; mutants exhibit a Class E Vps phenotype
0.556 6.86E-272 YPL002C SNF8 hom Component of the ESCRT-II complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; appears to be functionally related to SNF7; involved in glucose derepression
0.499 1.19E-210 YMR077C VPS20 hom Myristoylated subunit of ESCRTIII, the endosomal sorting complex required for transport of transmembrane proteins into the multivesicular body pathway to the lysosomal/vacuolar lumen; cytoplasmic protein recruited to endosomal membranes
0.421 1.87E-144 YGR122W YGR122W hom Protein that may be involved in pH regulation; probable ortholog of A. nidulans PalC, which is involved in pH regulation and binds to the ESCRT-III complex; null mutant does not properly process Rim101p and has decreased resistance to rapamycin; GFP-fusion protein is cytoplasmic; relative distribution to cytoplasm increases upon DNA replication stress
0.392 5.99E-124 YPR173C VPS4 hom AAA-ATPase involved in multivesicular body (MVB) protein sorting, ATP-bound Vps4p localizes to endosomes and catalyzes ESCRT-III disassembly and membrane release; ATPase activity is activated by Vta1p; regulates cellular sterol metabolism
0.384 9.11E-118 YMR154C RIM13 hom Calpain-like cysteine protease; involved in proteolytic activation of Rim101p in response to alkaline pH; localizes to punctate structures in alkaline conditions and in vps4 mutant; has similarity to A. nidulans palB
0.383 8.15E-118 YNL294C RIM21 hom pH sensor molecule, component of the RIM101 pathway; has a role in cell wall construction and alkaline pH response; is glycosylated and phosphorylated; interacts with Dfg16p and Rim9p to form a pH-sensing complex; localization to the plasma membrane is dependent on Dfg16p and Rim9p; has similarity to A. nidulans PalH
0.379 7.42E-115 YHL027W RIM101 hom Cys2His2 zinc-finger transcriptional repressor; involved in alkaline responsive gene repression as part of adaptation to a alkaline conditions; involved in cell wall assembly; required for alkaline pH-stimulated haploid invasive growth and sporulation; activated by alkaline-dependent proteolytic processing which results in removal of the C-terminal tail; similar to A. nidulans PacC
0.374 6.62E-112 YGL045W RIM8 hom Protein involved in proteolytic activation of Rim101p in response to alkaline pH; interacts with ESCRT-1 subunits Stp22p and Vps28p; essential for anaerobic growth; member of the arrestin-related trafficking adaptor family
0.358 5.02E-102 YHR012W VPS29 hom Endosomal protein that is a subunit of the membrane-associated retromer complex essential for endosome-to-Golgi retrograde transport; forms a subcomplex with Vps35p and Vps26p that selects cargo proteins for endosome-to-Golgi retrieval
0.355 3.06E-100 YOR036W PEP12 hom Target membrane receptor (t-SNARE) for vesicular intermediates traveling between the Golgi apparatus and the vacuole; controls entry of biosynthetic, endocytic, and retrograde traffic into the prevacuolar compartment; syntaxin
0.353 6.97E-99 YJL154C VPS35 hom Endosomal subunit of membrane-associated retromer complex required for retrograde transport; receptor that recognizes retrieval signals on cargo proteins, forms subcomplex with Vps26p and Vps29p that selects cargo proteins for retrieval; interacts with Ypt7p