YPL070W / MUK1

Cytoplasmic protein of unknown function containing a Vps9 domain; computational analysis of large-scale protein-protein interaction data suggests a possible role in transcriptional regulation

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL070W / MUK1

Click on Significant Values for Screen Details ID:SGTC_43|Compound:0570-0105|FD-Score:-3.08|P-value:5.14E-4 ID:SGTC_183|Compound:3914-0051|FD-Score:4.33|P-value:2.04E-6 ID:SGTC_280|Compound:3448-3607|FD-Score:3.43|P-value:1.32E-4 ID:SGTC_284|Compound:0988-0104|FD-Score:3.00|P-value:7.24E-4 ID:SGTC_286|Compound:k060-0067|FD-Score:-3.15|P-value:3.88E-4 ID:SGTC_303|Compound:1348-1668|FD-Score:-4.44|P-value:1.09E-6 ID:SGTC_316|Compound:k060-0003|FD-Score:3.84|P-value:2.28E-5 ID:SGTC_548|Compound:1436-0017|FD-Score:3.08|P-value:5.37E-4 ID:SGTC_725|Compound:1497-0963|FD-Score:3.02|P-value:6.76E-4 ID:SGTC_941|Compound:3237-0776|FD-Score:6.62|P-value:9.16E-13 ID:SGTC_1116|Compound:jasmonic acid|FD-Score:4.16|P-value:4.81E-6 ID:SGTC_1455|Compound:4262-0120|FD-Score:-3.04|P-value:5.85E-4 ID:SGTC_1514|Compound:1189-1591|FD-Score:-3.25|P-value:2.62E-4 ID:SGTC_1736|Compound:st036774|FD-Score:3.91|P-value:1.63E-5 ID:SGTC_1740|Compound:st038286|FD-Score:3.50|P-value:1.01E-4 ID:SGTC_1767|Compound:st044992|FD-Score:3.03|P-value:6.45E-4 ID:SGTC_1930|Compound:st074634|FD-Score:3.62|P-value:5.84E-5 ID:SGTC_1986|Compound:st071812|FD-Score:-3.33|P-value:1.92E-4 ID:SGTC_2052|Compound:5265182|FD-Score:3.31|P-value:2.19E-4 ID:SGTC_2055|Compound:5235184|FD-Score:3.36|P-value:1.81E-4 ID:SGTC_2438|Compound:5259590|FD-Score:-3.06|P-value:5.52E-4 ID:SGTC_2496|Compound:diffractaic acid|FD-Score:2.95|P-value:8.58E-4 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:-3.07|P-value:5.33E-4 ID:SGTC_2686|Compound:alizarin|FD-Score:-3.71|P-value:3.72E-5 ID:SGTC_2690|Compound:usnic acid|FD-Score:2.94|P-value:8.94E-4 ID:SGTC_2955|Compound:9076254|FD-Score:3.47|P-value:1.12E-4 ID:SGTC_3329|Compound:9141233|FD-Score:5.13|P-value:2.51E-8 ID:SGTC_3332|Compound:9141069|FD-Score:4.54|P-value:6.77E-7 ID:SGTC_3352|Compound:9151559|FD-Score:3.50|P-value:9.78E-5 ID:SGTC_3353|Compound:9151644|FD-Score:-4.10|P-value:6.19E-6 ID:SGTC_43|Compound:0570-0105|FD-Score:-3.08|P-value:5.14E-4 ID:SGTC_183|Compound:3914-0051|FD-Score:4.33|P-value:2.04E-6 ID:SGTC_280|Compound:3448-3607|FD-Score:3.43|P-value:1.32E-4 ID:SGTC_284|Compound:0988-0104|FD-Score:3.00|P-value:7.24E-4 ID:SGTC_286|Compound:k060-0067|FD-Score:-3.15|P-value:3.88E-4 ID:SGTC_303|Compound:1348-1668|FD-Score:-4.44|P-value:1.09E-6 ID:SGTC_316|Compound:k060-0003|FD-Score:3.84|P-value:2.28E-5 ID:SGTC_548|Compound:1436-0017|FD-Score:3.08|P-value:5.37E-4 ID:SGTC_725|Compound:1497-0963|FD-Score:3.02|P-value:6.76E-4 ID:SGTC_941|Compound:3237-0776|FD-Score:6.62|P-value:9.16E-13 ID:SGTC_1116|Compound:jasmonic acid|FD-Score:4.16|P-value:4.81E-6 ID:SGTC_1455|Compound:4262-0120|FD-Score:-3.04|P-value:5.85E-4 ID:SGTC_1514|Compound:1189-1591|FD-Score:-3.25|P-value:2.62E-4 ID:SGTC_1736|Compound:st036774|FD-Score:3.91|P-value:1.63E-5 ID:SGTC_1740|Compound:st038286|FD-Score:3.50|P-value:1.01E-4 ID:SGTC_1767|Compound:st044992|FD-Score:3.03|P-value:6.45E-4 ID:SGTC_1930|Compound:st074634|FD-Score:3.62|P-value:5.84E-5 ID:SGTC_1986|Compound:st071812|FD-Score:-3.33|P-value:1.92E-4 ID:SGTC_2052|Compound:5265182|FD-Score:3.31|P-value:2.19E-4 ID:SGTC_2055|Compound:5235184|FD-Score:3.36|P-value:1.81E-4 ID:SGTC_2438|Compound:5259590|FD-Score:-3.06|P-value:5.52E-4 ID:SGTC_2496|Compound:diffractaic acid|FD-Score:2.95|P-value:8.58E-4 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:-3.07|P-value:5.33E-4 ID:SGTC_2686|Compound:alizarin|FD-Score:-3.71|P-value:3.72E-5 ID:SGTC_2690|Compound:usnic acid|FD-Score:2.94|P-value:8.94E-4 ID:SGTC_2955|Compound:9076254|FD-Score:3.47|P-value:1.12E-4 ID:SGTC_3329|Compound:9141233|FD-Score:5.13|P-value:2.51E-8 ID:SGTC_3332|Compound:9141069|FD-Score:4.54|P-value:6.77E-7 ID:SGTC_3352|Compound:9151559|FD-Score:3.50|P-value:9.78E-5 ID:SGTC_3353|Compound:9151644|FD-Score:-4.10|P-value:6.19E-6

