YPL072W / UBP16

Deubiquitinating enzyme anchored to the outer mitochondrial membrane, probably not important for general mitochondrial functioning, but may perform a more specialized function at mitochondria

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL072W / UBP16

Click on Significant Values for Screen Details ID:SGTC_44|Compound:0929-0055|FD-Score:3.53|P-value:1.06E-4 ID:SGTC_77|Compound:0828-0286|FD-Score:-3.39|P-value:2.70E-4 ID:SGTC_378|Compound:3970-0959|FD-Score:3.14|P-value:4.73E-4 ID:SGTC_383|Compound:2324-0395|FD-Score:-3.40|P-value:2.55E-4 ID:SGTC_425|Compound:3825-7017|FD-Score:-3.48|P-value:1.87E-4 ID:SGTC_664|Compound:1222-0054|FD-Score:3.92|P-value:1.95E-5 ID:SGTC_717|Compound:1532-0246|FD-Score:3.41|P-value:1.70E-4 ID:SGTC_839|Compound:0122-0028|FD-Score:4.23|P-value:4.52E-6 ID:SGTC_842|Compound:0271-0008|FD-Score:5.16|P-value:3.27E-8 ID:SGTC_936|Compound:3005-4620|FD-Score:2.99|P-value:8.30E-4 ID:SGTC_979|Compound:1426-2828|FD-Score:3.23|P-value:3.39E-4 ID:SGTC_1064|Compound:honokiol|FD-Score:3.36|P-value:2.05E-4 ID:SGTC_1070|Compound:indatraline|FD-Score:3.55|P-value:9.63E-5 ID:SGTC_1136|Compound:pergolide|FD-Score:4.69|P-value:4.42E-7 ID:SGTC_1161|Compound:k007-0610|FD-Score:3.12|P-value:5.18E-4 ID:SGTC_1243|Compound:0416-0003|FD-Score:3.12|P-value:5.11E-4 ID:SGTC_1377|Compound:2944-0135|FD-Score:3.01|P-value:7.65E-4 ID:SGTC_1650|Compound:st011916|FD-Score:-3.20|P-value:5.43E-4 ID:SGTC_1809|Compound:st050081|FD-Score:-3.95|P-value:2.65E-5 ID:SGTC_1817|Compound:st052116|FD-Score:-3.64|P-value:9.92E-5 ID:SGTC_1841|Compound:st054148|FD-Score:3.17|P-value:4.18E-4 ID:SGTC_2233|Compound:sulbentine|FD-Score:4.12|P-value:7.68E-6 ID:SGTC_2286|Compound:7945697|FD-Score:3.04|P-value:6.89E-4 ID:SGTC_2313|Compound:7726885|FD-Score:4.43|P-value:1.76E-6 ID:SGTC_2369|Compound:9071472|FD-Score:4.67|P-value:4.94E-7 ID:SGTC_2378|Compound:9074213|FD-Score:3.74|P-value:4.38E-5 ID:SGTC_2438|Compound:5259590|FD-Score:3.29|P-value:2.65E-4 ID:SGTC_2528|Compound:xanthyletin|FD-Score:-4.01|P-value:2.02E-5 ID:SGTC_2539|Compound:epi(13)torulosol|FD-Score:6.49|P-value:6.00E-12 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:3.32|P-value:2.36E-4 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:3.31|P-value:2.45E-4 ID:SGTC_2596|Compound:sinensetin|FD-Score:-4.40|P-value:3.21E-6 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:5.06|P-value:6.05E-8 ID:SGTC_2696|Compound:st077691|FD-Score:4.27|P-value:3.75E-6 ID:SGTC_2699|Compound:st077704|FD-Score:4.10|P-value:8.38E-6 ID:SGTC_2725|Compound:haloperidol|FD-Score:-3.35|P-value:3.11E-4 ID:SGTC_2810|Compound:7959871|FD-Score:4.08|P-value:9.17E-6 ID:SGTC_2896|Compound:9052656|FD-Score:3.75|P-value:4.21E-5 ID:SGTC_2918|Compound:7977171|FD-Score:5.20|P-value:2.73E-8 ID:SGTC_2966|Compound:9084041|FD-Score:3.33|P-value:2.33E-4 