YPL068C_p

Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and is induced in response to the DNA-damaging agent MMS

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL068C / YPL068C

Click on Significant Values for Screen Details ID:SGTC_70|Compound:0141-0289|FD-Score:-3.52|P-value:8.18E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:3.84|P-value:1.71E-4 ID:SGTC_354|Compound:2783-3500|FD-Score:4.77|P-value:4.80E-6 ID:SGTC_567|Compound:1080-0542|FD-Score:3.61|P-value:3.81E-4 ID:SGTC_653|Compound:0203-0016|FD-Score:3.44|P-value:6.66E-4 ID:SGTC_723|Compound:4182-0001|FD-Score:-3.58|P-value:6.81E-4 ID:SGTC_730|Compound:1436-0052|FD-Score:4.57|P-value:1.10E-5 ID:SGTC_775|Compound:4577-0580|FD-Score:-3.88|P-value:2.60E-4 ID:SGTC_870|Compound:0573-2213|FD-Score:3.81|P-value:1.89E-4 ID:SGTC_915|Compound:methyl methanesulfonate (MMS)|FD-Score:-3.57|P-value:6.99E-4 ID:SGTC_1067|Compound:clotrimazole|FD-Score:3.40|P-value:7.51E-4 ID:SGTC_1129|Compound:3453-1384|FD-Score:-5.40|P-value:5.89E-7 ID:SGTC_1372|Compound:2752-0194|FD-Score:3.39|P-value:7.68E-4 ID:SGTC_1448|Compound:4255-0083|FD-Score:-3.81|P-value:3.27E-4 ID:SGTC_1450|Compound:4112-4260|FD-Score:-5.17|P-value:1.63E-6 ID:SGTC_1490|Compound:4089-0339|FD-Score:-3.48|P-value:9.38E-4 ID:SGTC_1503|Compound:4585-0012|FD-Score:-3.61|P-value:6.18E-4 ID:SGTC_1588|Compound:farnesol|FD-Score:3.67|P-value:3.07E-4 ID:SGTC_1589|Compound:2',5'-dimethoxyflavone|FD-Score:3.61|P-value:3.75E-4 ID:SGTC_1831|Compound:st055328|FD-Score:-3.55|P-value:7.47E-4 ID:SGTC_1877|Compound:wortmannin|FD-Score:4.07|P-value:7.52E-5 ID:SGTC_1966|Compound:st070145|FD-Score:6.68|P-value:3.33E-10 ID:SGTC_2192|Compound:5915882|FD-Score:3.52|P-value:5.16E-4 ID:SGTC_2618|Compound:avocadyne|FD-Score:-4.18|P-value:8.78E-5 ID:SGTC_2752|Compound:diclazuril|FD-Score:-3.55|P-value:7.47E-4 ID:SGTC_2814|Compound:7977482|FD-Score:-4.66|P-value:1.40E-5 ID:SGTC_2940|Compound:9060638|FD-Score:-3.91|P-value:2.33E-4 ID:SGTC_2954|Compound:9074818|FD-Score:-3.79|P-value:3.51E-4 ID:SGTC_3276|Compound:9139060|FD-Score:3.82|P-value:1.88E-4 ID:SGTC_3279|Compound:9140807|FD-Score:-3.49|P-value:9.18E-4 ID:SGTC_3296|Compound:9122258|FD-Score:-3.76|P-value:3.86E-4 ID:SGTC_3313|Compound:9133968|FD-Score:4.42|P-value:1.98E-5 ID:SGTC_3335|Compound:9143315|FD-Score:4.47|P-value:1.62E-5 ID:SGTC_3354|Compound:9151612|FD-Score:4.02|P-value:9.19E-5 ID:SGTC_70|Compound:0141-0289|FD-Score:-3.52|P-value:8.18E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:3.84|P-value:1.71E-4 ID:SGTC_354|Compound:2783-3500|FD-Score:4.77|P-value:4.80E-6 ID:SGTC_567|Compound:1080-0542|FD-Score:3.61|P-value:3.81E-4 ID:SGTC_653|Compound:0203-0016|FD-Score:3.44|P-value:6.66E-4 ID:SGTC_723|Compound:4182-0001|FD-Score:-3.58|P-value:6.81E-4 ID:SGTC_730|Compound:1436-0052|FD-Score:4.57|P-value:1.10E-5 ID:SGTC_775|Compound:4577-0580|FD-Score:-3.88|P-value:2.60E-4 ID:SGTC_870|Compound:0573-2213|FD-Score:3.81|P-value:1.89E-4 ID:SGTC_915|Compound:methyl methanesulfonate (MMS)|FD-Score:-3.57|P-value:6.99E-4 