YPL069C / BTS1

Geranylgeranyl diphosphate synthase, increases the intracellular pool of geranylgeranyl diphosphate, suppressor of bet2 mutation that causes defective geranylgeranylation of small GTP-binding proteins that mediate vesicular traffic

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL069C / BTS1

Click on Significant Values for Screen Details ID:SGTC_210|Compound:3551-0445|FD-Score:10.40|P-value:2.66E-9 ID:SGTC_227|Compound:fluconazole|FD-Score:6.61|P-value:9.68E-5 ID:SGTC_269|Compound:exalamide|FD-Score:9.54|P-value:4.09E-8 ID:SGTC_296|Compound:1222-0039|FD-Score:9.96|P-value:1.09E-8 ID:SGTC_305|Compound:1682-2595|FD-Score:5.85|P-value:4.76E-4 ID:SGTC_363|Compound:0455-0021|FD-Score:5.97|P-value:3.77E-4 ID:SGTC_417|Compound:st075190|FD-Score:8.17|P-value:2.14E-6 ID:SGTC_445|Compound:e6 berbamine|FD-Score:6.42|P-value:1.45E-4 ID:SGTC_451|Compound:chloral hydrate|FD-Score:5.54|P-value:8.75E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-6.00|P-value:4.65E-4 ID:SGTC_459|Compound:nigericin|FD-Score:9.96|P-value:1.07E-8 ID:SGTC_465|Compound:cgp-37157|FD-Score:-8.27|P-value:2.31E-6 ID:SGTC_467|Compound:ro 31-8220|FD-Score:-6.81|P-value:8.24E-5 ID:SGTC_482|Compound:fipronil|FD-Score:5.63|P-value:7.41E-4 ID:SGTC_487|Compound:nimodipine|FD-Score:-5.89|P-value:5.71E-4 ID:SGTC_489|Compound:paxilline|FD-Score:7.15|P-value:2.80E-5 ID:SGTC_504|Compound:lovastatin|FD-Score:6.86|P-value:5.54E-5 ID:SGTC_524|Compound:r073-0010|FD-Score:7.75|P-value:6.30E-6 ID:SGTC_561|Compound:1550-0330|FD-Score:6.23|P-value:2.17E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:9.10|P-value:1.55E-7 ID:SGTC_576|Compound:1073-0113|FD-Score:9.95|P-value:1.10E-8 ID:SGTC_617|Compound:3770-0098|FD-Score:8.47|P-value:9.31E-7 ID:SGTC_637|Compound:1181-0519|FD-Score:11.60|P-value:3.78E-11 ID:SGTC_639|Compound:0833-0042|FD-Score:8.35|P-value:1.32E-6 ID:SGTC_682|Compound:0kpi-0099|FD-Score:13.80|P-value:5.19E-15 ID:SGTC_688|Compound:0527-0193|FD-Score:6.06|P-value:3.11E-4 ID:SGTC_689|Compound:0833-0039|FD-Score:5.47|P-value:9.95E-4 ID:SGTC_699|Compound:0375-0592|FD-Score:7.65|P-value:8.20E-6 ID:SGTC_727|Compound:3032-0951|FD-Score:8.83|P-value:3.39E-7 ID:SGTC_768|Compound:0384-0033|FD-Score:10.30|P-value:3.66E-9 ID:SGTC_788|Compound:1182-0090|FD-Score:5.86|P-value:4.64E-4 ID:SGTC_813|Compound:k007-0158|FD-Score:9.34|P-value:7.45E-8 ID:SGTC_834|Compound:0312-0008|FD-Score:5.79|P-value:5.37E-4 ID:SGTC_871|Compound:0574-0004|FD-Score:9.00|P-value:2.04E-7 ID:SGTC_875|Compound:0709-0210|FD-Score:12.70|P-value:5.87E-13 ID:SGTC_888|Compound:0916-0002|FD-Score:7.46|P-value:1.31E-5 ID:SGTC_917|Compound:harmaline|FD-Score:12.70|P-value:4.73E-13 ID:SGTC_959|Compound:1222-0044|FD-Score:6.55|P-value:1.10E-4 ID:SGTC_1026|Compound:k007-1105|FD-Score:9.28|P-value:9.12E-8 ID:SGTC_1036|Compound:k216-0215|FD-Score:9.10|P-value:1.55E-7 ID:SGTC_1055|Compound:3448-0672|FD-Score:11.40|P-value:8.54E-11 