ID:SGTC_2981|Compound:9013952|FD-Score:3.32|P-value:2.40E-4 ID:SGTC_2985|Compound:9022375|FD-Score:3.17|P-value:4.29E-4 ID:SGTC_3093|Compound:9117344|FD-Score:3.07|P-value:6.20E-4 ID:SGTC_3124|Compound:9127567|FD-Score:5.04|P-value:6.51E-8 ID:SGTC_3158|Compound:9100007|FD-Score:3.96|P-value:1.66E-5 ID:SGTC_3189|Compound:9110682|FD-Score:5.14|P-value:3.83E-8 ID:SGTC_3233|Compound:9132340|FD-Score:3.25|P-value:3.14E-4 ID:SGTC_3249|Compound:9135183|FD-Score:3.13|P-value:4.96E-4 ID:SGTC_3254|Compound:9136651|FD-Score:3.06|P-value:6.43E-4 ID:SGTC_3311|Compound:9131146|FD-Score:-3.72|P-value:7.00E-5 ID:SGTC_3324|Compound:9138759|FD-Score:4.02|P-value:1.26E-5 ID:SGTC_3344|Compound:9148862|FD-Score:-3.24|P-value:4.73E-4 ID:SGTC_3348|Compound:9149464|FD-Score:-3.78|P-value:5.48E-5 ID:SGTC_44|Compound:0929-0055|FD-Score:3.53|P-value:1.06E-4 ID:SGTC_77|Compound:0828-0286|FD-Score:-3.39|P-value:2.70E-4 ID:SGTC_378|Compound:3970-0959|FD-Score:3.14|P-value:4.73E-4 ID:SGTC_383|Compound:2324-0395|FD-Score:-3.40|P-value:2.55E-4 ID:SGTC_425|Compound:3825-7017|FD-Score:-3.48|P-value:1.87E-4 ID:SGTC_664|Compound:1222-0054|FD-Score:3.92|P-value:1.95E-5 ID:SGTC_717|Compound:1532-0246|FD-Score:3.41|P-value:1.70E-4 ID:SGTC_839|Compound:0122-0028|FD-Score:4.23|P-value:4.52E-6 ID:SGTC_842|Compound:0271-0008|FD-Score:5.16|P-value:3.27E-8 ID:SGTC_936|Compound:3005-4620|FD-Score:2.99|P-value:8.30E-4 ID:SGTC_979|Compound:1426-2828|FD-Score:3.23|P-value:3.39E-4 ID:SGTC_1064|Compound:honokiol|FD-Score:3.36|P-value:2.05E-4 ID:SGTC_1070|Compound:indatraline|FD-Score:3.55|P-value:9.63E-5 ID:SGTC_1136|Compound:pergolide|FD-Score:4.69|P-value:4.42E-7 ID:SGTC_1161|Compound:k007-0610|FD-Score:3.12|P-value:5.18E-4 ID:SGTC_1243|Compound:0416-0003|FD-Score:3.12|P-value:5.11E-4 ID:SGTC_1377|Compound:2944-0135|FD-Score:3.01|P-value:7.65E-4 ID:SGTC_1650|Compound:st011916|FD-Score:-3.20|P-value:5.43E-4 ID:SGTC_1809|Compound:st050081|FD-Score:-3.95|P-value:2.65E-5 ID:SGTC_1817|Compound:st052116|FD-Score:-3.64|P-value:9.92E-5 ID:SGTC_1841|Compound:st054148|FD-Score:3.17|P-value:4.18E-4 ID:SGTC_2233|Compound:sulbentine|FD-Score:4.12|P-value:7.68E-6 ID:SGTC_2286|Compound:7945697|FD-Score:3.04|P-value:6.89E-4 ID:SGTC_2313|Compound:7726885|FD-Score:4.43|P-value:1.76E-6 ID:SGTC_2369|Compound:9071472|FD-Score:4.67|P-value:4.94E-7 ID:SGTC_2378|Compound:9074213|FD-Score:3.74|P-value:4.38E-5 ID:SGTC_2438|Compound:5259590|FD-Score:3.29|P-value:2.65E-4 ID:SGTC_2528|Compound:xanthyletin|FD-Score:-4.01|P-value:2.02E-5 ID:SGTC_2539|Compound:epi(13)torulosol|FD-Score:6.49|P-value:6.00E-12 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:3.32|P-value:2.36E-4 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:3.31|P-value:2.45E-4 ID:SGTC_2596|Compound:sinensetin|FD-Score:-4.40|P-value:3.21E-6 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:5.06|P-value:6.05E-8 