ID:SGTC_1067|Compound:clotrimazole|FD-Score:3.40|P-value:7.51E-4 ID:SGTC_1129|Compound:3453-1384|FD-Score:-5.40|P-value:5.89E-7 ID:SGTC_1372|Compound:2752-0194|FD-Score:3.39|P-value:7.68E-4 ID:SGTC_1448|Compound:4255-0083|FD-Score:-3.81|P-value:3.27E-4 ID:SGTC_1450|Compound:4112-4260|FD-Score:-5.17|P-value:1.63E-6 ID:SGTC_1490|Compound:4089-0339|FD-Score:-3.48|P-value:9.38E-4 ID:SGTC_1503|Compound:4585-0012|FD-Score:-3.61|P-value:6.18E-4 ID:SGTC_1588|Compound:farnesol|FD-Score:3.67|P-value:3.07E-4 ID:SGTC_1589|Compound:2',5'-dimethoxyflavone|FD-Score:3.61|P-value:3.75E-4 ID:SGTC_1831|Compound:st055328|FD-Score:-3.55|P-value:7.47E-4 ID:SGTC_1877|Compound:wortmannin|FD-Score:4.07|P-value:7.52E-5 ID:SGTC_1966|Compound:st070145|FD-Score:6.68|P-value:3.33E-10 ID:SGTC_2192|Compound:5915882|FD-Score:3.52|P-value:5.16E-4 ID:SGTC_2618|Compound:avocadyne|FD-Score:-4.18|P-value:8.78E-5 ID:SGTC_2752|Compound:diclazuril|FD-Score:-3.55|P-value:7.47E-4 ID:SGTC_2814|Compound:7977482|FD-Score:-4.66|P-value:1.40E-5 ID:SGTC_2940|Compound:9060638|FD-Score:-3.91|P-value:2.33E-4 ID:SGTC_2954|Compound:9074818|FD-Score:-3.79|P-value:3.51E-4 ID:SGTC_3276|Compound:9139060|FD-Score:3.82|P-value:1.88E-4 ID:SGTC_3279|Compound:9140807|FD-Score:-3.49|P-value:9.18E-4 ID:SGTC_3296|Compound:9122258|FD-Score:-3.76|P-value:3.86E-4 ID:SGTC_3313|Compound:9133968|FD-Score:4.42|P-value:1.98E-5 ID:SGTC_3335|Compound:9143315|FD-Score:4.47|P-value:1.62E-5 ID:SGTC_3354|Compound:9151612|FD-Score:4.02|P-value:9.19E-5

Top fitness defect scores for YPL068C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1966 st070145 6.68 16.1 µM 3.33E-10 5 1.17E-11
2 SGTC_354 2783-3500 4.77 4.9 µM 4.80E-6 cell wall 32 9.28E-7
3 SGTC_730 1436-0052 4.57 41.2 µM 1.10E-5 mitochondrial processes 6 2.46E-6
4 SGTC_3335 9143315 4.47 29.6 µM 1.62E-5 fatty acid desaturase (OLE1) 8 3.85E-6
5 SGTC_3313 9133968 4.42 57.0 µM 1.98E-5 4 4.88E-6
6 SGTC_1877 wortmannin 4.07 25.0 µM 7.52E-5 92 2.32E-5
7 SGTC_3354 9151612 4.02 71.4 µM 9.19E-5 6 2.93E-5
8 SGTC_118 0083-0097 3.84 135.3 µM 1.71E-4 translation 143 6.06E-5
9 SGTC_3276 9139060 3.82 49.5 µM 1.88E-4 60S ribosome export 3 6.76E-5
10 SGTC_870 0573-2213 3.81 57.6 µM 1.89E-4 ERG2 21 6.82E-5
11 SGTC_1588 farnesol 3.67 29.9 µM 3.07E-4 14 1.20E-4
12 SGTC_1589 2',5'-dimethoxyflavone 3.61 47.2 µM 3.75E-4 28 1.51E-4
13 SGTC_567 1080-0542 3.61 68.4 µM 3.81E-4 19 1.54E-4
14 SGTC_2192 5915882 3.52 198.5 µM 5.16E-4 RNA processing & uracil transport 33 2.19E-4
15 SGTC_653 0203-0016 3.44 55.2 µM 6.66E-4 35 2.95E-4
16 SGTC_1067 clotrimazole 3.40 1.4 µM 7.51E-4 azole & statin 59 3.39E-4
17 SGTC_1372 2752-0194 3.39 270.0 µM 7.68E-4 32 3.48E-4
18 SGTC_1994 st072947 3.29 40.9 µM 0.00104 40 4.93E-4
19 SGTC_1963 st076565 3.25 50.3 µM 0.00117 34 5.70E-4
20 SGTC_2914 7968218 3.24 45.3 µM 0.00123 25 6.03E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.102 2.98E-9 YDR494W RSM28 hom Mitochondrial ribosomal protein of the small subunit; genetic interactions suggest a possible role in promoting translation initiation