ID:SGTC_1086|Compound:cerivastatin|FD-Score:5.87|P-value:4.61E-4 ID:SGTC_1097|Compound:itavastatin|FD-Score:10.40|P-value:2.91E-9 ID:SGTC_1144|Compound:3486-0183|FD-Score:7.26|P-value:2.16E-5 ID:SGTC_1237|Compound:0330-0133|FD-Score:6.12|P-value:2.74E-4 ID:SGTC_1317|Compound:1273-0028|FD-Score:7.49|P-value:1.21E-5 ID:SGTC_1352|Compound:1496-0991|FD-Score:-6.57|P-value:1.41E-4 ID:SGTC_1394|Compound:3474-0001|FD-Score:8.13|P-value:2.34E-6 ID:SGTC_1495|Compound:4469-0029|FD-Score:5.72|P-value:6.13E-4 ID:SGTC_1547|Compound:harmine|FD-Score:10.80|P-value:7.44E-10 ID:SGTC_1581|Compound:himbacine|FD-Score:7.77|P-value:6.08E-6 ID:SGTC_1586|Compound:deoxycorticosterone acetate|FD-Score:5.72|P-value:6.18E-4 ID:SGTC_1595|Compound:6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin|FD-Score:15.40|P-value:2.49E-18 ID:SGTC_1638|Compound:st008370|FD-Score:8.36|P-value:1.26E-6 ID:SGTC_1743|Compound:st037606|FD-Score:7.09|P-value:3.20E-5 ID:SGTC_1752|Compound:st044819|FD-Score:17.10|P-value:4.98E-22 ID:SGTC_1754|Compound:st042065|FD-Score:8.12|P-value:2.42E-6 ID:SGTC_1760|Compound:st045453|FD-Score:12.60|P-value:7.44E-13 ID:SGTC_1764|Compound:st044502|FD-Score:17.00|P-value:7.98E-22 ID:SGTC_1788|Compound:fluconazole|FD-Score:6.17|P-value:2.48E-4 ID:SGTC_1803|Compound:st050068|FD-Score:5.95|P-value:3.90E-4 ID:SGTC_1846|Compound:st056244|FD-Score:7.23|P-value:2.30E-5 ID:SGTC_1870|Compound:st057514|FD-Score:6.05|P-value:3.17E-4 ID:SGTC_1892|Compound:st058411|FD-Score:12.70|P-value:4.66E-13 ID:SGTC_1900|Compound:st060200|FD-Score:5.87|P-value:4.61E-4 ID:SGTC_1991|Compound:st073000|FD-Score:7.65|P-value:8.29E-6 ID:SGTC_2010|Compound:4012422|FD-Score:-5.71|P-value:8.19E-4 ID:SGTC_2013|Compound:4024628|FD-Score:6.98|P-value:4.19E-5 ID:SGTC_2031|Compound:5180455|FD-Score:8.84|P-value:3.32E-7 ID:SGTC_2067|Compound:5224629|FD-Score:-7.40|P-value:2.12E-5 ID:SGTC_2074|Compound:5212007|FD-Score:5.96|P-value:3.86E-4 ID:SGTC_2124|Compound:5246320|FD-Score:9.01|P-value:1.99E-7 ID:SGTC_2299|Compound:7976368|FD-Score:5.93|P-value:4.09E-4 ID:SGTC_2350|Compound:9023895|FD-Score:9.78|P-value:1.93E-8 ID:SGTC_2361|Compound:9034121|FD-Score:6.67|P-value:8.50E-5 ID:SGTC_2377|Compound:9073351|FD-Score:6.23|P-value:2.17E-4 ID:SGTC_2389|Compound:9091542|FD-Score:6.49|P-value:1.25E-4 ID:SGTC_2396|Compound:5342950|FD-Score:7.09|P-value:3.25E-5 ID:SGTC_2397|Compound:5161689|FD-Score:-8.35|P-value:1.88E-6 ID:SGTC_2401|Compound:5128683|FD-Score:-6.50|P-value:1.65E-4 ID:SGTC_2414|Compound:st077232|FD-Score:-13.30|P-value:6.82E-14 ID:SGTC_2415|Compound:st077333|FD-Score:7.49|P-value:1.24E-5 ID:SGTC_2481|Compound:5478948|FD-Score:-6.84|P-value:7.71E-5 ID:SGTC_2483|Compound:5729050|FD-Score:12.90|P-value:2.56E-13 ID:SGTC_2487|Compound:5918373|FD-Score:13.40|P-value:3.02E-14 ID:SGTC_2495|Compound:cafestol|FD-Score:6.73|P-value:7.43E-5 ID:SGTC_2498|Compound:4'-Methoxychalcone|FD-Score:-6.63|P-value:1.24E-4 