ID:SGTC_2696|Compound:st077691|FD-Score:4.27|P-value:3.75E-6 ID:SGTC_2699|Compound:st077704|FD-Score:4.10|P-value:8.38E-6 ID:SGTC_2725|Compound:haloperidol|FD-Score:-3.35|P-value:3.11E-4 ID:SGTC_2810|Compound:7959871|FD-Score:4.08|P-value:9.17E-6 ID:SGTC_2896|Compound:9052656|FD-Score:3.75|P-value:4.21E-5 ID:SGTC_2918|Compound:7977171|FD-Score:5.20|P-value:2.73E-8 ID:SGTC_2966|Compound:9084041|FD-Score:3.33|P-value:2.33E-4 ID:SGTC_2981|Compound:9013952|FD-Score:3.32|P-value:2.40E-4 ID:SGTC_2985|Compound:9022375|FD-Score:3.17|P-value:4.29E-4 ID:SGTC_3093|Compound:9117344|FD-Score:3.07|P-value:6.20E-4 ID:SGTC_3124|Compound:9127567|FD-Score:5.04|P-value:6.51E-8 ID:SGTC_3158|Compound:9100007|FD-Score:3.96|P-value:1.66E-5 ID:SGTC_3189|Compound:9110682|FD-Score:5.14|P-value:3.83E-8 ID:SGTC_3233|Compound:9132340|FD-Score:3.25|P-value:3.14E-4 ID:SGTC_3249|Compound:9135183|FD-Score:3.13|P-value:4.96E-4 ID:SGTC_3254|Compound:9136651|FD-Score:3.06|P-value:6.43E-4 ID:SGTC_3311|Compound:9131146|FD-Score:-3.72|P-value:7.00E-5 ID:SGTC_3324|Compound:9138759|FD-Score:4.02|P-value:1.26E-5 ID:SGTC_3344|Compound:9148862|FD-Score:-3.24|P-value:4.73E-4 ID:SGTC_3348|Compound:9149464|FD-Score:-3.78|P-value:5.48E-5

Top fitness defect scores for YPL072W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2539 epi(13)torulosol 6.49 80.0 µM 6.00E-12 3 4.22E-11
2 SGTC_2918 7977171 5.20 22.1 µM 2.73E-8 12 1.02E-7
3 SGTC_842 0271-0008 5.16 11.1 µM 3.27E-8 heme biosynthesis & mitochondrial translocase 10 1.21E-7
4 SGTC_3189 9110682 5.14 49.5 µM 3.83E-8 15 1.40E-7
5 SGTC_2598 perillyl alcohol 5.06 100.0 µM 6.05E-8 9 2.13E-7
6 SGTC_3124 9127567 5.04 49.5 µM 6.51E-8 DNA damage response 9 2.28E-7
7 SGTC_1136 pergolide 4.69 1.1 µM 4.42E-7 21 1.34E-6
8 SGTC_2369 9071472 4.67 200.0 µM 4.94E-7 8 1.48E-6
9 SGTC_2313 7726885 4.43 200.0 µM 1.76E-6 RPP1 & pyrimidine depletion 24 4.81E-6
10 SGTC_2696 st077691 4.27 74.3 µM 3.75E-6 21 9.66E-6
11 SGTC_839 0122-0028 4.23 230.0 µM 4.52E-6 RSC complex & mRNA processing 32 1.15E-5
12 SGTC_2233 sulbentine 4.12 40.4 µM 7.68E-6 55 1.87E-5
13 SGTC_2699 st077704 4.10 54.6 µM 8.38E-6 endomembrane recycling 45 2.03E-5
14 SGTC_2810 7959871 4.08 45.5 µM 9.17E-6 copper-dependent oxidative stress 35 2.21E-5
15 SGTC_3324 9138759 4.02 60.8 µM 1.26E-5 18 2.97E-5
16 SGTC_3158 9100007 3.96 49.5 µM 1.66E-5 20 3.83E-5
17 SGTC_664 1222-0054 3.92 14.9 µM 1.95E-5 sphingolipid biosynthesis & PDR1 38 4.44E-5
18 SGTC_2896 9052656 3.75 71.4 µM 4.21E-5 endomembrane recycling 131 9.02E-5
19 SGTC_2378 9074213 3.74 121.4 µM 4.38E-5 RSC complex & mRNA processing 23 9.35E-5
20 SGTC_1070 indatraline 3.55 8.8 µM 9.63E-5 60S ribosome export 38 1.94E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.109 2.13E-10 YKL004W AUR1 het Phosphatidylinositol:ceramide phosphoinositol transferase (IPC synthase), required for sphingolipid synthesis; can mutate to confer aureobasidin A resistance
