YPL066W / RGL1

Regulator of Rho1p signaling, cofactor of Tus1p; required for the localization of Tus1p during all phases of cytokinesis; green fluorescent protein (GFP)-fusion protein localizes to the bud neck and cytoplasm; null mutant is viable and exhibits growth defect on a non-fermentable (respiratory) carbon source

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL066W / RGL1

Click on Significant Values for Screen Details ID:SGTC_13|Compound:0199-0087|FD-Score:6.93|P-value:2.22E-9 ID:SGTC_35|Compound:0133-0054|FD-Score:6.26|P-value:5.98E-8 ID:SGTC_53|Compound:0973-0023|FD-Score:3.99|P-value:3.64E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:11.10|P-value:3.06E-21 ID:SGTC_71|Compound:0417-1750|FD-Score:14.50|P-value:1.05E-34 ID:SGTC_91|Compound:0417-1751|FD-Score:5.96|P-value:2.31E-7 ID:SGTC_98|Compound:0074-0023|FD-Score:-3.86|P-value:5.53E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:12.30|P-value:8.92E-26 ID:SGTC_172|Compound:1112-0046|FD-Score:3.77|P-value:7.04E-4 ID:SGTC_206|Compound:4546-0025|FD-Score:11.50|P-value:1.69E-22 ID:SGTC_211|Compound:3455-0679|FD-Score:7.09|P-value:9.73E-10 ID:SGTC_237|Compound:nikkomycin|FD-Score:5.32|P-value:3.40E-6 ID:SGTC_305|Compound:1682-2595|FD-Score:3.87|P-value:5.25E-4 ID:SGTC_332|Compound:4112-0506|FD-Score:5.17|P-value:6.15E-6 ID:SGTC_351|Compound:caspofungin|FD-Score:10.50|P-value:2.24E-19 ID:SGTC_354|Compound:2783-3500|FD-Score:18.70|P-value:1.41E-56 ID:SGTC_360|Compound:0957-0399|FD-Score:6.04|P-value:1.60E-7 ID:SGTC_397|Compound:arbidol|FD-Score:4.25|P-value:1.62E-4 ID:SGTC_428|Compound:3448-4153|FD-Score:3.99|P-value:3.71E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:7.42|P-value:1.70E-10 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:3.69|P-value:8.91E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:6.33|P-value:4.30E-8 ID:SGTC_534|Compound:k292-0788|FD-Score:3.72|P-value:8.16E-4 ID:SGTC_548|Compound:1436-0017|FD-Score:6.10|P-value:1.22E-7 ID:SGTC_550|Compound:4123-0385|FD-Score:5.02|P-value:1.06E-5 ID:SGTC_586|Compound:0957-0265|FD-Score:6.40|P-value:3.08E-8 ID:SGTC_612|Compound:0302-0167|FD-Score:3.70|P-value:8.71E-4 ID:SGTC_639|Compound:0833-0042|FD-Score:4.37|P-value:1.09E-4 ID:SGTC_652|Compound:0437-0092|FD-Score:-3.72|P-value:8.23E-4 ID:SGTC_666|Compound:0272-0154|FD-Score:7.74|P-value:2.84E-11 ID:SGTC_710|Compound:3448-4187|FD-Score:4.69|P-value:3.65E-5 ID:SGTC_711|Compound:k292-0785|FD-Score:7.55|P-value:8.57E-11 ID:SGTC_790|Compound:1575-0012|FD-Score:5.32|P-value:3.30E-6 ID:SGTC_847|Compound:0342-0274|FD-Score:4.11|P-value:2.53E-4 ID:SGTC_883|Compound:0850-0245|FD-Score:7.74|P-value:2.90E-11 ID:SGTC_916|Compound:4466-0038|FD-Score:12.10|P-value:5.55E-25 ID:SGTC_928|Compound:2764-0428|FD-Score:5.87|P-value:3.37E-7 ID:SGTC_964|Compound:1287-0107|FD-Score:11.40|P-value:2.88E-22 ID:SGTC_979|Compound:1426-2828|FD-Score:-3.80|P-value:6.55E-4 