ID:SGTC_2499|Compound:avocadenofuran|FD-Score:-6.90|P-value:6.78E-5 ID:SGTC_2514|Compound:salinomycin|FD-Score:7.34|P-value:1.76E-5 ID:SGTC_2525|Compound:harmine|FD-Score:6.39|P-value:1.55E-4 ID:SGTC_2602|Compound:kawain|FD-Score:-5.69|P-value:8.43E-4 ID:SGTC_2633|Compound:5,7-dihydroxyisoflavone|FD-Score:7.71|P-value:7.13E-6 ID:SGTC_2647|Compound:atorvastatin|FD-Score:8.52|P-value:8.04E-7 ID:SGTC_2648|Compound:atorvastatin|FD-Score:8.09|P-value:2.62E-6 ID:SGTC_2665|Compound:lovastatin|FD-Score:5.75|P-value:5.79E-4 ID:SGTC_2695|Compound:st077686|FD-Score:-6.89|P-value:6.98E-5 ID:SGTC_2736|Compound:butenafine|FD-Score:5.58|P-value:8.13E-4 ID:SGTC_2753|Compound:fluvastatin|FD-Score:8.64|P-value:5.90E-7 ID:SGTC_2772|Compound:vinpocetine|FD-Score:-5.76|P-value:7.43E-4 ID:SGTC_2776|Compound:terbinafine|FD-Score:9.21|P-value:1.13E-7 ID:SGTC_2856|Compound:9022925|FD-Score:-6.48|P-value:1.72E-4 ID:SGTC_2900|Compound:5328528|FD-Score:5.56|P-value:8.46E-4 ID:SGTC_2902|Compound:5787006|FD-Score:7.44|P-value:1.38E-5 ID:SGTC_2925|Compound:9010536|FD-Score:5.75|P-value:5.85E-4 ID:SGTC_2928|Compound:9011484|FD-Score:7.03|P-value:3.67E-5 ID:SGTC_2953|Compound:9074162|FD-Score:-6.66|P-value:1.17E-4 ID:SGTC_3019|Compound:9081971|FD-Score:-6.17|P-value:3.28E-4 ID:SGTC_3105|Compound:9121040|FD-Score:8.09|P-value:2.64E-6 ID:SGTC_3253|Compound:9135987|FD-Score:-6.04|P-value:4.29E-4 ID:SGTC_3281|Compound:9140613|FD-Score:-5.95|P-value:5.10E-4 ID:SGTC_3298|Compound:9116858|FD-Score:-6.84|P-value:7.83E-5 ID:SGTC_3314|Compound:9135860|FD-Score:6.68|P-value:8.34E-5 ID:SGTC_3323|Compound:9138564|FD-Score:-6.67|P-value:1.13E-4 ID:SGTC_3330|Compound:9141424|FD-Score:-6.54|P-value:1.49E-4 ID:SGTC_3346|Compound:9158254|FD-Score:-6.53|P-value:1.53E-4 ID:SGTC_210|Compound:3551-0445|FD-Score:10.40|P-value:2.66E-9 ID:SGTC_227|Compound:fluconazole|FD-Score:6.61|P-value:9.68E-5 ID:SGTC_269|Compound:exalamide|FD-Score:9.54|P-value:4.09E-8 ID:SGTC_296|Compound:1222-0039|FD-Score:9.96|P-value:1.09E-8 ID:SGTC_305|Compound:1682-2595|FD-Score:5.85|P-value:4.76E-4 ID:SGTC_363|Compound:0455-0021|FD-Score:5.97|P-value:3.77E-4 ID:SGTC_417|Compound:st075190|FD-Score:8.17|P-value:2.14E-6 ID:SGTC_445|Compound:e6 berbamine|FD-Score:6.42|P-value:1.45E-4 ID:SGTC_451|Compound:chloral hydrate|FD-Score:5.54|P-value:8.75E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-6.00|P-value:4.65E-4 ID:SGTC_459|Compound:nigericin|FD-Score:9.96|P-value:1.07E-8 ID:SGTC_465|Compound:cgp-37157|FD-Score:-8.27|P-value:2.31E-6 ID:SGTC_467|Compound:ro 31-8220|FD-Score:-6.81|P-value:8.24E-5 ID:SGTC_482|Compound:fipronil|FD-Score:5.63|P-value:7.41E-4 ID:SGTC_487|Compound:nimodipine|FD-Score:-5.89|P-value:5.71E-4 ID:SGTC_489|Compound:paxilline|FD-Score:7.15|P-value:2.80E-5 ID:SGTC_504|Compound:lovastatin|FD-Score:6.86|P-value:5.54E-5 ID:SGTC_524|Compound:r073-0010|FD-Score:7.75|P-value:6.30E-6 