0.096 2.33E-8 YLR101C_d YLR101C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified, essential ORF ERG27/YLR100W
0.095 3.13E-8 YIR013C GAT4 hom Protein containing GATA family zinc finger motifs
0.090 1.82E-7 YPL091W GLR1 hom Cytosolic and mitochondrial glutathione oxidoreductase; converts oxidized glutathione to reduced glutathione; mitochondrial but not cytosolic form has a role in resistance to hyperoxia; protein abundance increases in response to DNA replication stress
0.083 1.68E-6 YKR053C YSR3 hom Dihydrosphingosine 1-phosphate phosphatase; membrane protein involved in sphingolipid metabolism; YSR3 has a paralog, LCB3, that arose from the whole genome duplication
0.082 2.20E-6 YBR201W DER1 hom Endoplasmic reticulum membrane protein, required for ER-associated protein degradation of misfolded or unassembled proteins; N- and C- termini protrude into the cytoplasm, has similarity to Dfm1p
0.082 2.22E-6 YOR172W YRM1 hom Zn2-Cys6 zinc-finger transcription factor that activates genes involved in multidrug resistance; paralog of Yrr1p, acting on an overlapping set of target genes
0.081 2.60E-6 YKR070W_p YKR070W_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.080 3.30E-6 YIR025W MND2 hom Subunit of the anaphase-promoting complex (APC); necessary for maintaining sister chromatid cohesion in prophase I of meiosis by inhibiting premature ubiquitination and subsequent degradation of substrates by the APC(Ama1) ubiquitin ligase
0.079 4.17E-6 YPL130W SPO19 hom Meiosis-specific prospore protein; required to produce bending force necessary for proper assembly of the prospore membrane during sporulation; identified as a weak high-copy suppressor of the spo1-1 ts mutation
0.079 4.68E-6 YPL233W NSL1 het Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; required for accurate chromosome segregation
0.075 1.43E-5 YDR367W KEI1 het Component of inositol phosphorylceramide (IPC) synthase; forms a complex with Aur1p and regulates its activity; required for IPC synthase complex localization to the Golgi; post-translationally processed by Kex2p; KEI1 is an essential gene
0.072 3.02E-5 YBR176W ECM31 hom Ketopantoate hydroxymethyltransferase, required for pantothenic acid biosynthesis, converts 2-oxoisovalerate into 2-dehydropantoate
0.072 3.07E-5 YJR033C RAV1 hom Subunit of the RAVE complex (Rav1p, Rav2p, Skp1p), which promotes assembly of the V-ATPase holoenzyme; required for transport between the early and late endosome/PVC and for localization of TGN membrane proteins; potential Cdc28p substrate
0.071 4.32E-5 YDR126W SWF1 hom Palmitoyltransferase that acts on transmembrane proteins, including the SNAREs Snc1p, Syn8p, Tlg1p and likely all SNAREs; contains an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain; may have a role in vacuole fusion