ID:SGTC_1033|Compound:k072-0102|FD-Score:3.76|P-value:7.19E-4 ID:SGTC_1088|Compound:bifonazole|FD-Score:3.76|P-value:7.27E-4 ID:SGTC_1090|Compound:efavirenz|FD-Score:5.90|P-value:3.03E-7 ID:SGTC_1092|Compound:toremifene|FD-Score:4.65|P-value:4.21E-5 ID:SGTC_1107|Compound:amlodipine|FD-Score:4.01|P-value:3.42E-4 ID:SGTC_1116|Compound:jasmonic acid|FD-Score:4.65|P-value:4.08E-5 ID:SGTC_1179|Compound:1021-1431|FD-Score:4.23|P-value:1.70E-4 ID:SGTC_1199|Compound:1638-0010|FD-Score:3.70|P-value:8.78E-4 ID:SGTC_1230|Compound:0170-0365|FD-Score:3.76|P-value:7.26E-4 ID:SGTC_1263|Compound:0774-1208|FD-Score:3.84|P-value:5.69E-4 ID:SGTC_1270|Compound:0831-1170|FD-Score:4.22|P-value:1.75E-4 ID:SGTC_1323|Compound:1348-1351|FD-Score:-3.77|P-value:7.24E-4 ID:SGTC_1402|Compound:3909-7673|FD-Score:5.83|P-value:4.01E-7 ID:SGTC_1528|Compound:arabinosylhypoxanthine|FD-Score:3.67|P-value:9.60E-4 ID:SGTC_1604|Compound:st002052|FD-Score:4.03|P-value:3.25E-4 ID:SGTC_1665|Compound:st014639|FD-Score:4.04|P-value:3.16E-4 ID:SGTC_1715|Compound:st032160|FD-Score:6.17|P-value:9.08E-8 ID:SGTC_1790|Compound:st045711|FD-Score:4.58|P-value:5.33E-5 ID:SGTC_1809|Compound:st050081|FD-Score:5.05|P-value:9.64E-6 ID:SGTC_1831|Compound:st055328|FD-Score:3.92|P-value:4.50E-4 ID:SGTC_1862|Compound:st057513|FD-Score:-4.11|P-value:2.57E-4 ID:SGTC_1880|Compound:MG-132|FD-Score:-3.85|P-value:5.68E-4 ID:SGTC_2001|Compound:4023502|FD-Score:-3.68|P-value:9.30E-4 ID:SGTC_2003|Compound:4023581|FD-Score:8.82|P-value:4.13E-14 ID:SGTC_2007|Compound:4011539|FD-Score:-7.31|P-value:3.20E-10 ID:SGTC_2011|Compound:4012611|FD-Score:-6.07|P-value:1.46E-7 ID:SGTC_2049|Compound:5262831|FD-Score:3.70|P-value:8.66E-4 ID:SGTC_2122|Compound:5258151|FD-Score:6.54|P-value:1.53E-8 ID:SGTC_2177|Compound:5811945|FD-Score:4.60|P-value:4.90E-5 ID:SGTC_2253|Compound:7938677|FD-Score:3.72|P-value:8.09E-4 ID:SGTC_2301|Compound:7769476|FD-Score:5.68|P-value:7.51E-7 ID:SGTC_2310|Compound:7668677|FD-Score:5.28|P-value:4.00E-6 ID:SGTC_2328|Compound:6201408|FD-Score:-3.91|P-value:4.70E-4 ID:SGTC_2400|Compound:5203494|FD-Score:6.22|P-value:6.91E-8 ID:SGTC_2434|Compound:5670830|FD-Score:-4.00|P-value:3.66E-4 ID:SGTC_2479|Compound:5617353|FD-Score:5.48|P-value:1.76E-6 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:-4.08|P-value:2.78E-4 ID:SGTC_2528|Compound:xanthyletin|FD-Score:-3.94|P-value:4.37E-4 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:4.29|P-value:1.43E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:9.65|P-value:1.62E-16 ID:SGTC_2584|Compound:androsterone|FD-Score:7.57|P-value:7.56E-11 ID:SGTC_2619|Compound:obliquin|FD-Score:9.20|P-value:3.45E-15 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:4.63|P-value:4.52E-5 ID:SGTC_2742|Compound:clothiapine|FD-Score:3.94|P-value:4.31E-4 ID:SGTC_2787|Compound:5284540|FD-Score:-4.18|P-value:2.07E-4 ID:SGTC_2790|Compound:5423970|FD-Score:4.49|P-value:7.21E-5 