ID:SGTC_561|Compound:1550-0330|FD-Score:6.23|P-value:2.17E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:9.10|P-value:1.55E-7 ID:SGTC_576|Compound:1073-0113|FD-Score:9.95|P-value:1.10E-8 ID:SGTC_617|Compound:3770-0098|FD-Score:8.47|P-value:9.31E-7 ID:SGTC_637|Compound:1181-0519|FD-Score:11.60|P-value:3.78E-11 ID:SGTC_639|Compound:0833-0042|FD-Score:8.35|P-value:1.32E-6 ID:SGTC_682|Compound:0kpi-0099|FD-Score:13.80|P-value:5.19E-15 ID:SGTC_688|Compound:0527-0193|FD-Score:6.06|P-value:3.11E-4 ID:SGTC_689|Compound:0833-0039|FD-Score:5.47|P-value:9.95E-4 ID:SGTC_699|Compound:0375-0592|FD-Score:7.65|P-value:8.20E-6 ID:SGTC_727|Compound:3032-0951|FD-Score:8.83|P-value:3.39E-7 ID:SGTC_768|Compound:0384-0033|FD-Score:10.30|P-value:3.66E-9 ID:SGTC_788|Compound:1182-0090|FD-Score:5.86|P-value:4.64E-4 ID:SGTC_813|Compound:k007-0158|FD-Score:9.34|P-value:7.45E-8 ID:SGTC_834|Compound:0312-0008|FD-Score:5.79|P-value:5.37E-4 ID:SGTC_871|Compound:0574-0004|FD-Score:9.00|P-value:2.04E-7 ID:SGTC_875|Compound:0709-0210|FD-Score:12.70|P-value:5.87E-13 ID:SGTC_888|Compound:0916-0002|FD-Score:7.46|P-value:1.31E-5 ID:SGTC_917|Compound:harmaline|FD-Score:12.70|P-value:4.73E-13 ID:SGTC_959|Compound:1222-0044|FD-Score:6.55|P-value:1.10E-4 ID:SGTC_1026|Compound:k007-1105|FD-Score:9.28|P-value:9.12E-8 ID:SGTC_1036|Compound:k216-0215|FD-Score:9.10|P-value:1.55E-7 ID:SGTC_1055|Compound:3448-0672|FD-Score:11.40|P-value:8.54E-11 ID:SGTC_1086|Compound:cerivastatin|FD-Score:5.87|P-value:4.61E-4 ID:SGTC_1097|Compound:itavastatin|FD-Score:10.40|P-value:2.91E-9 ID:SGTC_1144|Compound:3486-0183|FD-Score:7.26|P-value:2.16E-5 ID:SGTC_1237|Compound:0330-0133|FD-Score:6.12|P-value:2.74E-4 ID:SGTC_1317|Compound:1273-0028|FD-Score:7.49|P-value:1.21E-5 ID:SGTC_1352|Compound:1496-0991|FD-Score:-6.57|P-value:1.41E-4 ID:SGTC_1394|Compound:3474-0001|FD-Score:8.13|P-value:2.34E-6 ID:SGTC_1495|Compound:4469-0029|FD-Score:5.72|P-value:6.13E-4 ID:SGTC_1547|Compound:harmine|FD-Score:10.80|P-value:7.44E-10 ID:SGTC_1581|Compound:himbacine|FD-Score:7.77|P-value:6.08E-6 ID:SGTC_1586|Compound:deoxycorticosterone acetate|FD-Score:5.72|P-value:6.18E-4 ID:SGTC_1595|Compound:6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin|FD-Score:15.40|P-value:2.49E-18 ID:SGTC_1638|Compound:st008370|FD-Score:8.36|P-value:1.26E-6 ID:SGTC_1743|Compound:st037606|FD-Score:7.09|P-value:3.20E-5 ID:SGTC_1752|Compound:st044819|FD-Score:17.10|P-value:4.98E-22 ID:SGTC_1754|Compound:st042065|FD-Score:8.12|P-value:2.42E-6 ID:SGTC_1760|Compound:st045453|FD-Score:12.60|P-value:7.44E-13 ID:SGTC_1764|Compound:st044502|FD-Score:17.00|P-value:7.98E-22 ID:SGTC_1788|Compound:fluconazole|FD-Score:6.17|P-value:2.48E-4 ID:SGTC_1803|Compound:st050068|FD-Score:5.95|P-value:3.90E-4 ID:SGTC_1846|Compound:st056244|FD-Score:7.23|P-value:2.30E-5 ID:SGTC_1870|Compound:st057514|FD-Score:6.05|P-value:3.17E-4 ID:SGTC_1892|Compound:st058411|FD-Score:12.70|P-value:4.66E-13 