Top fitness defect scores for YPL070W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_941 3237-0776 6.62 460.0 µM 9.16E-13 2 1.75E-11
2 SGTC_3329 9141233 5.13 27.6 µM 2.51E-8 3 1.49E-7
3 SGTC_3332 9141069 4.54 11.2 µM 6.77E-7 6 2.76E-6
4 SGTC_183 3914-0051 4.33 30.6 µM 2.04E-6 60S ribosome export 13 7.35E-6
5 SGTC_1116 jasmonic acid 4.16 1.6 µM 4.81E-6 19 1.57E-5
6 SGTC_1736 st036774 3.91 51.0 µM 1.63E-5 33 4.64E-5
7 SGTC_316 k060-0003 3.84 58.6 µM 2.28E-5 17 6.27E-5
8 SGTC_1930 st074634 3.62 34.3 µM 5.84E-5 RNA pol III & RNase P/MRP 49 1.45E-4
9 SGTC_3352 9151559 3.50 45.6 µM 9.78E-5 21 2.29E-4
10 SGTC_1740 st038286 3.50 13.2 µM 1.01E-4 44 2.35E-4
11 SGTC_2955 9076254 3.47 12.2 µM 1.12E-4 28 2.58E-4
12 SGTC_280 3448-3607 3.43 3.0 µM 1.32E-4 60S ribosome export 21 2.99E-4
13 SGTC_2055 5235184 3.36 200.0 µM 1.81E-4 ERG2 57 3.95E-4
14 SGTC_2052 5265182 3.31 7.1 µM 2.19E-4 50 4.68E-4
15 SGTC_548 1436-0017 3.08 110.0 µM 5.37E-4 TSC3-RPN4 76 0.00104
16 SGTC_1767 st044992 3.03 70.3 µM 6.45E-4 59 0.00123
17 SGTC_725 1497-0963 3.02 19.0 µM 6.76E-4 copper-dependent oxidative stress 55 0.00128
18 SGTC_284 0988-0104 3.00 32.6 µM 7.24E-4 heme requiring 34 0.00136
19 SGTC_2496 diffractaic acid 2.95 79.8 µM 8.58E-4 64 0.00158
20 SGTC_2690 usnic acid 2.94 100.0 µM 8.94E-4 81 0.00164