ID:SGTC_2803|Compound:7707263|FD-Score:4.88|P-value:1.83E-5 ID:SGTC_2832|Compound:7992762|FD-Score:5.34|P-value:3.15E-6 ID:SGTC_2836|Compound:9010338|FD-Score:-5.36|P-value:2.88E-6 ID:SGTC_2912|Compound:7964298|FD-Score:14.00|P-value:1.10E-32 ID:SGTC_2968|Compound:9090663|FD-Score:3.75|P-value:7.50E-4 ID:SGTC_3288|Compound:9119690|FD-Score:4.85|P-value:2.03E-5 ID:SGTC_3311|Compound:9131146|FD-Score:4.69|P-value:3.60E-5 ID:SGTC_3321|Compound:9137793|FD-Score:4.42|P-value:9.31E-5 ID:SGTC_3342|Compound:9147791|FD-Score:3.80|P-value:6.49E-4 ID:SGTC_3351|Compound:9150312|FD-Score:6.34|P-value:4.10E-8 ID:SGTC_13|Compound:0199-0087|FD-Score:6.93|P-value:2.22E-9 ID:SGTC_35|Compound:0133-0054|FD-Score:6.26|P-value:5.98E-8 ID:SGTC_53|Compound:0973-0023|FD-Score:3.99|P-value:3.64E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:11.10|P-value:3.06E-21 ID:SGTC_71|Compound:0417-1750|FD-Score:14.50|P-value:1.05E-34 ID:SGTC_91|Compound:0417-1751|FD-Score:5.96|P-value:2.31E-7 ID:SGTC_98|Compound:0074-0023|FD-Score:-3.86|P-value:5.53E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:12.30|P-value:8.92E-26 ID:SGTC_172|Compound:1112-0046|FD-Score:3.77|P-value:7.04E-4 ID:SGTC_206|Compound:4546-0025|FD-Score:11.50|P-value:1.69E-22 ID:SGTC_211|Compound:3455-0679|FD-Score:7.09|P-value:9.73E-10 ID:SGTC_237|Compound:nikkomycin|FD-Score:5.32|P-value:3.40E-6 ID:SGTC_305|Compound:1682-2595|FD-Score:3.87|P-value:5.25E-4 ID:SGTC_332|Compound:4112-0506|FD-Score:5.17|P-value:6.15E-6 ID:SGTC_351|Compound:caspofungin|FD-Score:10.50|P-value:2.24E-19 ID:SGTC_354|Compound:2783-3500|FD-Score:18.70|P-value:1.41E-56 ID:SGTC_360|Compound:0957-0399|FD-Score:6.04|P-value:1.60E-7 ID:SGTC_397|Compound:arbidol|FD-Score:4.25|P-value:1.62E-4 ID:SGTC_428|Compound:3448-4153|FD-Score:3.99|P-value:3.71E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:7.42|P-value:1.70E-10 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:3.69|P-value:8.91E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:6.33|P-value:4.30E-8 ID:SGTC_534|Compound:k292-0788|FD-Score:3.72|P-value:8.16E-4 ID:SGTC_548|Compound:1436-0017|FD-Score:6.10|P-value:1.22E-7 ID:SGTC_550|Compound:4123-0385|FD-Score:5.02|P-value:1.06E-5 ID:SGTC_586|Compound:0957-0265|FD-Score:6.40|P-value:3.08E-8 ID:SGTC_612|Compound:0302-0167|FD-Score:3.70|P-value:8.71E-4 ID:SGTC_639|Compound:0833-0042|FD-Score:4.37|P-value:1.09E-4 ID:SGTC_652|Compound:0437-0092|FD-Score:-3.72|P-value:8.23E-4 ID:SGTC_666|Compound:0272-0154|FD-Score:7.74|P-value:2.84E-11 ID:SGTC_710|Compound:3448-4187|FD-Score:4.69|P-value:3.65E-5 ID:SGTC_711|Compound:k292-0785|FD-Score:7.55|P-value:8.57E-11 ID:SGTC_790|Compound:1575-0012|FD-Score:5.32|P-value:3.30E-6 ID:SGTC_847|Compound:0342-0274|FD-Score:4.11|P-value:2.53E-4 ID:SGTC_883|Compound:0850-0245|FD-Score:7.74|P-value:2.90E-11 ID:SGTC_916|Compound:4466-0038|FD-Score:12.10|P-value:5.55E-25 ID:SGTC_928|Compound:2764-0428|FD-Score:5.87|P-value:3.37E-7 