0.098 1.37E-8 YMR230W RPS10B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S10, no bacterial homolog; RPS10B has a paralog, RPS10A, that arose from the whole genome duplication
0.090 1.73E-7 YKL132C RMA1 hom Putative dihydrofolate synthetase; has similarity to Fol3p and to E. coli folylpolyglutamate synthetase/dihydrofolate synthetase; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.083 1.32E-6 YIL058W_d YIL058W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.079 4.35E-6 YNL064C YDJ1 hom Type I HSP40 co-chaperone; involved in regulation of HSP90 and HSP70 functions; critical for determining cell size at Start as a function of growth rate; involved in protein translocation across membranes; member of the DnaJ family
0.073 2.38E-5 YLR287C-A RPS30A hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S30, no bacterial homolog; RPS30A has a paralog, RPS30B, that arose from the whole genome duplication
0.073 2.52E-5 YMR278W PGM3 hom Phosphoglucomutase, catalyzes interconversion of glucose-1-phosphate and glucose-6-phospate; transcription induced in response to stress; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; non-essential
0.069 6.65E-5 YHL001W RPL14B hom Ribosomal 60S subunit protein L14B; homologous to mammalian ribosomal protein L14, no bacterial homolog; RPL14B has a paralog, RPL14A, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
0.068 7.96E-5 YNL166C BNI5 hom Protein involved in organization of septins at the mother-bud neck, may interact directly with the Cdc11p septin, localizes to bud neck in a septin-dependent manner
0.067 9.85E-5 YDR217C RAD9 hom DNA damage-dependent checkpoint protein; required for cell-cycle arrest in G1/S, intra-S, and G2/M; transmits checkpoint signal by activating Rad53p and Chk1p; hyperphosphorylated by Mec1p and Tel1p; multiple cyclin dependent kinase consensus sites and the C-terminal BRCT domain contribute to DNA damage checkpoint activation; potential Cdc28p substrate
0.067 1.15E-4 YLR004C THI73 hom Putative plasma membrane permease proposed to be involved in carboxylic acid uptake and repressed by thiamine; substrate of Dbf2p/Mob1p kinase; transcription is altered if mitochondrial dysfunction occurs
0.066 1.38E-4 YLR363C NMD4 hom Protein that may be involved in nonsense-mediated mRNA decay; interacts with Nam7p, relocalizes from nucleus to cytoplasmic foci upon DNA replication stress
0.066 1.43E-4 YMR158W MRPS8 hom Mitochondrial ribosomal protein of the small subunit
0.064 2.01E-4 YHR194W MDM31 hom Mitochondrial protein that may have a role in phospholipid metabolism; inner membrane protein with similarity to Mdm32p; required for normal mitochondrial morphology and inheritance; interacts genetically with MMM1, MMM2, MDM10, MDM12, and MDM34
0.064 2.32E-4 YNL157W IGO1 hom Protein required for initiation of G0 program; prevents degradation of nutrient-regulated mRNAs via the 5'-3' mRNA decay pathway; phosphorylated by Rim15p; GFP protein localizes to the cytoplasm and nucleus; similar to Igo2p