ID:SGTC_1900|Compound:st060200|FD-Score:5.87|P-value:4.61E-4 ID:SGTC_1991|Compound:st073000|FD-Score:7.65|P-value:8.29E-6 ID:SGTC_2010|Compound:4012422|FD-Score:-5.71|P-value:8.19E-4 ID:SGTC_2013|Compound:4024628|FD-Score:6.98|P-value:4.19E-5 ID:SGTC_2031|Compound:5180455|FD-Score:8.84|P-value:3.32E-7 ID:SGTC_2067|Compound:5224629|FD-Score:-7.40|P-value:2.12E-5 ID:SGTC_2074|Compound:5212007|FD-Score:5.96|P-value:3.86E-4 ID:SGTC_2124|Compound:5246320|FD-Score:9.01|P-value:1.99E-7 ID:SGTC_2299|Compound:7976368|FD-Score:5.93|P-value:4.09E-4 ID:SGTC_2350|Compound:9023895|FD-Score:9.78|P-value:1.93E-8 ID:SGTC_2361|Compound:9034121|FD-Score:6.67|P-value:8.50E-5 ID:SGTC_2377|Compound:9073351|FD-Score:6.23|P-value:2.17E-4 ID:SGTC_2389|Compound:9091542|FD-Score:6.49|P-value:1.25E-4 ID:SGTC_2396|Compound:5342950|FD-Score:7.09|P-value:3.25E-5 ID:SGTC_2397|Compound:5161689|FD-Score:-8.35|P-value:1.88E-6 ID:SGTC_2401|Compound:5128683|FD-Score:-6.50|P-value:1.65E-4 ID:SGTC_2414|Compound:st077232|FD-Score:-13.30|P-value:6.82E-14 ID:SGTC_2415|Compound:st077333|FD-Score:7.49|P-value:1.24E-5 ID:SGTC_2481|Compound:5478948|FD-Score:-6.84|P-value:7.71E-5 ID:SGTC_2483|Compound:5729050|FD-Score:12.90|P-value:2.56E-13 ID:SGTC_2487|Compound:5918373|FD-Score:13.40|P-value:3.02E-14 ID:SGTC_2495|Compound:cafestol|FD-Score:6.73|P-value:7.43E-5 ID:SGTC_2498|Compound:4'-Methoxychalcone|FD-Score:-6.63|P-value:1.24E-4 ID:SGTC_2499|Compound:avocadenofuran|FD-Score:-6.90|P-value:6.78E-5 ID:SGTC_2514|Compound:salinomycin|FD-Score:7.34|P-value:1.76E-5 ID:SGTC_2525|Compound:harmine|FD-Score:6.39|P-value:1.55E-4 ID:SGTC_2602|Compound:kawain|FD-Score:-5.69|P-value:8.43E-4 ID:SGTC_2633|Compound:5,7-dihydroxyisoflavone|FD-Score:7.71|P-value:7.13E-6 ID:SGTC_2647|Compound:atorvastatin|FD-Score:8.52|P-value:8.04E-7 ID:SGTC_2648|Compound:atorvastatin|FD-Score:8.09|P-value:2.62E-6 ID:SGTC_2665|Compound:lovastatin|FD-Score:5.75|P-value:5.79E-4 ID:SGTC_2695|Compound:st077686|FD-Score:-6.89|P-value:6.98E-5 ID:SGTC_2736|Compound:butenafine|FD-Score:5.58|P-value:8.13E-4 ID:SGTC_2753|Compound:fluvastatin|FD-Score:8.64|P-value:5.90E-7 ID:SGTC_2772|Compound:vinpocetine|FD-Score:-5.76|P-value:7.43E-4 ID:SGTC_2776|Compound:terbinafine|FD-Score:9.21|P-value:1.13E-7 ID:SGTC_2856|Compound:9022925|FD-Score:-6.48|P-value:1.72E-4 ID:SGTC_2900|Compound:5328528|FD-Score:5.56|P-value:8.46E-4 ID:SGTC_2902|Compound:5787006|FD-Score:7.44|P-value:1.38E-5 ID:SGTC_2925|Compound:9010536|FD-Score:5.75|P-value:5.85E-4 ID:SGTC_2928|Compound:9011484|FD-Score:7.03|P-value:3.67E-5 ID:SGTC_2953|Compound:9074162|FD-Score:-6.66|P-value:1.17E-4 ID:SGTC_3019|Compound:9081971|FD-Score:-6.17|P-value:3.28E-4 ID:SGTC_3105|Compound:9121040|FD-Score:8.09|P-value:2.64E-6 ID:SGTC_3253|Compound:9135987|FD-Score:-6.04|P-value:4.29E-4 ID:SGTC_3281|Compound:9140613|FD-Score:-5.95|P-value:5.10E-4 ID:SGTC_3298|Compound:9116858|FD-Score:-6.84|P-value:7.83E-5 ID:SGTC_3314|Compound:9135860|FD-Score:6.68|P-value:8.34E-5 ID:SGTC_3323|Compound:9138564|FD-Score:-6.67|P-value:1.13E-4 ID:SGTC_3330|Compound:9141424|FD-Score:-6.54|P-value:1.49E-4 ID:SGTC_3346|Compound:9158254|FD-Score:-6.53|P-value:1.53E-4