ID:SGTC_964|Compound:1287-0107|FD-Score:11.40|P-value:2.88E-22 ID:SGTC_979|Compound:1426-2828|FD-Score:-3.80|P-value:6.55E-4 ID:SGTC_1033|Compound:k072-0102|FD-Score:3.76|P-value:7.19E-4 ID:SGTC_1088|Compound:bifonazole|FD-Score:3.76|P-value:7.27E-4 ID:SGTC_1090|Compound:efavirenz|FD-Score:5.90|P-value:3.03E-7 ID:SGTC_1092|Compound:toremifene|FD-Score:4.65|P-value:4.21E-5 ID:SGTC_1107|Compound:amlodipine|FD-Score:4.01|P-value:3.42E-4 ID:SGTC_1116|Compound:jasmonic acid|FD-Score:4.65|P-value:4.08E-5 ID:SGTC_1179|Compound:1021-1431|FD-Score:4.23|P-value:1.70E-4 ID:SGTC_1199|Compound:1638-0010|FD-Score:3.70|P-value:8.78E-4 ID:SGTC_1230|Compound:0170-0365|FD-Score:3.76|P-value:7.26E-4 ID:SGTC_1263|Compound:0774-1208|FD-Score:3.84|P-value:5.69E-4 ID:SGTC_1270|Compound:0831-1170|FD-Score:4.22|P-value:1.75E-4 ID:SGTC_1323|Compound:1348-1351|FD-Score:-3.77|P-value:7.24E-4 ID:SGTC_1402|Compound:3909-7673|FD-Score:5.83|P-value:4.01E-7 ID:SGTC_1528|Compound:arabinosylhypoxanthine|FD-Score:3.67|P-value:9.60E-4 ID:SGTC_1604|Compound:st002052|FD-Score:4.03|P-value:3.25E-4 ID:SGTC_1665|Compound:st014639|FD-Score:4.04|P-value:3.16E-4 ID:SGTC_1715|Compound:st032160|FD-Score:6.17|P-value:9.08E-8 ID:SGTC_1790|Compound:st045711|FD-Score:4.58|P-value:5.33E-5 ID:SGTC_1809|Compound:st050081|FD-Score:5.05|P-value:9.64E-6 ID:SGTC_1831|Compound:st055328|FD-Score:3.92|P-value:4.50E-4 ID:SGTC_1862|Compound:st057513|FD-Score:-4.11|P-value:2.57E-4 ID:SGTC_1880|Compound:MG-132|FD-Score:-3.85|P-value:5.68E-4 ID:SGTC_2001|Compound:4023502|FD-Score:-3.68|P-value:9.30E-4 ID:SGTC_2003|Compound:4023581|FD-Score:8.82|P-value:4.13E-14 ID:SGTC_2007|Compound:4011539|FD-Score:-7.31|P-value:3.20E-10 ID:SGTC_2011|Compound:4012611|FD-Score:-6.07|P-value:1.46E-7 ID:SGTC_2049|Compound:5262831|FD-Score:3.70|P-value:8.66E-4 ID:SGTC_2122|Compound:5258151|FD-Score:6.54|P-value:1.53E-8 ID:SGTC_2177|Compound:5811945|FD-Score:4.60|P-value:4.90E-5 ID:SGTC_2253|Compound:7938677|FD-Score:3.72|P-value:8.09E-4 ID:SGTC_2301|Compound:7769476|FD-Score:5.68|P-value:7.51E-7 ID:SGTC_2310|Compound:7668677|FD-Score:5.28|P-value:4.00E-6 ID:SGTC_2328|Compound:6201408|FD-Score:-3.91|P-value:4.70E-4 ID:SGTC_2400|Compound:5203494|FD-Score:6.22|P-value:6.91E-8 ID:SGTC_2434|Compound:5670830|FD-Score:-4.00|P-value:3.66E-4 ID:SGTC_2479|Compound:5617353|FD-Score:5.48|P-value:1.76E-6 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:-4.08|P-value:2.78E-4 ID:SGTC_2528|Compound:xanthyletin|FD-Score:-3.94|P-value:4.37E-4 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:4.29|P-value:1.43E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:9.65|P-value:1.62E-16 ID:SGTC_2584|Compound:androsterone|FD-Score:7.57|P-value:7.56E-11 ID:SGTC_2619|Compound:obliquin|FD-Score:9.20|P-value:3.45E-15 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:4.63|P-value:4.52E-5 ID:SGTC_2742|Compound:clothiapine|FD-Score:3.94|P-value:4.31E-4 