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.125 3.08E-13 YBR273C UBX7 hom UBX (ubiquitin regulatory X) domain-containing protein; interacts with Cdc48p; UBX7 has a paralog, UBX6, that arose from the whole genome duplication
0.114 3.20E-11 YJL152W_d YJL152W_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.104 1.77E-9 YGL184C STR3 hom Peroxisomal cystathionine beta-lyase, converts cystathionine into homocysteine; may be redox regulated by Gto1p
0.102 3.52E-9 YML099C ARG81 hom Zinc-finger transcription factor of the Zn(2)-Cys(6) binuclear cluster domain type, involved in the regulation of arginine-responsive genes; acts with Arg80p and Arg82p
0.094 5.18E-8 YPR168W NUT2 het Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; required for transcriptional activation and has a role in basal transcription; protein abundance increases in response to DNA replication stress
0.091 1.18E-7 YDR169C STB3 hom Ribosomal RNA processing element (RRPE)-binding protein; involved in the glucose-induced transition from quiescence to growth; restricted to nucleus in quiescent cells, released into cytoplasm after glucose repletion; binds Sin3p; relative distribution to the nucleus increases upon DNA replication stress
0.088 3.26E-7 YJL020C BBC1 hom Protein possibly involved in assembly of actin patches; interacts with an actin assembly factor Las17p and with the SH3 domains of Type I myosins Myo3p and Myo5p; localized predominantly to cortical actin patches
0.087 3.91E-7 YCR068W ATG15 hom Lipase required for intravacuolar lysis of autophagic bodies and Cvt bodies; targeted to intravacuolar vesicles during autophagy via the multivesicular body (MVB) pathway
0.083 1.50E-6 YPL123C RNY1 hom Vacuolar RNase of the T(2) family, relocalizes to the cytosol where it cleaves tRNAs upon oxidative or stationary phase stress; promotes apoptosis under stress conditions and this function is independent of its catalytic activity
0.083 1.62E-6 YNL103W MET4 het Leucine-zipper transcriptional activator, responsible for the regulation of the sulfur amino acid pathway, requires different combinations of the auxiliary factors Cbf1p, Met28p, Met31p and Met32p
0.082 1.88E-6 YNR009W NRM1 hom Transcriptional co-repressor of MBF (MCB binding factor)-regulated gene expression; Nrm1p associates stably with promoters via MBF to repress transcription upon exit from G1 phase
0.081 2.59E-6 YNL311C SKP2 hom F-box protein of unknown function predicted to be part of an SCF ubiquitin protease complex; involved in regulating protein levels of sulfur metabolism enzymes; may interact with ribosomes, based on co-purification experiments
0.080 3.10E-6 YAR035W YAT1 hom Outer mitochondrial carnitine acetyltransferase, minor ethanol-inducible enzyme involved in transport of activated acyl groups from the cytoplasm into the mitochondrial matrix; phosphorylated
0.080 3.75E-6 YHR188C GPI16 het Transmembrane protein subunit of the glycosylphosphatidylinositol transamidase complex that adds GPIs to newly synthesized proteins; human PIG-Tp homolog
0.078 6.25E-6 YEL068C_p YEL068C_p hom Protein of unknown function; expressed at both mRNA and protein levels