Top fitness defect scores for YPL069C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1752 st044819 17.10 83.0 µM 4.98E-22 1 9.69E-66
2 SGTC_1764 st044502 17.00 93.5 µM 7.98E-22 1 4.31E-65
3 SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 15.40 67.5 µM 2.49E-18 1 5.11E-54
4 SGTC_682 0kpi-0099 13.80 17.0 µM 5.19E-15 2 1.58E-43
5 SGTC_2487 5918373 13.40 44.0 µM 3.02E-14 1 4.09E-41
6 SGTC_2483 5729050 12.90 27.2 µM 2.56E-13 1 3.47E-38
7 SGTC_1892 st058411 12.70 7.4 µM 4.66E-13 1 2.29E-37
8 SGTC_917 harmaline 12.70 728.1 nM 4.73E-13 ergosterol biosynthesis 1 2.40E-37
9 SGTC_875 0709-0210 12.70 25.7 µM 5.87E-13 fatty acid desaturase (OLE1) 3 4.73E-37
10 SGTC_1760 st045453 12.60 10.4 µM 7.44E-13 NEO1-PIK1 20 9.95E-37
11 SGTC_637 1181-0519 11.60 7.3 µM 3.78E-11 fatty acid desaturase (OLE1) 15 2.31E-31
12 SGTC_1055 3448-0672 11.40 86.0 µM 8.54E-11 2 2.99E-30
13 SGTC_1547 harmine 10.80 94.2 µM 7.44E-10 ergosterol biosynthesis 3 2.66E-27
14 SGTC_210 3551-0445 10.40 56.8 µM 2.66E-9 14 1.44E-25
15 SGTC_1097 itavastatin 10.40 7.2 µM 2.91E-9 azole & statin 3 1.90E-25
16 SGTC_768 0384-0033 10.30 77.3 µM 3.66E-9 fatty acid desaturase (OLE1) 13 3.90E-25
17 SGTC_459 nigericin 9.96 15.3 µM 1.07E-8 5 1.10E-23
18 SGTC_296 1222-0039 9.96 74.9 µM 1.09E-8 1 1.18E-23
19 SGTC_576 1073-0113 9.95 22.7 µM 1.10E-8 redox potentiating 2 1.22E-23
20 SGTC_2350 9023895 9.78 38.9 µM 1.93E-8 ergosterol biosynthesis 1 7.01E-23

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.198 5.34E-31 YJL204C RCY1 hom F-box protein involved in recycling plasma membrane proteins internalized by endocytosis; localized to sites of polarized growth
0.191 8.49E-29 YHR072W ERG7 het Lanosterol synthase, an essential enzyme that catalyzes the cyclization of squalene 2,3-epoxide, a step in ergosterol biosynthesis
0.190 1.57E-28 YML075C HMG1 hom HMG-CoA reductase; catalyzes the conversion of HMG-CoA to mevalonate, which is a rate-limiting step in sterol biosynthesis; one of two isozymes; localizes to the nuclear envelope; overproduction induces the formation of karmellae; forms foci at the nuclear periphery upon DNA replication stress
0.189 2.91E-28 YHR007C ERG11 het Lanosterol 14-alpha-demethylase; catalyzes the C-14 demethylation of lanosterol to form 4,4''-dimethyl cholesta-8,14,24-triene-3-beta-ol in the ergosterol biosynthesis pathway; member of the cytochrome P450 family; associated and coordinately regulated with the P450 reductase Ncp1p
0.176 1.04E-24 YER031C YPT31 hom Rab family GTPase; involved in the exocytic pathway; mediates intra-Golgi traffic or the budding of post-Golgi vesicles from the trans-Golgi; YPT31 has a paralog, YPT32, that arose from the whole genome duplication