ID:SGTC_2787|Compound:5284540|FD-Score:-4.18|P-value:2.07E-4 ID:SGTC_2790|Compound:5423970|FD-Score:4.49|P-value:7.21E-5 ID:SGTC_2803|Compound:7707263|FD-Score:4.88|P-value:1.83E-5 ID:SGTC_2832|Compound:7992762|FD-Score:5.34|P-value:3.15E-6 ID:SGTC_2836|Compound:9010338|FD-Score:-5.36|P-value:2.88E-6 ID:SGTC_2912|Compound:7964298|FD-Score:14.00|P-value:1.10E-32 ID:SGTC_2968|Compound:9090663|FD-Score:3.75|P-value:7.50E-4 ID:SGTC_3288|Compound:9119690|FD-Score:4.85|P-value:2.03E-5 ID:SGTC_3311|Compound:9131146|FD-Score:4.69|P-value:3.60E-5 ID:SGTC_3321|Compound:9137793|FD-Score:4.42|P-value:9.31E-5 ID:SGTC_3342|Compound:9147791|FD-Score:3.80|P-value:6.49E-4 ID:SGTC_3351|Compound:9150312|FD-Score:6.34|P-value:4.10E-8

Top fitness defect scores for YPL066W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_354 2783-3500 18.70 4.9 µM 1.41E-56 cell wall 2 3.39E-78
2 SGTC_71 0417-1750 14.50 47.8 µM 1.05E-34 Golgi 4 1.13E-47
3 SGTC_2912 7964298 14.00 10.9 µM 1.10E-32 cell wall 7 7.37E-45
4 SGTC_138 0850-0259 12.30 40.9 µM 8.92E-26 cell wall 25 3.16E-35
5 SGTC_916 4466-0038 12.10 42.0 nM 5.55E-25 cell wall 4 4.04E-34
6 SGTC_206 4546-0025 11.50 72.0 µM 1.69E-22 NEO1 11 1.17E-30
7 SGTC_964 1287-0107 11.40 19.4 µM 2.88E-22 cell wall 4 2.45E-30
8 SGTC_58 0957-0393 11.10 9.0 µM 3.06E-21 cell wall 64 6.60E-29
9 SGTC_351 caspofungin 10.50 25.0 nM 2.24E-19 cell wall 7 2.61E-26
10 SGTC_2582 agaric acid 9.65 100.0 µM 1.62E-16 redox potentiating 73 2.49E-22
11 SGTC_2619 obliquin 9.20 87.9 µM 3.45E-15 cell wall 28 1.76E-20
12 SGTC_2003 4023581 8.82 200.0 µM 4.13E-14 cell wall signaling 5 5.54E-19
13 SGTC_666 0272-0154 7.74 136.0 µM 2.84E-11 cell wall 11 4.86E-15
14 SGTC_883 0850-0245 7.74 24.6 µM 2.90E-11 cell wall 6 5.00E-15
15 SGTC_2584 androsterone 7.57 48.7 µM 7.56E-11 cell wall 28 1.89E-14
16 SGTC_711 k292-0785 7.55 179.0 µM 8.57E-11 DNA intercalators 2 2.25E-14
17 SGTC_453 enantio-paf c16 7.42 10.0 µM 1.70E-10 17 5.84E-14
18 SGTC_211 3455-0679 7.09 143.5 µM 9.73E-10 2 6.56E-13
19 SGTC_13 0199-0087 6.93 65.0 µM 2.22E-9 ERG2 3 2.06E-12
20 SGTC_2122 5258151 6.54 111.7 µM 1.53E-8 4 2.98E-11

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.414 9.55E-139 YJL099W CHS6 hom Member of the ChAPs (Chs5p-Arf1p-binding proteins) family; part of the exomer complex that mediates export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane; CHS6 has a paralog, BCH2, that arose from the whole genome duplication
0.409 2.80E-135 YLR331C_d JIP3_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene MID2
0.394 5.08E-125 YBL061C SKT5 hom Activator of Chs3p (chitin synthase III) during vegetative growth; recruits Chs3p to the bud neck via interaction with Bni4p; SKT5 has a paralog, SHC1, that arose from the whole genome duplication
0.380 1.02E-115 YBR023C CHS3 hom Chitin synthase III, catalyzes the transfer of N-acetylglucosamine (GlcNAc) to chitin; required for synthesis of the majority of cell wall chitin, the chitin ring during bud emergence, and spore wall chitosan
0.356 1.03E-100 YMR124W_p YMR124W_p hom Protein of unknown function; GFP-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; interacts with Crm1p in two-hybrid assay; YMR124W is not an essential gene; predicted to have a role in organelle organization
0.334 5.18E-88 YOL003C PFA4 hom Palmitoyltransferase with autoacylation activity, required for palmitoylation of amino acid permeases containing a C-terminal Phe-Trp-Cys site; required for modification of Chs3p; member of the DHHC family of putative palmitoyltransferases
0.325 1.97E-83 YJL159W HSP150 hom O-mannosylated heat shock protein; secreted and covalently attached to the cell wall via beta-1,3-glucan and disulfide bridges; required for cell wall stability; induced by heat shock, oxidative stress, and nitrogen limitation; HSP150 has a paralog, PIR3, that arose from the whole genome duplication
0.320 8.26E-81 YML117W NAB6 hom Putative RNA-binding protein that associates with mRNAs encoding cell wall proteins in high-throughput studies; deletion mutants display increased sensitivity to some cell wall disrupting agents; expression negatively regulated by cAMP
0.319 2.14E-80 YLL021W SPA2 hom Component of the polarisome, which functions in actin cytoskeletal organization during polarized growth; acts as a scaffold for Mkk1p and Mpk1p cell wall integrity signaling components; potential Cdc28p substrate
0.317 3.72E-79 YDR351W SBE2 hom Protein involved in the transport of cell wall components from the Golgi to the cell surface; required for bud growth
0.311 3.17E-76 YDL203C ACK1 hom Protein that functions upstream of Pkc1p in the cell wall integrity pathway; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; non-tagged Ack1p is detected in purified mitochondria
0.306 1.53E-73 YLL043W FPS1 hom Plasma membrane channel, member of major intrinsic protein (MIP) family; involved in efflux of glycerol and in uptake of acetic acid and the trivalent metalloids arsenite and antimonite; phosphorylated by Hog1p MAPK under acetate stress
0.302 7.44E-72 YLL032C YLL032C hom Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLL032C is not an essential gene
0.300 8.55E-71 YDR348C PAL1 hom Protein of unknown function thought to be involved in endocytosis; Pal1p physically interacts with Ede1p and is found at endocytic sites at the cell periphery during the early stages of endocytosis; green fluorescent protein (GFP)-fusion protein also localizes to the bud neck; potential Cdc28p substrate; similar to the S. pombe Pal1 protein; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.289 1.82E-65 YJR142W_p YJR142W_p hom Putative protein of unknown function; GST fusion protein is a Dbf2p-Mob1p phosphorylation target in a proteome chip analysis; synthetic lethal with PH085 deletion; plays a role in restricting Ty1 transposition; nudix hydrolase family member