0.175 2.27E-24 YGL045W RIM8 hom Protein involved in proteolytic activation of Rim101p in response to alkaline pH; interacts with ESCRT-1 subunits Stp22p and Vps28p; essential for anaerobic growth; member of the arrestin-related trafficking adaptor family
0.172 9.83E-24 YGR122W YGR122W hom Protein that may be involved in pH regulation; probable ortholog of A. nidulans PalC, which is involved in pH regulation and binds to the ESCRT-III complex; null mutant does not properly process Rim101p and has decreased resistance to rapamycin; GFP-fusion protein is cytoplasmic; relative distribution to cytoplasm increases upon DNA replication stress
0.169 8.15E-23 YMR154C RIM13 hom Calpain-like cysteine protease; involved in proteolytic activation of Rim101p in response to alkaline pH; localizes to punctate structures in alkaline conditions and in vps4 mutant; has similarity to A. nidulans palB
0.164 1.73E-21 YML126C ERG13 het 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) synthase, catalyzes the formation of HMG-CoA from acetyl-CoA and acetoacetyl-CoA; involved in the second step in mevalonate biosynthesis
0.163 2.39E-21 YJR102C VPS25 hom Component of the ESCRT-II complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome
0.158 3.00E-20 YHL027W RIM101 hom Cys2His2 zinc-finger transcriptional repressor; involved in alkaline responsive gene repression as part of adaptation to a alkaline conditions; involved in cell wall assembly; required for alkaline pH-stimulated haploid invasive growth and sporulation; activated by alkaline-dependent proteolytic processing which results in removal of the C-terminal tail; similar to A. nidulans PacC
0.158 4.92E-20 YCR094W CDC50 hom Endosomal protein that interacts with phospholipid flippase Drs2p; interaction with Cdc50p is essential for Drs2p catalytic activity; mutations affect cell polarity and polarized growth; similar to Lem3p; CDC50 has a paralog, YNR048W, that arose from the whole genome duplication
0.156 1.34E-19 YPL065W VPS28 hom Component of the ESCRT-I complex (Stp22p, Srn2p, Vps28p, and Mvb12p), which is involved in ubiquitin-dependent sorting of proteins into the endosome; conserved C-terminal domain interacts with ESCRT-III subunit Vps20p
0.152 8.46E-19 YLR025W SNF7 hom One of four subunits of the endosomal sorting complex required for transport III (ESCRT-III); involved in the sorting of transmembrane proteins into the multivesicular body (MVB) pathway; recruited from the cytoplasm to endosomal membranes
0.152 9.24E-19 YNL294C RIM21 hom pH sensor molecule, component of the RIM101 pathway; has a role in cell wall construction and alkaline pH response; is glycosylated and phosphorylated; interacts with Dfg16p and Rim9p to form a pH-sensing complex; localization to the plasma membrane is dependent on Dfg16p and Rim9p; has similarity to A. nidulans PalH